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AR074843A1 - Dihidropiridona -amidas como moduladores de p2x7 - Google Patents

Dihidropiridona -amidas como moduladores de p2x7

Info

Publication number
AR074843A1
AR074843A1 ARP090105035A ARP090105035A AR074843A1 AR 074843 A1 AR074843 A1 AR 074843A1 AR P090105035 A ARP090105035 A AR P090105035A AR P090105035 A ARP090105035 A AR P090105035A AR 074843 A1 AR074843 A1 AR 074843A1
Authority
AR
Argentina
Prior art keywords
alkyl
hydrogen
optionally substituted
dihydropiridone
amidas
Prior art date
Application number
ARP090105035A
Other languages
English (en)
Inventor
Joan Marie Caroon
Francisco Javier Lopez-Tapia
Nancy Elisabeth Krauss
Keith Adrian Murray Walker
Shu-Hai Zhao
Jacob Berger
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of AR074843A1 publication Critical patent/AR074843A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Se describen los compuestos para el tratamiento de enfermedades asociadas con el receptor purinérgico de P2X7. Reivindicación 1: Un compuesto de la fórmula o sales farmacéuticamente aceptables del mismo, en la que: m es el número 0 ó 1; n es el número 0 ó 1; R1 es heteroarilo opcionalmente sustituido; R2 es: arilo opcionalmente sustituido; heteroarilo opcionalmente sustituido; cicloalquilo C3-6; o alquilo C1-6; R3 es: hidrógeno; alquilo C1-6; alquilcarbonilalquilo; o alcoxicarbonilalquilo; R4 y R5 con Independencia entre si son: hidrógeno; o alquilo C1-6; y Ra es hidrogeno; alquilo C1-6; hidroxi -alquilo C1-6; (alcoxi C1-6)-alquilo C1-6.
ARP090105035A 2008-12-23 2009-12-22 Dihidropiridona -amidas como moduladores de p2x7 AR074843A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US20348208P 2008-12-23 2008-12-23

Publications (1)

Publication Number Publication Date
AR074843A1 true AR074843A1 (es) 2011-02-16

Family

ID=41664810

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP090105035A AR074843A1 (es) 2008-12-23 2009-12-22 Dihidropiridona -amidas como moduladores de p2x7

Country Status (14)

Country Link
US (1) US8372865B2 (es)
EP (1) EP2385939A1 (es)
JP (1) JP5478637B2 (es)
KR (1) KR101381074B1 (es)
CN (1) CN102264723B (es)
AR (1) AR074843A1 (es)
AU (1) AU2009331659B2 (es)
BR (1) BRPI0923498A2 (es)
CA (1) CA2745864A1 (es)
IL (1) IL213417A0 (es)
MX (1) MX2011006232A (es)
SG (1) SG172336A1 (es)
TW (1) TW201028396A (es)
WO (1) WO2010072597A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011072012A2 (en) * 2009-12-08 2011-06-16 Vanderbilt University Improved methods and compositions for vein harvest and autografting
WO2015099107A1 (ja) 2013-12-26 2015-07-02 塩野義製薬株式会社 含窒素６員環誘導体およびそれらを含有する医薬組成物
ES2896400T3 (es) 2014-08-01 2022-02-24 Nuevolution As Compuestos activos frente a bromdominios
MX391647B (es) 2015-04-24 2025-03-21 Shionogi & Co Derivados heterociclicos de seis miembros y composicion farmaceutica que los comprende.
KR20180134860A (ko) 2016-02-15 2018-12-19 체엠엠 - 포르슝스첸트룸 퓨어 몰레쿨라레 메디친 게엠베하 암의 치료를 위한 taf1 억제제
WO2018074390A1 (ja) 2016-10-17 2018-04-26 塩野義製薬株式会社 二環性含窒素複素環誘導体およびそれらを含有する医薬組成物

