[go: up one dir, main page]

AR075084A1 - Metodo de preparacion de quinolinil -oxidifenil - ciclopropanodicarboxamidas e intermediarios correspondientes - Google Patents

Metodo de preparacion de quinolinil -oxidifenil - ciclopropanodicarboxamidas e intermediarios correspondientes

Info

Publication number
AR075084A1
AR075084A1 ARP090103685A ARP090103685A AR075084A1 AR 075084 A1 AR075084 A1 AR 075084A1 AR P090103685 A ARP090103685 A AR P090103685A AR P090103685 A ARP090103685 A AR P090103685A AR 075084 A1 AR075084 A1 AR 075084A1
Authority
AR
Argentina
Prior art keywords
formula
preparation
oxidifenil
cyclopropanodicarboxamids
quinolinil
Prior art date
Application number
ARP090103685A
Other languages
English (en)
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Publication of AR075084A1 publication Critical patent/AR075084A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Quinoline Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Método de preparacion de quinolinil-oxidifenil-ciclopropanodicarboxamidas, que comprende poner en contacto un compuesto de formula (1) con un compuesto de formula (2), en condiciones tales que se forme un compuesto de formula (3), donde X es un grupo saliente R1, R2 y R3 son cada uno independientemente H, F o Cl; R4 es metilo o un resto de formula (4), donde Y es CH2, O NH o N-CH3 y x es 2, 3 o 4. Preparacion de compuestos intermedios usados para preparar el compuesto de formula (3).
ARP090103685A 2008-09-26 2009-09-24 Metodo de preparacion de quinolinil -oxidifenil - ciclopropanodicarboxamidas e intermediarios correspondientes AR075084A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US10045208P 2008-09-26 2008-09-26

Publications (1)

Publication Number Publication Date
AR075084A1 true AR075084A1 (es) 2011-03-09

Family

ID=42058136

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP090103685A AR075084A1 (es) 2008-09-26 2009-09-24 Metodo de preparacion de quinolinil -oxidifenil - ciclopropanodicarboxamidas e intermediarios correspondientes

Country Status (8)

Country Link
US (1) US8314232B2 (es)
EP (1) EP2339918A4 (es)
JP (1) JP5587324B2 (es)
CN (1) CN102227164A (es)
AR (1) AR075084A1 (es)
TW (1) TW201035017A (es)
UY (1) UY32142A (es)
WO (1) WO2010036831A1 (es)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20110075016A (ko) 2008-10-14 2011-07-05 닝 시 화합물 및 사용 방법
TW201920110A (zh) 2009-01-16 2019-06-01 美商艾克塞里克斯公司 包含n-(4-{[6,7-雙(甲氧基)喹啉-4-基]氧基}苯基)-n'-(4-氟苯基)環丙烷-1,1-二甲醯胺之蘋果酸鹽之醫藥組合物及其用途
EP2408300B1 (en) 2009-03-21 2016-05-11 Sunshine Lake Pharma Co., Ltd. Amino ester derivatives, salts thereof and methods of use
UA108618C2 (uk) 2009-08-07 2015-05-25 Застосування c-met-модуляторів в комбінації з темозоломідом та/або променевою терапією для лікування раку
PH12012502142A1 (en) * 2010-04-29 2017-04-21 Deciphera Pharmaceuticals Llc Cyclopropyl dicarboxamides and analogs exhibiting anti-cancer and anti-proliferative activities
LT2593090T (lt) 2010-07-16 2022-01-10 Exelixis, Inc. C-met moduliatoriaus farmacinės kompozicijos
MX352926B (es) 2010-09-27 2017-12-14 Exelixis Inc Inhibidores dobles de met y factor de crecimiento endotelial vascular (vegf) para el tratamiento de cancer de prostata resistente a la castracion y metastasis osteoblasticas en los huesos.
EP2673262B1 (en) 2011-02-10 2021-11-03 Exelixis, Inc. Processes for preparing quinoline compounds and pharmaceutical compositions containing such compounds
US20120252840A1 (en) 2011-04-04 2012-10-04 Exelixis, Inc. Method of Treating Cancer
AR086242A1 (es) 2011-05-02 2013-11-27 Exelixis Inc Procedimiento de tratar el dolor por cancer y cancer de huesos
CA2848512A1 (en) 2011-09-22 2013-03-28 Exelixis, Inc. Method for treating osteoporosis
ES2765013T3 (es) 2011-10-20 2020-06-05 Exelixis Inc Procedimiento para preparar derivados de quinolina
US9861624B2 (en) 2012-05-02 2018-01-09 Exelixis, Inc. Method of treating cancer
CN103664776B (zh) * 2012-09-26 2016-05-04 正大天晴药业集团股份有限公司 一种酪氨酸激酶抑制剂及其中间体的制备方法
CN102977014B (zh) 2012-11-05 2015-01-07 沈阳药科大学 新的喹啉类化合物及其用途
CN102964308B (zh) * 2012-11-30 2015-03-18 中国药科大学 新型嘧啶类化合物、其制备方法、包含此类化合物的药物组合物及其用途
CN103044263A (zh) * 2013-01-14 2013-04-17 中国药科大学 一种治疗囊性纤维化药物的中间体的制备方法
CN103965104B (zh) * 2013-01-29 2017-09-29 正大天晴药业集团股份有限公司 一种酪氨酸激酶抑制剂及其中间体的制备方法
EP2970126B1 (en) 2013-03-15 2019-03-06 Exelixis, Inc. Metabolites of n-(4-{[6,7-bis(methyloxy)quinolin-4-yl]oxy}phenyl)-n'-(4-fluorophenyl) cyclopropane-1,1-dicarboxamide
US11564915B2 (en) 2013-04-04 2023-01-31 Exelixis, Inc. Cabozantinib dosage form and use in the treatment of cancer
IL247035B2 (en) 2014-02-14 2023-03-01 Exelixis Inc Crystalline solid forms of n-{4-[(7,6-dimethoxyquinolin-4-yl)oxy]phenyl}-n'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide, processes for preparation and methods of use
CN106255499A (zh) 2014-03-17 2016-12-21 埃克塞里艾克西斯公司 卡博替尼制剂的给药
JP6789923B2 (ja) 2014-07-31 2020-11-25 エグゼリクシス， インコーポレイテッド フッ素１８標識化カボザンチニブ及びその類似体の調製方法
AU2015301097B2 (en) 2014-08-05 2021-03-04 Exelixis, Inc. Drug combinations to treat multiple myeloma
CN105218445B (zh) * 2015-08-25 2018-05-22 江苏中邦制药有限公司 一种酪氨酸激酶抑制剂Foretinib的制备方法
CA3020749A1 (en) 2016-04-15 2017-10-19 Exelixis, Inc. Method of treating renal cell carcinoma using n-(4-(6,7-dimethoxyquinolin-4-yloxy) phenyl)-n'-(4-fluoropheny)cyclopropane-1,1-dicarboxamide, (2s)-hydroxybutanedioate
CN110117254B (zh) * 2019-06-20 2022-05-13 江苏君若药业有限公司 卡博替尼的制备方法
CN112194622A (zh) * 2020-09-24 2021-01-08 上海毕得医药科技有限公司 一种5-氯喹啉-4-醇的合成方法
WO2024110606A1 (en) 2022-11-25 2024-05-30 Synthon B.V. A process for preparation of cabozantinib or tivozanib

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL2392565T3 (pl) * 2003-09-26 2014-08-29 Exelixis Inc Modulatory c-Met i sposoby stosowania
CA2553433A1 (en) 2004-01-23 2005-08-11 Amgen Inc. Quinoline quinazoline pyridine and pyrimidine compounds and their use in the treatment of inflammation angiogenesis and cancer

Also Published As

Publication number Publication date
EP2339918A4 (en) 2012-06-06
CN102227164A (zh) 2011-10-26
US8314232B2 (en) 2012-11-20
JP5587324B2 (ja) 2014-09-10
JP2012503671A (ja) 2012-02-09
US20100081805A1 (en) 2010-04-01
WO2010036831A1 (en) 2010-04-01
EP2339918A1 (en) 2011-07-06
TW201035017A (en) 2010-10-01
UY32142A (es) 2010-05-31

Similar Documents

Publication Publication Date Title
AR075084A1 (es) Metodo de preparacion de quinolinil -oxidifenil - ciclopropanodicarboxamidas e intermediarios correspondientes
UY32606A (es) Sulfonamidas nematocidas
CO6231035A2 (es) Novedoso compuesto heteromonociclico que tiene propiedades superiores como agente farmaceutico
CR9421A (es) Compuestos heterociclicos fusionados
CR20110049A (es) Derivados de benzazepina y su uso como antagonistas de histamina h3
BRPI0516911A (pt) método para a preparação de um composto e composto de anilina
CR9805A (es) Proceso para la produccion de amidas
GT200500286A (es) Analogos de anilino-pirimidina
EA201390877A1 (ru) Замещенные 6,6-конденсированные азотсодержащие гетероциклические соединения и их применение
TW200637550A (en) Thiazole-4-carboxamide derivatives as mGluR5 antagonists
UY31232A1 (es) Compuestos derivados de dibenzotifenilamino-cromen-4-onas activas sustituidas y sus isomeros y aplicaciones
MX2013004242A (es) Sulfonamidas nematocidas.
UY31750A (es) Compuestos y composiciones como inhibidores de quinasa
AR073136A1 (es) Compuestos de pirrol
EA200900635A1 (ru) Антагонисты прогестеронового рецептора
BR112013018732A2 (pt) novos derivados de amida de aril-benzocicloalquila
CO2022002000A2 (es) Nuevos inhibidores heterocíclicos de monoacilglicerol lipasa (magl)
MX2022003023A (es) Compuestos heterociclicos.
CL2023002429A1 (es) Derivados novedosos de pirimidin-2-il sulfonamida
CO6150147A2 (es) Derivados de 5,6-bisaril-2-piridin-carboxamida su preparacion y su aplicacion en terapeutica como antagonistas de los receptores de urotensina ii
WO2007025889A3 (en) Dyes containing a thiol group
BR112013008675A2 (pt) métodos e composições para o tratamento de diabetes e dislipidemia
PE20130179A1 (es) Nuevos derivados terciarios de 8-hidroxiquinolina-7-carboxamida
BR112021026899A2 (pt) Compostos heterocíclicos
PE20141168A1 (es) Derivados de pirazolidin-3-ona

Legal Events

Date Code Title Description
FA Abandonment or withdrawal