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AR050692A1 - Derivados de triazolopiridinilsulfanilo como inhibidores de quinasa map p38; composiciones farmaceuticas que los contienen y su uso en la fabricacion de medicamentos para el tratamiento de enfermedades mediadas por tnf o por p38 - Google Patents

Derivados de triazolopiridinilsulfanilo como inhibidores de quinasa map p38; composiciones farmaceuticas que los contienen y su uso en la fabricacion de medicamentos para el tratamiento de enfermedades mediadas por tnf o por p38

Info

Publication number
AR050692A1
AR050692A1 ARP050103357A ARP050103357A AR050692A1 AR 050692 A1 AR050692 A1 AR 050692A1 AR P050103357 A ARP050103357 A AR P050103357A AR P050103357 A ARP050103357 A AR P050103357A AR 050692 A1 AR050692 A1 AR 050692A1
Authority
AR
Argentina
Prior art keywords
independently selected
optionally substituted
halo
substituents independently
conr5r6
Prior art date
Application number
ARP050103357A
Other languages
English (en)
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0418015A external-priority patent/GB0418015D0/en
Application filed by Pfizer filed Critical Pfizer
Publication of AR050692A1 publication Critical patent/AR050692A1/es

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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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Abstract

Uso de este compuesto en el tratamiento de una enfermedad, trastorno o afeccion mediada por TNF, o una enfermedad, trastorno o afeccion mediada por p38, en particular las enfermedades alérgicas y no alérgicas de las vías respiratorias, más particularmente enfermedades obstructivas o inflamatorias de las vías respiratorias, preferiblemente la enfermedad pulmonar obstructiva cronica. Reivindicacion 1: Un compuesto de formula (1), o una sal y/o solvato (incluyendo hidrato) farmacéuticamente aceptable del mismo, en la que: R1 es CH3, S(O)pCH3, S(O)pCH2CH3, CH2CH3, H o CH2S(O)pCH3; R1a es CH3 o CH2CH3, donde cada uno CH3 y CH2CH3 está opcionalmente sustituido con uno o más sustituyentes hidroxi; R2 es heteroarilo, heterociclilo, arilo, o carbociclilo; R3 es heteroarilo, heterociclilo, arilo, carbociclilo o R7; R7 es alquilo C1-6 (opcionalmente sustituido con uno o más sustituyentes seleccionados independientemente entre OH, halo, NR5R6, alcoxi C1-6, - S(O)palquiloC1-6, CO2H, CONR5R6, heteroarilo, heterociclilo, arilo, carbociclilo, ariloxi, carbocicliloxi, heteroariloxi y heterocicliloxi); p es 0, 1 o 2; cada uno de R5 y R6 se selecciona independientemente entre H y alquilo C1-4, estando dicho alquilo C1-4 opcionalmente sustituido con uno o más sustituyentes seleccionados independientemente entre OH y halo; o R5 y R6, junto con el nitrogeno al que están unidos forman un grupo piperazinilo, piperidinilo, morfolinilo o pirrolidinilo, (estando cada uno de dichos piperazinilo, piperidinilo, morfolinilo y pirrolidinilo opcionalmente sustituido con uno o más OH); cada ôariloö significa independientemente fenilo o naftilo, estando dicho fenilo o naftilo opcionalmente sustituido con uno o más sustituyentes seleccionados independientemente entre halo, -CN, -CO2H, OH, CONR5R6, NR5R6, R8 y R9; cada R8 se selecciona independientemente entre alquilo C1-6, alcoxi C1-6, -CO2alquiloC1-6, -S(O)alquiloC1-6, -COalquiloC1-6 y cicloaquilo C3-7; cada R8 está opcionalmente sustituido con uno o más sustituyentes seleccionados independientemente entre: alcoxi C1-6 (opcionalmente sustituido con uno o más sustituyentes seleccionados independientemente entre OH, halo, CO2H, CONR5R6 y NR5R6); S(O)palquiloC1-6 (opcionalmente sustituido con uno o más sustituyentes seleccionados independientemente entre OH, halo, CO2H, CONR5R6 y NR5R6); OH; halo; NR5R6; CO2H; CONR5R6; y R9; R9 es heteroarilo2, heterociclilo2, arilo2, carbociclilo2, aril2oxi, carbociclilo2oxi, heteroaril2oxi o heterociclil2oxi; ôarilo2ö significa fenilo o naftilo, estando dicho fenilo o naftilo opcionalmente sustituido con uno o más sustituyentes seleccionados independientemente entre halo, -CN, -CO2H, OH, NR5R6 y CONR5R6; ôcarbocicliloö significa un sistema de anillo mono o bicíclico, saturado o parcialmente insaturado C3-10 en el anillo, opcionalmente sustituido con uno o más sustituyentes seleccionados independientemente entre halo, -CN, -CO2H, OH, NR5R6, CONR5R6, R8 y R9; ôcarbociclilo2ö significa un sistema de anillo mono o bicíclico, saturado o parcialmente insaturado C3-10 en el anillo, opcionalmente sustituido con uno o más sustituyentes seleccionados independientemente entre halo, -CN, - CO2H, NR5R6, OH y CONR5R6; cada ôheterocicliloö, y ôheterociclilo2ö, independientemente, significa un grupo mono o bicíclico saturado o parcialmente insaturado de 3 a 10 miembros que comprende de 1 a 4 heteroátomos en el anillo seleccionados independientemente entre N, O, y S; cada ôheteroariloö y cada ôheteroarilo2ö, independientemente, significa un grupo aromático mono o bicíclico de 5 a 10 miembros que comprende de 1 a 4 heteroátomos en el anillo seleccionados independientemente entre N, O y S (donde el numero total de átomos de S en el anillo no excede de 1, y el numero total de átomos de O en el anillo no excede de 1); cada grupo ôheterocicliloö y cada grupo ôheteroariloö está, independientemente, opcionalmente sustituido en uno o más átomos de carbono en el anillo con uno o más sustituyentes seleccionados independientemente entre halo, -CN, -CO2H, OH, NR5R6, CONR5R6, R8 y R9, y opcionalmente sustituido en uno o más átomos de nitrogeno en el anillo con uno o más sustituyentes seleccionados independientemente entre H y alquilo C1-6; y cada grupo ôheterociclilo2ö y cada grupo ôheteroarilo2ö está, independientemente, opcionalmente sustituido en uno o más átomos de carbono en el anillo con uno o más sustituyentes seleccionados independientemente entre halo, -CN, -CO2H, NR5R6, OH y CONR5R6, y opcionalmente sustituido en uno o más átomos de nitrogeno en el anillo con uno o más sustituyentes seleccionados independientemente entre H y alquilo C1- 6.
ARP050103357A 2004-08-12 2005-08-11 Derivados de triazolopiridinilsulfanilo como inhibidores de quinasa map p38; composiciones farmaceuticas que los contienen y su uso en la fabricacion de medicamentos para el tratamiento de enfermedades mediadas por tnf o por p38 AR050692A1 (es)

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