AR065390A1 - Derivados de 1h-pirrolo[3, 2-c]piridina, metodos para su preparacion y su uso en la fabricacion de medicamentos para el tratamiento de diversos tipos de cancer. - Google Patents
Derivados de 1h-pirrolo[3, 2-c]piridina, metodos para su preparacion y su uso en la fabricacion de medicamentos para el tratamiento de diversos tipos de cancer.Info
- Publication number
- AR065390A1 AR065390A1 ARP080100678A ARP080100678A AR065390A1 AR 065390 A1 AR065390 A1 AR 065390A1 AR P080100678 A ARP080100678 A AR P080100678A AR P080100678 A ARP080100678 A AR P080100678A AR 065390 A1 AR065390 A1 AR 065390A1
- Authority
- AR
- Argentina
- Prior art keywords
- atoms
- hal
- nhet
- nar
- medicines
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title abstract 2
- 239000003814 drug Substances 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 201000011510 cancer Diseases 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 3
- 229910006074 SO2NH2 Inorganic materials 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 125000004429 atom Chemical group 0.000 abstract 2
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 2
- 125000000896 monocarboxylic acid group Chemical group 0.000 abstract 2
- 229920006395 saturated elastomer Polymers 0.000 abstract 2
- 125000000565 sulfonamide group Chemical group 0.000 abstract 2
- -1 COOA Chemical group 0.000 abstract 1
- 240000000543 Pentas lanceolata Species 0.000 abstract 1
- 125000002618 bicyclic heterocycle group Chemical group 0.000 abstract 1
- 230000004663 cell proliferation Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 125000002911 monocyclic heterocycle group Chemical group 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 125000004434 sulfur atom Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Virology (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- AIDS & HIV (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Son inhibidoras de la proliferacion celular / vitalidad celular y se pueden emplear en medicamentos para el tratamiento de tumores. Se proveen ademas metodos para su preparacion. Reivindicacion 1. Compuestos de (1)en donde R1 es H, A, -[C(R6)2]nAr, -[C(R6)2]nHet o -[C(R6)2]ncicloalqui1o, R2 es H o A, R3, R4 son en cada caso, de modo independiente entre sí, H, A, Hal, CN, -[C(R6)2]nAr, -[C(R6)2]nHet -[C(R6)2]ncicloalquilo, R5 es H, A, -[C(R6)2]nAr, -[C(R6)2]nHet o -[C(R6)2]ncicloalquilo, R6 es Ho alquilo con 1-6 átomos de C, A, A' son en cada caso, de modo independiente entre sí, alquilo no ramificado o ramificado con 1-10 átomos de C, en donde uno o dos grupos CH2 pueden estar reemplazados por átomos de O o S y/o por grupos -CH=CH y/otambién 1-7 átomos de H pueden estar reemplazados por F, Hal es F, Cl, Br o I, Ar es un carbociclo no sustituido o mono-, di-, tri-, tetra- o pentasustituido con OH, OA, SH, SA, SOA, SO2A, Hal, NO2, NH2, NHA, NAA', A, SO2NH2, SO2NHA, SO2NAA', CONH2,CONHA, CONAA', NACOA', NASO2A', COOH, COOA, COA, CHO y/o CN saturado, insaturado o aromático con 5-14 átomos de C, Het es un heterociclo mono- o bicíclico saturado, insaturado o aromático con 1 a 4 átomos de N, O y/o S, que puede no estar sustituidoo que puede estar mono- o disustituido con OH, OA, SOA, SO2A, Hal, NO2, NH2, NHA, NAA', A, SO2NH2, SO2NHA, SO2NAA', CONH2, CONHA, CONAA', NACOA', NASO2A', COOH, COOA, CHO, COA y/o CN, n es 0,1 o 2, así como sus derivados, solvatos, sales, tautomerosy estereoisomeros de utilidad farmacéutica, incluyendo sus mezclas en todas las proporciones.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102007008419A DE102007008419A1 (de) | 2007-02-21 | 2007-02-21 | 4-(Pyrrolopyridinyl)-pyrimidinyl-2-amin-derivate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR065390A1 true AR065390A1 (es) | 2009-06-03 |
Family
ID=39410261
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP080100678A AR065390A1 (es) | 2007-02-21 | 2008-02-20 | Derivados de 1h-pirrolo[3, 2-c]piridina, metodos para su preparacion y su uso en la fabricacion de medicamentos para el tratamiento de diversos tipos de cancer. |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US8293891B2 (es) |
| EP (1) | EP2121682B1 (es) |
| JP (1) | JP5508026B2 (es) |
| KR (1) | KR20090110948A (es) |
| CN (1) | CN101616918A (es) |
| AR (1) | AR065390A1 (es) |
| AU (1) | AU2008217297B2 (es) |
| BR (1) | BRPI0808167A2 (es) |
| CA (1) | CA2678691C (es) |
| DE (1) | DE102007008419A1 (es) |
| DK (1) | DK2121682T3 (es) |
| EA (1) | EA200901100A1 (es) |
| ES (1) | ES2427594T3 (es) |
| IL (1) | IL200470A (es) |
| MX (1) | MX2009008864A (es) |
| PT (1) | PT2121682E (es) |
| WO (1) | WO2008101587A1 (es) |
| ZA (1) | ZA200906539B (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007140263A2 (en) * | 2006-05-26 | 2007-12-06 | University Of Louisville Research Foundation, Inc. | Macrophage migration inhibitory factor antagonists and methods of using same |
| WO2011038234A2 (en) | 2009-09-24 | 2011-03-31 | University Of Louisville Research Foundation, Inc. | Novel iodo pyrimidine derivatives useful for the treatment of macrophage migration inhibitory factor (mif)-implicated diseases and conditions |
| WO2011146824A1 (en) | 2010-05-20 | 2011-11-24 | University Of Louisville Research Foundation, Inc. | Methods and compositions for modulating ocular damage |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5747469A (en) | 1991-03-06 | 1998-05-05 | Board Of Regents, The University Of Texas System | Methods and compositions comprising DNA damaging agents and p53 |
| GB9904387D0 (en) | 1999-02-25 | 1999-04-21 | Pharmacia & Upjohn Spa | Antitumour synergistic composition |
| PL206142B1 (pl) * | 2001-01-09 | 2010-07-30 | Merck Patent Gmbhmerck Patent Gmbh | Kompozycja i zestaw farmaceutyczny do leczenia nowotworów i przerzutów nowotworowych oraz ich zastosowanie |
| GB0308466D0 (en) | 2003-04-11 | 2003-05-21 | Novartis Ag | Organic compounds |
| WO2006038001A1 (en) * | 2004-10-06 | 2006-04-13 | Celltech R & D Limited | Aminopyrimidine derivatives as jnk inhibitors |
-
2007
- 2007-02-21 DE DE102007008419A patent/DE102007008419A1/de not_active Withdrawn
-
2008
- 2008-01-28 ES ES08707340T patent/ES2427594T3/es active Active
- 2008-01-28 PT PT87073409T patent/PT2121682E/pt unknown
- 2008-01-28 DK DK08707340.9T patent/DK2121682T3/da active
- 2008-01-28 JP JP2009550227A patent/JP5508026B2/ja not_active Expired - Fee Related
- 2008-01-28 BR BRPI0808167-0A patent/BRPI0808167A2/pt not_active IP Right Cessation
- 2008-01-28 EA EA200901100A patent/EA200901100A1/ru unknown
- 2008-01-28 US US12/527,671 patent/US8293891B2/en not_active Expired - Fee Related
- 2008-01-28 WO PCT/EP2008/000634 patent/WO2008101587A1/de not_active Ceased
- 2008-01-28 KR KR1020097019557A patent/KR20090110948A/ko not_active Withdrawn
- 2008-01-28 MX MX2009008864A patent/MX2009008864A/es not_active Application Discontinuation
- 2008-01-28 EP EP08707340.9A patent/EP2121682B1/de not_active Not-in-force
- 2008-01-28 CN CN200880005794A patent/CN101616918A/zh active Pending
- 2008-01-28 CA CA2678691A patent/CA2678691C/en not_active Expired - Fee Related
- 2008-01-28 AU AU2008217297A patent/AU2008217297B2/en not_active Ceased
- 2008-02-20 AR ARP080100678A patent/AR065390A1/es unknown
-
2009
- 2009-08-18 IL IL200470A patent/IL200470A/en active IP Right Grant
- 2009-09-18 ZA ZA200906539A patent/ZA200906539B/xx unknown
-
2012
- 2012-06-19 US US13/527,008 patent/US8557977B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| WO2008101587A1 (de) | 2008-08-28 |
| CA2678691C (en) | 2015-09-08 |
| US8293891B2 (en) | 2012-10-23 |
| AU2008217297A1 (en) | 2008-08-28 |
| AU2008217297B2 (en) | 2013-01-17 |
| JP5508026B2 (ja) | 2014-05-28 |
| CA2678691A1 (en) | 2008-08-28 |
| DE102007008419A1 (de) | 2008-08-28 |
| ES2427594T3 (es) | 2013-10-31 |
| CN101616918A (zh) | 2009-12-30 |
| EA200901100A1 (ru) | 2010-02-26 |
| ZA200906539B (en) | 2010-06-30 |
| US20110092527A1 (en) | 2011-04-21 |
| MX2009008864A (es) | 2009-08-28 |
| US8557977B2 (en) | 2013-10-15 |
| DK2121682T3 (da) | 2013-09-08 |
| IL200470A (en) | 2014-02-27 |
| BRPI0808167A2 (pt) | 2014-07-08 |
| KR20090110948A (ko) | 2009-10-23 |
| PT2121682E (pt) | 2013-10-17 |
| EP2121682A1 (de) | 2009-11-25 |
| EP2121682B1 (de) | 2013-07-10 |
| JP2010519230A (ja) | 2010-06-03 |
| US20120264999A1 (en) | 2012-10-18 |
| IL200470A0 (en) | 2010-04-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |