AR075534A1 - Derivados de piridazinona sustituida por heteroarilo - Google Patents
Derivados de piridazinona sustituida por heteroariloInfo
- Publication number
- AR075534A1 AR075534A1 ARP100100503A ARP100100503A AR075534A1 AR 075534 A1 AR075534 A1 AR 075534A1 AR P100100503 A ARP100100503 A AR P100100503A AR P100100503 A ARP100100503 A AR P100100503A AR 075534 A1 AR075534 A1 AR 075534A1
- Authority
- AR
- Argentina
- Prior art keywords
- lower alkyl
- alkyl
- alkylene
- alkoxy
- fluor
- Prior art date
Links
- 125000000217 alkyl group Chemical group 0.000 abstract 63
- 125000002947 alkylene group Chemical group 0.000 abstract 9
- 125000003545 alkoxy group Chemical group 0.000 abstract 8
- 229910052736 halogen Inorganic materials 0.000 abstract 4
- 150000002367 halogens Chemical class 0.000 abstract 4
- 125000001072 heteroaryl group Chemical group 0.000 abstract 4
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 4
- 125000001424 substituent group Chemical group 0.000 abstract 4
- 125000003118 aryl group Chemical group 0.000 abstract 3
- JCXJVPUVTGWSNB-UHFFFAOYSA-N Nitrogen dioxide Chemical compound O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 abstract 2
- 125000000304 alkynyl group Chemical group 0.000 abstract 2
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 2
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000000896 monocarboxylic acid group Chemical group 0.000 abstract 2
- 125000002757 morpholinyl group Chemical group 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 125000004193 piperazinyl group Chemical group 0.000 abstract 2
- 125000003386 piperidinyl group Chemical group 0.000 abstract 2
- 229940123773 Phosphodiesterase 10A inhibitor Drugs 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- -1 cycloalq uyl Chemical group 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 125000000719 pyrrolidinyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Diabetes (AREA)
- Addiction (AREA)
- Psychology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Heart & Thoracic Surgery (AREA)
- Emergency Medicine (AREA)
- Cardiology (AREA)
- Endocrinology (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Composicion farmacéutica, proceso de preparacion, y usos como inhibidores de PDE10A, como medicamentos. Reivindicacion 1: Compuestos de la formula (1) en la que R1 es heteroarilo que puede estar opcionalmente sustituido de 1 a 4 veces por sustituyentes elegidos con independencia entre el grupo formado por alquilo inferior, alcoxi inferior, fluor-alquilo inferior, fluor-alcoxi inferior, (alquilo inferior)-SO2, fluor-(alquilo inferior)-SO2, halogeno, (alcoxi inferior)-alquilo inferior, ciano, NO2, morfolinilo, NH2-SO2, N(H,alquilo inferior)-SO2, N(alquilo inferior)2-SO2, pirrolidinil-SO2, piperidinil-SO2, morfolinil-So2, hidroxi, COOH, COO-alquilo inferior, (alquilo inferior)-C(O)O, CO-alquilo inferior, CONH2, CON(H,alquilo inferior), CON(alquilo inferior)2, (alquilo inferior)-CO-NH, (alquilo inferior)-CO-N(alquilo inferior), NH2-CO-alquilo inferior, NH(alquilo inferior)-CO-alquilo inferior, N(alquilo inferior)2-CO-alquilo inferior, NH2, N(H,alquilo inferior), N(alquilo inferior)2, NH2-alquilo inferior, N(H,alquilo inferior)-alquilo inferior, N(alquilo inferior)2-alquilo inferior, cicloalquilo, piperidinilo, piperazinilo y (N-alquilo inferior)-piperazinilo; R2 es arilo o heteroarilo, dichos arilo o heteroarilo pueden estar opcionalmente sustituidos de 1 a 4 veces por sustituyente elegidos con independencia entre el grupo formado por halogeno, ciano, alquilo inferior, alcoxi inferior, fluor-alquilo inferior, alquinilo inferior, (alquilo inferior)-SO2, COOH, CONH2, NH2-SO2, COO-alquilo inferior, (alcoxi inferior)-alquilo inferior, CON-(H, alquilo inferior), CON(alquilo inferior)2, N(H,alquilo inferior)-SO2, N(alquilo inferior)2-SO2, alquenilo inferior, hidroxi, NO2, morfolinilo, piperidinilo, piperazinilo, (N-alquilo inferior)-piperazinilo, pirrolidinilo, (alquilo inferior)-C(O)O, (alquilo inferior)-CO-NH, (alquilo inferior)-CO-N (alquilo inferior), NH2-CO-alquilo inferior, NH(alquilo inferior)-CO-alquilo inferior, N-(alquilo inferior)2-CO-alquilo inferior, CO-alquilo inferior, NH2, N(H,alquilo inferior), N(alquilo inferior) 2, NH2-alquilo inferior, N(H,alquilo inferior)-alquilo inferior, N(alquilo inferior)2-alquilo inferior, tri(alquilo inferior)silil-alquinilo inferior y cicloalquilo, o en la que dos sustituyentes de posiciones adyacentes del arilo o heteroarilo están unidos entre sí para formar un anillo y dichos dos sustituyentes unidos son alquileno inferior, dioxo-alquileno inferior, dioxo-fluor-alquileno inferior, NH-alquileno inferior, N(alquilo inferior)-alquileno inferior, alquileno inferior-NH-alquileno inferior, alquileno inferior-N-(alquilo inferior)-alquileno inferior, NH-C(O)-alquileno inferior, N(alquilo inferior)-C(O)-alquileno inferior, alquileno inferior-NH-C(O)-alquileno inferior, alquileno inferior-N-(alquilo inferior)-C(O)-alquileno inferior, C(O)-NH-alquileno inferior o C(O)-N(alquilo inferior)-alquileno inferior; R3 es hidrogeno, alquilo inferior, fluor-alquilo inferior, alcoxi inferior, fluor-alcoxi inferior, halogeno, hidroxi o fenilo; R4 es hidrogeno, alquilo inferior, fluor-alquilo inferior, alcoxi inferior, fluor-alcoxi inferior, halogeno, hidroxi o fenilo; y sus sales y ésteres farmacéuticamente aceptables.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09153391 | 2009-02-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR075534A1 true AR075534A1 (es) | 2011-04-06 |
Family
ID=42312870
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP100100503A AR075534A1 (es) | 2009-02-23 | 2010-02-22 | Derivados de piridazinona sustituida por heteroarilo |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US9187455B2 (es) |
| EP (1) | EP2398795B1 (es) |
| JP (1) | JP5518902B2 (es) |
| KR (1) | KR101363091B1 (es) |
| CN (1) | CN102325766B (es) |
| AR (1) | AR075534A1 (es) |
| AU (1) | AU2010215428B2 (es) |
| BR (1) | BRPI1008007A2 (es) |
| CA (1) | CA2749867C (es) |
| ES (1) | ES2526251T3 (es) |
| IL (1) | IL213983A (es) |
| MX (1) | MX2011008360A (es) |
| SG (1) | SG173671A1 (es) |
| TW (1) | TW201033193A (es) |
| WO (1) | WO2010094762A1 (es) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2561181T3 (es) * | 2009-02-05 | 2016-02-24 | Takeda Pharmaceutical Company Limited | Compuestos de piridazinona |
| WO2012020780A1 (ja) * | 2010-08-10 | 2012-02-16 | 武田薬品工業株式会社 | 複素環化合物およびその用途 |
| WO2012112946A1 (en) | 2011-02-18 | 2012-08-23 | Allergan, Inc. | Substituted 6,7-dialkoxy-3-isoquinolinol derivatives as inhibitors of phosphodiesterase 10 (pde10a) |
| WO2014071044A1 (en) | 2012-11-01 | 2014-05-08 | Allergan, Inc. | Substituted 6,7-dialkoxy-3-isoquinoline derivatives as inhibitors of phosphodiesterase 10 (pde10a) |
| UY35341A (es) | 2013-02-21 | 2014-09-30 | Takeda Pharmaceutical | Método de producción de compuestos de piridazinona |
| PT3060550T (pt) * | 2013-10-21 | 2019-08-27 | Merck Patent Gmbh | Compostos de heteroarilo como inibidores de btk e utilizações dos mesmos |
| US9200016B2 (en) | 2013-12-05 | 2015-12-01 | Allergan, Inc. | Substituted 6, 7-dialkoxy-3-isoquinoline derivatives as inhibitors of phosphodiesterase 10 (PDE 10A) |
| CN103772352B (zh) * | 2014-01-16 | 2017-01-18 | 四川百利药业有限责任公司 | 哒嗪酮类衍生物及其制备方法和用途 |
| AU2019387370A1 (en) | 2018-11-30 | 2021-06-10 | Nuvation Bio Inc. | Pyrrole and pyrazole compounds and methods of use thereof |
| KR102718721B1 (ko) | 2021-12-14 | 2024-10-18 | 안희철 | 무선태그 장치 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE60312342T2 (de) * | 2002-09-09 | 2007-07-12 | Amgen Inc., Thousand Oaks | 1,4,5-substituierte 1,2-dihydro-pyrazol-3-one und 3-alkoxy-1h-pyrazole derivate als tnf-alpha und interleukin senkende wirkstoffe zur behandlung von entzündungen |
| JPWO2004029043A1 (ja) | 2002-09-25 | 2006-01-26 | 宇部興産株式会社 | ピラゾール化合物 |
| CA2534432A1 (en) | 2003-07-31 | 2005-02-10 | Bayer Pharmaceuticals Corporation | Methods for treating diabetes and related disorders using pde10a inhibitors |
| CA2650976A1 (en) | 2006-05-02 | 2007-11-15 | Pfizer Products Inc. | Bicyclic heteroaryl compounds as pde10 inhibitors |
| ES2523580T3 (es) * | 2008-01-11 | 2014-11-27 | Albany Molecular Research, Inc. | Piridoindoles substituidos con (1-Azinona) |
| MX2011005449A (es) * | 2008-12-04 | 2011-06-09 | Hoffmann La Roche | Derivados de piridazinona. |
-
2010
- 2010-02-16 US US12/705,988 patent/US9187455B2/en not_active Expired - Fee Related
- 2010-02-19 CA CA2749867A patent/CA2749867C/en not_active Expired - Fee Related
- 2010-02-19 CN CN201080008620.XA patent/CN102325766B/zh not_active Expired - Fee Related
- 2010-02-19 EP EP10711618.8A patent/EP2398795B1/en not_active Not-in-force
- 2010-02-19 WO PCT/EP2010/052116 patent/WO2010094762A1/en not_active Ceased
- 2010-02-19 SG SG2011058278A patent/SG173671A1/en unknown
- 2010-02-19 JP JP2011550576A patent/JP5518902B2/ja not_active Expired - Fee Related
- 2010-02-19 MX MX2011008360A patent/MX2011008360A/es active IP Right Grant
- 2010-02-19 KR KR1020117019449A patent/KR101363091B1/ko not_active Expired - Fee Related
- 2010-02-19 BR BRPI1008007A patent/BRPI1008007A2/pt not_active Application Discontinuation
- 2010-02-19 ES ES10711618.8T patent/ES2526251T3/es active Active
- 2010-02-19 AU AU2010215428A patent/AU2010215428B2/en not_active Ceased
- 2010-02-22 TW TW099105041A patent/TW201033193A/zh unknown
- 2010-02-22 AR ARP100100503A patent/AR075534A1/es unknown
-
2011
- 2011-07-07 IL IL213983A patent/IL213983A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| ES2526251T3 (es) | 2015-01-08 |
| AU2010215428B2 (en) | 2016-06-23 |
| KR101363091B1 (ko) | 2014-02-13 |
| EP2398795B1 (en) | 2014-10-15 |
| AU2010215428A1 (en) | 2011-08-11 |
| WO2010094762A1 (en) | 2010-08-26 |
| EP2398795A1 (en) | 2011-12-28 |
| CA2749867A1 (en) | 2010-08-26 |
| MX2011008360A (es) | 2011-08-24 |
| CN102325766A (zh) | 2012-01-18 |
| SG173671A1 (en) | 2011-09-29 |
| US20100216793A1 (en) | 2010-08-26 |
| IL213983A (en) | 2016-07-31 |
| CN102325766B (zh) | 2015-03-18 |
| KR20110111495A (ko) | 2011-10-11 |
| TW201033193A (en) | 2010-09-16 |
| IL213983A0 (en) | 2011-08-31 |
| CA2749867C (en) | 2017-06-06 |
| BRPI1008007A2 (pt) | 2016-03-15 |
| JP5518902B2 (ja) | 2014-06-11 |
| JP2012518619A (ja) | 2012-08-16 |
| US9187455B2 (en) | 2015-11-17 |
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