AR066267A1 - Derivados de piperidina como antagonistas del receptor de taquiquinina - Google Patents
Derivados de piperidina como antagonistas del receptor de taquiquininaInfo
- Publication number
- AR066267A1 AR066267A1 ARP080101711A ARP080101711A AR066267A1 AR 066267 A1 AR066267 A1 AR 066267A1 AR P080101711 A ARP080101711 A AR P080101711A AR P080101711 A ARP080101711 A AR P080101711A AR 066267 A1 AR066267 A1 AR 066267A1
- Authority
- AR
- Argentina
- Prior art keywords
- ylcarbonyl
- methyl
- dion
- ylmethylcarbonyl
- piperidin
- Prior art date
Links
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical class C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 title 1
- 239000002464 receptor antagonist Substances 0.000 title 1
- 229940044551 receptor antagonist Drugs 0.000 title 1
- -1 carbamoylmethyl Chemical group 0.000 abstract 112
- 229910052801 chlorine Inorganic materials 0.000 abstract 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
- 239000000460 chlorine Substances 0.000 abstract 3
- 125000001309 chloro group Chemical group Cl* 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 3
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 2
- 125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 abstract 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
- YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical compound C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 125000006125 ethylsulfonyl group Chemical group 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 125000001153 fluoro group Chemical group F* 0.000 abstract 1
- WFKAJVHLWXSISD-UHFFFAOYSA-N isobutyramide Chemical group CC(C)C(N)=O WFKAJVHLWXSISD-UHFFFAOYSA-N 0.000 abstract 1
- 125000005322 morpholin-1-yl group Chemical group 0.000 abstract 1
- 125000004482 piperidin-4-yl group Chemical group N1CCC(CC1)* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Urology & Nephrology (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
Reivindicacion 1: Un compuesto caracterizado por la formula: 1 donde es: (1) carbamoilmetilo, (2) metilsulfoniletilcarbonilo, (3) aminosulfonilpropilcarbonilo, (4) fenilsulfoniletilcarbonilo, (5) piridin-2-ilcarbonilo, (6) 5-metoxicarbonilpiridin-2-ilcarbonilo, (7) 5-hidroxipiridin-2-ilcarbonilo, (8) 6-hidroxipiridin-2-ilcarbonilo, (9) 5-bromopiridin-2-ilcarbonilo, (10) 6-metilpiridin-2-ilcarbonilo, (11) 5-carbamoilpiridin-2-ilcarbonilo, (12) 2-aminopiridin-5-ilcarbonilo, (13) 2-acetilaminopiridin-5-ilcarbonilo, (14) piridin-3-ilcarbonilo, (15) pirazin-2-ilcarbonilo, (16) pirimidin-5-ilcarbonilo, (17) 2-aminopirimidin-5-ilcarbonilo, (18) 2-acetilaminopirimidin-5-ilcarbonilo, (19) 2-metoxicarbonilaminopirimidin-5-ilcarbonilo, (20) azetidin-3-ilcarbonilo, (21) 1-ter-butoxicarbonilazetidin-3-ilcarbonilo, (22) 1-(1-hidroxi-1-metiletilcarbonil)azetidin-3-ilcarbonilo, (23) 1-hidroximetilcarbonilazetidin-3-ilcarbonilo, (24) adamantan-1-ilcarbonilo, (25) 1-carbamoil-1-metiletilcarbonilo, (26) dimetilaminometilcarbonilo, (27)1,2,3,4-tetrahidropirimidin2,4-dion-1-ilmetilcarbonilo, (28)2,3,5,6-tetrahidropirimidin2, 6-dion-4-ilmetilcarbonilo, (29) 1-hidroximetilcarbonilpiperidin-4-ilcarbonilo, (30) 1-etoxicarbonilpiperidin-4-ilcarbonilo, (31) 1-isopropoxicarbonilpiperidin-4-ilcarbonilo, (32) 1-ciclopropilsulfonilpiperidin-4-ilcarbonilo, (33) 1-(1-hidroxietilcarbonil)piperidin-4-ilcarbonilo, (34) 5,5-dimetiloxazolidin2,4-dion-3-ilmetilcarbonilo,(35) 5,5-dimetiloxazolidin2,4-dion-3-iletilcarbonilo, (36) oxazolidin2,4-dion-3-ilmetilcarbonilo, (37)1-(2-hidroxi-2-metilpropilcarbonil)piperidin-4-ilcarbonilo, (38) 3-metilimidazolidin4,4-dimetil-2,5-dion-1-ilmetilcarbonilo, (39) 4,4-dimetilpiperidin2,6-dion-1-ilmetilcarbonilo, (40) morfolin-2,6-dion-1-ilmetilcarbonilo, (41) imidazol-2-ilcarbonilo, (42) imidazol-4-ilcarbonilo, (43) 5,5-dimetiloxazolidin2,4-dion-3-iletilo, (44) 5,5-dimetiloxazolidin2,4-dion-3-ilpropilo, (45) 6-cloropiridazin-3-ilo, (46) 6-acetilaminopiridazin-3-ilo, (47) 5-metil-1,3,4-tiadiazol-2-ilo, (48) 5-acetilaminopiridin-2-ilo, (49) 4-nitrotiazol-2-ilo, (50) 2,2,2-tricloroetoxicarbonilo, (51) etilsulfonilo, (52) ciclopropilsulfonilo, (53)isobutilsulfonilo, (54) 1-benciloxicarbonilpiperidin-4-ilsulfonilo, (55) 1-hidroximetilcarbonilpiperidin-4-ilsulfonilo, (56) etoxietilsulfonilo, (57) hidroxietilsulfonilo, (58) morfolin-1-iletilsulfonilo, (59) 5,5-dimetiloxazolidin2,4-dion-3-iletilsulfonilo, (60) indol-6-ilcarbonilo, (61) bencimidazol-6-ilcarbonilo, (62) benzotiazol-2-ilcarbonilo, (63) tiazol-2-ilcarbonilo, (64) ciclopropilaminocarbonilmetilo, (65) 4-hidroxipiperidin-1-ilcarbonilmetilo, (66) 1-ter-butoxicarbonilpiperidin-4-ilo, (67) piperidin-4-ilo, (68) 1-isopropoxicarbonilpiperidin-4-ilo, (69) 1-aminocarbonilcarbonilpiperidin-4-ilo, (70) 1-carbamoilpiperidin-4-ilo, (71) 1-hidroximetilcarbonilpiperidin-4-ilo, (72) 1-(1-hidroxi-1-metiletilcarbonil)piperidin-4-ilo, (73) 1-carbamoil-1-metiletilo, (74) 1-acetilpiperidin-4-ilmetilo, (75) 4-carbamoilpiperidin-1-ilcarbonilmetilo, (76) 3-oxopiperazin-1-ilcarbonilmetilo, (77) metoxicarboniletilo, (78) carbamoiletilo, (79)ciclopenten-3-on-1-ilo, (80) 4,4-dimetilciclohexen-3-on-1-ilo, (81) 2-hidroxi-1-metiletilo, (82) 1-carbamoiletilo, (83) 2-metilsulfonil-1-metiletilo, (84) 3-hidroxi-3-metilbutilo, (85) 4-acetilaminobenzoílo, (86) 4-cianobenzoílo, (87) 4-carbamoilbenzoílo, (88) 10-canfosulfonilo, (89) 6-cloropiridazin-3-ilo, (90) piridin-2-ilo, (91)1-(1-hidroxi-1-metiletilcarbonil)piperidin-4-ilcarbonilo, (92) 1-metoximetilcarbonilpiperidin-4-ilcarbonilo, (93) 1-aminocarbonilpiperidin-4-ilcarbonilo(94) 1-aminocarbonilcarbonilpiperidin-4-ilcarbonilo (95) 1-isopropilpiperidin-4-ilcarbonilo, (96)1-(1-hidroxiciclopropilcarbonil)piperidin-4-ilcarbonilo, (97) tetrazol-5-ilmetilcarbonilo, (98) 1-(tetrazol-1-ilmetilcarbonil)piperidin-4-ilcarbonilo,(99)1-(acetilaminometilcarbonil)piperidin-4-ilcarbonilo, (100) 2-hidroxietilcarbonilo, (101) tiomorfolin-1,1-dioxido-4-ilmetilcarbonilo, (102) dimetilaminosulfonilo, (103) 4-acetilaminofenilsulfonilo, (104) piridin-2-ilsulfonilo, (105) piridin-3-ilsulfonilo, (106) 6-cloropiridin-3-ilsulfonilo, (107) 6-(morfolin-1-il)piridin-3-ilsulfonilo, (108) piperidin-3-ilcarbonilo (109) 1-ter-butoxicarbonilpiperidin-3-ilcarbonilo (110) 1-metoxicarbonilpiperidin-3-ilcarbonilo, (111) 1-acetilpiperidin-3-ilcarbonilo, (112) 1-hidroximetilcarbonilpiperidin-3-ilcarbonilo, (113) 1-(1-hidroxi-1-metiletilcarbonil) piperidin-3-ilcarbonilo, (114) 1-metilsulfonilmetilcarbonilpiperidin-3-ilcarbonilo, (115) 1-metilsulfonilpiperidin-3-ilcarbonilo, (116) 1-aminocarbonilcarbonilpiperidin-3-ilcarbonilo, (117) 4-hidroximetilcarbonilaminociclohexan-1-ilcarbonilo, (118) 4-metoximetilcarbonilaminociclohexan-1-ilcarbonilo, (119) 4-aminocarbonilaminociclohexan-1-ilcarbonilo, (120) 4-aminocarbonilcarbonilaminociclohexan-1-ilcarbonilo, (121) 4-metilsulfonilaminociclohexan-1-ilcarbonilo, (122) tetrahidrofuran-3-ilcarbonilo, (123) tiazolidin-2-on-4-ilcarbonilo, (124) 1-ter-butoxicarbonilpirrolidin-3-ilcarbonilo, (125) 1-metoxicarbonilpirrolidin-3-ilcarbonilo o (126) 1-hidroximetilcarbonilpirrolidin-3-ilcarbonilo; R2 es metilo o ciclopropilo; R3 es un átomo de hidrogeno o metilo; R4 es un átomo de cloro o trifluorometilo; R5 es un átomo de cloro o trifluorometilo; yun grupo representado por la formula 2 es un grupo representado por la formula 3 donde R6 es un átomo de hidrogeno, metilo, etilo o isopropilo; R7 es un átomo de hidrogeno, metilo o átomo de cloro; y R8 es un átomo de hidrogeno, un átomo de fluor,un átomo de cloro o metilo; o 3-metiltiofen-2-ilo; o una sal del mismo.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2007114858 | 2007-04-24 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR066267A1 true AR066267A1 (es) | 2009-08-05 |
Family
ID=39926204
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP080101711A AR066267A1 (es) | 2007-04-24 | 2008-04-23 | Derivados de piperidina como antagonistas del receptor de taquiquinina |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20080275085A1 (es) |
| AR (1) | AR066267A1 (es) |
| CL (1) | CL2008001162A1 (es) |
| PE (1) | PE20090277A1 (es) |
| TW (1) | TW200906408A (es) |
| WO (1) | WO2008133344A2 (es) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2011195452A (ja) * | 2008-07-18 | 2011-10-06 | Taiho Yakuhin Kogyo Kk | アミド構造を有する新規ウラシル化合物又はその塩 |
| EP2336105B9 (en) | 2008-09-19 | 2014-09-17 | Takeda Pharmaceutical Company Limited | Nitrogen-containing heterocyclic compound and use of same |
| TW201400457A (zh) * | 2012-03-29 | 2014-01-01 | Toray Industries | 六氫菸鹼酸衍生物及其醫藥用途 |
| US10098350B2 (en) | 2013-04-15 | 2018-10-16 | E. I. Du Pont De Nemours And Company | Fungicidal amides |
| JPWO2017099049A1 (ja) * | 2015-12-07 | 2018-09-27 | キッセイ薬品工業株式会社 | Ｎｋ１受容体拮抗剤 |
| WO2024084363A1 (en) | 2022-10-18 | 2024-04-25 | Pfizer Inc. | Use of patatin-like phospholipase domain-containing protein 3 compounds |
| JP2025535295A (ja) | 2022-10-18 | 2025-10-24 | ファイザー・インク | パタチン様ホスホリパーゼドメイン含有タンパク質３（ｐｎｐｌａ３）修飾因子 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0919245A3 (en) * | 1991-09-20 | 2000-11-15 | Glaxo Group Limited | NK-1 receptor antagonist and a systemic antiinflammatory corticosteroid for the treatment of emesis |
| HUP0200139A3 (en) * | 1999-02-24 | 2003-01-28 | Hoffmann La Roche | 3-phenylpyridine derivatives and their use as nk-1 receptor antagonists, process for their preparation and pharmaceutical compositions containing them |
| BR0311425A (pt) * | 2002-05-31 | 2005-03-15 | Takeda Pharmaceutical | Composto, pró-droga, método para preparar o composto, álcool oticamente ativo, e amina oticamemte ativa, e para prevenir e/ou tratar anormalidades ou doenças, medicamento, e, uso do composto ou de uma pró-droga deste |
| CA2552965A1 (en) * | 2004-01-14 | 2005-07-28 | Takeda Pharmaceutical Company Limited | Carboxamide derivative and use thereof |
| TW200606152A (en) * | 2004-07-02 | 2006-02-16 | Tanabe Seiyaku Co | Piperidine compound and process for preparing the same |
| JP2007197428A (ja) * | 2005-12-28 | 2007-08-09 | Tanabe Seiyaku Co Ltd | 医薬組成物 |
-
2008
- 2008-04-23 US US12/081,926 patent/US20080275085A1/en not_active Abandoned
- 2008-04-23 AR ARP080101711A patent/AR066267A1/es unknown
- 2008-04-23 WO PCT/JP2008/058304 patent/WO2008133344A2/en not_active Ceased
- 2008-04-23 CL CL2008001162A patent/CL2008001162A1/es unknown
- 2008-04-23 TW TW097114785A patent/TW200906408A/zh unknown
- 2008-04-23 PE PE2008000700A patent/PE20090277A1/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| TW200906408A (en) | 2009-02-16 |
| PE20090277A1 (es) | 2009-04-06 |
| US20080275085A1 (en) | 2008-11-06 |
| WO2008133344A2 (en) | 2008-11-06 |
| WO2008133344A3 (en) | 2009-11-12 |
| CL2008001162A1 (es) | 2008-11-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |