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ECSP077424A - Derivados de quinuclidina y su uso como antagonistas del receptor muscarínico m3 - Google Patents

Derivados de quinuclidina y su uso como antagonistas del receptor muscarínico m3

Info

Publication number
ECSP077424A
ECSP077424A EC2007007424A ECSP077424A ECSP077424A EC SP077424 A ECSP077424 A EC SP077424A EC 2007007424 A EC2007007424 A EC 2007007424A EC SP077424 A ECSP077424 A EC SP077424A EC SP077424 A ECSP077424 A EC SP077424A
Authority
EC
Ecuador
Prior art keywords
quinuclidine
antagonist
derivatives
compounds
muscarinic
Prior art date
Application number
EC2007007424A
Other languages
English (en)
Inventor
Stephen Paul Collingwood
Brian Cox
Urs Baettig
Simon James Watson
Neil John Press
Sudhakar Devidasrao Garad
Hyungchul Kim
Dimitris Papoutsakis
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=33515948&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ECSP077424(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of ECSP077424A publication Critical patent/ECSP077424A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/16—Central respiratory analeptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Cosmetics (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Los compuestos de la fórmula I; en forma de sal o ión anfotérico, en donde R1, R2, R3, y R4 tienen los significados indicados en la memoria descriptiva, son útiles para el tratamiento de condiciones que sean mediadas por el receptor muscarínico M3, en especial enfermedades inflamatorias u obstructivas de las vías respiratorias. También se describen composiciones farmacéuticas que contienen los compuestos, y un proceso para la preparación de los compuestos.
EC2007007424A 2004-11-02 2007-04-27 Derivados de quinuclidina y su uso como antagonistas del receptor muscarínico m3 ECSP077424A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0424284.8A GB0424284D0 (en) 2004-11-02 2004-11-02 Organic compounds

Publications (1)

Publication Number Publication Date
ECSP077424A true ECSP077424A (es) 2007-05-30

Family

ID=33515948

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2007007424A ECSP077424A (es) 2004-11-02 2007-04-27 Derivados de quinuclidina y su uso como antagonistas del receptor muscarínico m3

Country Status (33)

Country Link
US (2) US7723356B2 (es)
EP (2) EP1811999B1 (es)
JP (1) JP4950896B2 (es)
KR (1) KR101252307B1 (es)
CN (1) CN101056634B (es)
AR (1) AR054090A1 (es)
AT (1) ATE481099T1 (es)
AU (1) AU2005300710B2 (es)
BR (1) BRPI0517945A (es)
CA (1) CA2583237C (es)
CY (1) CY1110952T1 (es)
DE (1) DE602005023639D1 (es)
DK (1) DK1811999T3 (es)
EC (1) ECSP077424A (es)
ES (1) ES2353142T3 (es)
GB (1) GB0424284D0 (es)
HR (1) HRP20100693T1 (es)
IL (1) IL182695A0 (es)
JO (1) JO2613B1 (es)
MA (1) MA29080B1 (es)
MX (1) MX2007005189A (es)
MY (1) MY145207A (es)
NO (1) NO20072371L (es)
NZ (1) NZ554302A (es)
PE (1) PE20060609A1 (es)
PL (1) PL1811999T3 (es)
PT (1) PT1811999E (es)
RU (1) RU2399620C2 (es)
SI (1) SI1811999T1 (es)
TN (1) TNSN07164A1 (es)
TW (1) TW200628154A (es)
WO (1) WO2006048225A1 (es)
ZA (1) ZA200702772B (es)

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