AR063125A1 - Ensayo elisa para la deteccion de vegf - Google Patents
Ensayo elisa para la deteccion de vegfInfo
- Publication number
- AR063125A1 AR063125A1 ARP070104393A AR063125A1 AR 063125 A1 AR063125 A1 AR 063125A1 AR P070104393 A ARP070104393 A AR P070104393A AR 063125 A1 AR063125 A1 AR 063125A1
- Authority
- AR
- Argentina
- Prior art keywords
- vegf
- antibody
- biological sample
- binds
- detection
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
- G01N33/57496—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving intracellular compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
-
- G01N33/57595—
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/475—Assays involving growth factors
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biotechnology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Endocrinology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Hospice & Palliative Care (AREA)
- Oncology (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
La actividad del factor de crecimiento endotelial vascular (VEGF) en el torrente sanguíneo de un paciente o en otra muestra biologica puede servir como índice de diagnostico y pronostico para el cáncer, diabetes, afecciones cardíacas y otras patologías. Los métodos de ensayo ELISA de tipo ôsándwichö que utilizan anticuerpos y los kits de deteccion de VEGF como antígeno se proporcionan para detectar los tipos de niveles de VEGF en muestras biologicas de modelos animales y pacientes humanos y pueden ser utilizados como índice de diagnostico y pronostico. Reivindicacion 1: Un método para la deteccion de formas selectivas del factor de crecimiento endotelial vascular (VEGF) (VEGF110+) en una muestra biologica que comprende los siguientes pasos: (a) poner en contacto e incubar la muestra biologica con un reactivo de captura inmovilizado en un soporte solido, en el que el reactivo de captura es un anticuerpo que reconoce el mismo epítopo que el anticuerpo 5C3 contra VEGF humano. Dicho anticuerpo monoclonal se une específicamente a residuos del VEGF humano superiores a 110; (b) separar la nuestra biologica de los reactivos de captura inmovilizados; (c) poner en contacto el complejo ôreactivo de captura-molécula dianaö inmovilizado con un anticuerpo detectable que se una a los dominios de union del receptor KDR y/o FLT1 del VEGF o que se une a un epítopo en VECF110; y (d) medir el nivel del VEGF110+ unido a los reactivos de captura a través un método de deteccion del anticuerpo detectable.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US82820306P | 2006-10-04 | 2006-10-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR063125A1 true AR063125A1 (es) | 2008-12-30 |
Family
ID=39301650
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP070104393 AR063125A1 (es) | 2006-10-04 | 2007-10-03 | Ensayo elisa para la deteccion de vegf |
| ARP170100313A AR107561A2 (es) | 2006-10-04 | 2017-02-08 | Ensayo elisa para la detección de vegf |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP170100313A AR107561A2 (es) | 2006-10-04 | 2017-02-08 | Ensayo elisa para la detección de vegf |
Country Status (24)
| Country | Link |
|---|---|
| US (5) | US20080227119A1 (es) |
| EP (3) | EP2457929B1 (es) |
| JP (1) | JP6025294B2 (es) |
| KR (2) | KR101551984B1 (es) |
| CN (2) | CN101523220B (es) |
| AR (2) | AR063125A1 (es) |
| AU (1) | AU2007319654B2 (es) |
| BR (1) | BRPI0715239A2 (es) |
| CA (1) | CA2663012C (es) |
| DK (2) | DK2457929T3 (es) |
| ES (2) | ES2584322T3 (es) |
| HR (1) | HRP20140675T1 (es) |
| HU (1) | HUE030082T2 (es) |
| IL (1) | IL197374A (es) |
| MX (2) | MX2009003562A (es) |
| NZ (1) | NZ613646A (es) |
| PL (2) | PL2069798T3 (es) |
| PT (1) | PT2069798E (es) |
| RS (1) | RS53387B (es) |
| RU (2) | RU2517301C2 (es) |
| SI (2) | SI2069798T1 (es) |
| TW (2) | TWI541251B (es) |
| WO (1) | WO2008060777A2 (es) |
| ZA (1) | ZA200901518B (es) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050009110A1 (en) * | 2003-07-08 | 2005-01-13 | Xiao-Jia Chang | Methods of producing antibodies for diagnostics and therapeutics |
| AR063125A1 (es) | 2006-10-04 | 2008-12-30 | Genentech Inc | Ensayo elisa para la deteccion de vegf |
| WO2011031986A1 (en) | 2009-09-10 | 2011-03-17 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Office Of Technology Transfer, National Institutes Of Health | Assays for soluble il-15 receptor alpha |
| CN103180737A (zh) * | 2010-07-19 | 2013-06-26 | 霍夫曼-拉罗奇有限公司 | 鉴定响应抗癌疗法的可能性升高的患者的方法 |
| WO2012010549A1 (en) * | 2010-07-19 | 2012-01-26 | F. Hoffmann-La Roche Ag | Method to identify a patient with an increased likelihood of responding to an anti-cancer therapy |
| CN102207504A (zh) * | 2011-03-23 | 2011-10-05 | 北京华创远航科技有限公司 | 一种酶联检测试剂盒及其制备方法 |
| CN102435743B (zh) * | 2011-09-15 | 2014-10-15 | 北京健平九星生物医药科技有限公司 | 一种酶联检测试剂盒及其制备方法 |
| CN102426240B (zh) * | 2011-09-19 | 2014-10-15 | 北京健平金星生物科技有限公司 | 一种酶联检测试剂盒及其制备方法 |
| EP2795335B1 (en) * | 2011-12-19 | 2017-09-06 | F. Hoffmann-La Roche AG | Method for the detection of free binding partner of a multispecific binder |
| AU2013207778B2 (en) | 2012-01-13 | 2017-10-12 | Genentech, Inc. | Biological markers for identifying patients for treatment with VEGF antagonists |
| WO2013113663A1 (en) * | 2012-02-01 | 2013-08-08 | F. Hoffmann-La Roche Ag | Method for the detection of a binding partner of a multispecific binder |
| CN102645530B (zh) * | 2012-04-06 | 2014-06-18 | 上海蓝怡科技有限公司 | 甲状腺素酶联免疫体外诊断试剂盒中酶结合物稀释液的制备方法 |
| JP6226976B2 (ja) | 2012-07-13 | 2017-11-08 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | 多重特異性結合物を検出するための方法 |
| EP4331605A3 (en) | 2013-09-13 | 2024-05-22 | F. Hoffmann-La Roche AG | Methods and compositions comprising purified recombinant polypeptides |
| JP6546178B2 (ja) | 2013-09-13 | 2019-07-17 | ジェネンテック， インコーポレイテッド | 細胞株中の宿主細胞タンパク質及び組換えポリペプチド産物を検出及び定量化するための組成物並びに方法 |
| EP3057581B1 (en) | 2013-10-17 | 2019-09-04 | Sartar Therapeutics Ltd | Compositions comprising phosphodiesterase inhibitors for use in the treatment of a solid tumor in a human patient |
| RU2589286C1 (ru) * | 2015-02-03 | 2016-07-10 | Федеральное государственное бюджетное научное учреждение "Томский научно-исследовательский институт онкологии" (Томский НИИ онкологии) | Способ прогнозирования исхода заболевания у больных метастатическим раком почки |
| RU2622005C2 (ru) * | 2015-11-24 | 2017-06-08 | Федеральное государственное бюджетное учреждение "Государственный научный центр дерматовенерологии и косметологии" Минздрава России (ФГБУ ГНЦДК Минздрава России) | СПОСОБ ПОЛУЧЕНИЯ СЕЛЕКТИВНОГО ИММУНОСОРБЕНТА ДЛЯ УДАЛЕНИЯ АНТИТЕЛ-IgG К ДЕСМОГЛЕИНУ 3 ТИПА ИЗ СЫВОРОТКИ КРОВИ БОЛЬНЫХ ПУЗЫРЧАТКОЙ |
| CN105510595A (zh) * | 2015-12-01 | 2016-04-20 | 邹检平 | 基于量子点CdTe检测人血清中VEGF浓度的试剂盒及其使用方法 |
| JP2019523404A (ja) | 2016-07-15 | 2019-08-22 | エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト | 全ｖｅｇｆ−ａのレベルを検出するための方法及び手段 |
| CN107167588A (zh) * | 2017-03-28 | 2017-09-15 | 马杰 | 用于检测血清中血管内皮生长因子的抗体及试剂盒 |
| RU2732013C1 (ru) * | 2019-12-11 | 2020-09-10 | Федеральное бюджетное учреждение науки "Государственный научный центр прикладной микробиологии и биотехнологии" Федеральной службы по надзору в сфере защиты прав потребителей и благополучия человека (ФБУН ГНЦ ПМБ) | Способ сенсибилизации планшета для иммуноферментного анализа нерастворимыми белковыми антигенами |
| CN111044734A (zh) * | 2019-12-30 | 2020-04-21 | 上海复星长征医学科学有限公司 | 一种用于检测血管内皮生长因子的检测试剂盒及其制备方法和使用方法 |
| KR102676458B1 (ko) | 2021-05-20 | 2024-06-19 | 대한민국 | 보툴리눔 독소 a에 특이적인 항체, 이를 생산하는 하이브리도마 세포주, 및 이를 이용한 보툴리눔 독소 a 진단 키트 |
| CN117805397A (zh) * | 2024-02-29 | 2024-04-02 | 军科正源（北京）药物研究有限责任公司 | 检测游离vegf的方法 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| SE337223B (es) | 1967-05-23 | 1971-08-02 | Pharmacia Ab | |
| US3720760A (en) | 1968-09-06 | 1973-03-13 | Pharmacia Ab | Method for determining the presence of reagin-immunoglobulins(reagin-ig)directed against certain allergens,in aqueous samples |
| DE2031216A1 (de) | 1969-06-19 | 1971-01-14 | Citizen Watch Co Ltd , Tokio | Tag und Datum Stellvorrichtung fur Uhren mit Kalender |
| US3691016A (en) | 1970-04-17 | 1972-09-12 | Monsanto Co | Process for the preparation of insoluble enzymes |
| US3940475A (en) | 1970-06-11 | 1976-02-24 | Biological Developments, Inc. | Radioimmune method of assaying quantitatively for a hapten |
| CA1023287A (en) | 1972-12-08 | 1977-12-27 | Boehringer Mannheim G.M.B.H. | Process for the preparation of carrier-bound proteins |
| US4195128A (en) | 1976-05-03 | 1980-03-25 | Bayer Aktiengesellschaft | Polymeric carrier bound ligands |
| US4330440A (en) | 1977-02-08 | 1982-05-18 | Development Finance Corporation Of New Zealand | Activated matrix and method of activation |
| CA1093991A (en) | 1977-02-17 | 1981-01-20 | Hideo Hirohara | Enzyme immobilization with pullulan gel |
| US4229537A (en) | 1978-02-09 | 1980-10-21 | New York University | Preparation of trichloro-s-triazine activated supports for coupling ligands |
| US4376110A (en) | 1980-08-04 | 1983-03-08 | Hybritech, Incorporated | Immunometric assays using monoclonal antibodies |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US4737456A (en) | 1985-05-09 | 1988-04-12 | Syntex (U.S.A.) Inc. | Reducing interference in ligand-receptor binding assays |
| IE922437A1 (en) | 1991-07-25 | 1993-01-27 | Idec Pharma Corp | Recombinant antibodies for human therapy |
| US7005505B1 (en) * | 1995-08-25 | 2006-02-28 | Genentech, Inc. | Variants of vascular endothelial cell growth factor |
| US6020473A (en) | 1995-08-25 | 2000-02-01 | Genentech, Inc. | Nucleic acids encoding variants of vascular endothelial cell growth factor |
| DE19532347A1 (de) | 1995-09-04 | 1997-03-06 | Bayer Ag | 4-Thiocarbamoyl-1-(3-pyrazolyl)-pyrazole |
| US6750044B1 (en) * | 1996-10-17 | 2004-06-15 | Genentech, Inc. | Variants of vascular endothelial cell growth factor having antagonistic properties, nucleic acids encoding the same and host cells comprising those nucleic acids |
| NZ500078A (en) | 1997-04-07 | 2001-10-26 | Genentech Inc | Humanized anti-VEGF antibodies and their use in inhibiting VEGF-induced angiogenesis in mammals |
| JP3591264B2 (ja) * | 1997-12-24 | 2004-11-17 | 富士レビオ株式会社 | Ｖｅｇｆ１２１特異的モノクローナル抗体及び測定方法 |
| US7078382B1 (en) | 1999-11-02 | 2006-07-18 | Genentech, Inc. | Modulation of eNOS activity and therapeutic uses thereof |
| KR100749982B1 (ko) | 1999-11-16 | 2007-08-16 | 제넨테크, 인크. | 혈관 내피 성장 인자용 ｅｌｉｓａ |
| RU2271010C2 (ru) * | 2004-03-31 | 2006-02-27 | Общество с ограниченной ответственностью "Фирма МонА" | Способ иммуноферментного анализа для определения фактора виллебранда, моноклональное антитело к фактору виллебранда (варианты) и штамм гибридных культивируемых клеток животных mus. musculus l. - продуцент моноклональных антител к фактору виллебранда (варианты) |
| US20060257901A1 (en) * | 2005-03-24 | 2006-11-16 | Beth Israel Deaconess Medical Center | Methods of diagnosing fetal trisomy 13 or a risk of fetal trisomy 13 during pregnancy |
| AR063125A1 (es) | 2006-10-04 | 2008-12-30 | Genentech Inc | Ensayo elisa para la deteccion de vegf |
-
2007
- 2007-10-03 AR ARP070104393 patent/AR063125A1/es active IP Right Grant
- 2007-10-03 BR BRPI0715239-6A patent/BRPI0715239A2/pt active Search and Examination
- 2007-10-03 ZA ZA200901518A patent/ZA200901518B/en unknown
- 2007-10-03 PL PL07868362T patent/PL2069798T3/pl unknown
- 2007-10-03 CN CN200780036803.0A patent/CN101523220B/zh not_active Expired - Fee Related
- 2007-10-03 WO PCT/US2007/080310 patent/WO2008060777A2/en not_active Ceased
- 2007-10-03 HU HUE11189401A patent/HUE030082T2/en unknown
- 2007-10-03 JP JP2009531581A patent/JP6025294B2/ja not_active Expired - Fee Related
- 2007-10-03 AU AU2007319654A patent/AU2007319654B2/en not_active Ceased
- 2007-10-03 TW TW102139875A patent/TWI541251B/zh not_active IP Right Cessation
- 2007-10-03 MX MX2009003562A patent/MX2009003562A/es unknown
- 2007-10-03 NZ NZ61364607A patent/NZ613646A/en not_active IP Right Cessation
- 2007-10-03 RU RU2009116611/15A patent/RU2517301C2/ru active
- 2007-10-03 KR KR1020097009095A patent/KR101551984B1/ko not_active Expired - Fee Related
- 2007-10-03 HR HRP20140675TT patent/HRP20140675T1/hr unknown
- 2007-10-03 DK DK11189401.0T patent/DK2457929T3/en active
- 2007-10-03 PT PT78683620T patent/PT2069798E/pt unknown
- 2007-10-03 KR KR1020157005110A patent/KR101720887B1/ko not_active Expired - Fee Related
- 2007-10-03 SI SI200731464T patent/SI2069798T1/sl unknown
- 2007-10-03 ES ES11189401.0T patent/ES2584322T3/es active Active
- 2007-10-03 SI SI200731810A patent/SI2457929T1/sl unknown
- 2007-10-03 PL PL11189401.0T patent/PL2457929T3/pl unknown
- 2007-10-03 ES ES07868362.0T patent/ES2470682T3/es active Active
- 2007-10-03 US US11/866,560 patent/US20080227119A1/en not_active Abandoned
- 2007-10-03 EP EP11189401.0A patent/EP2457929B1/en active Active
- 2007-10-03 CN CN201310406549.6A patent/CN103454434B/zh not_active Expired - Fee Related
- 2007-10-03 EP EP16167119.3A patent/EP3103812B1/en active Active
- 2007-10-03 RS RSP20140350 patent/RS53387B/sr unknown
- 2007-10-03 CA CA2663012A patent/CA2663012C/en active Active
- 2007-10-03 TW TW96137100A patent/TWI429654B/zh not_active IP Right Cessation
- 2007-10-03 EP EP07868362.0A patent/EP2069798B1/en active Active
- 2007-10-03 DK DK07868362T patent/DK2069798T3/da active
-
2009
- 2009-03-03 IL IL197374A patent/IL197374A/en active IP Right Grant
- 2009-04-02 MX MX2014011461A patent/MX342791B/es unknown
-
2010
- 2010-06-17 US US12/817,827 patent/US8449885B2/en not_active Expired - Fee Related
-
2012
- 2012-10-25 US US13/660,563 patent/US9146245B2/en active Active
-
2014
- 2014-02-05 RU RU2014104113/15A patent/RU2014104113A/ru not_active Application Discontinuation
-
2015
- 2015-07-30 US US14/814,139 patent/US9625462B2/en not_active Expired - Fee Related
-
2017
- 2017-02-08 AR ARP170100313A patent/AR107561A2/es unknown
- 2017-03-13 US US15/456,846 patent/US20170276683A1/en not_active Abandoned
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