AR060931A1 - Producto farmaceutico recubierto para la administracion intraoral de nicotina y su uso y elaboracion - Google Patents
Producto farmaceutico recubierto para la administracion intraoral de nicotina y su uso y elaboracionInfo
- Publication number
- AR060931A1 AR060931A1 ARP070102085A ARP070102085A AR060931A1 AR 060931 A1 AR060931 A1 AR 060931A1 AR P070102085 A ARP070102085 A AR P070102085A AR P070102085 A ARP070102085 A AR P070102085A AR 060931 A1 AR060931 A1 AR 060931A1
- Authority
- AR
- Argentina
- Prior art keywords
- nicotine
- administration
- coating
- coated
- preparation
- Prior art date
Links
- SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 title abstract 11
- 229960002715 nicotine Drugs 0.000 title abstract 11
- SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 title abstract 11
- 239000000825 pharmaceutical preparation Substances 0.000 title 1
- 229940127557 pharmaceutical product Drugs 0.000 title 1
- 239000011248 coating agent Substances 0.000 abstract 3
- 238000000576 coating method Methods 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 3
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 abstract 3
- 229960000281 trometamol Drugs 0.000 abstract 3
- 241000208125 Nicotiana Species 0.000 abstract 2
- 235000002637 Nicotiana tabacum Nutrition 0.000 abstract 2
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 229940112822 chewing gum Drugs 0.000 abstract 2
- 235000015218 chewing gum Nutrition 0.000 abstract 2
- 235000003599 food sweetener Nutrition 0.000 abstract 2
- 239000000779 smoke Substances 0.000 abstract 2
- 239000003765 sweetening agent Substances 0.000 abstract 2
- 108010010803 Gelatin Proteins 0.000 abstract 1
- 239000000654 additive Substances 0.000 abstract 1
- 239000011247 coating layer Substances 0.000 abstract 1
- 229920000159 gelatin Polymers 0.000 abstract 1
- 239000008273 gelatin Substances 0.000 abstract 1
- 235000019322 gelatine Nutrition 0.000 abstract 1
- 235000011852 gelatine desserts Nutrition 0.000 abstract 1
- 239000010410 layer Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000006186 oral dosage form Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/465—Nicotine; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Physiology (AREA)
- Nutrition Science (AREA)
- Zoology (AREA)
- Diabetes (AREA)
- Hospice & Palliative Care (AREA)
- Psychology (AREA)
- Child & Adolescent Psychology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Formas de dosificacion oral recubiertas para la administracion de nicotina en cualquier forma a un sujeto mediante la rápida administracion intraoral de nicotina, que comprenden al menos un nucleo, nicotina en cualquier forma y/o un agente imitador de la nicotina, al menos una capa de recubrimiento y opcionalmente al menos uno o varios aditivos adicionales, en donde dicha al menos una capa de recubrimiento contiene buffer, en donde se usa al menos trometamol como agente de buffer. También se contempla un método para la administracion de nicotina en cualquier forma, un método para la reduccion de la necesidad de fumar o usar tabaco, así como un método para producir dicho producto recubierto y el uso de dicho producto para obtener una rápida captacion intraoral de nicotina. Reivindicacion 24: Un dispositivo para administrar nicotina en cualquier forma a un sujeto, que comprende un producto recubierto de acuerdo con cualquiera de las reivindicaciones 1-23 y al menos otro medio o método adicional para obtener la reduccion de la necesidad de fumar o usar tabaco. Reivindicacion 38: Una goma de mascar recubierta que contiene nicotina, donde el nucleo de la goma de mascar comprende nicotina en cualquier forma, una base de goma, trometamol, uno o varios endulzantes y uno o varios saborizantes, y donde el recubrimiento es un recubrimiento duro que comprende nicotina en cualquier forma, trometamol, uno o varios endulzantes y gelatina.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0601090 | 2006-05-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR060931A1 true AR060931A1 (es) | 2008-07-23 |
Family
ID=38694149
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP070102085A AR060931A1 (es) | 2006-05-16 | 2007-05-15 | Producto farmaceutico recubierto para la administracion intraoral de nicotina y su uso y elaboracion |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US20070269492A1 (es) |
| EP (1) | EP2023928A4 (es) |
| JP (1) | JP5254213B2 (es) |
| KR (1) | KR101414063B1 (es) |
| CN (1) | CN101472591A (es) |
| AR (1) | AR060931A1 (es) |
| AU (1) | AU2007250589B2 (es) |
| BR (1) | BRPI0712068A2 (es) |
| CA (1) | CA2652500C (es) |
| MX (1) | MX2008014726A (es) |
| NO (1) | NO20084987L (es) |
| NZ (1) | NZ572758A (es) |
| RU (1) | RU2448707C2 (es) |
| TW (1) | TW200810755A (es) |
| WO (1) | WO2007133141A1 (es) |
| ZA (1) | ZA200810618B (es) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8252321B2 (en) | 2004-09-13 | 2012-08-28 | Chrono Therapeutics, Inc. | Biosynchronous transdermal drug delivery for longevity, anti-aging, fatigue management, obesity, weight loss, weight management, delivery of nutraceuticals, and the treatment of hyperglycemia, alzheimer's disease, sleep disorders, parkinson's disease, aids, epilepsy, attention deficit disorder, nicotine addiction, cancer, headache and pain control, asthma, angina, hypertension, depression, cold, flu and the like |
| US8642016B2 (en) | 2006-07-21 | 2014-02-04 | Jsrnti, Llc | Medicinal delivery system, and related methods |
| KR101122469B1 (ko) * | 2007-04-02 | 2012-07-12 | 파킨슨즈 인스티튜트 | 처치 치료의 부작용을 감소시키기 위한 방법 및 조성물 |
| GB2468424B (en) * | 2007-04-02 | 2011-11-09 | Parkinson S Inst | Methods and compositions for reduction of side effects of therapeutic treatments |
| US20080286341A1 (en) * | 2007-05-16 | 2008-11-20 | Sven-Borje Andersson | Buffered coated nicotine containing products |
| AR071420A1 (es) * | 2008-05-01 | 2010-06-16 | Smithkline Beecham Corp | Composicion de pastilla para chupar oral que comprende un principio activo de nicotina y procedimiento para fabricarla |
| AU2013219211B2 (en) * | 2008-05-01 | 2016-05-12 | North Star OpCo Limited | Nicotine lozenge compositions |
| ES2401912T3 (es) | 2008-09-17 | 2013-04-25 | Siegfried Ltd. | Granulado que contiene nicotina |
| JP2012505878A (ja) | 2008-10-14 | 2012-03-08 | マクニール アーベー | 複数部分口内剤形及びその使用 |
| DK2198865T3 (da) * | 2008-12-19 | 2012-01-16 | Siegfried Ltd | Nikotinholdigt produkt |
| US20100247586A1 (en) * | 2009-03-27 | 2010-09-30 | Andreas Hugerth | Multi-Portion Intra-Oral Dosage Form With Organoleptic Properties |
| WO2010145653A1 (en) * | 2009-06-19 | 2010-12-23 | Fertin Pharma A/S | Buffered gum base for high ph release |
| WO2011101860A1 (en) * | 2010-02-18 | 2011-08-25 | Jatin Vasant Thakkar | Nicotine-containing soft gelatin pastilles |
| US20110268809A1 (en) | 2010-04-28 | 2011-11-03 | Paul Andrew Brinkley | Nicotine-Containing Pharmaceutical Compositions |
| US20110274628A1 (en) | 2010-05-07 | 2011-11-10 | Borschke August J | Nicotine-containing pharmaceutical compositions |
| EP2729148A4 (en) | 2011-07-06 | 2015-04-22 | Parkinson S Inst | COMPOSITIONS AND METHOD FOR THE TREATMENT OF SYMPTOMS IN PATIENTS WITH MORBUS PARKINSON |
| US9629392B2 (en) | 2011-09-22 | 2017-04-25 | R.J. Reynolds Tobacco Company | Translucent smokeless tobacco product |
| US9474303B2 (en) | 2011-09-22 | 2016-10-25 | R.J. Reynolds Tobacco Company | Translucent smokeless tobacco product |
| US20130078307A1 (en) | 2011-09-22 | 2013-03-28 | Niconovum Usa, Inc. | Nicotine-containing pharmaceutical composition |
| US9084439B2 (en) | 2011-09-22 | 2015-07-21 | R.J. Reynolds Tobacco Company | Translucent smokeless tobacco product |
| US9907748B2 (en) | 2011-10-21 | 2018-03-06 | Niconovum Usa, Inc. | Excipients for nicotine-containing therapeutic compositions |
| US20130177646A1 (en) * | 2012-01-05 | 2013-07-11 | Mcneil Ab | Solid Nicotine-Comprising Dosage Form with Reduced Organoleptic Disturbance |
| US9763928B2 (en) | 2012-02-10 | 2017-09-19 | Niconovum Usa, Inc. | Multi-layer nicotine-containing pharmaceutical composition |
| US9044035B2 (en) | 2012-04-17 | 2015-06-02 | R.J. Reynolds Tobacco Company | Remelted ingestible products |
| FR2993778B1 (fr) * | 2012-07-30 | 2016-06-17 | Pf Medicament | Pastilles a cinetiques multiples de liberation de principes actifs |
| CN102926277B (zh) * | 2012-11-14 | 2015-05-20 | 湖南中烟工业有限责任公司 | 一种β-环糊精-g-乳酸共聚物的应用 |
| US9375033B2 (en) | 2014-02-14 | 2016-06-28 | R.J. Reynolds Tobacco Company | Tobacco-containing gel composition |
| EP3250258A4 (en) | 2015-01-28 | 2018-09-05 | Chrono Therapeutics, Inc. | Drug delivery methods and systems |
| US10679516B2 (en) | 2015-03-12 | 2020-06-09 | Morningside Venture Investments Limited | Craving input and support system |
| US20170172995A1 (en) * | 2015-09-08 | 2017-06-22 | Venkateswara Rao Repaka | Pharmaceutical compositions of Nicotine and process for preparation thereof |
| US20170165252A1 (en) | 2015-12-10 | 2017-06-15 | Niconovum Usa Inc. | Protein-enriched therapeutic composition |
| AU2018205529B2 (en) | 2017-01-06 | 2023-08-10 | Morningside Venture Investments Limited | Transdermal drug delivery devices and methods |
| CA3085062C (en) * | 2017-12-08 | 2022-08-16 | Fertin Pharma A/S | Nicotine tablet |
| US11596779B2 (en) | 2018-05-29 | 2023-03-07 | Morningside Venture Investments Limited | Drug delivery methods and systems |
| MX2021000466A (es) | 2018-07-13 | 2021-03-25 | Mcneil Ab | Goma de mascar que comprende nicotina. |
| MA54245A (fr) | 2018-11-16 | 2022-02-23 | Morningside Venture Investments Ltd | Système d'administration transdermique de médicaments à régulation thermique |
| US20230053622A1 (en) | 2020-01-15 | 2023-02-23 | Mcneil Ab | Lozenge |
| SE544672C2 (en) * | 2020-05-07 | 2022-10-11 | Liw Innovation Ab | New compositions for oral or nasal use |
| EP4419103A1 (en) * | 2021-10-21 | 2024-08-28 | McNeil AB | Nicotine chewing gum |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3901248A (en) * | 1970-07-22 | 1975-08-26 | Leo Ab | Chewable smoking substitute composition |
| US3877468A (en) * | 1970-07-22 | 1975-04-15 | Leo Ab | Chewable tobacco substitute composition |
| US3845217A (en) * | 1972-11-16 | 1974-10-29 | Helsingborg L Ab | Buffered smoking substitute compositions |
| GB8301659D0 (en) * | 1983-01-21 | 1983-02-23 | Leo Ab | Smoking substitutes |
| US5783207A (en) * | 1985-05-01 | 1998-07-21 | University Of Utah Research Foundation | Selectively removable nicotine-containing dosage form for use in the transmucosal delivery of nicotine |
| GB8615676D0 (en) * | 1986-06-26 | 1986-07-30 | Stoppers Co Ltd | Nicotine containing lozenge |
| US5004651A (en) * | 1989-01-24 | 1991-04-02 | Abbott Laboratories | Stabilizing system for solid dosage forms |
| US5824334A (en) * | 1989-09-05 | 1998-10-20 | University Of Utah Research Foundation | Tobacco substitute |
| US5167242A (en) * | 1990-06-08 | 1992-12-01 | Kabi Pharmacia Aktiebolaq | Nicotine-impermeable container and method of fabricating the same |
| EP0620706A1 (en) * | 1992-01-06 | 1994-10-26 | E.I. Du Pont De Nemours And Company | Tablet formulation with internal desiccant |
| SE9303574D0 (sv) * | 1993-11-01 | 1993-11-01 | Kabi Pharmacia Ab | Composition for drug delivery and method the manufacturing thereof |
| US5889028A (en) * | 1996-02-09 | 1999-03-30 | Mayo Foundation For Medical Education And Research | Colonic delivery of nicotine to treat inflammatory bowel disease |
| US5810081A (en) * | 1997-02-24 | 1998-09-22 | Cobb; Delwin E. | Wear structure for bore hole separation device |
| US6264981B1 (en) * | 1999-10-27 | 2001-07-24 | Anesta Corporation | Oral transmucosal drug dosage using solid solution |
| US20030175349A1 (en) * | 2001-01-30 | 2003-09-18 | Council Of Scientific And Industrial Research | Pharmaceutical compostion for extended/sustained release of a therapeutically active ingredient |
| SE0102197D0 (sv) * | 2001-06-20 | 2001-06-20 | Pharmacia Ab | New product and use and manufacture thereof |
| US20040037879A1 (en) * | 2001-11-02 | 2004-02-26 | Adusumilli Prasad S. | Oral controlled release forms useful for reducing or preventing nicotine cravings |
| AU2003227691B2 (en) * | 2002-05-03 | 2008-05-15 | Hexal Ag | Stable pharmaceutical formulation for a combination of a statin and an ace inhibitor |
| US7157100B2 (en) * | 2002-06-04 | 2007-01-02 | J.B. Chemicals & Pharmaceuticals Ltd. | Pharmaceutical composition for controlled drug delivery system |
| US20030049307A1 (en) * | 2002-08-15 | 2003-03-13 | Gyurik Robert J. | Pharmaceutical composition |
| US20040052851A1 (en) * | 2002-09-16 | 2004-03-18 | Graff Allan H. | Modified release oral dosage form |
-
2006
- 2006-06-01 US US11/444,775 patent/US20070269492A1/en not_active Abandoned
-
2007
- 2007-04-18 CA CA2652500A patent/CA2652500C/en not_active Expired - Fee Related
- 2007-04-18 MX MX2008014726A patent/MX2008014726A/es active IP Right Grant
- 2007-04-18 RU RU2008149508/15A patent/RU2448707C2/ru not_active IP Right Cessation
- 2007-04-18 NZ NZ572758A patent/NZ572758A/en not_active IP Right Cessation
- 2007-04-18 CN CNA2007800232492A patent/CN101472591A/zh active Pending
- 2007-04-18 JP JP2009510917A patent/JP5254213B2/ja not_active Expired - Fee Related
- 2007-04-18 AU AU2007250589A patent/AU2007250589B2/en not_active Ceased
- 2007-04-18 BR BRPI0712068-0A patent/BRPI0712068A2/pt not_active Application Discontinuation
- 2007-04-18 WO PCT/SE2007/000365 patent/WO2007133141A1/en not_active Ceased
- 2007-04-18 EP EP07748030A patent/EP2023928A4/en not_active Withdrawn
- 2007-04-18 KR KR1020087030673A patent/KR101414063B1/ko not_active Expired - Fee Related
- 2007-05-15 TW TW096117125A patent/TW200810755A/zh unknown
- 2007-05-15 AR ARP070102085A patent/AR060931A1/es not_active Application Discontinuation
-
2008
- 2008-11-27 NO NO20084987A patent/NO20084987L/no not_active Application Discontinuation
- 2008-12-15 ZA ZA2008/10618A patent/ZA200810618B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| TW200810755A (en) | 2008-03-01 |
| MX2008014726A (es) | 2009-02-04 |
| NO20084987L (no) | 2009-02-16 |
| EP2023928A1 (en) | 2009-02-18 |
| NZ572758A (en) | 2011-01-28 |
| KR101414063B1 (ko) | 2014-07-18 |
| US20070269492A1 (en) | 2007-11-22 |
| CN101472591A (zh) | 2009-07-01 |
| AU2007250589B2 (en) | 2011-04-14 |
| CA2652500A1 (en) | 2007-11-22 |
| EP2023928A4 (en) | 2012-08-29 |
| CA2652500C (en) | 2014-07-29 |
| RU2008149508A (ru) | 2010-06-27 |
| WO2007133141A1 (en) | 2007-11-22 |
| JP2009537514A (ja) | 2009-10-29 |
| BRPI0712068A2 (pt) | 2012-01-17 |
| AU2007250589A1 (en) | 2007-11-22 |
| KR20090024161A (ko) | 2009-03-06 |
| ZA200810618B (en) | 2010-02-24 |
| RU2448707C2 (ru) | 2012-04-27 |
| JP5254213B2 (ja) | 2013-08-07 |
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