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MX2010009658A - Derivados de azetidina. - Google Patents

Derivados de azetidina.

Info

Publication number
MX2010009658A
MX2010009658A MX2010009658A MX2010009658A MX2010009658A MX 2010009658 A MX2010009658 A MX 2010009658A MX 2010009658 A MX2010009658 A MX 2010009658A MX 2010009658 A MX2010009658 A MX 2010009658A MX 2010009658 A MX2010009658 A MX 2010009658A
Authority
MX
Mexico
Prior art keywords
optionally substituted
ring atoms
formula
substituted monocyclic
faah
Prior art date
Application number
MX2010009658A
Other languages
English (en)
Inventor
Stephen Roughley
Steven Walls
Terrence Hart
Rachel Parsons
Paul Brough
Christopher Graham
Alba Macias
Original Assignee
Vernalis R&D Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB0804006.5A external-priority patent/GB0804006D0/en
Priority claimed from GBGB0821694.7A external-priority patent/GB0821694D0/en
Application filed by Vernalis R&D Ltd filed Critical Vernalis R&D Ltd
Publication of MX2010009658A publication Critical patent/MX2010009658A/es

Links

Classifications

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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
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    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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Abstract

La presente invención se refiere a compuestos de fórmula (I) inhibidores de amida hidrolasa de ácido graso, (FAAH), y los cuales son útiles en el tratamiento de enfermedades o condiciones médicas las cuales se benefician de la inhibición de actividad de FAAH, tales como ansiedad, dolor por depresión, inflamación y trastornos alimenticios, de sueño, neurodegenerativos y de movimiento: Fórmula (I) en donde Ar1 es fenilo opcionalmente sustituido o heteroarilo monocíclico opcionalmente sustituido que tiene 5 o 6 átomos en el anillo; Ar2 es fenilo opcionalmente sustituido, heteroarilo monocíclico opcionalmente sustituido que tiene 5 o 6 átomos en el anillo, o heteroarilo bicíclico fusionado opcionalmente sustituido que tiene 5 o 6 átomos en el anillo en cada anillo fusionado; y Ar3 es un radical divalente seleccionado a partir del grupo que consiste de radicales fenileno opcionalmente sustituido y heteroarileno monocíclico opcionalmente sustituido que tienen 5 o 6 átomos en el anillo.
MX2010009658A 2008-03-04 2009-02-27 Derivados de azetidina. MX2010009658A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB0804006.5A GB0804006D0 (en) 2008-03-04 2008-03-04 Azetidine derivatives
GBGB0821694.7A GB0821694D0 (en) 2008-11-27 2008-11-27 Azetidine derivatives
PCT/GB2009/000568 WO2009109743A1 (en) 2008-03-04 2009-02-27 Azetidine derivatives

Publications (1)

Publication Number Publication Date
MX2010009658A true MX2010009658A (es) 2010-09-30

Family

ID=40613126

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2010009658A MX2010009658A (es) 2008-03-04 2009-02-27 Derivados de azetidina.

Country Status (18)

Country Link
US (6) US8450346B2 (es)
EP (1) EP2265578B1 (es)
JP (2) JP5624894B2 (es)
CN (1) CN102015635B (es)
AU (1) AU2009220974B2 (es)
BR (1) BRPI0909782B8 (es)
CA (1) CA2717750C (es)
DK (1) DK2265578T3 (es)
EA (1) EA017842B1 (es)
ES (1) ES2550367T3 (es)
HU (1) HUE025411T2 (es)
IL (1) IL207768A (es)
MX (1) MX2010009658A (es)
NZ (1) NZ587532A (es)
PL (1) PL2265578T3 (es)
PT (1) PT2265578E (es)
WO (1) WO2009109743A1 (es)
ZA (1) ZA201006270B (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0909782B8 (pt) 2008-03-04 2021-05-25 Vernalis R&D Ltd composto derivado de azetidina e composição farmacêutica compreendendo dito composto
US20130150346A1 (en) 2010-01-08 2013-06-13 Quest Ventures Ltd. Use of FAAH Inhibitors for Treating Parkinson's Disease and Restless Legs Syndrome
WO2011123719A2 (en) 2010-03-31 2011-10-06 Ironwood Pharmaceuticals, Inc. Use of faah inhibitors for treating abdominal, visceral and pelvic pain
KR101273566B1 (ko) * 2011-09-05 2013-06-11 한국과학기술연구원 신규한 아제티딘 유도체 및 이를 함유하는 항우울제 조성물
AU2013202982C1 (en) * 2012-01-06 2017-01-05 Novartis Ag Heterocyclic compounds and methods for their use
WO2016014975A2 (en) 2014-07-25 2016-01-28 Northeastern University Urea/carbamates faah magl or dual faah/magl inhibitors and uses thereof
JOP20190072A1 (ar) * 2016-10-13 2019-04-07 Glaxosmithkline Ip Dev Ltd مشتقات 1، 3 سيكلوبوتان ثنائي الاستبدال أو آزيتيدين كمثبطات للإنزيم المخلق للبروستاجلاندين d المكون للدم
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