AR075988A1 - Compuesto de piridiloxi - pirrolidina inhibidor de recaptacion de serotonina y norepinefrina, composicion farmaceutica que lo comprende y su uso para la manufactura de un medicamento util para el tratamiento de dolor cronico - Google Patents
Compuesto de piridiloxi - pirrolidina inhibidor de recaptacion de serotonina y norepinefrina, composicion farmaceutica que lo comprende y su uso para la manufactura de un medicamento util para el tratamiento de dolor cronicoInfo
- Publication number
- AR075988A1 AR075988A1 ARP100101017A ARP100101017A AR075988A1 AR 075988 A1 AR075988 A1 AR 075988A1 AR P100101017 A ARP100101017 A AR P100101017A AR P100101017 A ARP100101017 A AR P100101017A AR 075988 A1 AR075988 A1 AR 075988A1
- Authority
- AR
- Argentina
- Prior art keywords
- manufacture
- pharmaceutical composition
- treatment
- chronic pain
- inhibitor
- Prior art date
Links
- 208000000094 Chronic Pain Diseases 0.000 title abstract 2
- 208000002193 Pain Diseases 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- RWRDLPDLKQPQOW-UHFFFAOYSA-N tetrahydropyrrole Natural products C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 229940126601 medicinal product Drugs 0.000 title 1
- 238000011084 recovery Methods 0.000 title 1
- QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 title 1
- -1 chloro, bromo, methyl Chemical group 0.000 abstract 4
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 2
- 125000001153 fluoro group Chemical group F* 0.000 abstract 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 2
- 125000006645 (C3-C4) cycloalkyl group Chemical group 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 229940121991 Serotonin and norepinephrine reuptake inhibitor Drugs 0.000 abstract 1
- 125000004981 cycloalkylmethyl group Chemical group 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 abstract 1
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Compuesto de piridiloxi-pirrolidina, inhibidor de recaptacion de serotonina y norepinefrina, de la formula (1) o una sal del mismo farmacéuticamente aceptable, donde R1 se selecciona a partir del grupo que consiste de n-propilo, isobutilo, cicloalquilo C3-4, y cicloalquilmetilo C3-4; n es 1 o 2; y cada R2 se selecciona independientemente a partir del grupo que consiste de fluoro, cloro, bromo, metilo, etilo, trifluorometilo, metoxi, etoxi, ciclopropilmetiloxi, trifluorometoxi, metilamino, ciclopropilamino y t-butilcarbonilamino, siempre que cuando n es 2, al menos uno de R2 es fluoro, cloro, bromo, metilo, etilo, trifluorometilo, metoxi, o etoxi. Composicion farmacéutica que lo comprende. Su uso para la manufactura de un medicamento util para el tratamiento de dolor cronico en un mamífero.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16807909P | 2009-04-09 | 2009-04-09 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR075988A1 true AR075988A1 (es) | 2011-05-11 |
Family
ID=42698378
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP100101017A AR075988A1 (es) | 2009-04-09 | 2010-03-29 | Compuesto de piridiloxi - pirrolidina inhibidor de recaptacion de serotonina y norepinefrina, composicion farmaceutica que lo comprende y su uso para la manufactura de un medicamento util para el tratamiento de dolor cronico |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US8173821B2 (es) |
| EP (1) | EP2417124B1 (es) |
| JP (1) | JP2012523416A (es) |
| KR (1) | KR101378260B1 (es) |
| CN (1) | CN102388036A (es) |
| AR (1) | AR075988A1 (es) |
| AU (1) | AU2010234610B2 (es) |
| BR (1) | BRPI1014382A2 (es) |
| CA (1) | CA2758251C (es) |
| EA (1) | EA201171230A1 (es) |
| ES (1) | ES2446644T3 (es) |
| MX (1) | MX2011010658A (es) |
| TW (1) | TW201103908A (es) |
