[go: up one dir, main page]

AR058737A1 - Compuestos de benzoazepina con actividad hipotensora hidrosoluble y composicion farmaceutica inyectable que los comprende. - Google Patents

Compuestos de benzoazepina con actividad hipotensora hidrosoluble y composicion farmaceutica inyectable que los comprende.

Info

Publication number
AR058737A1
AR058737A1 ARP060105779A ARP060105779A AR058737A1 AR 058737 A1 AR058737 A1 AR 058737A1 AR P060105779 A ARP060105779 A AR P060105779A AR P060105779 A ARP060105779 A AR P060105779A AR 058737 A1 AR058737 A1 AR 058737A1
Authority
AR
Argentina
Prior art keywords
hypotensor
hydrosoluble
understands
activity
pharmaceutical composition
Prior art date
Application number
ARP060105779A
Other languages
English (en)
Inventor
Makoto Komatsu
Fumitaka Goto
Yasuhiro Menjo
Keigo Yamada
Takakuni Matsuda
Yusuke Kato
Original Assignee
Otsuka Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37877008&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR058737(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Otsuka Pharma Co Ltd filed Critical Otsuka Pharma Co Ltd
Publication of AR058737A1 publication Critical patent/AR058737A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/5532—Seven-(or more) membered rings
    • C07F9/5535—Seven-(or more) membered rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/5532—Seven-(or more) membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

Un compuesto de benzoazepina representado por la formula general (1), o su sal en la cual R representa un átomo de H, un grupo hidroxi opcionalmente protegido por un grupo protector, etc., R1 representa un átomo de H o un grupo hidroxi-protector, y X representa un átomo de O o un átomo de S. Este compuesto de benzoazepina y sus sales tienen una alta hidrosolubilidad y se pueden utilizar convenientemente para inyecciones.
ARP060105779A 2005-12-27 2006-12-26 Compuestos de benzoazepina con actividad hipotensora hidrosoluble y composicion farmaceutica inyectable que los comprende. AR058737A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2005375457 2005-12-27

Publications (1)

Publication Number Publication Date
AR058737A1 true AR058737A1 (es) 2008-02-20

Family

ID=37877008

Family Applications (2)

Application Number Title Priority Date Filing Date
ARP060105779A AR058737A1 (es) 2005-12-27 2006-12-26 Compuestos de benzoazepina con actividad hipotensora hidrosoluble y composicion farmaceutica inyectable que los comprende.
ARP160104016A AR107193A2 (es) 2005-12-27 2016-12-26 Compuesto de benzoazepina hidrosoluble y composición farmacéutica

Family Applications After (1)

Application Number Title Priority Date Filing Date
ARP160104016A AR107193A2 (es) 2005-12-27 2016-12-26 Compuesto de benzoazepina hidrosoluble y composición farmacéutica

Country Status (22)

Country Link
US (6) US20100004206A1 (es)
EP (2) EP1968990B1 (es)
JP (2) JP4644287B2 (es)
KR (1) KR101008931B1 (es)
CN (1) CN101346390B (es)
AR (2) AR058737A1 (es)
AU (1) AU2006330277B2 (es)
BR (1) BRPI0620715A2 (es)
CA (1) CA2633929A1 (es)
CY (1) CY1116208T1 (es)
DK (1) DK1968990T3 (es)
ES (1) ES2533007T3 (es)
IL (1) IL191935A (es)
MY (1) MY146042A (es)
NO (1) NO342436B1 (es)
PL (1) PL1968990T3 (es)
PT (1) PT1968990E (es)
RU (1) RU2418804C2 (es)
SI (1) SI1968990T1 (es)
TW (1) TWI323257B (es)
WO (1) WO2007074915A1 (es)
ZA (1) ZA200805011B (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5590780B2 (ja) * 2007-06-26 2014-09-17 大塚製薬株式会社 医薬
TWI459947B (zh) * 2007-06-26 2014-11-11 Otsuka Pharma Co Ltd 苯并氮呯化合物及藥學製劑
AU2009257174A1 (en) * 2008-06-09 2009-12-17 Dimerix Bioscience Pty Ltd Novel receptor hetero-dimers/-oligomers
CN102020609A (zh) * 2009-09-17 2011-04-20 北京本草天源药物研究院 托伐普坦晶体或无定形物及其制备方法
DE102010041263A1 (de) * 2010-09-23 2012-03-29 Siemens Medical Instruments Pte. Ltd. Hörgerätegehäuse mit Dichtungslippe
TWI633887B (zh) 2012-05-31 2018-09-01 大塚製藥股份有限公司 用於預防及／或治療多囊性腎臟病之藥物
AU2013366872A1 (en) * 2012-12-28 2015-07-02 Otsuka Pharmaceutical Co., Ltd. Injectable depot formulation comprising optically active tolvaptan and process of producing the same
TW201605488A (zh) 2013-10-15 2016-02-16 大塚製藥股份有限公司 用以預防及／或治療多囊腎病之藥物
BR112019000290B1 (pt) * 2016-07-07 2022-10-18 Cyclerion Therapeutics, Inc Prófármacos de fósforo dos estimuladores da sgc
JP2021014406A (ja) * 2017-10-25 2021-02-12 トーアエイヨー株式会社 バソプレシン受容体拮抗剤
KR20210121128A (ko) 2019-01-30 2021-10-07 오츠카 세이야쿠 가부시키가이샤 벤조아제핀 화합물의 제조 방법
JP7130879B2 (ja) * 2019-03-28 2022-09-05 大塚製薬株式会社 ベンゾアゼピン化合物含有医薬組成物
KR20210144810A (ko) * 2019-03-28 2021-11-30 오츠카 세이야쿠 가부시키가이샤 벤조아제핀 화합물-함유 동결건조 조성물
TW202246216A (zh) * 2021-02-10 2022-12-01 大陸商上海森輝醫藥有限公司 苯并氮雜環庚烯類化合物及其製備方法和醫藥用途
CN118593441A (zh) * 2024-06-07 2024-09-06 南京海纳医药科技股份有限公司 一种含有托伐普坦磷酸钠的冻干组合物及其制备方法
CN119684210A (zh) * 2024-12-09 2025-03-25 广东赛烽医药科技有限公司 托伐普坦磷酸钠化合物及其制备方法和应用

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5043273A (en) 1989-08-17 1991-08-27 Monsanto Company Phosphorylated glycosidase inhibitor prodrugs
US5258510A (en) * 1989-10-20 1993-11-02 Otsuka Pharma Co Ltd Benzoheterocyclic compounds
US5753677A (en) * 1989-10-20 1998-05-19 Otsuka Pharmaceutical Co., Ltd. Benzoheterocyclic compounds
CA2066104C (en) 1991-04-19 2003-05-27 Hidenori Ogawa Benzazepine derivatives as vasopressin antagonists
US5466683A (en) * 1994-08-25 1995-11-14 Teva Pharmaceutical Industries Ltd. Water-soluble analogs of carbamazepine
GB9602080D0 (en) 1996-02-02 1996-04-03 Pfizer Ltd Pharmaceutical compounds
JP4210355B2 (ja) 1997-07-03 2009-01-14 大塚製薬株式会社 固形製剤組成物
DE19750002A1 (de) * 1997-11-12 1999-05-20 Solvay Pharm Gmbh Phosphonsäure-substituierte Benzazepinon-N-essigsäurederivate sowie Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
US5972882A (en) * 1997-12-15 1999-10-26 University Of Kansas Medical Center Treatment of polycystic kidney disease using vasopressin V2 receptor antagonists
US6436989B1 (en) * 1997-12-24 2002-08-20 Vertex Pharmaceuticals, Incorporated Prodrugs of aspartyl protease inhibitors
TWI322689B (en) 2003-02-24 2010-04-01 Otsuka Pharma Co Ltd Method for treating severe heart failure and medicament therefor

Also Published As

Publication number Publication date
ZA200805011B (en) 2009-11-25
JP2011046731A (ja) 2011-03-10
EP2674436A1 (en) 2013-12-18
KR20080078916A (ko) 2008-08-28
EP1968990A1 (en) 2008-09-17
US20120277189A1 (en) 2012-11-01
IL191935A (en) 2013-07-31
NO20082630L (no) 2008-09-16
KR101008931B1 (ko) 2011-01-17
US20130331358A1 (en) 2013-12-12
SI1968990T1 (sl) 2015-05-29
US20120277188A1 (en) 2012-11-01
AR107193A2 (es) 2018-03-28
US20110098250A1 (en) 2011-04-28
TWI323257B (en) 2010-04-11
MY146042A (en) 2012-06-15
JP2009521397A (ja) 2009-06-04
US9303052B2 (en) 2016-04-05
PL1968990T3 (pl) 2015-06-30
EP1968990B1 (en) 2015-02-11
US20110082110A1 (en) 2011-04-07
CY1116208T1 (el) 2017-02-08
HK1121461A1 (en) 2009-04-24
TW200734309A (en) 2007-09-16
JP5550522B2 (ja) 2014-07-16
JP4644287B2 (ja) 2011-03-02
RU2418804C2 (ru) 2011-05-20
AU2006330277B2 (en) 2011-10-06
WO2007074915A1 (en) 2007-07-05
US9809609B2 (en) 2017-11-07
US20100004206A1 (en) 2010-01-07
IL191935A0 (en) 2008-12-29
CN101346390A (zh) 2009-01-14
WO2007074915A8 (en) 2007-11-08
BRPI0620715A2 (pt) 2011-11-22
NO342436B1 (no) 2018-05-22
CN101346390B (zh) 2011-11-09
ES2533007T3 (es) 2015-04-06
AU2006330277A1 (en) 2007-07-05
RU2008130887A (ru) 2010-02-10
CA2633929A1 (en) 2007-07-05
PT1968990E (pt) 2015-03-16
DK1968990T3 (da) 2015-04-27

Similar Documents

Publication Publication Date Title
AR058737A1 (es) Compuestos de benzoazepina con actividad hipotensora hidrosoluble y composicion farmaceutica inyectable que los comprende.
AR059748A1 (es) Nuevas composiciones herbicidas sinergeticas
ATE536349T1 (de) In der 2-stellung durch phenyl substituierte 1h- benzimidazol-4-carbonsäureamide sind wirksame parp-inhibitoren
AR053547A1 (es) Composiciones de sales anti transpirantes de aluminio o aluminio- zirconio de eficacia acrecentada que contienen sal (es) de calcio y betaina
AR058569A1 (es) Inhibidores de histona desacetilasa para mejorar la actividad de agentes antifungicos
CO6341610A2 (es) Compuesto heterociclilo aromatico que contiene nitrogeno.
EA200901329A1 (ru) Применение пиридин-2-окси-3-карбонамидов в качестве защитных средств
AR061134A1 (es) Derivados de tioxantina
CL2004000076A1 (es) Compuestos derivados de indol, inhibidores de polimerasa, sales; composicion farmaceutica que los comprende; procedimiento de preparacion de dichos compuestos; compuestos intermediarios; y uso del compuesto para tratar una infeccion causada por el vi
PA8620301A1 (es) Inhibidores heterociclil amino de 11-beta-hidrosiesteroide deshidrogenasa tipo 1
CY1112377T1 (el) Μεθοδος και συνθεσεις για τη θεραπευτικη aντιμετωπιση των αιματολογικων κακοηθειων
GT200600339A (es) Inhibidores macrociclicos del virus de la hepatitis c
AR061238A1 (es) Compuestos de oxilmilo macrociclico inhibidores de proteasa de hepatitis c
UY27909A1 (es) Composicion herbicida
NI200700107A (es) (bifenil) ácidos carboxílicos y sus derivados
AR063942A1 (es) Compuestos de oximilo aciclico inhibidores de proteasa del virus de hepatitis c
BR112018017303A2 (pt) composto tipo piridazinona ou seu sal, e herbicida compreendendo o mesmo
AR056049A1 (es) 2-(2,6-dimetil-morfolin-4-il-n-[5-(6-morfolin-4-il-4-oxo-4h-piran-2-il)-9h-tioxanten-2-il]-acetamida,como inhibidor de la quinasa atm
ECSP055745A (es) Derivados de 1-(4-bencil-piperazin-1-il)-3-fenil-propenona
GT200200032A (es) Nuevo sistema estabilizador para estabilizacion de polimeros halogenados
AR056502A1 (es) Empleo de ésteres de lactato para mejorar el efecto de los agentes protectores de las plantas
AR077429A1 (es) Compuestos hidroxiasenapina sus derivados y composiciones farmaceuticas que comprenden los mismos
ES2529385T3 (es) Métodos y sustancias para la obtención de compuestos de piridinio sustituidos sobre N
CR9692A (es) Derivados de 2-oxo-imidazol sustituidos con dihidroxialquilo en n
UY30009A1 (es) Compuestos benzoilpirazol y herbicidas que los contienen

Legal Events

Date Code Title Description
FC Refusal