AR065909A1 - Agentes terapeuticos 685 - Google Patents
Agentes terapeuticos 685Info
- Publication number
- AR065909A1 AR065909A1 ARP080101362A ARP080101362A AR065909A1 AR 065909 A1 AR065909 A1 AR 065909A1 AR P080101362 A ARP080101362 A AR P080101362A AR P080101362 A ARP080101362 A AR P080101362A AR 065909 A1 AR065909 A1 AR 065909A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl group
- substituted
- hydroxy
- fluorine
- group
- Prior art date
Links
- 239000003814 drug Substances 0.000 title 1
- 229940124597 therapeutic agent Drugs 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- 125000006274 (C1-C3)alkoxy group Chemical group 0.000 abstract 3
- 125000004178 (C1-C4) alkyl group Chemical class 0.000 abstract 3
- 229910052731 fluorine Inorganic materials 0.000 abstract 3
- 239000011737 fluorine Substances 0.000 abstract 3
- 125000001153 fluoro group Chemical group F* 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- GCNTZFIIOFTKIY-UHFFFAOYSA-N 4-hydroxypyridine Chemical compound OC1=CC=NC=C1 GCNTZFIIOFTKIY-UHFFFAOYSA-N 0.000 abstract 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical group [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
- 208000012902 Nervous system disease Diseases 0.000 abstract 1
- 208000025966 Neurological disease Diseases 0.000 abstract 1
- 208000008589 Obesity Diseases 0.000 abstract 1
- 229910052801 chlorine Chemical group 0.000 abstract 1
- 239000000460 chlorine Chemical group 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 235000020824 obesity Nutrition 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 208000020016 psychiatric disease Diseases 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Child & Adolescent Psychology (AREA)
- Endocrinology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Se describen ciertos compuestos 4,5,6,7-tetrahidropirrol[3,2-c]piridin-4-ona y 4,5- dihidropirroI[3,2-c]pidin-4-ona de formula 1, procedimientos para preparar dichos compuestos, y una formulacion farmacéutica. Compuestos utiles en el tratamiento dela obesidad, trastornos psiquiátricos y neurologicos. Reivindicacion 1: Un compuesto de formula 1 en la cual R1 representa un grupo alquilo C3-7 o un grupo alquilsulfonilo C3-7 y adicionalmente cuando R2 representa un grupo alquilo C1-4 sustituidocon hidroxi o con un grupo alcoxi C1-3, entonces R1 representa un grupo alquilo C3-7 sustituido con uno o más fluor, o un grupo alquilsulfonilo C3-7 sustituido con uno o más fluor; R2 representa un grupo alquilo C1-4 opcionalmente sustituido conhidroxi o un grupo alcoxi C1-3; ---- es un enlace adicional opcional entre las posiciones 6 y 7 pero solo cuando R2 representa un grupo alquilo C1-4 sustituido con hidroxi o con un grupo alcoxi C1-3; y R3 representa fluor o cloro; o una salfarmacéuticamente aceptable del mismo.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US90978507P | 2007-04-03 | 2007-04-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR065909A1 true AR065909A1 (es) | 2009-07-08 |
Family
ID=39592749
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP080101362A AR065909A1 (es) | 2007-04-03 | 2008-04-01 | Agentes terapeuticos 685 |
Country Status (3)
| Country | Link |
|---|---|
| AR (1) | AR065909A1 (es) |
| UY (1) | UY30996A1 (es) |
| WO (1) | WO2008120000A1 (es) |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003027114A1 (en) * | 2001-09-24 | 2003-04-03 | Bayer Pharmaceuticals Corporation | Preparation and use of 1,5,6,7-tetrahydropyrrolo[3,2-c]pyridine derivatives for treatment of obesity |
| AR056560A1 (es) * | 2005-10-06 | 2007-10-10 | Astrazeneca Ab | Pirrolopiridinonas como moduladores cb1 |
-
2008
- 2008-04-01 AR ARP080101362A patent/AR065909A1/es unknown
- 2008-04-02 UY UY30996A patent/UY30996A1/es unknown
- 2008-04-02 WO PCT/GB2008/001165 patent/WO2008120000A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| WO2008120000A1 (en) | 2008-10-09 |
| UY30996A1 (es) | 2008-11-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |