AR059972A1 - Administracion intranasal o inhalacional de virosomas - Google Patents
Administracion intranasal o inhalacional de virosomasInfo
- Publication number
- AR059972A1 AR059972A1 ARP070101114A ARP070101114A AR059972A1 AR 059972 A1 AR059972 A1 AR 059972A1 AR P070101114 A ARP070101114 A AR P070101114A AR P070101114 A ARP070101114 A AR P070101114A AR 059972 A1 AR059972 A1 AR 059972A1
- Authority
- AR
- Argentina
- Prior art keywords
- intranasal
- influenza
- composition
- inhalational administration
- virosomes
- Prior art date
Links
- 239000000203 mixture Substances 0.000 abstract 6
- 206010022000 influenza Diseases 0.000 abstract 5
- 239000000277 virosome Substances 0.000 abstract 4
- 239000000427 antigen Substances 0.000 abstract 2
- 102000036639 antigens Human genes 0.000 abstract 2
- 108091007433 antigens Proteins 0.000 abstract 2
- 230000004044 response Effects 0.000 abstract 2
- 230000009885 systemic effect Effects 0.000 abstract 2
- 230000003612 virological effect Effects 0.000 abstract 2
- GNENVASJJIUNER-UHFFFAOYSA-N 2,4,6-tricyclohexyloxy-1,3,5,2,4,6-trioxatriborinane Chemical compound C1CCCCC1OB1OB(OC2CCCCC2)OB(OC2CCCCC2)O1 GNENVASJJIUNER-UHFFFAOYSA-N 0.000 abstract 1
- 241000700605 Viruses Species 0.000 abstract 1
- 239000002671 adjuvant Substances 0.000 abstract 1
- 231100000433 cytotoxic Toxicity 0.000 abstract 1
- 230000001472 cytotoxic effect Effects 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- 230000028993 immune response Effects 0.000 abstract 1
- 229960001438 immunostimulant agent Drugs 0.000 abstract 1
- 230000006698 induction Effects 0.000 abstract 1
- 229960003971 influenza vaccine Drugs 0.000 abstract 1
- 150000002632 lipids Chemical class 0.000 abstract 1
- 230000007108 local immune response Effects 0.000 abstract 1
- 210000004698 lymphocyte Anatomy 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 229940126601 medicinal product Drugs 0.000 abstract 1
- 210000004779 membrane envelope Anatomy 0.000 abstract 1
- 239000002245 particle Substances 0.000 abstract 1
- 229960005486 vaccine Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/145—Orthomyxoviridae, e.g. influenza virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5252—Virus inactivated (killed)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5258—Virus-like particles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
- A61K2039/541—Mucosal route
- A61K2039/543—Mucosal route intranasal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55516—Proteins; Peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/70—Multivalent vaccine
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16211—Influenzavirus B, i.e. influenza B virus
- C12N2760/16234—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
Abstract
Composicion de virosomas de influenza que comprenden envolturas reconstituidas de dicho virus, donde las envolturas virales están totalmente derivadas de partículas virales de influenza, donde no se agrega lípido de una fuente externa a los virosomas reconstituidos, donde los virosomas comprenden los antígenos de influenza hemoaglutinina y/o neuroaminidasa o derivados de los mismos, donde no se agrega adyuvante y/o estimulante inmune a la composicion y donde la composicion es para administracion intranasal o inhalacional, composicion que está caracterizada porque una sola administracion intranasal o inhalacional a un ser humano es suficiente para la induccion de una respuesta inmune sistémica y/o una respuesta inmune local y/o una respuesta de linfocitos citotoxicos contra dichos antígenos de influenza, respuesta sistémica que está en concordancia con los criterios CHMP (Comité para productos medicinales ara uso humano) para una vacuna de influenza y donde la dosis de hemoaglutinina por cepa viral por administracion intranasal o inhalacional es menor de o igual a 30 ?g. La invencion también provee el uso de virosomas de influenza reconstituidos para la fabricacion de dicha composicion y formulaciones de vacuna preparadas para dicho uso. Dispositivo para administracion intranasal o inhalacional.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US78446206P | 2006-03-22 | 2006-03-22 | |
| EP06111534 | 2006-03-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR059972A1 true AR059972A1 (es) | 2008-05-14 |
Family
ID=38038698
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP070101114A AR059972A1 (es) | 2006-03-22 | 2007-03-20 | Administracion intranasal o inhalacional de virosomas |
Country Status (21)
| Country | Link |
|---|---|
| EP (2) | EP2158921B1 (es) |
| JP (1) | JP5285595B2 (es) |
| KR (1) | KR20090016659A (es) |
| AR (1) | AR059972A1 (es) |
| AT (2) | ATE539766T1 (es) |
| AU (1) | AU2007228736B2 (es) |
| BR (1) | BRPI0709864A2 (es) |
| CA (1) | CA2646895A1 (es) |
| DE (1) | DE602007003815D1 (es) |
| DK (2) | DK2158921T3 (es) |
| EA (1) | EA014532B1 (es) |
| ES (2) | ES2375436T3 (es) |
| HR (2) | HRP20100144T1 (es) |
| IL (1) | IL193840A (es) |
| MY (1) | MY142996A (es) |
| NO (1) | NO20084452L (es) |
| PL (2) | PL2158921T3 (es) |
| PT (2) | PT2158921E (es) |
| SA (1) | SA07280116B1 (es) |
| SI (2) | SI2158921T1 (es) |
| WO (1) | WO2007107585A1 (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20110150926A1 (en) * | 2008-08-01 | 2011-06-23 | Mohammed Alsharifi | Influenza vaccines |
| JP2014511119A (ja) * | 2010-11-02 | 2014-05-08 | インムノライフ，エセ．ア．デ セー．ウーベ． | Ｈ１ｎ１亜型インフルエンザパンデミックウイルスに対する新型ワクチン |
| US11523988B2 (en) | 2018-11-29 | 2022-12-13 | Catalent U.K. Swindon Zydis Limited | Oral dispersible vaccine comprising virosomes |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9018690D0 (en) * | 1990-08-24 | 1990-10-10 | Wellcome Found | Vaccines |
| EP1447080A1 (en) * | 2003-02-13 | 2004-08-18 | Bestewil Holding B.V. | Method for producing virosome-like particles |
| AR056245A1 (es) * | 2003-06-19 | 2007-10-03 | Bestewil Holding Bv | Membranas virales reconstituidas funcionales que contienen un coadyuvante |
-
2007
- 2007-03-20 AR ARP070101114A patent/AR059972A1/es not_active Application Discontinuation
- 2007-03-21 AU AU2007228736A patent/AU2007228736B2/en not_active Ceased
- 2007-03-21 AT AT09178084T patent/ATE539766T1/de active
- 2007-03-21 PL PL09178084T patent/PL2158921T3/pl unknown
- 2007-03-21 SA SA07280116A patent/SA07280116B1/ar unknown
- 2007-03-21 PT PT09178084T patent/PT2158921E/pt unknown
- 2007-03-21 ES ES09178084T patent/ES2375436T3/es active Active
- 2007-03-21 DK DK09178084.1T patent/DK2158921T3/da active
- 2007-03-21 AT AT07727166T patent/ATE451931T1/de active
- 2007-03-21 DK DK07727166.6T patent/DK1996229T3/da active
- 2007-03-21 PT PT07727166T patent/PT1996229E/pt unknown
- 2007-03-21 HR HR20100144T patent/HRP20100144T1/hr unknown
- 2007-03-21 JP JP2009500864A patent/JP5285595B2/ja not_active Expired - Fee Related
- 2007-03-21 EP EP09178084A patent/EP2158921B1/en not_active Not-in-force
- 2007-03-21 SI SI200730842T patent/SI2158921T1/sl unknown
- 2007-03-21 ES ES07727166T patent/ES2338382T3/es active Active
- 2007-03-21 BR BRPI0709864-2A patent/BRPI0709864A2/pt not_active IP Right Cessation
- 2007-03-21 WO PCT/EP2007/052690 patent/WO2007107585A1/en not_active Ceased
- 2007-03-21 EA EA200870361A patent/EA014532B1/ru not_active IP Right Cessation
- 2007-03-21 SI SI200730184T patent/SI1996229T1/sl unknown
- 2007-03-21 PL PL07727166T patent/PL1996229T3/pl unknown
- 2007-03-21 MY MYPI20083534A patent/MY142996A/en unknown
- 2007-03-21 KR KR1020087025693A patent/KR20090016659A/ko not_active Ceased
- 2007-03-21 EP EP07727166A patent/EP1996229B1/en not_active Not-in-force
- 2007-03-21 DE DE602007003815T patent/DE602007003815D1/de active Active
- 2007-03-21 CA CA002646895A patent/CA2646895A1/en not_active Abandoned
-
2008
- 2008-09-02 IL IL193840A patent/IL193840A/en not_active IP Right Cessation
- 2008-10-22 NO NO20084452A patent/NO20084452L/no not_active Application Discontinuation
-
2012
- 2012-01-05 HR HR20120013T patent/HRP20120013T1/hr unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal | ||
| FA | Abandonment or withdrawal |