AR052879A1 - Procedimiento para preparar derivados de beta aminoacidos quirales por hidrogenacion asimetrica - Google Patents
Procedimiento para preparar derivados de beta aminoacidos quirales por hidrogenacion asimetricaInfo
- Publication number
- AR052879A1 AR052879A1 ARP060100175A AR052879A1 AR 052879 A1 AR052879 A1 AR 052879A1 AR P060100175 A ARP060100175 A AR P060100175A AR 052879 A1 AR052879 A1 AR 052879A1
- Authority
- AR
- Argentina
- Prior art keywords
- procedure
- amino acids
- asymmetric hydrogenation
- chiral amino
- prepare beta
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 150000001413 amino acids Chemical class 0.000 title 1
- 238000009876 asymmetric hydrogenation reaction Methods 0.000 title 1
- VURFVHCLMJOLKN-UHFFFAOYSA-N diphosphane Chemical compound PP VURFVHCLMJOLKN-UHFFFAOYSA-N 0.000 abstract 2
- -1 acrylic amino acid Chemical class 0.000 abstract 1
- 150000003863 ammonium salts Chemical class 0.000 abstract 1
- 238000011914 asymmetric synthesis Methods 0.000 abstract 1
- 150000001576 beta-amino acids Chemical class 0.000 abstract 1
- 238000005984 hydrogenation reaction Methods 0.000 abstract 1
- 239000003446 ligand Substances 0.000 abstract 1
- 239000002243 precursor Substances 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 239000000758 substrate Substances 0.000 abstract 1
- 229910052723 transition metal Inorganic materials 0.000 abstract 1
- 150000003624 transition metals Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
La presente invencion se refiere a un procedimiento para la preparacion eficiente de derivados de beta aminoácidos enriquecidos enantioméricamente que son utiles en la síntesis asimétrica de moléculas biologicamente activas. El procedimiento comprende una hidrogenacion enantioselectiva de un sustrato derivado de beta aminoácido acrílico proquiral en presencia de una sal de amonio y un precursor de metal de transicion complejado con un ligando de ferrocenil difosfina quiral.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US64669705P | 2005-01-24 | 2005-01-24 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR052879A1 true AR052879A1 (es) | 2007-04-11 |
Family
ID=36587261
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP060100175 AR052879A1 (es) | 2005-01-24 | 2006-01-17 | Procedimiento para preparar derivados de beta aminoacidos quirales por hidrogenacion asimetrica |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP1856028A1 (es) |
| JP (1) | JP2008528503A (es) |
| CN (1) | CN101175714A (es) |
| AR (1) | AR052879A1 (es) |
| AU (1) | AU2006208297A1 (es) |
| CA (1) | CA2594494A1 (es) |
| TW (1) | TW200637805A (es) |
| WO (1) | WO2006081151A1 (es) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009084024A2 (en) | 2007-11-02 | 2009-07-09 | Glenmark Generics Limited | A process for the preparation of r-sit agliptin and its pharmaceutically acceptable salts thereof |
| CN102271504B (zh) | 2008-12-31 | 2014-08-20 | 凯瑞斯德股份有限公司 | 用于制备N-酰化-4-芳基β-氨基酸衍生物的方法和中间体 |
| EP2223923A1 (en) | 2009-02-25 | 2010-09-01 | Esteve Química, S.A. | Process for the preparation of a chiral beta aminoacid derivative and intermediates thereof |
| IT1395596B1 (it) * | 2009-06-30 | 2012-10-16 | Dipharma Francis Srl | Procedimento per la preparazione di sitagliptin |
| CZ303113B6 (cs) | 2010-03-16 | 2012-04-11 | Zentiva, K.S. | Zpusob prípravy sitagliptinu |
| EP2547682A1 (en) | 2010-03-31 | 2013-01-23 | Teva Pharmaceutical Industries Ltd. | Solid state forms of sitagliptin salts |
| EP2576563B1 (en) | 2010-06-04 | 2016-05-11 | LEK Pharmaceuticals d.d. | A NOVEL SYNTHETIC APPROACH TO ß-AMINOBUTYRYL SUBSTITUTED COMPOUNDS |
| EP2392575A1 (en) | 2010-06-04 | 2011-12-07 | LEK Pharmaceuticals d.d. | A novel synthetic approach to ß-aminobutyryl substituted compounds |
| EP2397141A1 (en) | 2010-06-16 | 2011-12-21 | LEK Pharmaceuticals d.d. | Process for the synthesis of beta-amino acids and derivatives thereof |
| EP2609099A2 (en) | 2010-08-27 | 2013-07-03 | USV Limited | Sitagliptin, salts and polymorphs thereof |
| IN2010DE02164A (es) | 2010-09-13 | 2015-07-24 | Panacea Biotec Ltd | |
| EP2508506A1 (en) | 2011-04-08 | 2012-10-10 | LEK Pharmaceuticals d.d. | Preparation of sitagliptin intermediates |
| EP2527320A1 (en) | 2011-05-27 | 2012-11-28 | LEK Pharmaceuticals d.d. | Preparation of Sitagliptin Intermediates |
| WO2013013833A1 (en) | 2011-07-27 | 2013-01-31 | Farma Grs, D.O.O. | Process for the preparation of sitagliptin and its pharmaceutically acceptable salts |
| WO2013065066A1 (en) | 2011-11-02 | 2013-05-10 | Cadila Healthcare Limited | Processes for preparing 4-oxo-4-[3-(trifluoromethyl)-5,6- dihydro [l,2,41-triazolo[43-a]pyrazin-7(8h)-yl]-l-(2,4,5- trifluorophenyl)butan-2-amine |
| EP2615080A1 (en) | 2012-01-12 | 2013-07-17 | LEK Pharmaceuticals d.d. | Preparation of Optically Pure ß-Amino Acid Type Active Pharmaceutical Ingredients and Intermediates thereof |
| EP2674432A1 (en) | 2012-06-14 | 2013-12-18 | LEK Pharmaceuticals d.d. | New synthetic route for the preparation of ß aminobutyryl substituted 5,6,7,8-tetrahydro[1,4]diazolo[4,3-alpha]pyrazin-7-yl compounds |
| US9227901B2 (en) * | 2012-07-05 | 2016-01-05 | Abbvie Inc. | Process for preparing bicyclic amine derivatives |
| CN102898387B (zh) * | 2012-09-26 | 2015-01-07 | 浙江工业大学 | 管道化连续生产n-[(2z)-哌嗪-2-亚基]-2,2,2-三氟乙酰肼的方法 |
| CN105315286B (zh) * | 2014-07-30 | 2018-08-17 | 连云港润众制药有限公司 | 西格列汀的制备 |
| KR102359436B1 (ko) * | 2015-06-05 | 2022-02-09 | (주)아모레퍼시픽 | 메틸 2-프로필-6-(트리플루오로메틸) 니코티네이트의 제조방법 |
| CN105254519B (zh) * | 2015-11-25 | 2017-05-17 | 常州吉恩药业有限公司 | 一种西他列汀关键中间体的合成方法 |
| ES2733477T3 (es) | 2017-07-04 | 2019-11-29 | Fis Fabbrica Italiana Sintetici Spa | Procedimiento eficaz para la preparación de sitagliptina a través de una preparación muy eficaz del intermedio ácido 2,4,5-trifluorofenilacético |
| CN107325025B (zh) * | 2017-07-17 | 2019-04-09 | 中国科学院化学研究所 | 一种手性α-氨基酸衍生物及其制备方法 |
| CN113636950B (zh) * | 2020-05-11 | 2023-01-17 | 浙江医药股份有限公司新昌制药厂 | 一种手性4-芳基-β-氨基酸衍生物的制备方法 |
| WO2024121301A1 (en) | 2022-12-09 | 2024-06-13 | Krka, D.D., Novo Mesto | Process for the preparation of sitagliptin |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG42925A1 (en) * | 1993-10-01 | 1997-10-17 | Ciba Geigy Ag | Fluoroalkyl-substituted ferrocenyl diphosphines as ligands for homogeneous catalysts |
| AR043515A1 (es) * | 2003-03-19 | 2005-08-03 | Merck & Co Inc | Procedimiento para preparar derivados quirales beta aminoacidos mediante hidrogenacion asimetrica |
| TW200602293A (en) * | 2004-04-05 | 2006-01-16 | Merck & Co Inc | Process for the preparation of enantiomerically enriched beta amino acid derivatives |
-
2006
- 2006-01-17 AR ARP060100175 patent/AR052879A1/es unknown
- 2006-01-20 CA CA002594494A patent/CA2594494A1/en not_active Abandoned
- 2006-01-20 AU AU2006208297A patent/AU2006208297A1/en not_active Abandoned
- 2006-01-20 JP JP2007552303A patent/JP2008528503A/ja not_active Withdrawn
- 2006-01-20 WO PCT/US2006/002147 patent/WO2006081151A1/en not_active Ceased
- 2006-01-20 CN CNA2006800028725A patent/CN101175714A/zh active Pending
- 2006-01-20 EP EP06719111A patent/EP1856028A1/en not_active Withdrawn
- 2006-01-23 TW TW095102476A patent/TW200637805A/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2006081151A1 (en) | 2006-08-03 |
| TW200637805A (en) | 2006-11-01 |
| EP1856028A1 (en) | 2007-11-21 |
| CA2594494A1 (en) | 2006-08-03 |
| CN101175714A (zh) | 2008-05-07 |
| AU2006208297A1 (en) | 2006-08-03 |
| JP2008528503A (ja) | 2008-07-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |