AR051197A1 - Un procedimiento para obtener una microemulsion y sub-micron emulsion y composiciones - Google Patents
Un procedimiento para obtener una microemulsion y sub-micron emulsion y composicionesInfo
- Publication number
- AR051197A1 AR051197A1 ARP050103641A ARP050103641A AR051197A1 AR 051197 A1 AR051197 A1 AR 051197A1 AR P050103641 A ARP050103641 A AR P050103641A AR P050103641 A ARP050103641 A AR P050103641A AR 051197 A1 AR051197 A1 AR 051197A1
- Authority
- AR
- Argentina
- Prior art keywords
- microemulsion
- surfactant
- water
- temperature
- submicron emulsion
- Prior art date
Links
- 239000000839 emulsion Substances 0.000 title abstract 7
- 239000004530 micro-emulsion Substances 0.000 title abstract 6
- 239000000203 mixture Substances 0.000 title abstract 5
- 238000000034 method Methods 0.000 title abstract 3
- 239000004094 surface-active agent Substances 0.000 abstract 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 5
- 150000001875 compounds Chemical class 0.000 abstract 3
- 238000010438 heat treatment Methods 0.000 abstract 2
- 239000003921 oil Substances 0.000 abstract 2
- 235000019198 oils Nutrition 0.000 abstract 2
- 239000004480 active ingredient Substances 0.000 abstract 1
- 150000001298 alcohols Chemical class 0.000 abstract 1
- 239000010775 animal oil Substances 0.000 abstract 1
- 235000014113 dietary fatty acids Nutrition 0.000 abstract 1
- 238000004090 dissolution Methods 0.000 abstract 1
- 230000002500 effect on skin Effects 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 239000003925 fat Substances 0.000 abstract 1
- 239000000194 fatty acid Substances 0.000 abstract 1
- 229930195729 fatty acid Natural products 0.000 abstract 1
- 150000004665 fatty acids Chemical class 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- 150000002366 halogen compounds Chemical class 0.000 abstract 1
- 229910052500 inorganic mineral Inorganic materials 0.000 abstract 1
- 239000002480 mineral oil Substances 0.000 abstract 1
- 229920005862 polyol Polymers 0.000 abstract 1
- 150000003077 polyols Chemical class 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 150000004756 silanes Chemical class 0.000 abstract 1
- -1 siloxanes Chemical class 0.000 abstract 1
- 235000015112 vegetable and seed oil Nutrition 0.000 abstract 1
- 239000008158 vegetable oil Substances 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/06—Emulsions
- A61K8/062—Oil-in-water emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/06—Emulsions
- A61K8/068—Microemulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/12—Aerosols; Foams
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Dispersion Chemistry (AREA)
- Dermatology (AREA)
- Birds (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cosmetics (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Colloid Chemistry (AREA)
Abstract
Se provee un procedimiento para la preparacion de una composicion de microemulsion o emulsion submicrométrica de aceite en agua (aceite/agua) para el suministro dérmico de por lo menos un ingrediente farmacéuticamente activo, el método incluye los pasos de: a) mezclar una primera parte que incluye por lo menos uno del grupo que consiste en aceites animales, minerales o vegetales, silanos, siloxanos, ésteres, ácidos grasos, grasas, compuestos de halogeno o alcoholes alcoxilados; y uno o más de tensioactivos lipofilos; y una segunda parte que incluye agua y por lo menos un tensioactivo hidrofilo para lograr la homogeneidad; b) calentar la mezcla del paso a) a