AR050919A1 - Amidas del acido 5 y 6-aminoalquil indol-2-carboxilico 3-sustituidas y analogos relacionados como inhibidores de la caseina cinasa ie - Google Patents
Amidas del acido 5 y 6-aminoalquil indol-2-carboxilico 3-sustituidas y analogos relacionados como inhibidores de la caseina cinasa ieInfo
- Publication number
- AR050919A1 AR050919A1 ARP050103442A ARP050103442A AR050919A1 AR 050919 A1 AR050919 A1 AR 050919A1 AR P050103442 A ARP050103442 A AR P050103442A AR P050103442 A ARP050103442 A AR P050103442A AR 050919 A1 AR050919 A1 AR 050919A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- heterocycle
- aryl
- alkenyl
- compounds
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 239000002253 acid Substances 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 7
- 125000000623 heterocyclic group Chemical group 0.000 abstract 7
- 125000003118 aryl group Chemical group 0.000 abstract 5
- 150000001875 compounds Chemical class 0.000 abstract 5
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 4
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 1
- 125000004454 (C1-C6) alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 abstract 1
- SLXKOJJOQWFEFD-UHFFFAOYSA-N 6-aminohexanoic acid Chemical compound NCCCCCC(O)=O SLXKOJJOQWFEFD-UHFFFAOYSA-N 0.000 abstract 1
- 102000005403 Casein Kinases Human genes 0.000 abstract 1
- 108010031425 Casein Kinases Proteins 0.000 abstract 1
- QNAYBMKLOCPYGJ-UWTATZPHSA-N D-alanine Chemical compound C[C@@H](N)C(O)=O QNAYBMKLOCPYGJ-UWTATZPHSA-N 0.000 abstract 1
- -1 His Chemical compound 0.000 abstract 1
- 208000019022 Mood disease Diseases 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
- 210000003169 central nervous system Anatomy 0.000 abstract 1
- 208000037765 diseases and disorders Diseases 0.000 abstract 1
- 229910052736 halogen Chemical group 0.000 abstract 1
- 150000002367 halogens Chemical group 0.000 abstract 1
- 125000004356 hydroxy functional group Chemical group O* 0.000 abstract 1
- YCWSUKQGVSGXJO-NTUHNPAUSA-N nifuroxazide Chemical group C1=CC(O)=CC=C1C(=O)N\N=C\C1=CC=C([N+]([O-])=O)O1 YCWSUKQGVSGXJO-NTUHNPAUSA-N 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 208000019116 sleep disease Diseases 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Anesthesiology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
La presente describe y reivindica compuestos como inhibidores de la caseína cinasa Iépsilon humana, y métodos de uso de dichos compuestos para el tratamiento de enfermedades y trastornos del sistema nervioso central incluyendo trastornos del estado de ánimo y trastornos del sueno. También se describen y reivindican composiciones farmacéuticas que comprenden dichos compuestos. Reivindicacion 1: Un compuesto de formula (1) o de formula (2), o un estereoisomero, un enantiomero, un racemato o un tautomero de dicho compuesto, o una sal farmacéuticamente aceptable del mismo, en las que: X es S o S(O)n; R1 es H o alquilo C1-6; R2 es NR5R6; R3 es arilo o heterociclo; R4 es alquilo C1-6 o halogeno; R5 es H o alquilo C1-6; R6 es H o alquilo C1-6; R7 es CH2NR8R9 donde, R8 es H, alquilo C1-10, cicloalquilo C3-8, arilo, aril(alquilo C1-6), aril(alquenilo C2-6), diaril(alquenilo C2-6), heterociclo, heterociclo(alquilo C1-6), heterociclo(alquenilo C2-6), hidroxi(alquilo C1-6), dihidrox(alquilo C2- 6), acilo, alcoxicarbonilo C1-6, aril(alcoxi C1-6)carbonilo, carbamoil(alquilo C1-6) o P; R9 es H, alquilo C1-10, heterociclo(alquilo C1-6) o heterociclo(alquenilo C2-6); o R8 y R9 junto con el nitrogeno al que están unidos forman un heterociclo; y donde P es Gly, o L- o D-Ala, Val, Leu, Ile, Ser, Cys, Thr, Met, Pro, Phe, Tyr, Trp, His, Lys, Arg, Asp, Gly, Asn o Gln; m es 0, 1 o 2; y n es 1 o 2.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US60338004P | 2004-08-19 | 2004-08-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR050919A1 true AR050919A1 (es) | 2006-12-06 |
Family
ID=35311279
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP050103442A AR050919A1 (es) | 2004-08-19 | 2005-08-16 | Amidas del acido 5 y 6-aminoalquil indol-2-carboxilico 3-sustituidas y analogos relacionados como inhibidores de la caseina cinasa ie |
Country Status (26)
| Country | Link |
|---|---|
| US (2) | US7629376B2 (es) |
| EP (1) | EP1794122B1 (es) |
| JP (1) | JP4843608B2 (es) |
| KR (2) | KR20070043012A (es) |
| CN (1) | CN101006055B (es) |
| AR (1) | AR050919A1 (es) |
| AT (1) | ATE508112T1 (es) |
| AU (1) | AU2005277523B2 (es) |
| BR (1) | BRPI0514380A (es) |
| CA (1) | CA2577667C (es) |
| DE (1) | DE602005027858D1 (es) |
| GT (1) | GT200500214A (es) |
| IL (1) | IL181156A (es) |
| JO (1) | JO2724B1 (es) |
| MA (1) | MA28863B1 (es) |
| MX (1) | MX2007001382A (es) |
| NO (1) | NO20071466L (es) |
| NZ (1) | NZ552800A (es) |
| PA (1) | PA8642901A1 (es) |
| PE (1) | PE20060498A1 (es) |
| RU (1) | RU2369599C2 (es) |
| SV (1) | SV2006002192A (es) |
| TW (1) | TWI357897B (es) |
| UY (1) | UY29078A1 (es) |
| WO (1) | WO2006023467A1 (es) |
| ZA (1) | ZA200700651B (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9018238B2 (en) | 2009-02-12 | 2015-04-28 | Pharmadesign, Inc. | Inhibitor of casein kinase 1δ and casein kinase 1ε |
| WO2010121225A2 (en) * | 2009-04-17 | 2010-10-21 | Cylene Pharmaceuticals, Inc. | Method of treating disorders associated with protein kinase ck2 activity |
| CN104540831B (zh) | 2012-06-27 | 2017-11-07 | 4Sc探索有限责任公司 | 用于治疗癌症、自身免疫性炎症和cns紊乱的二氟二氧戊环‑氨基‑苯并咪唑激酶抑制剂 |
| CN111757879A (zh) | 2018-01-29 | 2020-10-09 | 卡地拉健康护理有限公司 | 用作抗菌剂的杂环化合物 |
| WO2022006377A2 (en) * | 2020-07-02 | 2022-01-06 | Mbq Pharma | Heterocyclic inhibitors of rho gtpases for the treatment of disease |
| US12209078B2 (en) | 2021-10-06 | 2025-01-28 | Mbq Pharma | Crystalline forms of carbazole inhibitors of RhoGTPase for the treatment of disease |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5296471A (en) | 1992-12-22 | 1994-03-22 | Glycomed Incorporated | Method for controlling o-desulfation of heparin and compositions produced thereby |
| IL146729A0 (en) * | 1999-06-08 | 2002-07-25 | Aventis Pharma Inc | Screening methods for altering circadian rhythm proteins |
| WO2001083472A1 (en) * | 2000-04-28 | 2001-11-08 | Acadia Pharmaceuticals, Inc. | Muscarinic agonists |
| CA2494962C (en) * | 2002-08-09 | 2011-06-14 | Merck & Co., Inc. | Tyrosine kinase inhibitors |
| US7402672B2 (en) * | 2003-12-11 | 2008-07-22 | Aventis Pharmaceuticals Inc. | Substituted 1H-pyrrolo[3,2-b, 3,2-c, and 2,3-c]pyridine-2-carboxamides and related analogs as inhibitors of casein kinase lepsilon |
-
2005
- 2005-07-24 JO JO2005108A patent/JO2724B1/en active
- 2005-08-09 GT GT200500214A patent/GT200500214A/es unknown
- 2005-08-10 SV SV2005002192A patent/SV2006002192A/es active IP Right Grant
- 2005-08-16 JP JP2007527928A patent/JP4843608B2/ja not_active Expired - Fee Related
- 2005-08-16 CN CN2005800284407A patent/CN101006055B/zh not_active Expired - Fee Related
- 2005-08-16 AR ARP050103442A patent/AR050919A1/es not_active Application Discontinuation
- 2005-08-16 EP EP05786210A patent/EP1794122B1/en not_active Expired - Lifetime
- 2005-08-16 KR KR1020077003922A patent/KR20070043012A/ko not_active Abandoned
- 2005-08-16 MX MX2007001382A patent/MX2007001382A/es active IP Right Grant
- 2005-08-16 WO PCT/US2005/029053 patent/WO2006023467A1/en not_active Ceased
- 2005-08-16 BR BRPI0514380-2A patent/BRPI0514380A/pt not_active IP Right Cessation
- 2005-08-16 AT AT05786210T patent/ATE508112T1/de not_active IP Right Cessation
- 2005-08-16 RU RU2007109783/04A patent/RU2369599C2/ru not_active IP Right Cessation
- 2005-08-16 AU AU2005277523A patent/AU2005277523B2/en not_active Ceased
- 2005-08-16 NZ NZ552800A patent/NZ552800A/en not_active IP Right Cessation
- 2005-08-16 KR KR1020137005469A patent/KR20130038409A/ko not_active Withdrawn
- 2005-08-16 CA CA2577667A patent/CA2577667C/en not_active Expired - Fee Related
- 2005-08-16 DE DE602005027858T patent/DE602005027858D1/de not_active Expired - Lifetime
- 2005-08-17 PE PE2005000955A patent/PE20060498A1/es not_active Application Discontinuation
- 2005-08-19 UY UY29078A patent/UY29078A1/es unknown
- 2005-08-19 PA PA20058642901A patent/PA8642901A1/es unknown
- 2005-08-19 TW TW094128283A patent/TWI357897B/zh not_active IP Right Cessation
-
2007
- 2007-01-22 ZA ZA200700651A patent/ZA200700651B/xx unknown
- 2007-02-04 IL IL181156A patent/IL181156A/en not_active IP Right Cessation
- 2007-02-13 US US11/674,385 patent/US7629376B2/en not_active Expired - Lifetime
- 2007-03-14 MA MA29757A patent/MA28863B1/fr unknown
- 2007-03-19 NO NO20071466A patent/NO20071466L/no not_active Application Discontinuation
-
2008
- 2008-11-12 US US12/269,216 patent/US7923466B2/en not_active Expired - Lifetime
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |