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AR074024A1 - Compuesto de arilazol-2-il-cianoetilamino enantiomericamente enriquecidos, composicion plaguicida y su uso para prevenir la infeccion parasitaria - Google Patents

Compuesto de arilazol-2-il-cianoetilamino enantiomericamente enriquecidos, composicion plaguicida y su uso para prevenir la infeccion parasitaria

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Publication number
AR074024A1
AR074024A1 ARP090104379A ARP090104379A AR074024A1 AR 074024 A1 AR074024 A1 AR 074024A1 AR P090104379 A ARP090104379 A AR P090104379A AR P090104379 A ARP090104379 A AR P090104379A AR 074024 A1 AR074024 A1 AR 074024A1
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Argentina
Prior art keywords
unsubstituted
alkyl
substituted
haloalkyl
halogen
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ARP090104379A
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English (en)
Inventor
Douglas Edward Wilkinson
Hyoung Ik Lee
Mark David Soll
Robert Toms Jacobs
Hir De Fallois Loic Patrick Le
Brent Christopher Beck
Scot Kevin Huber
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Merial Ltd
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Publication of AR074024A1 publication Critical patent/AR074024A1/es

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D249/00Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/16Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • C07D249/18Benzotriazoles
    • C07D249/20Benzotriazoles with aryl radicals directly attached in position 2
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/48Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
    • A01N43/561,2-Diazoles; Hydrogenated 1,2-diazoles
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/64Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with three nitrogen atoms as the only ring hetero atoms
    • A01N43/647Triazoles; Hydrogenated triazoles
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/90Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41921,2,3-Triazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • A61P33/10Anthelmintics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • A61P33/14Ectoparasiticides, e.g. scabicides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D231/00Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56Benzopyrazoles; Hydrogenated benzopyrazoles
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D249/00Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/16Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • C07D249/18Benzotriazoles
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Agronomy & Crop Science (AREA)
  • Environmental Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Dentistry (AREA)
  • Plant Pathology (AREA)
  • Pest Control & Pesticides (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Derivados de arilazol-2-il-cianoetilamino, composiciones que los contienen, procesos para su preparacion y su uso como plaguicidas. Reivindicacion 1: Un compuesto de arilazol-2-il-cianoetilamina de formula (1) caracterizado porque está sustancialmente enriquecido en un enantiomero, o una sal del mismo; donde P es C-R1 o N; Q es C-R2 o N; V es C-R8 o N; W es C-R9 o N; X es C-R10 o N; Y es C-R11 o N; R1, R2, R8, R9, R10 y R11 son en forma independiente entre si hidrogeno, amino, amido, ciano, nitro, halogeno, alquilo, alquenilo, alquinilo, cicloalquilo, hidroxialquilo, haloalquilo, alquiltio, haloalquiltio, ariltio, alcoxi, fenoxi, alcoxialcoxi, cicloalquiloxi, haloalcoxi, alquilcarbonilo, haloalquilcarbonilo, alcoxicarbonilo, haloalcoxicarbonilo, alquilsulfinilo, haloalquilsulfinilo, SF5, alquilsulfonilo, haloalquilsulfonilo, alquilamino, di(alquil)amino, alquilcarbonilamino, alquilaminoalcoxi, dialquilaminoalcoxi, alquilaminoalquilo, dialquilaminoalquilo, aminoalquilo, formilo, -C(O)OH, arilo no sustituido o sustituido, ariltio no sustituido o sustituido, ariloxi no sustituido o sustituido, o heteroarilo no sustituido o sustituido, donde los sustituyentes, en forma independiente entre sí, pueden ser uno o más de ciano, nitro, halogeno, alquilo, haloalquilo, alquiltio, haloalquiltio, ariltio, alcoxi, haloalcoxi, alquilcarbonilo, haloalquilcarbonilo, alcoxicarbonilo, haloalcoxicarbonilo, alquilsulfinilo, haloalquilsulfinilo, alquilsulfonilo, haloalquilsulfonilo, SF5 o metiltioamino; R3, R4 y R5 son en forma independiente entre sí hidrogeno, halogeno, alquilo, hidroxialquilo, alquiltioalquilo, haloalquilo. alquiloxialquilo, alquilsulfinilalquilo, alquilsulfonilalquilo, alquilsulfoniloxialquilo; cicloalquilo no sustituido o sustituido, donde los sustituyentes cada uno puede ser en forma independiente halogeno y alquilo; arilo no sustituido o sustituido, heteroarilo no sustituido o sustituido, donde los sustituyentes pueden ser cada uno en forma independiente entre sí ciano, nitro, halogeno, alquilo, haloalquilo, alquiltio, haloalquilo, ariltio, alcoxi, haloalcoxi, alquilcarbonilo, haloalquilcarbonilo, alcoxicarbonilo, haloalcoxicarbonilo, alquilsulfinilo, haloalquilsulfinilo, alquilsulfonilo, haloalquilsulfonilo, SF5, alquilamino, o di(alquil)amino; o R4 y R5 junto con el átomo de carbono al cual se encuentran unidos forman un anillo cicloalquilo; R6 es hidrogeno, alquilo, alcoxialquilo, alquilcarbonilo, haloalquilcarbonilo, alcoxicarbonilo, haloalcoxicarbonilo, alquiltiocarbonilo o bencilo no sustituido o sustituido, donde los sustituyentes pueden ser cada uno en forma independiente entre si ciano, nitro, halogeno, alquilo, haloalquilo, alquiltio, haloalquiltio, ariltio, alcoxi, haloalcoxi, alquilcarbonilo, haloalquilcarbonilo, alcoxicarbonilo, haloalcoxicarbonilo, alquilsulfinilo, haloalquilsulfinilo, alquilsulfonilo, haloalquilsulfonilo, SF5, alquilamino, o di(alquil)amino; R7 es hidrogeno, alquilo, cicloalquilo, haloalquilo, alcoxialquilo, alquilcarbonilo, haloalquilcarbonilo, alcoxicarbonilo, haloalcoxicarbonilo, alquiltiocarbonilo, heterociclilo; arilo no sustituido o sustituido, donde los sustituyentes pueden ser cada uno en forma independiente entre si ciano, nitro, halogeno, alquilo, cicloalquilo, haloalquilo, arilo no sustituido o sustituido, ariloxi no sustituido o sustituido, heteroarilo no sustituido o sustituido, ariltio no sustituido o sustituido, alquiltio, haloalquiltio. alcoxi, cicloalquiloxi, haloalcoxi, alquilcarbonilo, haloalquilcarbonilo, alcoxicarbonilo, haloalcoxicarbonilo, alquilsulfinilo, haloalquilsulfinilo, alquilsulfonilo, haloalquilsulfonilo, amino, alquilamino, di(alquil)amino, SF5, metiltioamino; o heteroarilo no sustituido o sustituido, donde los sustituyentes pueden ser cada uno en forma independiente entre si ciano, nitro, halogeno, alquilo, cicloalquilo, haloalquilo, arilo no sustituido o sustituido, ariloxi no sustituido o sustituido heteroarilo no sustituido o sustituido, ariltio no sustituido o sustituido, alquiltio, haloalquiltio, alcoxi, cicloalquiloxi, haloalcoxi, alquilcarbonilo, haloalquilcarbonilo, alcoxicarbonilo, haloalcoxicarbonilo, alquilsulfinilo, haloalquilsulfinilo, alquilsulfonilo, haloalquilsulfonilo, amino, alquilamino, di(alquil)amino, SF5, metiltioamino; Z es una union directa, C(O), C(S) o S(O)p; a es 1, 2 o 3; y p es 0, 1 o 2. Reivindicacion 13: Un derivado de arilazol-2-il-cianoetilamino pentafluorotiobenzamida caracterizado porque tiene la formula (2) donde P es C-R1 o N; Q es C-R2 o N; V es C-R8 o N; W es C-R9 o N; X es C-R10 o N; Y es C-R11 o N; R1, R2, R8, R9, R10 y R11 son en forma independiente entre si hidrogeno, amino, amido, ciano, nitro, halogeno, alquilo, alquenilo, alquinilo, cicloalquilo, hidroxialquilo, haloalquilo, alquiltio, haloalquiltio, ariltio, alcoxi, fenoxi, alcoxialcoxi, cicloalquiloxi, haloalcoxi, alquilcarbonilo, haloalquilcarbonilo, alcoxicarbonilo, haloalcoxicarbonilo, alquilsulfinilo, haloalquilsulfinilo, SF5, alquilsulfonilo, haloalquilsulfonilo, alquilamino, di(alquil)amino, alquilcarbonilamino, alquilaminoalcoxi, dialquilaminoalcoxi, alquilaminoalquilo, dialquilaminoalquilo, aminoalquilo, formilo, -C(O)OH, arilo no sustituido o sustituido, ariltio no sustituido o sustituido, ariloxi no sustituido o sustituido, o heteroarilo no sustituido o sustituido, donde los sustituyentes, en forma independiente entre sí, pueden ser uno o más de ciano, nitro, halogeno, alquilo, haloalquilo, alquiltio, haloalquiltio, ariltio, alcoxi, haloalcoxi, alquilcarbonilo, haloalquilcarbonilo, alcoxicarbonilo, haloalcoxicarbonilo, alquilsulfinilo, haloalquilsulfinilo, alquilsulfonilo, haloalquilsulfonilo, SF5 o metiltioamino; R3, R4 y R5 son en forma independiente entre si hidrogeno, halogeno, alquilo, hidroxialquilo, alquiltioalquilo, haloalquilo, alquiloxialquilo, alquilsulfinilalquilo, alquilsulfonilalquilo, alquilsulfoniloxialquilo; cicloalquilo no sustituido o sustituido, donde los sustituyentes cada uno puede ser en forma independiente halogeno y alquilo; arilo no sustituido o sustituido, heteroarilo no sustituido o sustituido, donde los sustituyentes pueden ser cada uno en forma independiente entre sí ciano, nitro, halogeno, alquilo, haloalquilo, alquiltio, haloalquiltio, arilo, alcoxi, haloalcoxi, alquilcarbonilo, haloalquilcarbonilo, alcoxicarbonilo, haloalcoxicarbonilo, alquilsulfinilo, haloalquilsulfinilo, alquilsulfonilo, haloalquilsulfonilo, SF5, alquilamino, o dialquilamino; o R4 y R5 junto con el átomo de carbono al cual se encuentran unidos forman un anillo cicloalquilo; R6 es hidrogeno, alquilo, alcoxialquilo, alquilcarbonilo, haloalquilcarbonilo, alcoxicarbonilo, haloalcoxicarbonilo, alquiltiocarbonilo o bencilo no sustituido o sustituido, donde los sustituyentes pueden ser cada uno en forma independiente entre sí ciano, nitro, halogeno, alquilo, haloalquilo, alquiltio, haloalquiltio, ariltio, alcoxi, haloalcoxi, alquilcarbonilo, haloalquilcarbonilo, alcoxicarbonilo, haloalcoxicarbonilo, alquilsulfinilo, haloalquilsulfinilo, alquilsulfonilo, haloalquilsulfonilo, SF5, alquilamino, o di(alquil)amino; a es 1, 2 o 3; R13a, R13b, R14a y R14b son cada uno en forma independiente entre si ciano, nitro, halogeno, alquilo, cicloalquilo, haloalquilo, arilo no sustituido o sustituido, heteroarilo no sustituido o sustituido, fenoxi no sustituido o sustituido, alquiltio, haloalquiltio, ariltio, alcoxi, cicloalquiloxi, haloalcoxi, alquilcarbonilo, haloalquilcarbonilo, alcoxicarbonilo, haloalcoxicarbonilo, alquilsulfinilo, haloalquilsulfinilo, alquilsulfonilo, haloalquilsulfonilo, SF5, alquilamino, di(alquil)amino, o metiltioamino; y a es 1, 2 o 3.
ARP090104379A 2008-11-14 2009-11-13 Compuesto de arilazol-2-il-cianoetilamino enantiomericamente enriquecidos, composicion plaguicida y su uso para prevenir la infeccion parasitaria AR074024A1 (es)

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US11465608P 2008-11-14 2008-11-14
US11466508P 2008-11-14 2008-11-14
US17613609P 2009-05-07 2009-05-07

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US (1) US8461176B2 (es)
EP (3) EP3498696A1 (es)
JP (2) JP5730208B2 (es)
KR (2) KR101715414B1 (es)
CN (1) CN102272105B (es)
AR (1) AR074024A1 (es)
AU (1) AU2009313920B2 (es)
BR (1) BRPI0921546A8 (es)
CA (2) CA2945453C (es)
CL (1) CL2011001123A1 (es)
CY (1) CY1121908T1 (es)
DK (1) DK3050874T3 (es)
EA (1) EA019606B1 (es)
ES (2) ES2551130T3 (es)
HR (1) HRP20190498T1 (es)
HU (1) HUE044046T2 (es)
LT (1) LT3050874T (es)
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PL (1) PL3050874T3 (es)
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SG (1) SG10201703698QA (es)
SI (1) SI3050874T1 (es)
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