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5399566A (en) * 1990-06-19 1995-03-21 Meiji Seika Kabushiki Kaisha Pyridine derivatives having angiotensin II antagonism
CZ403592A3 (en) 1992-02-20 1993-12-15 Hoechst Ag Arylcarbonylaminoalkyldihydrooxopyridines, process of their preparation and their use
DE4206045A1 (de) 1992-02-27 1993-09-02 Bayer Ag Sulfonylbenzyl substituierte pyridone
DE4215587A1 (de) 1992-05-12 1993-11-18 Bayer Ag Sulfonylbenzyl-substituierte Benzo- und Pyridopyridone
SE9704544D0 (sv) * 1997-12-05 1997-12-05 Astra Pharma Prod Novel compounds
BR9907300A (pt) 1998-01-27 2000-10-24 Aventis Pharm Prod Inc Inibidores do fator xa oxoaza-heterociclila substituìdos
HU229553B1 (en) 2000-06-12 2014-01-28 Eisai R & D Man Co 1,2-dihydropyridine compound, process for preparation of the same and use thereof
GB0129260D0 (en) 2001-12-06 2002-01-23 Eisai London Res Lab Ltd Pharmaceutical compositions and their uses
JP2005170790A (ja) 2002-01-09 2005-06-30 Ajinomoto Co Inc Ｎ−アルキルスルフォニル置換アミド誘導体
US7592357B2 (en) * 2004-02-20 2009-09-22 Smithkline Beecham Corporation Compounds
SA05260265A (ar) 2004-08-30 2005-12-03 استرازينيكا ايه بي مركبات جديدة
FR2878528B1 (fr) 2004-11-29 2008-05-16 Aventis Pharma Sa 2-alcoxy-3,4,5-trihydroxy-alkylamides, leur preparation, compositions les contenant et utilisation
HRP20110524T1 (hr) 2005-04-04 2011-08-31 Eisai R&D Management Co. Spojevi dihidropiridina za neurodegenerativne bolesti i demenciju
EP1875912A4 (en) 2005-04-08 2008-06-04 Eisai R&D Man Co Ltd MEANS OF TREATING UNWILLING MOVEMENTS
WO2007035428A1 (en) 2005-09-15 2007-03-29 Bristol-Myers Squibb Company Met kinase inhibitors
WO2008104472A1 (en) 2007-02-28 2008-09-04 F. Hoffmann-La Roche Ag 2, 4 -diaminopyrimidine derivatives and their use as p2x antagonists or as prodrugs thereof
GB0705882D0 (en) * 2007-03-27 2007-05-02 Glaxo Group Ltd Novel compounds
US20100168171A1 (en) * 2007-03-28 2010-07-01 Paul John Beswick Piperidinone Carboxamide Derivatives as P2X7 Modulators
US20100144727A1 (en) * 2007-03-29 2010-06-10 Paul John Beswick Oxazolidine and Morpholine Carboxamide Derivatives as P2X7 Modulators
WO2008125600A2 (en) * 2007-04-11 2008-10-23 Glaxo Group Limited Pyrazole derivatives as p2x7 modulators
WO2010072605A1 (en) * 2008-12-23 2010-07-01 F. Hoffmann-La Roche Ag Dihydropyridone amides as p2x7 modulators

Also Published As

Publication number Publication date
US8372865B2 (en) 2013-02-12
JP5478637B2 (ja) 2014-04-23
CN102264723B (zh) 2014-12-10
US20100160373A1 (en) 2010-06-24
WO2010072597A1 (en) 2010-07-01
TW201028396A (en) 2010-08-01
EP2385939A1 (en) 2011-11-16
MX2011006232A (es) 2011-06-24
SG172336A1 (en) 2011-07-28
KR101381074B1 (ko) 2014-04-11
CN102264723A (zh) 2011-11-30
JP2012513433A (ja) 2012-06-14
IL213417A0 (en) 2011-07-31
BRPI0923498A2 (pt) 2019-09-24
KR20110086768A (ko) 2011-07-29
AU2009331659A1 (en) 2011-06-23
CA2745864A1 (en) 2010-07-01
AU2009331659B2 (en) 2015-09-03

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