AR063018A1 - Moduladores de los receptores de la progesterona - Google Patents
Moduladores de los receptores de la progesteronaInfo
- Publication number
- AR063018A1 AR063018A1 ARP070104267A ARP070104267A AR063018A1 AR 063018 A1 AR063018 A1 AR 063018A1 AR P070104267 A ARP070104267 A AR P070104267A AR P070104267 A ARP070104267 A AR P070104267A AR 063018 A1 AR063018 A1 AR 063018A1
- Authority
- AR
- Argentina
- Prior art keywords
- progesterone receptors
- receptors modulators
- fluorodibenzo
- oxazepin
- pyrido
- Prior art date
Links
- 102000003998 progesterone receptors Human genes 0.000 title abstract 2
- 108090000468 progesterone receptors Proteins 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/34—Gestagens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Physical Education & Sports Medicine (AREA)
- Diabetes (AREA)
- Reproductive Health (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Dermatology (AREA)
- Urology & Nephrology (AREA)
- Gynecology & Obstetrics (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
La presente provee moduladores de los receptores de la progesterona, los cuales son compuestos de (cis)-8-fluorodibenzo[b,f]pirido[1,2-d]oxazepin-1-amina y los usos de ellos. Reivindicacion 1: Un compuesto de (cis)-8-fluorodibenzo[b,f]pirido[1,2- d]oxazepin-1-amina de acuerdo con la (formula 1) caracterizado porque R1 es (C1-4)alquilo, opcionalmente sustituido por uno o más átomos de halogeno; y R2 es seleccionado entre un grupo qeu consta de H, halogeno, (C1-6)alquilo y CN; y R3, R4 y R5 son cada uno independientemente H o F.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06121372 | 2006-09-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR063018A1 true AR063018A1 (es) | 2008-12-23 |
Family
ID=37813577
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP070104267A AR063018A1 (es) | 2006-09-27 | 2007-09-27 | Moduladores de los receptores de la progesterona |
Country Status (27)
| Country | Link |
|---|---|
| EP (1) | EP2066677B1 (es) |
| JP (1) | JP2010504943A (es) |
| KR (1) | KR20090064454A (es) |
| CN (1) | CN101522689B (es) |
| AR (1) | AR063018A1 (es) |
| AT (1) | ATE478078T1 (es) |
| AU (1) | AU2007302007B2 (es) |
| BR (1) | BRPI0716830A2 (es) |
| CA (1) | CA2664120A1 (es) |
| CL (1) | CL2007002788A1 (es) |
| CO (1) | CO6160325A2 (es) |
| CY (1) | CY1110846T1 (es) |
| DE (1) | DE602007008589D1 (es) |
| DK (1) | DK2066677T3 (es) |
| ES (1) | ES2349325T3 (es) |
| HR (1) | HRP20100526T1 (es) |
| IL (1) | IL197365A0 (es) |
| MX (1) | MX2009002804A (es) |
| NO (1) | NO20091016L (es) |
| NZ (1) | NZ575276A (es) |
| PE (1) | PE20071451A1 (es) |
| PL (1) | PL2066677T3 (es) |
| PT (1) | PT2066677E (es) |
| RU (1) | RU2009115643A (es) |
| SI (1) | SI2066677T1 (es) |
| TW (1) | TW200820975A (es) |
| WO (1) | WO2008037746A1 (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI297685B (en) | 2002-04-04 | 2008-06-11 | Organon Nv | Non-steroidal progesterone receptor modulators |
| CN101200429B (zh) * | 2006-12-13 | 2012-08-22 | 上海睿智化学研究有限公司 | 2-硝基-4,5-二卤代苯酚类和2-氨基-4,5-二卤代苯酚类及其盐及其合成方法 |
| US8063037B2 (en) | 2007-05-07 | 2011-11-22 | N. V. Organon | Progesterone receptor modulators |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU8852901A (en) * | 2000-09-07 | 2002-03-22 | Bayer Corporation | Cyclic and acyclic amidines and pharmaceutical compositions containing them for use as progesterone receptor binding agents |
| TWI297685B (en) * | 2002-04-04 | 2008-06-11 | Organon Nv | Non-steroidal progesterone receptor modulators |
-
2007
- 2007-09-26 RU RU2009115643/04A patent/RU2009115643A/ru not_active Application Discontinuation
- 2007-09-26 NZ NZ575276A patent/NZ575276A/en unknown
- 2007-09-26 HR HR20100526T patent/HRP20100526T1/hr unknown
- 2007-09-26 CA CA002664120A patent/CA2664120A1/en not_active Abandoned
- 2007-09-26 DE DE602007008589T patent/DE602007008589D1/de active Active
- 2007-09-26 WO PCT/EP2007/060225 patent/WO2008037746A1/en not_active Ceased
- 2007-09-26 AU AU2007302007A patent/AU2007302007B2/en not_active Ceased
- 2007-09-26 DK DK07820620.8T patent/DK2066677T3/da active
- 2007-09-26 EP EP07820620A patent/EP2066677B1/en active Active
- 2007-09-26 ES ES07820620T patent/ES2349325T3/es active Active
- 2007-09-26 MX MX2009002804A patent/MX2009002804A/es not_active Application Discontinuation
- 2007-09-26 KR KR1020097007645A patent/KR20090064454A/ko not_active Withdrawn
- 2007-09-26 BR BRPI0716830-6A patent/BRPI0716830A2/pt not_active IP Right Cessation
- 2007-09-26 CN CN2007800361667A patent/CN101522689B/zh not_active Expired - Fee Related
- 2007-09-26 JP JP2009529699A patent/JP2010504943A/ja not_active Ceased
- 2007-09-26 PT PT07820620T patent/PT2066677E/pt unknown
- 2007-09-26 AT AT07820620T patent/ATE478078T1/de active
- 2007-09-26 PL PL07820620T patent/PL2066677T3/pl unknown
- 2007-09-26 TW TW096135743A patent/TW200820975A/zh unknown
- 2007-09-26 SI SI200730404T patent/SI2066677T1/sl unknown
- 2007-09-27 CL CL200702788A patent/CL2007002788A1/es unknown
- 2007-09-27 AR ARP070104267A patent/AR063018A1/es not_active Application Discontinuation
- 2007-09-27 PE PE2007001315A patent/PE20071451A1/es not_active Application Discontinuation
-
2009
- 2009-03-03 IL IL197365A patent/IL197365A0/en unknown
- 2009-03-06 NO NO20091016A patent/NO20091016L/no not_active Application Discontinuation
- 2009-03-27 CO CO09031994A patent/CO6160325A2/es unknown
-
2010
- 2010-10-21 CY CY20101100942T patent/CY1110846T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HRP20100526T1 (hr) | 2010-11-30 |
| WO2008037746A1 (en) | 2008-04-03 |
| KR20090064454A (ko) | 2009-06-18 |
| CA2664120A1 (en) | 2008-04-03 |
| MX2009002804A (es) | 2009-03-31 |
| CL2007002788A1 (es) | 2008-04-18 |
| SI2066677T1 (sl) | 2010-12-31 |
| JP2010504943A (ja) | 2010-02-18 |
| AU2007302007A1 (en) | 2008-04-03 |
| EP2066677B1 (en) | 2010-08-18 |
| CN101522689A (zh) | 2009-09-02 |
| PT2066677E (pt) | 2010-11-10 |
| CO6160325A2 (es) | 2010-05-20 |
| AU2007302007B2 (en) | 2012-02-02 |
| RU2009115643A (ru) | 2010-11-10 |
| DK2066677T3 (da) | 2010-11-08 |
| TW200820975A (en) | 2008-05-16 |
| BRPI0716830A2 (pt) | 2013-11-05 |
| EP2066677A1 (en) | 2009-06-10 |
| ATE478078T1 (de) | 2010-09-15 |
| NO20091016L (no) | 2009-03-30 |
| DE602007008589D1 (de) | 2010-09-30 |
| CN101522689B (zh) | 2012-01-11 |
| NZ575276A (en) | 2011-07-29 |
| PL2066677T3 (pl) | 2011-02-28 |
| PE20071451A1 (es) | 2008-10-30 |
| ES2349325T3 (es) | 2010-12-30 |
| HK1126767A1 (en) | 2009-09-11 |
| IL197365A0 (en) | 2009-12-24 |
| CY1110846T1 (el) | 2015-06-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |