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NO20083726L - Spiroindolinon derivater - Google Patents

Spiroindolinon derivater

Info

Publication number
NO20083726L
NO20083726L NO20083726A NO20083726A NO20083726L NO 20083726 L NO20083726 L NO 20083726L NO 20083726 A NO20083726 A NO 20083726A NO 20083726 A NO20083726 A NO 20083726A NO 20083726 L NO20083726 L NO 20083726L
Authority
NO
Norway
Prior art keywords
spiroindolinone derivatives
spiroindolinone
derivatives
enantiomers
esters
Prior art date
Application number
NO20083726A
Other languages
English (en)
Inventor
Jin-Jun Liu
Zhuming Zhang
Qingjie Ding
Li Chen
Song Yang
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of NO20083726L publication Critical patent/NO20083726L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/20—Spiro-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Foreliggende oppfinnelse angår spiroindolinon-derivater med formelen I og enantiomerer og farmasøytisk akseptable salter og estere derav, som er anvendelige som antiproliferative midler, spesielt som anti-kreft-midler.
NO20083726A 2006-03-13 2008-08-29 Spiroindolinon derivater NO20083726L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US78195806P 2006-03-13 2006-03-13
US88175607P 2007-01-22 2007-01-22
PCT/EP2007/052038 WO2007104664A1 (en) 2006-03-13 2007-03-05 Spiroindolinone derivatives

Publications (1)

Publication Number Publication Date
NO20083726L true NO20083726L (no) 2008-11-25

Family

ID=38179455

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20083726A NO20083726L (no) 2006-03-13 2008-08-29 Spiroindolinon derivater

Country Status (15)

Country Link
US (1) US20070213341A1 (no)
EP (1) EP1996590B1 (no)
JP (1) JP5038337B2 (no)
KR (1) KR101131031B1 (no)
AR (1) AR059957A1 (no)
AT (1) ATE483711T1 (no)
AU (1) AU2007224505B2 (no)
BR (1) BRPI0709605A2 (no)
CA (1) CA2645062A1 (no)
DE (1) DE602007009650D1 (no)
IL (1) IL193641A0 (no)
NO (1) NO20083726L (no)
RU (1) RU2435771C2 (no)
TW (1) TW200801000A (no)
WO (1) WO2007104664A1 (no)

Families Citing this family (38)

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ES2320955B1 (es) * 2007-03-02 2010-03-16 Laboratorios Almirall S.A. Nuevos derivados de 3-((1,2,4)triazolo(4,3-a)piridin-7-il)benzamida.
ES2329639B1 (es) 2007-04-26 2010-09-23 Laboratorios Almirall S.A. Nuevos derivados de 4,8-difenilpoliazanaftaleno.
US7553833B2 (en) * 2007-05-17 2009-06-30 Hoffmann-La Roche Inc. 3,3-spiroindolinone derivatives
US8134001B2 (en) * 2007-12-14 2012-03-13 Hoffmann-La Roche Inc. Spiroindolinone derivatives
US7776875B2 (en) * 2007-12-19 2010-08-17 Hoffman-La Roche Inc. Spiroindolinone derivatives
US7723372B2 (en) * 2008-03-19 2010-05-25 Hoffman-La Roche Inc. Spiroindolinone derivatives
EP2108641A1 (en) 2008-04-11 2009-10-14 Laboratorios Almirall, S.A. New substituted spiro[cycloalkyl-1,3'-indo]-2'(1'H)-one derivatives and their use as p38 mitogen-activated kinase inhibitors
EP2113503A1 (en) * 2008-04-28 2009-11-04 Laboratorios Almirall, S.A. New substituted indolin-2-one derivatives and their use as p39 mitogen-activated kinase inhibitors
KR100915320B1 (ko) 2008-09-29 2009-09-03 (주)메디룬 생리통완화를 위한 휴대용 조합자극기
US20100190814A1 (en) 2009-01-26 2010-07-29 Li Chen Spiroindolinone derivative prodrugs
US7928233B2 (en) * 2009-02-10 2011-04-19 Hoffmann-La Roche Inc. Spiroindolinone pyridine derivatives
US8217051B2 (en) * 2009-02-17 2012-07-10 Hoffmann-La Roche Inc. Spiroindolinone derivatives
US8076482B2 (en) 2009-04-23 2011-12-13 Hoffmann-La Roche Inc. 3,3′-spiroindolinone derivatives
BR112012002214B1 (pt) 2009-07-31 2022-01-25 Global Alliance For Tb Drug Development Análogos de nitroimidazooxazina e nitroimidazooxazol, seus usos e composição farmacêutica
US8088815B2 (en) 2009-12-02 2012-01-03 Hoffman-La Roche Inc. Spiroindolinone pyrrolidines
US8288431B2 (en) 2010-02-17 2012-10-16 Hoffmann-La Roche Inc. Substituted spiroindolinones
US8217044B2 (en) 2010-04-28 2012-07-10 Hoffmann-La Roche Inc. Spiroindolinone pyrrolidines
JO2998B1 (ar) 2010-06-04 2016-09-05 Amgen Inc مشتقات بيبيريدينون كمثبطات mdm2 لعلاج السرطان
US9962459B2 (en) * 2010-07-02 2018-05-08 Basf Se Ultrathin fluid-absorbent cores
SG10201601802YA (en) * 2011-03-10 2016-04-28 Daiichi Sankyo Co Ltd Dispiropyrrolidine derivatives
MX352672B (es) 2011-09-27 2017-12-04 Amgen Inc Compuestos heterocíclicos como inhibidores de mdm2 para el tratamiento del cáncer.
TWI586668B (zh) 2012-09-06 2017-06-11 第一三共股份有限公司 二螺吡咯啶衍生物之結晶
JP6387013B2 (ja) 2012-12-20 2018-09-12 メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． Ｈｄｍ２阻害薬としての置換されたイミダゾピリジン類
US11407721B2 (en) 2013-02-19 2022-08-09 Amgen Inc. CIS-morpholinone and other compounds as MDM2 inhibitors for the treatment of cancer
CA2902856C (en) 2013-02-28 2021-02-16 Amgen Inc. A benzoic acid derivative mdm2 inhibitor for the treatment of cancer
CA2906538C (en) 2013-03-14 2021-02-02 Ana Gonzalez Buenrostro Heteroaryl acid morpholinone compounds as mdm2 inhibitors for the treatment of cancer
JOP20200296A1 (ar) 2013-06-10 2017-06-16 Amgen Inc عمليات صنع وأشكال بلورية من mdm2 مثبط
EP3164401B1 (en) 2014-07-03 2018-12-26 Boehringer Ingelheim International GmbH New spiro[3h-indole-3,2´-pyrrolidin]-2(1h)-one compounds and derivatives as mdm2-p53 inhibitors
US20160052938A1 (en) 2014-08-21 2016-02-25 Boehringer Ingelheim International Gmbh Spiro[3h-indole-3,2'-pyrrolidin]-2(1h)-one compounds and derivatives as mdm2-p53 inhibitors
KR102595395B1 (ko) 2015-02-20 2023-10-27 다이이찌 산쿄 가부시키가이샤 암의 병용 치료법
EP3284466A4 (en) 2015-04-13 2018-12-05 Daiichi Sankyo Company, Limited Treatment method combining mdm2 inhibitor and btk inhibitor
MX377009B (es) 2015-10-09 2025-03-07 Boehringer Ingelheim Int Nuevos compuestos de espiro[3h-indol-3,2´-pirrolidin]-2(1h)-ona y derivados como inhibidores de mdm2-p53.
CN109152843A (zh) 2016-05-20 2019-01-04 豪夫迈·罗氏有限公司 Protac抗体缀合物及其使用方法
EP3527226A4 (en) 2016-10-17 2020-06-17 Daiichi Sankyo Company, Limited COMBINATION THERAPY PROCEDURE WITH MDM2 INHIBITOR AND DNA METHYL TRANSFERASE INHIBITOR
EP3511334A1 (en) * 2018-01-16 2019-07-17 Adamed sp. z o.o. 1,2,3',5'-tetrahydro-2'h-spiro[indole-3,1'-pyrrolo[3,4-c]pyrrole]-2,3'-dione compounds as therapeutic agents activating tp53
EP3761925A4 (en) 2018-03-07 2021-12-08 Soovu Labs, Inc. SYSTEMS AND METHODS FOR IMPROVED PAIN RELIEF FROM THERMAL FIBER STIMULATION
WO2023056069A1 (en) 2021-09-30 2023-04-06 Angiex, Inc. Degrader-antibody conjugates and methods of using same
WO2024240858A1 (en) 2023-05-23 2024-11-28 Valerio Therapeutics Protac molecules directed against dna damage repair system and uses thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SK282166B6 (sk) * 1992-12-11 2001-11-06 Merck & Co., Inc. Spiropiperidínové deriváty, spôsob ich výroby a farmaceutický prostriedok s ich obsahom
DE60009915T2 (de) * 1999-07-21 2005-04-07 Astrazeneca Ab Verbindungen
AU2007224452A1 (en) * 2006-03-13 2007-09-20 F. Hoffmann-La Roche Ag Spiroindolinone derivatives

Also Published As

Publication number Publication date
EP1996590B1 (en) 2010-10-06
BRPI0709605A2 (pt) 2011-07-19
EP1996590A1 (en) 2008-12-03
JP2009529566A (ja) 2009-08-20
AR059957A1 (es) 2008-05-14
RU2435771C2 (ru) 2011-12-10
KR101131031B1 (ko) 2012-04-12
WO2007104664A1 (en) 2007-09-20
JP5038337B2 (ja) 2012-10-03
AU2007224505A1 (en) 2007-09-20
IL193641A0 (en) 2009-05-04
CA2645062A1 (en) 2007-09-20
DE602007009650D1 (de) 2010-11-18
TW200801000A (en) 2008-01-01
ATE483711T1 (de) 2010-10-15
US20070213341A1 (en) 2007-09-13
KR20080095279A (ko) 2008-10-28
RU2008140386A (ru) 2010-04-20
AU2007224505B2 (en) 2012-05-03

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