una temperatura de combinacion de fases en el rango de 40-99sC, preferentemente 45-95sC, más preferentemente 65-85sC, con mezclado continuo par obtener una microemulsion o emulsion submicrométrica; c) dejar enfriar a dicha microemulsion o emulsion submicrométrica; y d) agregar una tercera parte a dicha microemulsion o emulsion submicrométrica a una temperatura entre 2sC y dicha temperatura de combinacion de fases, premezclándose y calentándose dicha tercera parte, si es necesario, hasta la disolucion de los componentes, e incluyendo por lo menos un componente seleccionado entre el grupo que consiste en un compuesto tipo anfifílico, no tensioactivo, un tensioactivo y agua, con la condicion de que cuando la tercera parte incluye agua, también incluye un compuesto tipo anfifílico no tensioactivo y/o un tensioactivo. La temperatura de la combinacion de fases puede ser determinada visualmente porque se logra la translucidez en la composicion o por medidas tales como la conductividad que llega a un máximo y luego se mantiene en una meseta mientras se produce la combinacion de fases. Se ha hallado que mientras que si se logra un compuesto tipo anfifílico no tensioactivo tal como el poliol junto con la segunda parte, como seria el caso convencionalmente, no se forma una microemulsion o emulsion submicrométrica, agregando la así llamada tercera parte, se produce la combinacion de fases a una temperatura más baja que la que se esperaría y además, esta fase parece ayudar a mantener las características de la microemulsion o emulsion submicrométrica de la formulacion durante el almacenamiento a temperaturas normales.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US60627804P | 2004-08-31 | 2004-08-31 | |
| US67072205P | 2005-04-12 | 2005-04-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR051197A1 true AR051197A1 (es) | 2006-12-27 |
Family
ID=35999634
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP050103641A AR051197A1 (es) | 2004-08-31 | 2005-08-31 | Un procedimiento para obtener una microemulsion y sub-micron emulsion y composiciones |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US8460641B2 (es) |
| EP (2) | EP1796636B2 (es) |
| JP (1) | JP4972553B2 (es) |
| KR (1) | KR101243526B1 (es) |
| AR (1) | AR051197A1 (es) |
| AU (1) | AU2005279704B2 (es) |
| BR (1) | BRPI0514806A (es) |
| CA (1) | CA2578594C (es) |
| ES (1) | ES2429040T5 (es) |
| IL (1) | IL181632A (es) |
| PL (1) | PL1796636T5 (es) |
| RU (1) | RU2381023C2 (es) |
| TW (1) | TWI397427B (es) |
| WO (1) | WO2006024095A1 (es) |
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| US8119109B2 (en) | 2002-10-25 | 2012-02-21 | Foamix Ltd. | Foamable compositions, kits and methods for hyperhidrosis |
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| AR051197A1 (es) | 2004-08-31 | 2006-12-27 | Connetics Australia Pty Ltd | Un procedimiento para obtener una microemulsion y sub-micron emulsion y composiciones |
| US8449867B2 (en) * | 2004-08-31 | 2013-05-28 | Stiefel Research Australia Pty Ltd | Microemulsion and sub-micron emulsion process and compositions |
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| DE19904847A1 (de) * | 1999-02-08 | 2000-08-10 | Rwe Dea Ag | Öl-in-Wasser-Mikroemulsion enthaltend Alkanolammonium-Salze der Alkylsulfate und/oder Alkylpolyalkylenglykolethersulfate |
| DE19908559A1 (de) * | 1999-02-27 | 2000-09-07 | Cognis Deutschland Gmbh | PIT-Emulsionen |
| US7064114B2 (en) * | 1999-03-19 | 2006-06-20 | Parker Hughes Institute | Gel-microemulsion formulations |
