AR050156A1 - Derivados de benceno halogenados del acido aminoisoftalico sustituidos con macrociclos trimeros - Google Patents
Derivados de benceno halogenados del acido aminoisoftalico sustituidos con macrociclos trimerosInfo
- Publication number
- AR050156A1 AR050156A1 ARP050102136A ARP050102136A AR050156A1 AR 050156 A1 AR050156 A1 AR 050156A1 AR P050102136 A ARP050102136 A AR P050102136A AR P050102136 A ARP050102136 A AR P050102136A AR 050156 A1 AR050156 A1 AR 050156A1
- Authority
- AR
- Argentina
- Prior art keywords
- radical
- macrocicles
- aminoisoftalic
- metal ion
- acid replaced
- Prior art date
Links
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical class C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 title 1
- 239000002253 acid Substances 0.000 title 1
- 150000001413 amino acids Chemical class 0.000 abstract 2
- 229910021645 metal ion Chemical group 0.000 abstract 2
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 abstract 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 1
- 229910052794 bromium Inorganic materials 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000003745 diagnosis Methods 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 238000003384 imaging method Methods 0.000 abstract 1
- -1 inorganic base salts Chemical class 0.000 abstract 1
- 229910052740 iodine Inorganic materials 0.000 abstract 1
- 239000011630 iodine Substances 0.000 abstract 1
- 150000002678 macrocyclic compounds Chemical class 0.000 abstract 1
- 239000002184 metal Substances 0.000 abstract 1
- 150000007530 organic bases Chemical class 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/04—X-ray contrast preparations
- A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
- A61K49/0438—Organic X-ray contrast-enhancing agent comprising an iodinated group or an iodine atom, e.g. iopamidol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/085—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
- A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
- A61K49/106—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Radiology & Medical Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Oncology (AREA)
- Gastroenterology & Hepatology (AREA)
- Communicable Diseases (AREA)
- Heart & Thoracic Surgery (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
Abstract
Reivindicacion 1: Complejos metálicos de la formula general (1), caracterizado porque: Hal es bromo o yodo; A1 es el radical -CONH-(CH2)2-NH-CO-CH(CH3)-K; A2 es el radical -N(CH3)-CO-CH2-NH-CO-CH(CH3)-K; K es un macrociclo de la formula (2), donde X es un átomo de hidrogeno o un equivalente de ion metálico de los numeros atomicos 20-29, 39, 42, 44 o 57-83, con la condicion de que por lo menos dos X representen equivalentes de iones metálicos y que los grupos carboxi libres que puedan estar presente puedan ser sales de base orgánicas y/o inorgánicas o aminoácidos o amidas de aminoácidos, presentan muy buena solubilidad y un coeficiente de distribucion comparable al de los quelatos de Gd. Los nuevos compuestos también presentan un elevado contenido específico de elementos de contraste, baja viscosidad y osmolaridad, y con ello, buena tolerancia/compatibilidad, de manera que se prestan de manera excelente como sustancia de contraste para el diagnostico por imágenes de rayos X y resonancia magnética.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102004026103A DE102004026103A1 (de) | 2004-05-25 | 2004-05-25 | Trimere makrocyclisch substituierte Aminoisophthalsäure-Halogen-Benzolderivate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR050156A1 true AR050156A1 (es) | 2006-10-04 |
Family
ID=34967416
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP050102136A AR050156A1 (es) | 2004-05-25 | 2005-05-24 | Derivados de benceno halogenados del acido aminoisoftalico sustituidos con macrociclos trimeros |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20060120965A1 (es) |
| EP (1) | EP1748992A1 (es) |
| JP (1) | JP2008500293A (es) |
| AR (1) | AR050156A1 (es) |
| DE (1) | DE102004026103A1 (es) |
| GT (1) | GT200500123A (es) |
| PA (1) | PA8634301A1 (es) |
| PE (1) | PE20060365A1 (es) |
| SV (1) | SV2005002124A (es) |
| TW (1) | TW200616982A (es) |
| UY (1) | UY28919A1 (es) |
| WO (1) | WO2005115997A1 (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102007058220A1 (de) | 2007-12-03 | 2009-06-04 | Bayer Schering Pharma Aktiengesellschaft | Dimere macrocyclisch substituierte Benzolderivate |
| EP3101012A1 (en) | 2015-06-04 | 2016-12-07 | Bayer Pharma Aktiengesellschaft | New gadolinium chelate compounds for use in magnetic resonance imaging |
| KR102464647B1 (ko) | 2016-11-28 | 2022-11-08 | 바이엘 파마 악티엔게젤샤프트 | 자기 공명 영상화에 사용하기 위한 높은 이완도 가돌리늄 킬레이트 화합물 |
| WO2020104602A1 (en) | 2018-11-23 | 2020-05-28 | Bayer Aktiengesellschaft | Formulation of contrast media and process of preparation thereof |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5324503A (en) * | 1992-02-06 | 1994-06-28 | Mallinckrodt Medical, Inc. | Iodo-phenylated chelates for x-ray contrast |
| US5660814A (en) * | 1993-06-02 | 1997-08-26 | Dibra S.P.A. | Iodinated paramagnetic chelates, and their use as contrast agents |
| US7208140B2 (en) * | 2003-02-19 | 2007-04-24 | Schering Aktiengesellschaft | Trimeric macrocyclic substituted benzene derivatives |
| DE10307759B3 (de) * | 2003-02-19 | 2004-11-18 | Schering Ag | Trimere makrocyclisch substituierte Benzolderivate, deren Herstellung und Verwendung als Kontrastmittel sowie diese enthaltende pharmazeutische Mittel |
-
2004
- 2004-05-25 DE DE102004026103A patent/DE102004026103A1/de not_active Ceased
-
2005
- 2005-04-22 JP JP2007513721A patent/JP2008500293A/ja active Pending
- 2005-04-22 EP EP05741025A patent/EP1748992A1/de not_active Withdrawn
- 2005-04-22 WO PCT/EP2005/004493 patent/WO2005115997A1/de not_active Ceased
- 2005-05-20 GT GT200500123A patent/GT200500123A/es unknown
- 2005-05-24 AR ARP050102136A patent/AR050156A1/es not_active Application Discontinuation
- 2005-05-24 SV SV2005002124A patent/SV2005002124A/es not_active Application Discontinuation
- 2005-05-24 UY UY28919A patent/UY28919A1/es not_active Application Discontinuation
- 2005-05-24 TW TW094116905A patent/TW200616982A/zh unknown
- 2005-05-24 PE PE2005000577A patent/PE20060365A1/es not_active Application Discontinuation
- 2005-05-25 PA PA20058634301A patent/PA8634301A1/es unknown
- 2005-11-16 US US11/274,895 patent/US20060120965A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| GT200500123A (es) | 2006-03-17 |
| DE102004026103A1 (de) | 2005-12-22 |
| UY28919A1 (es) | 2005-12-30 |
| WO2005115997A1 (de) | 2005-12-08 |
| TW200616982A (en) | 2006-06-01 |
| PE20060365A1 (es) | 2006-05-27 |
| US20060120965A1 (en) | 2006-06-08 |
| PA8634301A1 (es) | 2006-07-03 |
| JP2008500293A (ja) | 2008-01-10 |
| EP1748992A1 (de) | 2007-02-07 |
| SV2005002124A (es) | 2005-12-06 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US8440168B2 (en) | Image-guided therapy of myocardial disease: composition, manufacturing and applications | |
| ES2626582T3 (es) | Formulación de producto de contraste y su procedimiento de preparación asociado | |
| ES2478442T3 (es) | Procedimiento de obtención de nuevos derivados de naftaleno para el diagnóstico in vivo de la enfermedad de Alzheimer | |
| RU2011139107A (ru) | Специфические соединения диарилгидантоина и диарилтиогидантоина | |
| ES2759312T3 (es) | Compuestos de aminocarbonilcarbamato | |
| JP2015007084A (ja) | 造影剤 | |
| Krasilnikova et al. | Cellular internalization and morphological analysis after intravenous injection of a highly hydrophilic octahedral rhenium cluster complex–a new promising X‐ray contrast agent | |
| JP2009149678A (ja) | 腫瘍画像化化合物 | |
| RU2008147002A (ru) | Новые соединения, обладающие сродством к амилоиду | |
| JPH04500964A (ja) | キレート組成物 | |
| BR112013010890A2 (pt) | método de tratamento ou prevenção de, pelo menos, uma doença ou condição e para reduzir o desenvolvimento de aterosclerose num sujeito deles necessitado e uso de composto | |
| AR050156A1 (es) | Derivados de benceno halogenados del acido aminoisoftalico sustituidos con macrociclos trimeros | |
| JPH05503107A (ja) | 新規磁気共鳴造影剤 | |
| UY28407A1 (es) | Agentes terapeuticos | |
| UY28408A1 (es) | Agentes terapeuticos | |
| CN104447406B (zh) | 一种α‑氰基‑4‑羟基肉桂酸衍生物及其制备方法和用途 | |
| BRPI1015323A2 (pt) | agente de formação de imagem, métodos para formar imagem de uma amostra biológica, e para detectar o estresse oxidativo em células, composição farmacêutica, e, composto precursor para a síntese de um agente de formação de imagem | |
| Jian et al. | Chiral pyclen-based heptadentate chelates as highly stable MRI contrast agents | |
| SE0500055D0 (sv) | Therapeutic agents 3 | |
| PE20070363A1 (es) | Complejos metalicos con contenido de perfluoroalquilo como medios de contraste en imagenes de resonancia magnetica y procedimientos para su preparacion | |
| US20040102417A1 (en) | Dicarba-closo-dodecaborane derivatives | |
| JP4541879B2 (ja) | ケイ皮酸二量体、その製造方法及び退行性脳疾患治療のためのその用途 | |
| JPH03197487A (ja) | テクネチウム―９９ｍの陽イオン錯体 | |
| JPH06506478A (ja) | 新規なヨード化された非イオン性のｘ−線造影剤、及びそれを合成する方法、更にそれを含有する薬剤 | |
| CN86105154A (zh) | 偕-二卤代-1，8-二氨基-4-氮杂-辛烷的制备方法 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |