AR066013A1 - Derivados de oxazolidinona, composiciones farmaceuticas que los contienen y su uso en el tratamiento o prevencion de una infeccion bacteriana. - Google Patents
Derivados de oxazolidinona, composiciones farmaceuticas que los contienen y su uso en el tratamiento o prevencion de una infeccion bacteriana.Info
- Publication number
- AR066013A1 AR066013A1 ARP080101486A ARP080101486A AR066013A1 AR 066013 A1 AR066013 A1 AR 066013A1 AR P080101486 A ARP080101486 A AR P080101486A AR P080101486 A ARP080101486 A AR P080101486A AR 066013 A1 AR066013 A1 AR 066013A1
- Authority
- AR
- Argentina
- Prior art keywords
- integer
- alkyl
- attached
- bond
- asterisk indicates
- Prior art date
Links
- 208000035143 Bacterial infection Diseases 0.000 title abstract 3
- 208000022362 bacterial infectious disease Diseases 0.000 title abstract 3
- 230000002265 prevention Effects 0.000 title abstract 3
- IZXIZTKNFFYFOF-UHFFFAOYSA-N 2-Oxazolidone Chemical class O=C1NCCO1 IZXIZTKNFFYFOF-UHFFFAOYSA-N 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 abstract 14
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 9
- 229910052757 nitrogen Inorganic materials 0.000 abstract 9
- 229910052739 hydrogen Inorganic materials 0.000 abstract 8
- 239000001257 hydrogen Substances 0.000 abstract 4
- 125000000816 ethylene group Chemical group [H]C([H])([*:1])C([H])([H])[*:2] 0.000 abstract 3
- 229910052736 halogen Inorganic materials 0.000 abstract 3
- 150000002367 halogens Chemical class 0.000 abstract 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- 229910052799 carbon Inorganic materials 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 2
- 125000003709 fluoroalkyl group Chemical group 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 2
- 125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 abstract 1
- -1 6,7-dihydro- [1,4] dioxino [2,3-c] pyridazin-3-yl Chemical group 0.000 abstract 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical group C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 239000011737 fluorine Substances 0.000 abstract 1
- 125000004428 fluoroalkoxy group Chemical group 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Empleo de los mismos en la produccion de un medicamento para la prevencion o el tratamiento de una infeccion bacteriana. Reivindicacion 1: El uso de un compuesto de formula (1).en la cual R1 representa hidrogeno, alcoxilo, halogeno o ciano; uno odos de U, V, W, y X representa(n) N y los restantes cada uno representa CH, o, en el caso de X, representa CRa; Ra representa hidrogeno o halogeno; R6 representa hidrogeno o alquilo C1-4; A representa N, B representa N, D representa un enlace, Erepresenta CH2 o CO, R2, R3, R4 y R5 cada uno representa H, m representa el entero 2, y n representa e! entero 1; o A representa N; B representa N; D representa un enlace; E representa CH2 o *-COCH2- en donde el asterisco indica el enlace que estáunido a B; R2, R3, R4 y R5 cada uno representa H, o R4 y R5 representan H y R2 y R3 en conjunto con el átomo de carbono al cual están unidos forman un grupo carbonilo, o R2 y R3 representan H y R4 y R5 en conjunto con el átomo de carbono al cualestán unidos forman un grupo carbonilo, o R2 y R4 representa H y R3 y R5 en conjunto forman un puente metileno; y m y n cada uno representa el entero 1; o A representa N, B representa C(OH), D representa un enlace, E representa CH2, R2, R3, R4 y R5cada uno representa H, y m y n cada uno representa el entero 1; o A representa N, B representa CH, d representa NR, E representa CH2, R2, R3, R4 y R5 cada uno representa H, Rb representa H o alquilo C1-4, y m y n cada uno representa el entero 1; o Arepresenta N, B representa CH, D representa NH, E representa CH2, R2, R3, R4 y R5 cada uno representa H, m representa el entero 2, y n representa el entero 0; o A representa C(OH), B representa N, D representa un enlace, E representa CH2, R2, R3, R4y R5 cada uno representa H, y m y n cada uno representa e! entero 1; o A representa N; B representa CH; D representa NRc; E representa CH2, CO o CH2CH2; R2, R3, R4 y R5 cada uno representa H y Rc representa H o alquilo C1-4, o Rc, R3, R4 y R5 cadauno representa H y R2 representa un grupo seleccionado de entre hidroxilo, alcoxilo C1-4, alcoxi C1-4-carbonilo, y carboxilo, o R3, R4 y R5 cada uno representa H y Rc forma en conjunto con R2 un puente etan-1,2-ilo; m representa el entero 1, y nrepresenta el entero 0; o A representa N; B representa CH; D representa *-CH(Rd)-N(Re)- en donde el asterisco indica el enlace que está unido a B; E representa CH2 o CO; Rd, R2, R3, R4 y R5 cada uno representa H y Re representa H o alquilo C1-4, oRe, R3, R4 y R5 cada uno representa H y Rd y R2 en conjunto forman un enlace, o Rd, R2, R3 y R5 cada uno representa H y Re y R4 en conjunto forman un puente metileno, o Rd, Re, R3, R4 y R5 cada uno representa H y R2 representa hidroxilo; mrepresenta el entero 1, y n representa el entero 0; o A representa N, B representa CH, D representa *-CONH- en donde el asterisco indica el enlace que está unido a B, E representa CH2, R2, R3, R4 y R5 cada uno representa H, m representa el entero 1,y n representa el entero 0; o A representa N, B representa CH, D) representa NH, E representa CH2 o CO, R2, R3 y R5 cada uno representa H y R4 representa hidroximetilo, m representa el entero 0, y n representa el entero 1; o A representa N, Brepresenta C(OH), D representa *-CH2-NH- en donde el asterisco indica e! enlace que está unido a B, E representa CH2, R2, R3, R4 y R5 cada uno representa H, m representa el entero 1, y n representa e! entero 0; o A representa N, B representa CH, Drepresenta *-CO-NH- en donde el asterisco indica el enlace que está unido a B, E representa CH2, R2, R3, R4 y R5 cada uno representa H, y m y n cada uno representa el entero 0; o A representa N, B representa CH, D representa *-CH2-N(Rf)- en donde elasterisco indica el enlace que está unido a B, E representa CH2, CH2CH2 o CO, R2, R3, R4 y R5 cada uno representa H, Rf representa H o alquilo C1-4, y m y n cada uno representa el entero 0; o A representa N; B representa CH; D representa NRg; Erepresenta CH2, CH2CH2, CO o *-COCH2- en donde el asterisco indica el enlace que está unido a B; R2, R3, R4 y R5 cada uno representa H; Rg representa H, alquilo C1-4 o alquilo C2-4que está mono- o di-substituido con hidroxilo; y m y n cada unorepresenta el entero 0; G representa fenilo que está no substituido, mono-substituido en las posiciones 3 o 4, o di-substituido en las posiciones 3 y 4, en donde cada sustituyente es independientemente seleccionado desde el conjunto que consiste enalquilo C1-4, alcoxilo C1-4, fluoroalquilo, fluoroalcoxilo, ciano, halogeno y -NRN1RN2; o G representa piridin-2-ilo que está mono-substituido en la posicion 5, en donde el sustituyente es seleccionado desde el conjunto que consiste en alquilo C1-4y fluoroalquilo; o G representa 6,7-dihidro-[1,4]dioxino[2,3-c]piridazin-3-ilo; o G representa un grupo seleccionado de entre el conjunto que consiste en formulas (2); en donde Rh representa hidrogeno o fluor; M representa CH o N; y Q y Q'representan de manera independiente O o S; y RN1 y RN2 representan de manera independiente alquilo C1-4, o en conjunto con el nitrogeno que los porta forman un anillo pirrolidina; o de una sal farmacéuticamente aceptable de un tal compuesto; en laproduccion de un medicamento para la prevencion o el tratamiento de una infeccion bacteriana.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IB2007051290 | 2007-04-11 | ||
| IB2007054587 | 2007-11-12 | ||
| IB2007054768 | 2007-11-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR066013A1 true AR066013A1 (es) | 2009-07-15 |
Family
ID=39682545
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP080101486A AR066013A1 (es) | 2007-04-11 | 2008-04-10 | Derivados de oxazolidinona, composiciones farmaceuticas que los contienen y su uso en el tratamiento o prevencion de una infeccion bacteriana. |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US8217029B2 (es) |
| EP (3) | EP2915813B1 (es) |
| JP (1) | JP5427770B2 (es) |
| KR (1) | KR101495269B1 (es) |
| CN (3) | CN102746296B (es) |
| AR (1) | AR066013A1 (es) |
| AU (1) | AU2008238904B2 (es) |
| BR (1) | BRPI0809977A8 (es) |
| CA (3) | CA2876879C (es) |
| CL (1) | CL2008001002A1 (es) |
| ES (3) | ES2557172T3 (es) |
| MX (3) | MX2009010642A (es) |
| PL (3) | PL2144910T3 (es) |
| RU (1) | RU2470022C2 (es) |
| TW (1) | TWI411434B (es) |
| WO (1) | WO2008126034A2 (es) |
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|---|---|---|---|---|
| ES2380398T3 (es) | 2007-12-18 | 2012-05-11 | Actelion Pharmaceuticals Ltd. | Derivados 5-aminociclilmetil-oxazolidin-2-ona |
| CA2713182C (en) | 2008-02-20 | 2016-09-13 | Actelion Pharmaceuticals Ltd | Azatricyclic antibiotic compounds |
| RU2501799C2 (ru) | 2008-02-22 | 2013-12-20 | Актелион Фармасьютикалз Лтд | Поизводные оксазолидинона |
| CA2731365A1 (en) | 2008-08-04 | 2010-02-11 | Actelion Pharmaceuticals Ltd | Tricyclic alkylaminomethyloxazolidinone derivatives |
| SI2344495T1 (sl) | 2008-10-07 | 2015-03-31 | Actelion Pharmaceuticals Ltd. | Spojine tricikličnega oksazolidinonskega antibiotika |
| US20110195949A1 (en) * | 2008-10-10 | 2011-08-11 | Actelion Pharmaceuticals Ltd. | 2-benzothiophenyl- and 2-naphthyl-oxazolidinones and their azaisostere analogues as antibacterial agents |
| FR2945533B1 (fr) * | 2009-05-12 | 2011-05-27 | Sanofi Aventis | Derives de cyclopenta°c!pyrrolyl-alkylcarbamates d'heterocycles a 5 chainons, leur preparation et leur application en therapeutique |
| EP2388260A1 (de) * | 2010-05-21 | 2011-11-23 | Archimica GmbH | Herstellungsverfahren für einen Inhibitor eines Blutgerinnungsfaktors |
| WO2012108376A1 (ja) | 2011-02-07 | 2012-08-16 | 第一三共株式会社 | アミノ基含有ピロリジノン誘導体 |
| WO2013021363A1 (en) | 2011-08-11 | 2013-02-14 | Actelion Pharmaceuticals Ltd | Quinazoline-2,4-dione derivatives |
| JP6030146B2 (ja) | 2011-11-08 | 2016-11-24 | アクテリオン ファーマシューティカルズ リミテッドＡｃｔｅｌｉｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｌｔｄ | ２−オキソ−オキサゾリジン−３，５−ジイル抗生物質誘導体 |
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| MA37756B1 (fr) | 2012-06-13 | 2018-09-28 | Hoffmann La Roche | Nouveaux composés diazaspirocycloalcane et azaspirocycloalcane |
| US9452990B2 (en) | 2012-06-20 | 2016-09-27 | Novartis Ag | Complement pathway modulators and uses thereof |
| WO2014024056A1 (en) | 2012-08-06 | 2014-02-13 | Daiichi Sankyo Company, Limited | Pyrrolidine derivatives with antibacterial properties |
| SI2900669T1 (sl) | 2012-09-25 | 2019-12-31 | F. Hoffmann-La Roche Ag | Derivati heksahidropirolo(3,4-C)pirola in sorodne spojine kot zaviralci avtotaksina (ATX) in kot zaviralci tvorbe lizofosfatidne kisline (LPA) za zdravljenje npr. bolezni ledvic |
| CN103012389A (zh) * | 2013-01-24 | 2013-04-03 | 中国药科大学 | 一种利伐沙班中间体的制备方法 |
| AR095079A1 (es) | 2013-03-12 | 2015-09-16 | Hoffmann La Roche | Derivados de octahidro-pirrolo[3,4-c]-pirrol y piridina-fenilo |
| UA118201C2 (uk) | 2013-11-26 | 2018-12-10 | Ф. Хоффманн-Ля Рош Аг | НОВИЙ ОКТАГІДРОЦИКЛОБУТА[1,2-c;3,4-c']ДИПІРОЛ-2-ІЛ |
| EA032357B1 (ru) | 2014-03-26 | 2019-05-31 | Ф. Хоффманн-Ля Рош Аг | Конденсированные [1,4]диазепиновые соединения в качестве ингибиторов продукции аутотаксина (atx) и лизофосфатидиловой кислоты (lpa) |
| CA2937616A1 (en) | 2014-03-26 | 2015-10-01 | F. Hoffmann-La Roche Ag | Bicyclic compounds as autotaxin (atx) and lysophosphatidic acid (lpa) production inhibitors |
| AR102256A1 (es) * | 2014-10-15 | 2017-02-15 | Actelion Pharmaceuticals Ltd | Derivados biaromáticos básicos antibacterianos con sustitución de aminoalcoxi |
| MA41168A (fr) | 2014-12-17 | 2017-10-24 | Acraf | Nouveaux composés antibactériens |
| MA41898A (fr) | 2015-04-10 | 2018-02-13 | Hoffmann La Roche | Dérivés de quinazolinone bicyclique |
| PE20180479A1 (es) | 2015-09-04 | 2018-03-07 | Hoffmann La Roche | Nuevos derivados de fenoximetilo |
| AU2016328535A1 (en) | 2015-09-24 | 2017-11-09 | F. Hoffmann-La Roche Ag | Bicyclic compounds as ATX inhibitors |
| JP6845230B2 (ja) | 2015-09-24 | 2021-03-17 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | デュアルａｔｘ／ｃａ阻害剤としての新規な二環式化合物 |
| EP3353176B1 (en) | 2015-09-24 | 2022-01-19 | F. Hoffmann-La Roche AG | Bicyclic compounds as atx inhibitors |
| EP3353178B1 (en) | 2015-09-24 | 2021-07-14 | F. Hoffmann-La Roche AG | Bicyclic compounds as dual atx/ca inhibitors |
| US10407412B2 (en) | 2015-12-10 | 2019-09-10 | Bracco Imaging S.P.A. | Dimeric contrast agents |
| KR102703312B1 (ko) | 2015-12-10 | 2024-09-05 | 브라코 이미징 에스.피.에이. | 조영제 |
| SI3889145T1 (sl) | 2015-12-17 | 2024-05-31 | Merck Patent Gmbh | 8-ciano-5-piperidino-kinolini kot antagonisti tlr7/8 in njihove uporabe za zdravljenje imunskih motenj |
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| JP6909234B2 (ja) | 2016-04-13 | 2021-07-28 | ブラッコ・イメージング・ソシエタ・ペル・アチオニＢｒａｃｃｏ Ｉｍａｇｉｎｇ Ｓ．Ｐ．Ａ． | 造影剤 |
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| CN110392679B (zh) | 2017-03-16 | 2023-04-07 | 豪夫迈·罗氏有限公司 | 可用作双重atx/ca抑制剂的杂环化合物 |
| JP7090099B2 (ja) | 2017-03-16 | 2022-06-23 | エフ．ホフマン－ラ ロシュ アーゲー | Ａｔｘインヒビターとしての新規二環式化合物 |
| EP4248968A3 (en) | 2017-07-18 | 2023-12-06 | Merck Patent GmbH | Tlr7/8 antagonists and uses thereof |
| US11401277B2 (en) * | 2017-11-29 | 2022-08-02 | Bugworks Research, Inc. | Anti-bacterial heterocyclic compounds and their synthesis |
| CN109265389B (zh) * | 2018-08-31 | 2020-08-18 | 南京富润凯德生物医药有限公司 | 2-(氨基甲基)-1-氧杂-7-氮杂螺[3.5]壬烷衍生物、中间体及其制备方法 |
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| TW200409637A (en) | 2002-06-26 | 2004-06-16 | Glaxo Group Ltd | Compounds |
| DE10247233A1 (de) * | 2002-10-10 | 2004-06-17 | Morphochem AG Aktiengesellschaft für kombinatorische Chemie | Neue Verbindungen, die Topoisomerase IV inhibieren |
| ATE411312T1 (de) * | 2002-12-04 | 2008-10-15 | Glaxo Group Ltd | Chinoline und stickstoffhaltige derivatedavon und deren verwendung als antibakterielle mittel |
| DE10316081A1 (de) | 2003-04-08 | 2004-10-21 | Morphochem AG Aktiengesellschaft für kombinatorische Chemie | Neue Verbindungen mit antibakterieller Aktivität |
| US7160888B2 (en) | 2003-08-22 | 2007-01-09 | Warner Lambert Company Llc | [1,8]naphthyridin-2-ones and related compounds for the treatment of schizophrenia |
| FR2872164B1 (fr) * | 2004-06-29 | 2006-11-17 | Aventis Pharma Sa | Derives de quinoleines-4-substituees, leur procede et intermediaires de preparation et les compositions pharmaceutiques qui les contiennent |
| WO2006024741A2 (fr) * | 2004-07-30 | 2006-03-09 | Palumed S.A. | Molecules hybrides qa ou q est une aminoquinoleine et a est un residu antibiotique, leur synthese et leurs utilisations en tant qu'agent antibacterien |
| WO2006032466A2 (en) | 2004-09-24 | 2006-03-30 | Actelion Pharmaceuticals Ltd | New bicyclic antibiotics |
| US7511035B2 (en) * | 2005-01-25 | 2009-03-31 | Glaxo Group Limited | Antibacterial agents |
| AR054608A1 (es) | 2005-08-08 | 2007-06-27 | Actelion Pharmaceuticals Ltd | Derivados de oxazolidinona enlazados a quinolonas como antibacterianos |
| ES2340531T3 (es) | 2005-10-21 | 2010-06-04 | Glaxo Group Limited | Compuestos triciclos peri-condensados utiles como agentes antibacterianos. |
| WO2007053498A1 (en) | 2005-11-01 | 2007-05-10 | Millennium Pharmaceuticals, Inc. | Compounds useful as antagonists of ccr2 |
| US7732460B2 (en) | 2005-12-22 | 2010-06-08 | Glaxo Group Limited | Heterocyclic compounds, their preparation and their use as antibacterials |
| US7888359B2 (en) | 2006-03-23 | 2011-02-15 | Actelion Pharmaceutical Ltd. | Cyclohexyl or piperidinyl carboxamide antibiotic derivatives |
| US7709496B2 (en) | 2006-04-06 | 2010-05-04 | Glaxo Group Limited | Antibacterial agents |
| GB0613208D0 (en) | 2006-07-03 | 2006-08-09 | Glaxo Group Ltd | Compounds |
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2008
- 2008-04-09 CL CL200801002A patent/CL2008001002A1/es unknown
- 2008-04-10 AR ARP080101486A patent/AR066013A1/es not_active Application Discontinuation
- 2008-04-10 TW TW097113021A patent/TWI411434B/zh not_active IP Right Cessation
- 2008-04-11 ES ES08737800.6T patent/ES2557172T3/es active Active
- 2008-04-11 MX MX2009010642A patent/MX2009010642A/es active IP Right Grant
- 2008-04-11 CN CN201210209027.2A patent/CN102746296B/zh not_active Expired - Fee Related
- 2008-04-11 JP JP2010502628A patent/JP5427770B2/ja not_active Expired - Fee Related
- 2008-04-11 PL PL08737800T patent/PL2144910T3/pl unknown
- 2008-04-11 EP EP15154086.1A patent/EP2915813B1/en not_active Not-in-force
- 2008-04-11 BR BRPI0809977A patent/BRPI0809977A8/pt not_active Application Discontinuation
- 2008-04-11 PL PL15154086T patent/PL2915813T3/pl unknown
- 2008-04-11 AU AU2008238904A patent/AU2008238904B2/en not_active Ceased
- 2008-04-11 PL PL15154003T patent/PL2905283T3/pl unknown
- 2008-04-11 KR KR1020097022518A patent/KR101495269B1/ko not_active Expired - Fee Related
- 2008-04-11 MX MX2011010275A patent/MX351590B/es unknown
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- 2008-04-11 ES ES15154003.6T patent/ES2618492T3/es active Active
- 2008-04-11 CN CN201210209094.4A patent/CN102746297B/zh not_active Expired - Fee Related
- 2008-04-11 RU RU2009141311/04A patent/RU2470022C2/ru not_active IP Right Cessation
- 2008-04-11 ES ES15154086.1T patent/ES2622961T3/es active Active
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- 2008-04-11 CA CA2876879A patent/CA2876879C/en not_active Expired - Fee Related
- 2008-04-11 EP EP15154003.6A patent/EP2905283B1/en not_active Not-in-force
- 2008-04-11 WO PCT/IB2008/051374 patent/WO2008126034A2/en not_active Ceased
- 2008-04-11 EP EP08737800.6A patent/EP2144910B1/en not_active Not-in-force
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