AR064809A1 - Formas cristalinas - Google Patents
Formas cristalinasInfo
- Publication number
- AR064809A1 AR064809A1 ARP070105447A ARP070105447A AR064809A1 AR 064809 A1 AR064809 A1 AR 064809A1 AR P070105447 A ARP070105447 A AR P070105447A AR P070105447 A ARP070105447 A AR P070105447A AR 064809 A1 AR064809 A1 AR 064809A1
- Authority
- AR
- Argentina
- Prior art keywords
- degrees
- crystalline
- lngstroms
- theta
- analyzed
- Prior art date
Links
- 239000013078 crystal Substances 0.000 title 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 abstract 3
- 229910052802 copper Inorganic materials 0.000 abstract 3
- 239000010949 copper Substances 0.000 abstract 3
- 230000005855 radiation Effects 0.000 abstract 3
- -1 2-tert-butylphenyl Chemical group 0.000 abstract 2
- 239000005950 Oxamyl Substances 0.000 abstract 2
- KZAUOCCYDRDERY-UHFFFAOYSA-N oxamyl Chemical compound CNC(=O)ON=C(SC)C(=O)N(C)C KZAUOCCYDRDERY-UHFFFAOYSA-N 0.000 abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 abstract 2
- 238000000634 powder X-ray diffraction Methods 0.000 abstract 2
- 208000019425 cirrhosis of liver Diseases 0.000 abstract 1
- 239000000843 powder Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/70—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/72—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms
- C07C235/74—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of a saturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C235/52—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Pain & Pain Management (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Peptides Or Proteins (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
La presente se refiere a formas cristalinas del acido (3S)-3-[N-(N'-(2-terc-butilfenil)oxamil)alaninil]amino-5-(2', 3', 5', 6', -tetrafluorofenoxi)-4-oxopentanoico (véase la formula 1). Se refiere además a composiciones farmacéuticas que comprenden dichas formas cristalinas y a la utilizacion de dichas composiciones farmacéuticas y dichas formas cristalinas en el tratamiento de varias afecciones, particularmente en el tratamiento de la fibrosis hepática. Reivindicacion 1: una forma cristalina del acido (3S)-3-[N-(N'-(2-terc-butilfenil)oxamil)alaninil]amino-5-(2', 3', 5', 6', -tetrafluorofenoxi)-4-oxopentanoico. Reivindicacion 2: una forma cristalina segun la reivindicacion 1, conocida como forma I, que comprende picos a 7,7, 14,1, 21,4, 26,6, y 29,4 grados dos theta (+- 0,1grados) cuando se analiza por difraccion de polvo por rayos X utilizando radiacion K-alfa1 del cobre (longitud de Lngstroms).Reivindicacion 3. una forma cristalina segun la reivindicacion 1, conocida como forma II, que comprende picos a 14,5, 17,3, 22,5, 25,0, y 26,8 grados dos theta (+- 0,1 grados) cuando se analiza por difraccion de polvo por rayos X utilizando radiacion K-alfa1 del cobre (longitud de Lngstroms).Reivindicacion 4: una forma cristalina segun la reivindicacion 1, conocida como forma III, que comprende un pico a 7,2 grados dos theta (+- 0,1 grados) cuando se analiza por difraccion de polvo por rayos X utilizando radiacion K-alfa1 del cobre (longitud de Lngstroms).
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US86874806P | 2006-12-06 | 2006-12-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR064809A1 true AR064809A1 (es) | 2009-04-29 |
Family
ID=39205161
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP070105447A AR064809A1 (es) | 2006-12-06 | 2007-12-05 | Formas cristalinas |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US7692038B2 (es) |
| EP (1) | EP2091910B1 (es) |
| JP (1) | JP5495787B2 (es) |
| KR (1) | KR101125932B1 (es) |
| CN (3) | CN101573328B (es) |
| AR (1) | AR064809A1 (es) |
| AU (1) | AU2007330478B2 (es) |
| CA (1) | CA2669849C (es) |
| CL (1) | CL2007003491A1 (es) |
| DK (1) | DK2091910T3 (es) |
| ES (1) | ES2524021T3 (es) |
| HN (1) | HN2007000536A (es) |
| IL (1) | IL198732A (es) |
| MX (1) | MX2009006055A (es) |
| NO (1) | NO338908B1 (es) |
| PA (1) | PA8759501A1 (es) |
| PE (1) | PE20081251A1 (es) |
| PL (1) | PL2091910T3 (es) |
| PT (1) | PT2091910E (es) |
| TW (1) | TWI345466B (es) |
| UY (1) | UY30758A1 (es) |
| WO (1) | WO2008068615A1 (es) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RS59494B1 (sr) * | 2010-02-12 | 2019-12-31 | Pfizer | Soli i polimorfi 8-fluoro-2-{4-[(metilamino)metil]fenil}-1,3,4,5-tetrahidro-6h-azepino[5,4, 3-cd]indol-6-ona |
| CN103113405B (zh) * | 2012-10-17 | 2016-03-02 | 上海日馨生物科技有限公司 | 苯磷硫胺多晶型体、制备方法及其应用 |
| NZ723859A (en) * | 2014-03-14 | 2023-01-27 | Servier Lab | Pharmaceutical compositions of therapeutically active compounds and their uses |
| SG11201609256SA (en) | 2014-05-12 | 2016-12-29 | Conatus Pharmaceuticals Inc | Treatment of the complications of chronic liver disease with caspase inhibitors |
| SG11201700958YA (en) * | 2014-09-08 | 2017-03-30 | Pfizer | Crystalline solid forms of 6-carboxy-2-(3,5-dichlorophenyl)-benzoxazole |
| HK1244274A1 (zh) | 2015-01-30 | 2018-08-03 | 生物医学谷探索股份有限公司 | C21h22ci2n4o2的晶型 |
| US20180044375A1 (en) | 2015-03-06 | 2018-02-15 | Concert Pharmaceuticals, Inc. | Deuterated emricasan |
| CN105017061B (zh) * | 2015-07-07 | 2017-03-29 | 苏州富士莱医药股份有限公司 | 一种恩利卡生的合成方法 |
| WO2017079566A1 (en) | 2015-11-05 | 2017-05-11 | Conatus Pharmaceuticals, Inc. | Caspase inhibitors for use in the treatment of liver cancer |
| US20190022043A1 (en) | 2015-12-31 | 2019-01-24 | Conatus Pharmaceuticals Inc. | Methods of using caspase inhibitors in treatment of liver disease |
| WO2018065902A1 (en) | 2016-10-05 | 2018-04-12 | Novartis Ag | Combination compositions comprising fxr agonists for treating or preventing a fibrotic,cirrhotic disease or disorder |
| TWI764977B (zh) * | 2017-01-23 | 2022-05-21 | 大陸商正大天晴藥業集團股份有限公司 | 作爲ｃａｓｐａｓｅ抑制劑的聯環化合物、含有其的藥物組合物及其應用 |
| WO2018172950A1 (en) * | 2017-03-23 | 2018-09-27 | Novartis Ag | Anhydrous crystalline forms of sodium (s)-2-(diphenylacetyl)-1,2,3,4-tetrahydro-6-methoxy-5-(phenylmethoxy)-3-isoquinolinecarboxylate |
| WO2018178129A1 (en) * | 2017-03-30 | 2018-10-04 | Merck Patent Gmbh | Crystalline form of (s)-[2-chloro-4-fluoro-5-(7-morpholin-4-ylquinazolin-4-yl)phenyl]-(6-methoxy-pyridazin-3-yl)-methanol |
| AR114251A1 (es) * | 2018-02-13 | 2020-08-12 | Syngenta Participations Ag | Formas cristalinas de n-[2-(2,4-diclorofenil)ciclobutil]-2-(trifluorometl)piridin-3-carboxamida |
| WO2020006341A1 (en) | 2018-06-29 | 2020-01-02 | Conatus Pharmaceuticals, Inc. | (s)-3-(2-(4-(benzyl)-3-oxopiperazin-1-yl)acetamido)-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid derivatives and related compounds as caspase inhibitors for treating cardiovascular diseases |
| BR112020024296A2 (pt) | 2018-08-27 | 2021-03-09 | Regeneron Pharmaceuticals, Inc. | Métodos para produção de um intermediário de purificação de proteína concentrado, para monitoramento e controle dos atributos de qualidade críticos em um intermediário de purificação de proteína e para monitorar e controlar os níveis de excipientes no fluido de cultura de células colhido e/ou intermediário de purificação de proteína, e, intermediário de purificação de proteína |
| CA3132613A1 (en) | 2019-03-07 | 2020-09-10 | Conatus Pharmaceuticals Inc. | Caspase inhibitors and methods of use thereof |
| EP4027999A4 (en) | 2019-09-10 | 2023-08-16 | Mirati Therapeutics, Inc. | Crystalline form of a multi-tyrosine kinase inhibitor, method of preparation, and use thereof |
| CN111351780A (zh) * | 2019-12-29 | 2020-06-30 | 中船重工（邯郸）派瑞特种气体有限公司 | 一种三氟甲基磺酰氟电解槽中电解液成分的分析方法 |
| JP2023524912A (ja) | 2020-04-23 | 2023-06-13 | サウザーン リサーチ インスチチュート | ４’－チオ－５－アザ－２’－デオキシシチジンを使用して血液がんを治療するための組成物及びその使用 |
| AU2021314329A1 (en) * | 2020-07-23 | 2023-02-23 | Pinotbio, Inc. | Polymorophs of 5-aza-4'-thio-2'-deoxycytidine |
| WO2022123062A1 (en) | 2020-12-11 | 2022-06-16 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Blocking caspase and/or fasl for preventing fatal outcome in covid-19 patients |
| KR102670554B1 (ko) | 2022-01-04 | 2024-05-30 | 주식회사 이노보테라퓨틱스 | 캐스파제 저해제로서의 신규한 이소인돌리논 유도체 화합물 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10199058I2 (de) * | 1991-07-30 | 2006-04-27 | Alcm Co | Kristalle von N-(trans-4-isopropylcyclohexylcarbonyl)-D-phenylalanin und Verfahren zu ihrer Herstellung |
| ES2105003T3 (es) * | 1993-05-12 | 1997-10-16 | Heumann Pharma Gmbh & Co | Forma estable y cristalina del bezafibrato. |
| US6197750B1 (en) | 1998-07-02 | 2001-03-06 | Idun Pharmaceuticals, Inc. | C-terminal modified oxamyl dipeptides as inhibitors of the ICE/ced-3 family of cysteine proteases |
| US7053056B2 (en) * | 1998-07-02 | 2006-05-30 | Idun Pharmaceuticals, Inc. | C-terminal modified oxamyl dipeptides as inhibitors of the ICE/ced-3 family of cysteine proteases |
| US6544951B2 (en) * | 1998-07-02 | 2003-04-08 | Idun Pharmaceuticals, Inc. | C-terminal modified oxamyl dipeptides as inhibitors of the ICE/ced-3 family of cysteine proteases |
| GB9923933D0 (en) * | 1999-10-08 | 1999-12-08 | Smithkline Beecham Lab | Novel pharmaceutical |
| WO2003050077A1 (fr) * | 2001-12-11 | 2003-06-19 | Kyorin Pharmaceutical Co., Ltd. | Cristaux stables de derive d'acide phenylpropionique substitue et procede de production associe |
| CN101217980A (zh) * | 2005-07-11 | 2008-07-09 | 辉瑞有限公司 | 治疗肝纤维化的抗madcam抗体和抗纤维化半胱天冬蛋白酶抑制剂的新组合 |
-
2007
- 2007-12-03 AU AU2007330478A patent/AU2007330478B2/en not_active Ceased
- 2007-12-03 ES ES07859033.8T patent/ES2524021T3/es active Active
- 2007-12-03 JP JP2009539823A patent/JP5495787B2/ja not_active Expired - Fee Related
- 2007-12-03 DK DK07859033.8T patent/DK2091910T3/en active
- 2007-12-03 EP EP07859033.8A patent/EP2091910B1/en active Active
- 2007-12-03 CN CN200780045311.8A patent/CN101573328B/zh not_active Expired - Fee Related
- 2007-12-03 PT PT78590338T patent/PT2091910E/pt unknown
- 2007-12-03 CN CN201410057544.1A patent/CN103923169B/zh not_active Expired - Fee Related
- 2007-12-03 PL PL07859033T patent/PL2091910T3/pl unknown
- 2007-12-03 CN CN201410058519.5A patent/CN103951583B/zh not_active Expired - Fee Related
- 2007-12-03 CA CA2669849A patent/CA2669849C/en active Active
- 2007-12-03 KR KR1020097011692A patent/KR101125932B1/ko not_active Expired - Fee Related
- 2007-12-03 MX MX2009006055A patent/MX2009006055A/es active IP Right Grant
- 2007-12-03 WO PCT/IB2007/003900 patent/WO2008068615A1/en not_active Ceased
- 2007-12-04 CL CL200703491A patent/CL2007003491A1/es unknown
- 2007-12-04 PA PA20078759501A patent/PA8759501A1/es unknown
- 2007-12-04 HN HN2007000536A patent/HN2007000536A/es unknown
- 2007-12-04 UY UY30758A patent/UY30758A1/es not_active Application Discontinuation
- 2007-12-05 TW TW096146304A patent/TWI345466B/zh not_active IP Right Cessation
- 2007-12-05 PE PE2007001720A patent/PE20081251A1/es not_active Application Discontinuation
- 2007-12-05 AR ARP070105447A patent/AR064809A1/es not_active Application Discontinuation
- 2007-12-06 US US11/951,801 patent/US7692038B2/en active Active
-
2009
- 2009-05-13 IL IL198732A patent/IL198732A/en active IP Right Grant
- 2009-05-14 NO NO20091892A patent/NO338908B1/no not_active IP Right Cessation
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Legal Events
| Date | Code | Title | Description |
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| FC | Refusal |