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AR067838A1 - Compuestos pirrolicos, composiciones farmaceuticas que los contienen y usos - Google Patents

Compuestos pirrolicos, composiciones farmaceuticas que los contienen y usos

Info

Publication number
AR067838A1
AR067838A1 ARP080100808A ARP080100808A AR067838A1 AR 067838 A1 AR067838 A1 AR 067838A1 AR P080100808 A ARP080100808 A AR P080100808A AR P080100808 A ARP080100808 A AR P080100808A AR 067838 A1 AR067838 A1 AR 067838A1
Authority
AR
Argentina
Prior art keywords
optionally substituted
methylmethanamine
pyrrol
group
ylsulfonyl
Prior art date
Application number
ARP080100808A
Other languages
English (en)
Inventor
Masahiro Kajino
Haruyuki Nishida
Koji Ono
Keizo Hirase
Yasuyoshi Arikawa
Original Assignee
Takeda Pharmaceutical
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Pharmaceutical filed Critical Takeda Pharmaceutical
Publication of AR067838A1 publication Critical patent/AR067838A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)

Abstract

Composiciones farmacéuticas y usos de las mismas como antiulcerosos. Reivindicacion 1: Un compuesto caracterizado por la formula (1) donde R1 es un grupo cíclico opcionalmente sustituido, R2 es un sustituyente, R3 es un grupo alquilo opcionalmente sustituido, un grupo acilo, hidroxi opcionalmente sustituido, amino opcionalmente sustituido, un átomo de halogeno, un grupo ciano o nitro, R4 y R5 son iguales o diferentes y cada uno es un átomo de H, un grupo alquilo opcionalmente sustituido, un grupo acilo, hidroxi opcionalmente sustituido, amino opcionalmente sustituido, un átomo de halogeno, un grupo ciano o nitro, R6 y R6' son iguales o diferentes y cada uno es un átomo de H o un grupo alquilo, y n es un numero entero de 0 a 3, con la salvedad que se excluyen 1-[5-(2-fluoropiridin-3-il)-1-(piridin-3-ilsulfonil)-1H-pirrol-3-il]-N-metilmetanamina, 1-[5-(2-cloropiridin-3-il)-1-(piridin-3-ilsulfonil)-1H-pirrol-3-il]-N-metilmetanamina, 1-[5-(2-fluoropiridin-3-il)-1-[(6-metoxipiridin-3-il]sulfonil]-1H-pirrol-3-il]-N-metilmetanamina, N-metil-1-[5-(2-metilpiridin-3-il)-1-(piridin-3-ilsulfonil)-1H-pirrol-3-il]metanamina, 1-{5-(2-fluoropiridin-3-il)-1-[(6-metilpiridin-3-il]sulfonil]-1H-pirrol-3-il}-N-metilmetanamina, y 1-[4-cloro-5-(2-fluoropiridin-3-il)-1-(piridin-3-ilsulfonil)-1H-pirrol-3-il]-N-metilmetanamina, o una sal del mismo.
ARP080100808A 2007-02-28 2008-02-27 Compuestos pirrolicos, composiciones farmaceuticas que los contienen y usos AR067838A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007050326 2007-02-28
JP2007256273 2007-09-28

Publications (1)

Publication Number Publication Date
AR067838A1 true AR067838A1 (es) 2009-10-28

Family

ID=39512511

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP080100808A AR067838A1 (es) 2007-02-28 2008-02-27 Compuestos pirrolicos, composiciones farmaceuticas que los contienen y usos

Country Status (9)

Country Link
US (1) US8933105B2 (es)
EP (2) EP2114917B1 (es)
JP (1) JP5432718B2 (es)
AR (1) AR067838A1 (es)
CA (1) CA2679305A1 (es)
CL (1) CL2008000592A1 (es)
PE (1) PE20090109A1 (es)
TW (1) TW200900064A (es)
WO (1) WO2008108380A2 (es)

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KR102126576B1 (ko) 2018-09-19 2020-06-24 주식회사 대웅제약 4-메톡시 피롤 유도체의 제조 방법
WO2021104256A1 (zh) * 2019-11-25 2021-06-03 杭州华东医药集团新药研究院有限公司 一种杂环衍生物、其药物组合物及用途
KR102432523B1 (ko) * 2020-06-17 2022-08-16 일동제약(주) 신규한 산 분비 억제제 및 이의 용도
CN111943932B (zh) * 2020-08-06 2023-07-14 四川国康药业有限公司 一种可以治疗消化性溃疡的3-吡啶磺酰-1-n-杂吡咯衍生物及其制备方法和用途
CN114149411B (zh) * 2020-09-08 2025-05-16 鲁南制药集团股份有限公司 一种沃诺拉赞中间体及其制备方法与应用
CN113620930B (zh) * 2021-07-12 2022-08-16 南京烁慧医药科技有限公司 一种含磺酰胺结构的化合物及其制备方法和应用、一种药物组合物及应用
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Also Published As

Publication number Publication date
PE20090109A1 (es) 2009-03-28
CL2008000592A1 (es) 2008-09-12
EP2114917A2 (en) 2009-11-11
US8933105B2 (en) 2015-01-13
CA2679305A1 (en) 2008-09-12
EP2364979A1 (en) 2011-09-14
WO2008108380A2 (en) 2008-09-12
EP2114917B1 (en) 2016-08-10
JP5432718B2 (ja) 2014-03-05
TW200900064A (en) 2009-01-01
WO2008108380A3 (en) 2009-04-16
US20080262042A1 (en) 2008-10-23
JP2010520153A (ja) 2010-06-10

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