| US6689387B1 (en) | 1999-09-23 | 2004-02-10 | Bioresponse Llc | Phytochemicals for treatment of mastalgia and endometriosis |
| US6455066B1 (en) * | 2000-03-10 | 2002-09-24 | Epicept Corporation | Intradermal-penetration agents for topical local anesthetic administration |
| FR2819427B1 (fr) * | 2001-01-18 | 2003-04-11 | Oreal | Nanoemulsion translucide, son procede de fabrication et ses utilisations dans les domaines cosmetique, dermatologique et/ou ophtalmologique |
| WO2002087692A1 (en) * | 2001-04-26 | 2002-11-07 | The Procter & Gamble Company | A method and apparatus for the treatment of cosmetic skin conditioins |
| DE10134805B4 (de) | 2001-07-17 | 2004-09-30 | Metzeler Automotive Profile Systems Gmbh | Dichtungsanordnung für ein Karosseriefenster, insbesondere eines Kraftfahrzeugs |
| DE10139580A1 (de) * | 2001-08-10 | 2003-02-20 | Beiersdorf Ag | Kosmetische und dermatologische Zubereitungen in Form von O/W-Emulsionen mit einem Gehalt an Sterinen und/oder C12-C40-Fettsäuren |
| US7544674B2 (en) | 2002-10-25 | 2009-06-09 | Galderma S.A. | Topical skin care composition |
| AR051197A1 (es) | 2004-08-31 | 2006-12-27 | Connetics Australia Pty Ltd | Un procedimiento para obtener una microemulsion y sub-micron emulsion y composiciones |
-
2005
- 2005-08-31 AR ARP050103641A patent/AR051197A1/es unknown
- 2005-08-31 JP JP2007528524A patent/JP4972553B2/ja not_active Expired - Lifetime
- 2005-08-31 WO PCT/AU2005/001321 patent/WO2006024095A1/en not_active Ceased
- 2005-08-31 PL PL05775966T patent/PL1796636T5/pl unknown
- 2005-08-31 RU RU2007111706/15A patent/RU2381023C2/ru active
- 2005-08-31 EP EP05775966.4A patent/EP1796636B2/en not_active Expired - Lifetime
- 2005-08-31 AU AU2005279704A patent/AU2005279704B2/en not_active Expired
- 2005-08-31 US US11/216,668 patent/US8460641B2/en active Active
- 2005-08-31 KR KR1020077007513A patent/KR101243526B1/ko not_active Expired - Lifetime
- 2005-08-31 CA CA2578594A patent/CA2578594C/en not_active Expired - Lifetime
- 2005-08-31 EP EP11187733A patent/EP2438910A1/en not_active Withdrawn
- 2005-08-31 TW TW094129904A patent/TWI397427B/zh not_active IP Right Cessation
- 2005-08-31 ES ES05775966.4T patent/ES2429040T5/es not_active Expired - Lifetime
- 2005-08-31 BR BRPI0514806-5A patent/BRPI0514806A/pt not_active Application Discontinuation
-
2007
- 2007-02-28 IL IL181632A patent/IL181632A/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| AU2005279704B2 (en) | 2010-05-13 |
| TWI397427B (zh) | 2013-06-01 |
| KR20070069155A (ko) | 2007-07-02 |
| TW200624124A (en) | 2006-07-16 |
| RU2007111706A (ru) | 2008-10-10 |
| EP1796636B2 (en) | 2016-12-14 |
| PL1796636T5 (pl) | 2017-10-31 |
| EP2438910A1 (en) | 2012-04-11 |
| JP4972553B2 (ja) | 2012-07-11 |
| JP2008511550A (ja) | 2008-04-17 |
| BRPI0514806A (pt) | 2008-06-24 |
| KR101243526B1 (ko) | 2013-03-20 |
| WO2006024095A1 (en) | 2006-03-09 |
| CA2578594C (en) | 2012-04-17 |
| WO2006024095A8 (en) | 2007-04-19 |
| US20060057168A1 (en) | 2006-03-16 |
| IL181632A (en) | 2015-01-29 |
| EP1796636B1 (en) | 2013-08-14 |
| CA2578594A1 (en) | 2006-03-09 |
| AU2005279704A1 (en) | 2006-03-09 |
| ES2429040T3 (es) | 2013-11-12 |
| PL1796636T3 (pl) | 2014-01-31 |
| HK1110198A1 (en) | 2008-07-11 |
| US8460641B2 (en) | 2013-06-11 |
| ES2429040T5 (es) | 2017-06-13 |
| EP1796636A4 (en) | 2011-03-02 |
| EP1796636A1 (en) | 2007-06-20 |
| IL181632A0 (en) | 2007-07-04 |
| RU2381023C2 (ru) | 2010-02-10 |
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