| WO (1) | WO2010117979A2 (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI438190B (zh) | 2008-07-24 | 2014-05-21 | Theravance Inc | ３－（苯氧基苯基甲基）吡咯啶化合物 |
| US20100267743A1 (en) * | 2009-04-15 | 2010-10-21 | Stangeland Eric L | 3-(phenoxypyrrolidin-3-yl-methyl)heteroaryl, 3-(phenylpyrrolidin-3-ylmethoxy)heteroaryl, and 3-(heteroarylpyrrolidin-3-ylmethoxy)heteroaryl compounds |
| MX2012000685A (es) | 2009-07-13 | 2012-02-28 | Theravance Inc | Compuesto de 3-fenoximetilpirrolidina. |
| WO2011011231A1 (en) * | 2009-07-21 | 2011-01-27 | Theravance, Inc. | 3-phenoxymethylpyrrolidine compounds |
| WO2012051103A1 (en) | 2010-10-11 | 2012-04-19 | Theravance, Inc. | Serotonin reuptake inhibitors |
| WO2012075239A1 (en) | 2010-12-03 | 2012-06-07 | Theravance, Inc. | Serotonin reuptake inhibitors |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL1004346C2 (nl) | 1996-10-23 | 1998-04-24 | Dsm Nv | Werkwijze voor het scheiden van een mengsel van enantiomeren in een geschikt oplosmiddel. |
| WO1998025920A1 (en) | 1996-12-10 | 1998-06-18 | Abbott Laboratories | 3-pyridyl enantiomers and their use as analgesics |
| EP1047690B1 (en) | 1997-12-19 | 2004-03-24 | Abbott Laboratories | Heterocyclic ether and thioether compounds useful in controlling chemical synaptic transmission |
| JP2003529547A (ja) | 1999-09-14 | 2003-10-07 | アボット・ラボラトリーズ | 化学シナプス伝達のコントロールに有効な３−ピロリジニルオキシ−３’−ピリジルエーテル化合物 |
| US20020151712A1 (en) | 1999-09-14 | 2002-10-17 | Nan-Horng Lin | 3-pyrrolidinyloxy-3'-pyridyl ether compounds useful for controlling chemical synaptic transmission |
| AP2006003771A0 (en) * | 2004-04-30 | 2006-10-31 | Warner Lambert Co | Substituted morpholine compounds for the treatmentof central nervous system disorders |
| KR20090031786A (ko) * | 2006-08-23 | 2009-03-27 | 화이자 프로덕츠 인코포레이티드 | 피페리딘 유도체 |
| MY157365A (en) | 2006-12-06 | 2016-05-31 | Smithkline Beecham Corp | Chemical compounds and uses |
| TWI438190B (zh) | 2008-07-24 | 2014-05-21 | Theravance Inc | ３－（苯氧基苯基甲基）吡咯啶化合物 |
-
2010
- 2010-03-29 AR ARP100101017A patent/AR075988A1/es unknown
- 2010-04-02 TW TW099110421A patent/TW201103908A/zh unknown
- 2010-04-06 US US12/754,800 patent/US8173821B2/en not_active Expired - Fee Related
- 2010-04-06 EP EP10713753.1A patent/EP2417124B1/en not_active Not-in-force
- 2010-04-06 BR BRPI1014382A patent/BRPI1014382A2/pt not_active IP Right Cessation
- 2010-04-06 KR KR1020117023570A patent/KR101378260B1/ko not_active Expired - Fee Related
- 2010-04-06 MX MX2011010658A patent/MX2011010658A/es active IP Right Grant
- 2010-04-06 CN CN2010800160763A patent/CN102388036A/zh active Pending
- 2010-04-06 CA CA2758251A patent/CA2758251C/en not_active Expired - Fee Related
- 2010-04-06 EA EA201171230A patent/EA201171230A1/ru unknown
- 2010-04-06 WO PCT/US2010/030038 patent/WO2010117979A2/en not_active Ceased
- 2010-04-06 JP JP2012504759A patent/JP2012523416A/ja active Pending
- 2010-04-06 ES ES10713753.1T patent/ES2446644T3/es active Active
- 2010-04-06 AU AU2010234610A patent/AU2010234610B2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| EP2417124A2 (en) | 2012-02-15 |
| US20100261762A1 (en) | 2010-10-14 |
| CA2758251C (en) | 2013-08-06 |
| CN102388036A (zh) | 2012-03-21 |
| AU2010234610B2 (en) | 2013-04-18 |
| TW201103908A (en) | 2011-02-01 |
| AU2010234610A1 (en) | 2011-10-06 |
| WO2010117979A2 (en) | 2010-10-14 |
| MX2011010658A (es) | 2011-10-21 |
| ES2446644T3 (es) | 2014-03-10 |
| KR101378260B1 (ko) | 2014-03-27 |
| KR20110123287A (ko) | 2011-11-14 |
| BRPI1014382A2 (pt) | 2016-04-05 |
| EP2417124B1 (en) | 2013-12-18 |
| WO2010117979A3 (en) | 2011-02-17 |
| EA201171230A1 (ru) | 2012-03-30 |
| JP2012523416A (ja) | 2012-10-04 |
| CA2758251A1 (en) | 2010-10-14 |
| US8173821B2 (en) | 2012-05-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |