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AR076029A1 - Anticuerpos anti- fcrh5 (receptor de translocacion asociado a la superfamilia de inmunoglobulina) e inmunoconjugados y metodos de uso - Google Patents

Anticuerpos anti- fcrh5 (receptor de translocacion asociado a la superfamilia de inmunoglobulina) e inmunoconjugados y metodos de uso

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Publication number
AR076029A1
AR076029A1 ARP100101079A ARP100101079A AR076029A1 AR 076029 A1 AR076029 A1 AR 076029A1 AR P100101079 A ARP100101079 A AR P100101079A AR P100101079 A ARP100101079 A AR P100101079A AR 076029 A1 AR076029 A1 AR 076029A1
Authority
AR
Argentina
Prior art keywords
hvr
sequence
seq
methods
immunocumpes
Prior art date
Application number
ARP100101079A
Other languages
English (en)
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42358044&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR076029(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of AR076029A1 publication Critical patent/AR076029A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/283—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against Fc-receptors, e.g. CD16, CD32, CD64
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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    • A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
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Abstract

La presente solicitud se refiere a composiciones del tema utiles para el tratamiento del tumor hematopoyético en los mamíferos y a los métodos que usan estas composiciones para lo mismo. Reivindicacion 1: Un anticuerpo anti-FcRH5 que comprende: (a) al menos una secuencia de HVR seleccionada del grupo que consiste en: (i) HVR-L1 que comprende la secuencia KASQDVSTAVA (SEQ ID Ns:26), (ii) HVR-L2 que comprende la secuencia SASYRYT (SEQ ID Ns:27), (iii) HVR-L3 que comprende la secuencia QQHFSSPRT (SEQ ID Ns:28), (iv) HVR-H1 que comprende la secuencia GFTFSSYAVS (SEQ ID Ns:35), (v) HVR-H2 que comprende la secuencia ATISSGGSLTFILDSVR (SEQ ID Ns:36), (vi) HVR-H3 que comprende la secuencia PIPDYYALDY (SEQ ID Ns:37); y (b) al menos una variante de HVR, en donde la variante de HVR comprende la modificacion de al menos un residuo de la secuencia descripta en la SEQ ID Ns: 26, 27, 28, 35, 36 o 37.
ARP100101079A 2009-04-01 2010-03-31 Anticuerpos anti- fcrh5 (receptor de translocacion asociado a la superfamilia de inmunoglobulina) e inmunoconjugados y metodos de uso AR076029A1 (es)

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