AR051008A1 - AMIDAS SUSTITUIDAS DE ACIDO TIENOPIRROLCARBOXILICO, AMIDAS DEL ACIDO PIRROLOTIAZOLCARBOXILICO Y ANALOGOS RELACIONADOS COMO INHIBIDORES DE LA CASEINA CINASA Ie - Google Patents
AMIDAS SUSTITUIDAS DE ACIDO TIENOPIRROLCARBOXILICO, AMIDAS DEL ACIDO PIRROLOTIAZOLCARBOXILICO Y ANALOGOS RELACIONADOS COMO INHIBIDORES DE LA CASEINA CINASA IeInfo
- Publication number
- AR051008A1 AR051008A1 ARP050103439A ARP050103439A AR051008A1 AR 051008 A1 AR051008 A1 AR 051008A1 AR P050103439 A ARP050103439 A AR P050103439A AR P050103439 A ARP050103439 A AR P050103439A AR 051008 A1 AR051008 A1 AR 051008A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- formula
- amidas
- acid
- heterocycle
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 239000002253 acid Substances 0.000 title 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 10
- 150000001875 compounds Chemical class 0.000 abstract 5
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 3
- 125000006700 (C1-C6) alkylthio group Chemical group 0.000 abstract 2
- 125000000623 heterocyclic group Chemical group 0.000 abstract 2
- 125000004890 (C1-C6) alkylamino group Chemical group 0.000 abstract 1
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 1
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 abstract 1
- 102000005403 Casein Kinases Human genes 0.000 abstract 1
- 108010031425 Casein Kinases Proteins 0.000 abstract 1
- 208000019022 Mood disease Diseases 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 210000003169 central nervous system Anatomy 0.000 abstract 1
- 208000037765 diseases and disorders Diseases 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 208000019116 sleep disease Diseases 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Cardiology (AREA)
- Anesthesiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Peptides Or Proteins (AREA)
Abstract
La presente describe y reivindica compuestos de fórmula (1) y (2), como inhibidores de la caseína cinasa Ie humana y métodos para utilizar dichos compuestos para tratar enfermedades y trastornos del sistema nervioso central, incluyendo trastornos del ánimo y trastornos del sueño. También se describen y se reivindican composiciones farmacéuticas que comprenden compuestos de fórmula (1) o fórmula (2) y un método de preparación de compuesto de fórmula (1) o fórmula (2). Reivindicación 1: Un compuesto de fórmula (1) o fórmula (2) en la que: X es S ó S(O)ₙ; R¹ es H o alquilo C₁₋₆; R² es NR⁵R⁶; R³ es arilo o heterociclo; R⁴ es H, alquilo C₁₋₆, alquenilo C₂₋₆, alquinilo C₂₋₆, aril-(alquilo C₁₋₆), heterociclo(alquilo C₁₋₆), alcoxi C₁₋₆, aril-(alcoxi C₁₋₆), heterociclo-(alcoxi C₁₋₆), CF₃, halógeno, SH, alquiltio C₁₋₆, aril-(alquiltio C₁₋₆), heterociclo-(alquiltio C₁₋₆), NO₂, NH₂, NR⁵R⁶, aril-(alquilamino C₁₋₆), heterociclo-(alquilamino C₁₋₆), o XR³ en el que X y R³ son como se ha definido anteriormente; R⁵ es H o alquilo C₁₋₆; R⁶ es H o alquilo C₁₋₆; L es N o CR⁷ en el que R⁷ es H o alquilo C₁₋₆; M es S, O ó NR⁸ en el que R⁸ es H, alquilo C₁₋₆, aril-(alquilo C₁₋₆), heterociclo-(alquilo C₁₋₆) o acilo; n es 1 ó 2; o uno de sus estereoisómeros, enantiómeros, racematos o tautómeros, o una de sus sales farmacéuticamente aceptables.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US60334704P | 2004-08-19 | 2004-08-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR051008A1 true AR051008A1 (es) | 2006-12-13 |
Family
ID=35695546
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP050103439A AR051008A1 (es) | 2004-08-19 | 2005-08-16 | AMIDAS SUSTITUIDAS DE ACIDO TIENOPIRROLCARBOXILICO, AMIDAS DEL ACIDO PIRROLOTIAZOLCARBOXILICO Y ANALOGOS RELACIONADOS COMO INHIBIDORES DE LA CASEINA CINASA Ie |
Country Status (30)
| Country | Link |
|---|---|
| US (2) | US7393867B2 (es) |
| EP (1) | EP1784409B1 (es) |
| JP (1) | JP4869232B2 (es) |
| KR (1) | KR20070045263A (es) |
| CN (1) | CN100562521C (es) |
| AR (1) | AR051008A1 (es) |
| AT (1) | ATE471326T1 (es) |
| AU (1) | AU2005272584B2 (es) |
| BR (1) | BRPI0514419A (es) |
| CA (1) | CA2577879C (es) |
| CY (1) | CY1110775T1 (es) |
| DE (1) | DE602005021889D1 (es) |
| DK (1) | DK1784409T3 (es) |
| ES (1) | ES2347166T3 (es) |
| GT (1) | GT200500215A (es) |
| HR (1) | HRP20100475T1 (es) |
| IL (1) | IL181158A0 (es) |
| JO (1) | JO2629B1 (es) |
| MY (1) | MY139831A (es) |
| PA (1) | PA8642801A1 (es) |
| PE (1) | PE20060630A1 (es) |
| PL (1) | PL1784409T3 (es) |
| PT (1) | PT1784409E (es) |
| RS (1) | RS51413B (es) |
| RU (1) | RU2403257C2 (es) |
| SI (1) | SI1784409T1 (es) |
| SV (1) | SV2006002190A (es) |
| TW (1) | TWI372149B (es) |
| UY (1) | UY29077A1 (es) |
| WO (1) | WO2006021000A2 (es) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005066135A2 (en) | 2003-12-29 | 2005-07-21 | Sepracor Inc. | Pyrrole and pyrazole daao inhibitors |
| US20070203111A1 (en) | 2006-01-06 | 2007-08-30 | Sepracor Inc. | Cycloalkylamines as monoamine reuptake inhibitors |
| JP5438975B2 (ja) | 2006-01-06 | 2014-03-12 | サノビオン ファーマシューティカルズ インク | テトラロン系モノアミン再取り込み阻害剤 |
| WO2007115185A2 (en) | 2006-03-31 | 2007-10-11 | Sepracor Inc. | Preparation of chiral amides and amines |
| US7884124B2 (en) | 2006-06-30 | 2011-02-08 | Sepracor Inc. | Fluoro-substituted inhibitors of D-amino acid oxidase |
| US7902252B2 (en) | 2007-01-18 | 2011-03-08 | Sepracor, Inc. | Inhibitors of D-amino acid oxidase |
| EP1955699A1 (en) * | 2007-02-08 | 2008-08-13 | Boehringer Ingelheim Pharma GmbH & Co. KG | Use of flibanserin for the treatment of insomnia |
| RU2470011C2 (ru) | 2007-05-31 | 2012-12-20 | Сепракор Инк. | Циклоалкиламины, содержащие в качестве заместителя фенил, как ингибиторы обратного захвата моноаминов |
| US9018238B2 (en) | 2009-02-12 | 2015-04-28 | Pharmadesign, Inc. | Inhibitor of casein kinase 1δ and casein kinase 1ε |
| KR20120030110A (ko) * | 2009-05-28 | 2012-03-27 | 버텍스 파마슈티칼스 인코포레이티드 | ｃ-ＭＥＴ 단백질 키나제의 아미노피라졸 트리아졸로티아디아졸 억제제 |
| ES2460065T3 (es) * | 2009-10-28 | 2014-05-13 | Pfizer Inc. | Derivados de imidazol como inhibidores de la caseína quinasa |
| DE102009058280A1 (de) * | 2009-12-14 | 2011-06-16 | Merck Patent Gmbh | Thiazolderivate |
| RU2562833C2 (ru) * | 2010-08-09 | 2015-09-10 | НБ Хелс Лаборатори Ко. Лтд. | Ингибитор казеинкиназы 1 дельта и казеинкиназы 1 е |
| CN109748927A (zh) * | 2017-11-03 | 2019-05-14 | 上海交通大学医学院附属瑞金医院 | 杂芳基酰胺类化合物、其制备方法、药用组合物及其应用 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE9702001D0 (sv) * | 1997-05-28 | 1997-05-28 | Astra Pharma Prod | Novel compounds |
| IL146729A0 (en) * | 1999-06-08 | 2002-07-25 | Aventis Pharma Inc | Screening methods for altering circadian rhythm proteins |
| US7402672B2 (en) * | 2003-12-11 | 2008-07-22 | Aventis Pharmaceuticals Inc. | Substituted 1H-pyrrolo[3,2-b, 3,2-c, and 2,3-c]pyridine-2-carboxamides and related analogs as inhibitors of casein kinase lepsilon |
-
2005
- 2005-07-18 JO JO2005104A patent/JO2629B1/en active
- 2005-08-09 SV SV2005002190A patent/SV2006002190A/es not_active Application Discontinuation
- 2005-08-09 GT GT200500215A patent/GT200500215A/es unknown
- 2005-08-16 AR ARP050103439A patent/AR051008A1/es unknown
- 2005-08-17 PE PE2005000956A patent/PE20060630A1/es not_active Application Discontinuation
- 2005-08-18 RS RSP-2010/0401A patent/RS51413B/sr unknown
- 2005-08-18 HR HR20100475T patent/HRP20100475T1/hr unknown
- 2005-08-18 KR KR1020077003865A patent/KR20070045263A/ko not_active Abandoned
- 2005-08-18 DE DE602005021889T patent/DE602005021889D1/de not_active Expired - Lifetime
- 2005-08-18 DK DK05826812.9T patent/DK1784409T3/da active
- 2005-08-18 JP JP2007528007A patent/JP4869232B2/ja not_active Expired - Fee Related
- 2005-08-18 PT PT05826812T patent/PT1784409E/pt unknown
- 2005-08-18 WO PCT/US2005/029383 patent/WO2006021000A2/en not_active Ceased
- 2005-08-18 AU AU2005272584A patent/AU2005272584B2/en not_active Ceased
- 2005-08-18 CA CA2577879A patent/CA2577879C/en not_active Expired - Fee Related
- 2005-08-18 CN CNB2005800269958A patent/CN100562521C/zh not_active Expired - Fee Related
- 2005-08-18 BR BRPI0514419-1A patent/BRPI0514419A/pt not_active Application Discontinuation
- 2005-08-18 PL PL05826812T patent/PL1784409T3/pl unknown
- 2005-08-18 RU RU2007109812/04A patent/RU2403257C2/ru not_active IP Right Cessation
- 2005-08-18 EP EP05826812A patent/EP1784409B1/en not_active Expired - Lifetime
- 2005-08-18 SI SI200531094T patent/SI1784409T1/sl unknown
- 2005-08-18 AT AT05826812T patent/ATE471326T1/de active
- 2005-08-18 ES ES05826812T patent/ES2347166T3/es not_active Expired - Lifetime
- 2005-08-18 MY MYPI20053879A patent/MY139831A/en unknown
- 2005-08-19 TW TW094128282A patent/TWI372149B/zh not_active IP Right Cessation
- 2005-08-19 UY UY29077A patent/UY29077A1/es not_active Application Discontinuation
- 2005-08-19 PA PA20058642801A patent/PA8642801A1/es unknown
-
2007
- 2007-02-04 IL IL181158A patent/IL181158A0/en unknown
- 2007-02-13 US US11/674,349 patent/US7393867B2/en not_active Expired - Lifetime
-
2008
- 2008-05-22 US US12/125,450 patent/US7652046B2/en not_active Expired - Lifetime
-
2010
- 2010-09-09 CY CY20101100823T patent/CY1110775T1/el unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |