MX2010006284A - Formulaciones farmaceuticas de fenilefrina y composiciones para la absorcion transmucosal. - Google Patents
Formulaciones farmaceuticas de fenilefrina y composiciones para la absorcion transmucosal.Info
- Publication number
- MX2010006284A MX2010006284A MX2010006284A MX2010006284A MX2010006284A MX 2010006284 A MX2010006284 A MX 2010006284A MX 2010006284 A MX2010006284 A MX 2010006284A MX 2010006284 A MX2010006284 A MX 2010006284A MX 2010006284 A MX2010006284 A MX 2010006284A
- Authority
- MX
- Mexico
- Prior art keywords
- phenylephrine
- compositions
- pharmaceutical formulations
- transmucosal absorption
- formulated
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 4
- SONNWYBIRXJNDC-VIFPVBQESA-N phenylephrine Chemical compound CNC[C@H](O)C1=CC=CC(O)=C1 SONNWYBIRXJNDC-VIFPVBQESA-N 0.000 title abstract 4
- 229960001802 phenylephrine Drugs 0.000 title abstract 4
- 238000010521 absorption reaction Methods 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 238000010579 first pass effect Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 210000002200 mouth mucosa Anatomy 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 238000012385 systemic delivery Methods 0.000 abstract 1
- 230000009885 systemic effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
- A61K9/0058—Chewing gums
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Physiology (AREA)
- Nutrition Science (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Zoology (AREA)
- Pulmonology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Emergency Medicine (AREA)
- Otolaryngology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Immunology (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Composiciones farmacéuticas que comprenden fenilefrina o una sal farmacéuticamente aceptable de la misma y métodos para administrar las composiciones farmacéuticas, en donde la composición se fórmula para la absorción sintética de fenilefrina que evita el metabolismo de primer paso; las composiciones de la invención se formulan para aplicarlas a la mucosa oral de un animal para permitir un suministro sintético mejorado de la forma terapéuticamente activa de fenilefrina.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1222307P | 2007-12-07 | 2007-12-07 | |
| PCT/US2008/085523 WO2009076165A1 (en) | 2007-12-07 | 2008-12-04 | Phenylephrine pharmaceutical formulations and compositions for transmucosal absorption |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2010006284A true MX2010006284A (es) | 2010-09-07 |
Family
ID=40510498
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2010006284A MX2010006284A (es) | 2007-12-07 | 2008-12-04 | Formulaciones farmaceuticas de fenilefrina y composiciones para la absorcion transmucosal. |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US20090280160A1 (es) |
| EP (1) | EP2237767A1 (es) |
| JP (1) | JP2011506337A (es) |
| KR (1) | KR20100102632A (es) |
| CN (1) | CN101938991A (es) |
| AR (1) | AR069572A1 (es) |
| AU (1) | AU2008335464A1 (es) |
| BR (1) | BRPI0820673A2 (es) |
| CA (1) | CA2709208A1 (es) |
| CL (1) | CL2008003615A1 (es) |
| CO (1) | CO6321221A2 (es) |
| MX (1) | MX2010006284A (es) |
| PE (1) | PE20091084A1 (es) |
| RU (1) | RU2010127737A (es) |
| TW (1) | TW200932208A (es) |
| WO (1) | WO2009076165A1 (es) |
| ZA (1) | ZA201004654B (es) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX361099B (es) * | 2013-02-13 | 2018-11-27 | Procter & Gamble | Medicamento con sabor a anís. |
| US20190008759A1 (en) * | 2014-07-03 | 2019-01-10 | Darren Rubin | Safer and more effective methods of transmucosal delivery for raising blood pressure and stimulating the body |
| MA41689A (fr) * | 2014-10-15 | 2017-08-22 | Bioxcel Corp | Prévention ou traitement de troubles du sommeil au moyen d'une formulation de dexmédétomidine |
| KR20230137362A (ko) * | 2016-05-05 | 2023-10-04 | 어퀘스티브 테라퓨틱스, 아이엔씨. | 강화된 전달 에프네프린 조성물 |
| US11273131B2 (en) | 2016-05-05 | 2022-03-15 | Aquestive Therapeutics, Inc. | Pharmaceutical compositions with enhanced permeation |
| US12427121B2 (en) | 2016-05-05 | 2025-09-30 | Aquestive Therapeutics, Inc. | Enhanced delivery epinephrine compositions |
| US12433850B2 (en) | 2016-05-05 | 2025-10-07 | Aquestive Therapeutics, Inc. | Enhanced delivery epinephrine and prodrug compositions |
| SG10202107367SA (en) | 2016-12-31 | 2021-08-30 | Bioxcel Therapeutics Inc | Use of sublingual dexmedetomidine for the treatment of agitation |
| WO2018130603A1 (en) | 2017-01-11 | 2018-07-19 | Ferring B.V. | A fast disintegrating pharmaceutical composition |
| WO2019021476A1 (ja) * | 2017-07-28 | 2019-01-31 | 社会医療法人蘇西厚生会 まつなみリサーチパーク | アレルギー症状の予防又は治療剤 |
| BR112020005948A2 (pt) * | 2017-09-27 | 2020-12-01 | Aquestive Therapeutics, Inc. | distribuição intensificada de composições de epinefrina e pró-fármaco |
| MX2020014000A (es) | 2018-06-27 | 2021-06-15 | Bioxcel Therapeutics Inc | Formulaciones en lámina que contienen dexmedetomidina y métodos para producirlas. |
| CA3145388A1 (en) | 2019-07-19 | 2021-01-28 | Bioxcel Therapeutics, Inc. | Non-sedating dexmedetomidine treatment regimens |
| US20210369721A1 (en) * | 2020-06-02 | 2021-12-02 | Mohamed Hussein Hamdan | Sublingual formulation for hypotension and syncope |
| US12286451B2 (en) | 2020-11-23 | 2025-04-29 | Medtech Products Inc. | Borate ester complexes of α-hydroxy carboxylic acids and their conjugate base buffers |
| US12465564B2 (en) | 2021-10-25 | 2025-11-11 | Aquestive Therapeutics, Inc. | Oral and nasal compositions and methods of treatment |
| US11806334B1 (en) | 2023-01-12 | 2023-11-07 | Bioxcel Therapeutics, Inc. | Non-sedating dexmedetomidine treatment regimens |
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| US3558768A (en) * | 1969-12-19 | 1971-01-26 | Sterling Drug Inc | Sustained release pharmaceutical compositions |
| US4291015A (en) * | 1979-08-14 | 1981-09-22 | Key Pharmaceuticals, Inc. | Polymeric diffusion matrix containing a vasodilator |
| US4427681A (en) * | 1982-09-16 | 1984-01-24 | Richardson-Vicks, Inc. | Thixotropic compositions easily convertible to pourable liquids |
| US5025019A (en) * | 1984-04-09 | 1991-06-18 | Analgesic Associates | Cough/cold mixtures comprising non-steroidal anti-inflammatory drugs |
| US4623664A (en) * | 1985-10-31 | 1986-11-18 | University Of Iowa Research Foundation | Oil suspended phenylephrine |
| US4764378A (en) * | 1986-02-10 | 1988-08-16 | Zetachron, Inc. | Buccal drug dosage form |
| US4792452A (en) * | 1987-07-28 | 1988-12-20 | E. R. Squibb & Sons, Inc. | Controlled release formulation |
| US5085865A (en) * | 1989-04-12 | 1992-02-04 | Warner-Lambert Company | Sustained release pharmaceutical preparations containing an analgesic and a decongestant |
| US5133974A (en) * | 1989-05-05 | 1992-07-28 | Kv Pharmaceutical Company | Extended release pharmaceutical formulations |
| CA2087435C (en) * | 1990-08-07 | 1998-05-05 | Scott Max Herbig | Use of interfacially-polymerized membranes in delivery devices |
| US5518730A (en) * | 1992-06-03 | 1996-05-21 | Fuisz Technologies Ltd. | Biodegradable controlled release flash flow melt-spun delivery system |
| US5458879A (en) * | 1994-03-03 | 1995-10-17 | The Procter & Gamble Company | Oral vehicle compositions |
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| US5827531A (en) * | 1994-12-02 | 1998-10-27 | The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration | Microcapsules and methods for making |
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| DK0946155T4 (da) * | 1996-12-23 | 2009-05-11 | Sla Pharma Ag | Farmaceutisk sammensætning til behandling af fækal inkontinens |
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| US6602521B1 (en) * | 1998-09-29 | 2003-08-05 | Impax Pharmaceuticals, Inc. | Multiplex drug delivery system suitable for oral administration |
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| US6114346A (en) * | 1999-10-22 | 2000-09-05 | Schering Corporation | Treating sleep disorders using desloratadine |
| SK287684B6 (sk) * | 1999-12-20 | 2011-06-06 | Schering Corporation | Pevná orálna farmaceutická dávková forma s predĺženým uvoľňovaním |
| SK287105B6 (sk) * | 1999-12-20 | 2009-12-07 | Schering Corporation | Dvojvrstvový orálny dávkový prostriedok s predĺženým uvoľňovaním |
| US6955821B2 (en) * | 2000-04-28 | 2005-10-18 | Adams Laboratories, Inc. | Sustained release formulations of guaifenesin and additional drug ingredients |
| WO2001089476A1 (en) * | 2000-05-19 | 2001-11-29 | Npd Llc | Chewing gums, lozenges, candies, tablets, liquids, and sprays for efficient delivery of medications and dietary supplements |
| WO2003009834A1 (en) * | 2000-08-17 | 2003-02-06 | Battey Alyce S | Oral delivery of pharmaceuticals via encapsulation |
| US20030236275A1 (en) * | 2002-06-20 | 2003-12-25 | Schering Corporation | Treatment methods of nasal congestion and nasal obstruction |
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| US20040122107A1 (en) * | 2002-09-13 | 2004-06-24 | Fine Jeffrey R | Method of alleviating barometric-induced symptoms in airline passengers |
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| US20070219253A1 (en) * | 2003-09-17 | 2007-09-20 | Gul Balwani | Decongestant / antihistaminic / expectorant compositions |
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| WO2005067865A1 (en) * | 2004-01-15 | 2005-07-28 | Oral Bioscience Pty. Limited | Oral anaesthetic gel |
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| US8940796B2 (en) * | 2006-02-21 | 2015-01-27 | Wyeth Llc | Phenylephrine liquid formulations |
| US20080014274A1 (en) * | 2006-07-14 | 2008-01-17 | Wyeth | Enhanced stability phenylephrine liquid compositions |
| US9005652B2 (en) * | 2006-07-25 | 2015-04-14 | Wyeth | Chewable tablet containing phenylephrine |
| US7378082B1 (en) * | 2007-11-05 | 2008-05-27 | Inspire Pharmaceuticals, Inc. | Method for treating allergic rhinitis without adverse effects |
-
2008
- 2008-12-03 PE PE2008002013A patent/PE20091084A1/es not_active Application Discontinuation
- 2008-12-04 US US12/328,429 patent/US20090280160A1/en not_active Abandoned
- 2008-12-04 WO PCT/US2008/085523 patent/WO2009076165A1/en not_active Ceased
- 2008-12-04 EP EP08858399A patent/EP2237767A1/en not_active Withdrawn
- 2008-12-04 AU AU2008335464A patent/AU2008335464A1/en not_active Abandoned
- 2008-12-04 CN CN2008801263844A patent/CN101938991A/zh active Pending
- 2008-12-04 TW TW097147189A patent/TW200932208A/zh unknown
- 2008-12-04 BR BRPI0820673-2A patent/BRPI0820673A2/pt not_active IP Right Cessation
- 2008-12-04 MX MX2010006284A patent/MX2010006284A/es not_active Application Discontinuation
- 2008-12-04 AR ARP080105286A patent/AR069572A1/es not_active Application Discontinuation
- 2008-12-04 KR KR1020107014733A patent/KR20100102632A/ko not_active Withdrawn
- 2008-12-04 CA CA2709208A patent/CA2709208A1/en not_active Abandoned
- 2008-12-04 JP JP2010537049A patent/JP2011506337A/ja not_active Withdrawn
- 2008-12-04 CL CL2008003615A patent/CL2008003615A1/es unknown
- 2008-12-04 RU RU2010127737/15A patent/RU2010127737A/ru not_active Application Discontinuation
-
2010
- 2010-07-01 ZA ZA2010/04654A patent/ZA201004654B/en unknown
- 2010-07-07 CO CO10082162A patent/CO6321221A2/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| EP2237767A1 (en) | 2010-10-13 |
| CN101938991A (zh) | 2011-01-05 |
| US20090280160A1 (en) | 2009-11-12 |
| CL2008003615A1 (es) | 2009-10-16 |
| TW200932208A (en) | 2009-08-01 |
| BRPI0820673A2 (pt) | 2015-06-16 |
| CA2709208A1 (en) | 2009-06-18 |
| CO6321221A2 (es) | 2011-09-20 |
| KR20100102632A (ko) | 2010-09-24 |
| RU2010127737A (ru) | 2012-01-20 |
| ZA201004654B (en) | 2011-03-30 |
| JP2011506337A (ja) | 2011-03-03 |
| WO2009076165A1 (en) | 2009-06-18 |
| PE20091084A1 (es) | 2009-07-23 |
| AU2008335464A1 (en) | 2009-06-18 |
| AR069572A1 (es) | 2010-02-03 |
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