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AR050188A1 - Compuestos heterociclicos condensados utiles en terapia como inhibidores de quinasas p38 y composiciones farmaceuticas que los contienen - Google Patents

Compuestos heterociclicos condensados utiles en terapia como inhibidores de quinasas p38 y composiciones farmaceuticas que los contienen

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Publication number
AR050188A1
AR050188A1 ARP050103125A ARP050103125A AR050188A1 AR 050188 A1 AR050188 A1 AR 050188A1 AR P050103125 A ARP050103125 A AR P050103125A AR P050103125 A ARP050103125 A AR P050103125A AR 050188 A1 AR050188 A1 AR 050188A1
Authority
AR
Argentina
Prior art keywords
independently represents
optionally substituted
substituents selected
alkyl
represent
Prior art date
Application number
ARP050103125A
Other languages
English (en)
Inventor
Carmen Almansa Rosales
Marina Virgili Bernado
Poveda Pedro Manuel Grima
Original Assignee
Uriach Y Compania S A J
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Uriach Y Compania S A J filed Critical Uriach Y Compania S A J
Publication of AR050188A1 publication Critical patent/AR050188A1/es

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    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
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Abstract

Un compuesto heterocíclico que comprende la formula general (1) donde: A representa C o N; B, D y E representan inependientemente CR4, NR5, N, O o S; con la condicion de que: a) cuando uno de B, D o E representa O o S, ninguno de los otros dos puede representar O o S; b) cuando A representa N, ninguno de B, D E puede representar O o S; y c) cuando A representa C, B representa CR4 y uno de D o E representa N o NR5, entonces el otro grupo D o E no puede representar NR5 o N; G representa N o C; R1 representa uno o más sustituyentes seleccionados de entre H, Ra, halogeno, -CN, -OH y -ORa; R2 representa uno o más sustituyentes seleccionados de entre H, halogeno, y C1-6 alquilo, y adicionalmente un sustituyente R2 también puede representar - ORb', -NO2, -CN, -CORb', -CO2Rb', -CONRb'Rb', -NRb'Rb', -NRb'CORb', -NRb'CONRb'Rb', -NRb'CO2Rb', -NRb'SO2Rb', -SRb', -SORb, -SO2Rb, -SO2NRb'Rb' o C1-6 alquilo opcionalmente sustituido por uno o más sustituyentes Rc; R3 representa H, C1-6 alquilo opcionalmente sustituido por uno o más sustituyentes seleccionados de entre Rc y Rd, o Cy opcionalmente sustituido por uno o más sustituyentes seleccionados de entre Rc, Rd y C1-6 alquilo opcionalmente sustituido por uno o más sustituyentes seleccionados de entre Rc y Rd; R4 representa independientemente H, Re, halogeno, -ORe', -NO2, -CN, -CORe', -CO2Re', -CONRe'Re', -NRe'Re', -NRe'CORe', -NRe'CONRe'Re', -NRe'CO2Re', -NRe'SO2Re, -SRe', -SORe, -SO2Re o -SO2NRe'Re'; R5 representa independientemente H, Re, -CORe, -CONReRe, -SORe o -SO2Re; cada Ra representa independientemente C1-6 alquilo ohaloC1-6alquilo; cada Rb representa independientemente C1-6alquilo o Cy, donde ambos grupos pueden estar opcionalmente sustituidos por uno o más sustituyentes seleccionados de entre Rd y Rf; cada Rb' representa independientemente H o Rb; cada Rc representa independientemente halogeno, -ORg', -NO2, -CN, -CORg', -CO2Rg', -CONRg'Rg', -NRg'Rg', -NRg'CORg', --NRgzCPNRg'Rg', -NRg'CO2Rg, - NRg'SO2Rg, -SRg', -SORg, -SO2Rg o -SO2NRg'Rg'; Rd representa Cy opcionalmente sustituido por uno o más sustituyentes Rf; cda Re representa independientemente C1-6 alquilo opcionalmente sustituido por uno o más sustituyentes seleccionados de entre Rc y Cy*, o Re representa Cy, donde cualquiera de los grupos Cy o Cy* puede estar opcionalmente sustituido por uno o más sustituyentes seleccionados de entre Rc y Rg; cada Re' representa independientemente H o Re; cada Rf representa independientemente halogeno, Rh, -ORh', -NO2, -CN, -CORh', -CO2Rh', -CONRh'Rh', -NRh'Rh', -NRh'CORh', -NRh'CONRh'Rh', -NRh'CO2Rh, -NRh'SO2Rh, -SRh', -SORh, -SO2Rh o -SO2NRh'Rh'; cada Rg representa independientemente Rd o C1-6 alquilo opcionalmente sustituido por uno o más sustituyentes seleccionados de entre Rd y Rf; cada rg' representa independientemente H o Rg; cada Rh representa independientemente C1-6 alquilo, haloC1-6alquilo o hidroxi C1-6alquilo; cada Rh' representa independientemente H o Rh; y Cy o Cy* en las definiciones anteriores representan un grupo carbocíclico monocíclico de 3 a 7 miembros o bocíclico de 8 a 12 miembros, parcialmente insaturado, saturado o aromático, que contiene opcionalmente de 1 a4 heteroátomos seleccionados de entre N, S y O, donde uno o más átomos de C, N o S pueden estar opcionalmente oxidados formando CO, N+O, SO o SO2 respectivamente, y donde dicho anillo o anillos pueden estar unidos al resto de la molécula a través de un átomo de C o N; o una sal del mismo.
ARP050103125A 2004-08-03 2005-07-27 Compuestos heterociclicos condensados utiles en terapia como inhibidores de quinasas p38 y composiciones farmaceuticas que los contienen AR050188A1 (es)

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