AR068130A1 - Derivados de tiadiazinona - Google Patents
Derivados de tiadiazinonaInfo
- Publication number
- AR068130A1 AR068130A1 ARP080103757A ARP080103757A AR068130A1 AR 068130 A1 AR068130 A1 AR 068130A1 AR P080103757 A ARP080103757 A AR P080103757A AR P080103757 A ARP080103757 A AR P080103757A AR 068130 A1 AR068130 A1 AR 068130A1
- Authority
- AR
- Argentina
- Prior art keywords
- nha
- naa
- hal
- mono
- so2naa
- Prior art date
Links
- 229910006074 SO2NH2 Inorganic materials 0.000 abstract 3
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 3
- 125000000565 sulfonamide group Chemical group 0.000 abstract 3
- 125000004429 atom Chemical group 0.000 abstract 2
- 125000006237 oxymethylenoxy group Chemical group [H]C([H])([*:1])[*:2] 0.000 abstract 2
- FPYJSJDOHRDAMT-KQWNVCNZSA-N 1h-indole-5-sulfonamide, n-(3-chlorophenyl)-3-[[3,5-dimethyl-4-[(4-methyl-1-piperazinyl)carbonyl]-1h-pyrrol-2-yl]methylene]-2,3-dihydro-n-methyl-2-oxo-, (3z)- Chemical compound C=1C=C2NC(=O)\C(=C/C3=C(C(C(=O)N4CCN(C)CC4)=C(C)N3)C)C2=CC=1S(=O)(=O)N(C)C1=CC=CC(Cl)=C1 FPYJSJDOHRDAMT-KQWNVCNZSA-N 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 102000004022 Protein-Tyrosine Kinases Human genes 0.000 abstract 1
- 108090000412 Protein-Tyrosine Kinases Proteins 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 235000010290 biphenyl Nutrition 0.000 abstract 1
- 239000004305 biphenyl Substances 0.000 abstract 1
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 125000002950 monocyclic group Chemical group 0.000 abstract 1
- 125000001624 naphthyl group Chemical group 0.000 abstract 1
- ZUOUZKKEUPVFJK-UHFFFAOYSA-N phenylbenzene Natural products C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Los compuestos de la formula (1) donde R1 es Ar1 o Het1; Het es un heterociclo saturado, insaturado o aromático monocíclico con 1 a 4 átomos de N, O y/o S, que puede no estar sustituido o que puede estar mono-, di- o trisustituido con B, Ar1 es fenilo naftilo o bifenilo no sustituido o mono-, di- o trisustituido con Hal, A, OH, OA, CN, CONH2, CONHA, CONAA', SO2NH2, SO2NHA, SO2NAA', NH2, NHA, NAA', SOA, SO2A, OCH2O y/u OCH2CH2O, Het1 es un heterociclo aromático mono- o bicíclico con 1 a 4 átomos de N, O y/o S que puede no estar sustituido o que puede estar mono- di- o trisustituido con Hal, A, OH, OA, CN, CONH2, CONHA, CONAA', SO2NH2, SO2NHA, SO2NAA', NH2, NHA, NAA', SOA, SO2A, OCH2O y/u OCH2CH2O, Q está ausente o es alquileno C1-4; B es OA, A, CONH2, CONHA, CONAA', SO2NH2, SO2NHA, SO2NAA', NH2, NHA, NAA', SOA, SO2A, O(CH2)nR2, CONA(CH2)nR2, CONH(CH2)nR2, Hal, CN, NA(CH2)nR2,NH(CH2)nR2, N=CH-N(CH3)2, o como en los restos de formulas (2); R2 es H, OH, OA, NH2, NHA, NAA', o como en los restos de formulas (3), A, A' son en cada caso, de modo independiente entre sí, alquilo no ramificado o ramificado C1-10, en donde 1-7 átomos de H pueden estar reemplazados por F, Cl y/o Br, alquilo cíclico C3-7 o cicloalquilalquileno C4-10, Hal es F, Cl, Br o I, n es 0, 1, 2 o 3, así como sus derivados, solvatos, sales, tautomeros y estereoisomeros de utilidad farmacéutica, incluyendo sus mezclas en todas las proporciones. Son inhibidores de las tirosina quinasas, en especial de la Met-quinasa, y pueden utilizarse, por ejemplo, para el tratamiento de tumores
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102007041115A DE102007041115A1 (de) | 2007-08-30 | 2007-08-30 | Thiadiazinonderivate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR068130A1 true AR068130A1 (es) | 2009-11-04 |
Family
ID=39952448
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP080103757A AR068130A1 (es) | 2007-08-30 | 2008-08-29 | Derivados de tiadiazinona |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US8211886B2 (es) |
| EP (1) | EP2181111B1 (es) |
| JP (1) | JP5524840B2 (es) |
| KR (1) | KR20100065171A (es) |
| CN (1) | CN101784544B (es) |
| AR (1) | AR068130A1 (es) |
| AU (1) | AU2008295193B2 (es) |
| BR (1) | BRPI0816058A2 (es) |
| CA (1) | CA2698062C (es) |
| DE (1) | DE102007041115A1 (es) |
| EA (1) | EA017393B1 (es) |
| ES (1) | ES2426356T3 (es) |
| IL (1) | IL204127A (es) |
| MX (1) | MX2010002096A (es) |
| WO (1) | WO2009030333A1 (es) |
| ZA (1) | ZA201002218B (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20130315895A1 (en) | 2010-07-01 | 2013-11-28 | Takeda Pharmaceutical Company Limited | COMBINATION OF A cMET INHIBITOR AND AN ANTIBODY TO HGF AND/OR cMET |
| US10398774B2 (en) | 2014-12-09 | 2019-09-03 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Human monoclonal antibodies against AXL |
| WO2016135041A1 (en) | 2015-02-26 | 2016-09-01 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Fusion proteins and antibodies comprising thereof for promoting apoptosis |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5795964A (en) | 1980-12-04 | 1982-06-15 | Morishita Seiyaku Kk | Preparation of 2-substituted-3(2h)-pyridazinone derivative |
| US4397854A (en) | 1981-05-14 | 1983-08-09 | Warner-Lambert Company | Substituted 6-phenyl-3(2H)-pyridazinones useful as cardiotonic agents |
| DE4310699A1 (de) * | 1993-04-01 | 1994-10-06 | Merck Patent Gmbh | Thiadiazinone |
| IL115889A0 (en) | 1994-11-14 | 1996-01-31 | Rohm & Haas | Pyridazinones and their use as fungicides |
| US5635494A (en) | 1995-04-21 | 1997-06-03 | Rohm And Haas Company | Dihydropyridazinones and pyridazinones and their use as fungicides and insecticides |
| GB9624482D0 (en) | 1995-12-18 | 1997-01-15 | Zeneca Phaema S A | Chemical compounds |
| DE19604388A1 (de) | 1996-02-07 | 1997-08-14 | Merck Patent Gmbh | Arylalkyl-diazinone |
| JP4471404B2 (ja) | 1996-02-13 | 2010-06-02 | アストラゼネカ ユーケイ リミテッド | Ｖｅｇｆインヒビターとしてのキナゾリン誘導体 |
| KR100489174B1 (ko) | 1996-03-05 | 2005-09-30 | 제네카-파마 소시에떼아노님 | 4-아닐리노퀴나졸린유도체 |
| GB9718972D0 (en) | 1996-09-25 | 1997-11-12 | Zeneca Ltd | Chemical compounds |
| GB9714249D0 (en) | 1997-07-08 | 1997-09-10 | Angiogene Pharm Ltd | Vascular damaging agents |
| AU738595B2 (en) | 1997-11-19 | 2001-09-20 | Kowa Co., Ltd. | Novel pyridazine derivatives and medicines containing the same as effective ingredients |
| TWI241295B (en) | 1998-03-02 | 2005-10-11 | Kowa Co | Pyridazine derivative and medicine containing the same as effect component |
| GB9900334D0 (en) | 1999-01-07 | 1999-02-24 | Angiogene Pharm Ltd | Tricylic vascular damaging agents |
| GB9900752D0 (en) | 1999-01-15 | 1999-03-03 | Angiogene Pharm Ltd | Benzimidazole vascular damaging agents |
| BR0111230A (pt) | 2000-05-31 | 2003-06-10 | Astrazeneca Ab | Composto, e, uso e processo para a preparação do mesmo |
| SK52003A3 (en) | 2000-07-07 | 2003-07-01 | Angiogene Pharm Ltd | Colchinol derivatives as angiogenesis inhibitors, method for their preparation and pharmaceutical composition comprising the same |
| BR0112224A (pt) | 2000-07-07 | 2003-06-10 | Angiogene Pharm Ltd | Composto, composição farmacêutica, uso de um composto ou de um sal, solvato ou pró-droga farmaceuticamente aceitável do mesmo, e, processo para preparar um composto |
| HUP0401984A3 (en) | 2001-10-31 | 2005-06-28 | Merck Patent Gmbh | Use of type 4 phosphodiesterase inhibitors for preparation of pharmaceutical compositions and combination with other active ingredients |
| DE102005055355A1 (de) | 2005-11-21 | 2007-10-31 | Merck Patent Gmbh | 3,6-Dihydro-2-oxo-6H-[1,3,4]thiadiazinderivate |
| DE102005055354A1 (de) | 2005-11-21 | 2007-10-31 | Merck Patent Gmbh | Substituierte 5-Phenyl-3,6-dihydro-2-oxo-6H-[1,3,4]thiadiazine |
| DE102006037478A1 (de) * | 2006-08-10 | 2008-02-14 | Merck Patent Gmbh | 2-(Heterocyclylbenzyl)-pyridazinonderivate |
| DE102007032507A1 (de) * | 2007-07-12 | 2009-04-02 | Merck Patent Gmbh | Pyridazinonderivate |
-
2007
- 2007-08-30 DE DE102007041115A patent/DE102007041115A1/de not_active Withdrawn
-
2008
- 2008-08-06 US US12/675,412 patent/US8211886B2/en not_active Expired - Fee Related
- 2008-08-06 CA CA2698062A patent/CA2698062C/en active Active
- 2008-08-06 EA EA201000364A patent/EA017393B1/ru not_active IP Right Cessation
- 2008-08-06 WO PCT/EP2008/006466 patent/WO2009030333A1/de not_active Ceased
- 2008-08-06 AU AU2008295193A patent/AU2008295193B2/en not_active Ceased
- 2008-08-06 ES ES08785386T patent/ES2426356T3/es active Active
- 2008-08-06 CN CN2008801040992A patent/CN101784544B/zh not_active Expired - Fee Related
- 2008-08-06 JP JP2010522210A patent/JP5524840B2/ja not_active Expired - Fee Related
- 2008-08-06 KR KR1020107006823A patent/KR20100065171A/ko not_active Withdrawn
- 2008-08-06 BR BRPI0816058 patent/BRPI0816058A2/pt not_active IP Right Cessation
- 2008-08-06 EP EP08785386.7A patent/EP2181111B1/de active Active
- 2008-08-06 MX MX2010002096A patent/MX2010002096A/es active IP Right Grant
- 2008-08-29 AR ARP080103757A patent/AR068130A1/es unknown
-
2010
- 2010-02-23 IL IL204127A patent/IL204127A/en active IP Right Grant
- 2010-03-29 ZA ZA2010/02218A patent/ZA201002218B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EA017393B1 (ru) | 2012-12-28 |
| KR20100065171A (ko) | 2010-06-15 |
| ZA201002218B (en) | 2010-12-29 |
| EP2181111B1 (de) | 2013-06-26 |
| IL204127A (en) | 2013-08-29 |
| CN101784544A (zh) | 2010-07-21 |
| MX2010002096A (es) | 2010-03-26 |
| AU2008295193A1 (en) | 2009-03-12 |
| AU2008295193B2 (en) | 2013-04-18 |
| ES2426356T3 (es) | 2013-10-22 |
| CA2698062A1 (en) | 2009-03-12 |
| EA201000364A1 (ru) | 2010-08-30 |
| CA2698062C (en) | 2016-05-31 |
| DE102007041115A1 (de) | 2009-03-05 |
| CN101784544B (zh) | 2012-08-29 |
| BRPI0816058A2 (pt) | 2015-03-31 |
| JP5524840B2 (ja) | 2014-06-18 |
| US8211886B2 (en) | 2012-07-03 |
| HK1146276A1 (en) | 2011-05-20 |
| WO2009030333A1 (de) | 2009-03-12 |
| JP2010536896A (ja) | 2010-12-02 |
| US20100311733A1 (en) | 2010-12-09 |
| EP2181111A1 (de) | 2010-05-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |