AR051300A1 - Derivados de indol como inhibidores de la adenilato ciclasa soluble - Google Patents
Derivados de indol como inhibidores de la adenilato ciclasa solubleInfo
- Publication number
- AR051300A1 AR051300A1 ARP050104008A ARP050104008A AR051300A1 AR 051300 A1 AR051300 A1 AR 051300A1 AR P050104008 A ARP050104008 A AR P050104008A AR P050104008 A ARP050104008 A AR P050104008A AR 051300 A1 AR051300 A1 AR 051300A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- acyl
- optionally
- aryl
- polysubstituted
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title abstract 2
- SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical class C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 title 1
- UDMBCSSLTHHNCD-KQYNXXCUSA-N adenosine 5'-monophosphate Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]1O UDMBCSSLTHHNCD-KQYNXXCUSA-N 0.000 title 1
- 230000001351 cycling effect Effects 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 31
- 125000002252 acyl group Chemical group 0.000 abstract 21
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 13
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 9
- 125000003118 aryl group Chemical group 0.000 abstract 9
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 9
- 229910052736 halogen Inorganic materials 0.000 abstract 9
- 150000002367 halogens Chemical class 0.000 abstract 8
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000001072 heteroaryl group Chemical group 0.000 abstract 3
- 125000004356 hydroxy functional group Chemical group O* 0.000 abstract 3
- 229910052757 nitrogen Inorganic materials 0.000 abstract 3
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 2
- 229910052760 oxygen Inorganic materials 0.000 abstract 2
- 229940124530 sulfonamide Drugs 0.000 abstract 2
- 150000003456 sulfonamides Chemical class 0.000 abstract 2
- 229910052717 sulfur Inorganic materials 0.000 abstract 2
- 102000030621 adenylate cyclase Human genes 0.000 abstract 1
- 108060000200 adenylate cyclase Proteins 0.000 abstract 1
- 125000002877 alkyl aryl group Chemical group 0.000 abstract 1
- 229940054051 antipsychotic indole derivative Drugs 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 150000002475 indoles Chemical class 0.000 abstract 1
- 125000001400 nonyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 abstract 1
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/40—Nitrogen atoms, not forming part of a nitro radical, e.g. isatin semicarbazone
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/16—Masculine contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D411/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms
- C07D411/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D411/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Saccharide Compounds (AREA)
Abstract
La presente se refiere a derivados de indol como inhibidores de la adenilato ciclasa soluble, su preparacion y su uso como medicamento. Reivindicacion 1: Compuestos caracterizados porque responden a la formula general (1) en la cual R1 es H, halogeno, CF3, cicloalquilo C3-6 que es opcionalmente polisaturado y opcionalmente polisustituido o es el grupo alquilo C1-6, arilo C1-6, acilo C1-6, halo-alquilo C1-6, alquilo C1-6-alquilo C1-6, alquilo C1-6-acilo C1-6, acilo C1-6-acilo C1-6, alquilo C1-6-arilo C1-6, arilo C1-6-alquilo C1-6 o CF3, en el cual alquilo C1-6, arilo C1-6, acilo C1-6, halo-alquilo C1-6, alquilo C1-6-alquilo C1-6, alquilo C1-6-acilo C1-6, acilo C1-6-acilo C1-6, alquilo C1-6-arilo C1-6 o arilo C1-6-alquilo C1-6 opcionalmente puede estar interrumpido una o varia veces, en forma igual o diferente por O, S o N o es el grupo sulfonil-alquilo C1-6, sulfonamida o ciano; R2 es halogeno, CF3, cicloalquilo C3-6 que es opcionalmente polisaturado y opcionalmente polisustituido o es el grupo alquilo C1-6, arilo C1-6, acilo C1-6, halo-alquilo C1-6, alquilo C1-6-alquilo C1-6, alquilo C1-6-acilo C1-6, acilo C1-6-acilo C1-6, alquilo C1-6-arilo C1-6, arilo C1-6-alquilo C1-6 o CF3, en el cual alquilo C1-6, arilo C1-6, acilo C1-6, halo-alquilo C1-6, alquilo C1-6-alquilo C1-6, alquilo C1-6-acilo C1-6, acilo C1-6-acilo C1-6, alquilo C1-6-arilo C1-6 o arilo C1-6-alquilo C1-6 opcionalmente puede estar interrumpido una o varia veces, en forma igual o diferente por O, S o N o es el grupo sulfonil-alquilo C1-6, sulfonamida o ciano; R3 es arilo C6-12, que opcionalmente puede estar mono o polisustituido en forma igual o diferente con halogeno, con alquilo C1-6 o acilo C1-6, que opcionalmente puede estar mono o polisustituido o que puede estar sustituido con alcoxi C1-6, hidroxi, ciano, CO2-(alquilo C1-6), N-(alquilo C1-6)2, CO-NR4R5 o con CF3, es heteroarilo C5-12, que opcionalmente puede estar mono o polisustituido en forma igual o diferente con halogeno, con alquilo C1-6, acilo C1-6, alcoxi C1-6, hidroxi, ciano, CO2-(alquilo C1-6), N-(alquilo C1-6)2, CO-NR4R5 o con CF3 o es cicloalquilo C3-6 que opcionalmente puede estar mono o polisustituido en forma igual o diferente con halogeno, CF3, hidroxi, ciano, CO2-(alquilo C1-6), alquilo C1-6, acilo C1-6, N-(alquilo C1-6)2, CO-NR4R5 o alcoxi C1-6; R4 es H, cicloalquilo C3-6 que opcionalmente puede estar mono o polisustituido en forma igual o diferente con alquilo C1-6, acilo C1-6, alcoxi C1-6 o CF3, es arilo C6-12, que opcionalmente puede estar mono o polisustituido en forma igual o diferente con halogeno, con alquilo C1-6, acilo C1-6, alcoxi C1-6, N-alquilo C1-6-alquilo C1-6, CF3 o ciano o es heteroarilo C5-12, que opcionalmente puede estar mono o polisustituido en forma igual o diferente con halogeno, con alquilo C1-6, acilo C1-6, alcoxi C1-6, N-alquilo C1-6-alquilo C1-6, CF3 o ciano o es alquilo C1-6 que puede estar sustituido de cualquier manera; R5 es H, cicloalquilo C3- 6 que opcionalmente puede estar mono o polisustituido en forma igual o diferente con alquilo C1-6, acilo C1-6, alcoxi C1-6 o CF3, es arilo C6-12, que opcionalmente puede estar mono o polisustituido en forma igual o diferente con halogeno, con alquilo C1-6, acilo C1-6, alcoxi C1-6, N-alquilo C1-6-alquilo C1-6, CF3 o ciano o es heteroarilo C5-12, que opcionalmente puede estar mono o polisustituido en forma igual o diferente con halogeno, con alquilo C1-6, acilo C1-6, alcoxi C1-6, N-alquilo C1-6-alquilo C1-6, CF3 o ciano o es alquilo C1-6 que puede estar sustituido de cualquier manera; R4 y R5 forman juntos un anillo de 5-8 miembros, que puede contener otros heteroátomos y X es el grupo sulfonilo, (CH2)n o carbonilo; Y es carbonilo o (CH2)n; Z es N, y n es 0-4.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102004047272A DE102004047272A1 (de) | 2004-09-24 | 2004-09-24 | Inhibitoren der löslichen Adenylatzyklase |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR051300A1 true AR051300A1 (es) | 2007-01-03 |
Family
ID=37600950
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP050104008A AR051300A1 (es) | 2004-09-24 | 2005-09-26 | Derivados de indol como inhibidores de la adenilato ciclasa soluble |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US20080004268A1 (es) |
| EP (1) | EP1802572B1 (es) |
| JP (1) | JP2008514572A (es) |
| KR (1) | KR20070054685A (es) |
| CN (1) | CN101084189A (es) |
| AR (1) | AR051300A1 (es) |
| AT (1) | ATE429419T1 (es) |
| AU (1) | AU2005287481A1 (es) |
| BR (1) | BRPI0516057A (es) |
| CA (1) | CA2581492A1 (es) |
| CR (1) | CR9058A (es) |
| DE (1) | DE502005007158D1 (es) |
| EA (1) | EA200700555A1 (es) |
| GT (1) | GT200500268A (es) |
| IL (1) | IL181739A0 (es) |
| MX (1) | MX2007003287A (es) |
| MY (1) | MY142839A (es) |
| NO (1) | NO20072078L (es) |
| PA (1) | PA8646301A1 (es) |
| PE (1) | PE20060696A1 (es) |
| SV (1) | SV2006002238A (es) |
| TW (1) | TW200615260A (es) |
| UY (1) | UY29141A1 (es) |
| ZA (1) | ZA200703307B (es) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070225284A1 (en) * | 2006-03-23 | 2007-09-27 | Bernd Buchmann | Inhibitors of soluble adenylate cyclase |
| CN102262159B (zh) * | 2010-05-27 | 2014-03-26 | 李建远 | 用于检测生育相关人睾丸和附睾表达305种精子定位蛋白的方法 |
| WO2017190050A1 (en) * | 2016-04-28 | 2017-11-02 | Cornell University | Inhibitors of soluble adenylyl cyclase |
| WO2019046465A2 (en) * | 2017-08-29 | 2019-03-07 | Rutgers, The State University Of New Jersey | THERAPEUTIC INDOLES |
| US11186549B2 (en) | 2017-08-29 | 2021-11-30 | Rutgers, The State University Of New Jersey | Therapeutic indazoles |
| CN108096244B (zh) * | 2018-01-25 | 2020-11-24 | 昆明医科大学 | 1-氢-2-吲哚酮-3-苄基/取代苄基-3-甲酸酯类化合物的用途 |
| EP3851853A1 (en) * | 2020-01-17 | 2021-07-21 | Biotechnologicky Ustav AV CR, v.v.i. | Method for separation of sperm with undamaged intact heads from sperm with damaged heads and somatic cells |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3786579B2 (ja) * | 1998-07-08 | 2006-06-14 | サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | 硫黄置換スルホニルアミノカルボン酸ｎ−アリールアミド、それらの製造、それらの使用、及びそれらを含む医薬製剤 |
| US7442805B2 (en) * | 2003-09-25 | 2008-10-28 | Wyeth | Substituted sulfonamide-indoles |
| US7417066B2 (en) * | 2005-06-08 | 2008-08-26 | Schering Ag | Inhibitors of soluble adenylate cyclase |
| US20070225284A1 (en) * | 2006-03-23 | 2007-09-27 | Bernd Buchmann | Inhibitors of soluble adenylate cyclase |
-
2005
- 2005-09-23 BR BRPI0516057-0A patent/BRPI0516057A/pt not_active IP Right Cessation
- 2005-09-23 MX MX2007003287A patent/MX2007003287A/es not_active Application Discontinuation
- 2005-09-23 AT AT05794403T patent/ATE429419T1/de not_active IP Right Cessation
- 2005-09-23 EP EP05794403A patent/EP1802572B1/de not_active Expired - Lifetime
- 2005-09-23 CN CNA2005800322659A patent/CN101084189A/zh active Pending
- 2005-09-23 JP JP2007532864A patent/JP2008514572A/ja active Pending
- 2005-09-23 TW TW094133179A patent/TW200615260A/zh unknown
- 2005-09-23 KR KR1020077006633A patent/KR20070054685A/ko not_active Withdrawn
- 2005-09-23 MY MYPI20054478A patent/MY142839A/en unknown
- 2005-09-23 EA EA200700555A patent/EA200700555A1/ru unknown
- 2005-09-23 AU AU2005287481A patent/AU2005287481A1/en not_active Abandoned
- 2005-09-23 DE DE502005007158T patent/DE502005007158D1/de not_active Expired - Fee Related
- 2005-09-23 CA CA002581492A patent/CA2581492A1/en not_active Abandoned
- 2005-09-26 UY UY29141A patent/UY29141A1/es not_active Application Discontinuation
- 2005-09-26 PA PA20058646301A patent/PA8646301A1/es unknown
- 2005-09-26 PE PE2005001108A patent/PE20060696A1/es not_active Application Discontinuation
- 2005-09-26 SV SV2005002238A patent/SV2006002238A/es not_active Application Discontinuation
- 2005-09-26 AR ARP050104008A patent/AR051300A1/es unknown
- 2005-09-26 GT GT200500268A patent/GT200500268A/es unknown
-
2007
- 2007-03-06 IL IL181739A patent/IL181739A0/en unknown
- 2007-04-18 CR CR9058A patent/CR9058A/es not_active Application Discontinuation
- 2007-04-23 ZA ZA200703307A patent/ZA200703307B/xx unknown
- 2007-04-23 NO NO20072078A patent/NO20072078L/no not_active Application Discontinuation
- 2007-08-07 US US11/835,164 patent/US20080004268A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| MX2007003287A (es) | 2007-10-11 |
| GT200500268A (es) | 2006-10-10 |
| DE502005007158D1 (de) | 2009-06-04 |
| EP1802572B1 (de) | 2009-04-22 |
| TW200615260A (en) | 2006-05-16 |
| KR20070054685A (ko) | 2007-05-29 |
| PA8646301A1 (es) | 2006-09-08 |
| ATE429419T1 (de) | 2009-05-15 |
| EP1802572A1 (de) | 2007-07-04 |
| EA200700555A1 (ru) | 2007-10-26 |
| SV2006002238A (es) | 2006-06-26 |
| IL181739A0 (en) | 2007-07-04 |
| US20080004268A1 (en) | 2008-01-03 |
| PE20060696A1 (es) | 2006-08-01 |
| CN101084189A (zh) | 2007-12-05 |
| CR9058A (es) | 2007-10-04 |
| BRPI0516057A (pt) | 2008-08-19 |
| ZA200703307B (en) | 2009-05-27 |
| JP2008514572A (ja) | 2008-05-08 |
| AU2005287481A1 (en) | 2006-03-30 |
| NO20072078L (no) | 2007-05-31 |
| MY142839A (en) | 2011-01-14 |
| CA2581492A1 (en) | 2006-03-30 |
| UY29141A1 (es) | 2006-04-28 |
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