AR058394A1 - USE OF BENZO- FUSIONATED HULEROCICLY DERIVATIVES OF SULFAMIDE FOR THE TREATMENT OF ADDICTION AND ABUSE OF SUBSTANCES - Google Patents
USE OF BENZO- FUSIONATED HULEROCICLY DERIVATIVES OF SULFAMIDE FOR THE TREATMENT OF ADDICTION AND ABUSE OF SUBSTANCESInfo
- Publication number
- AR058394A1 AR058394A1 ARP060105596A AR058394A1 AR 058394 A1 AR058394 A1 AR 058394A1 AR P060105596 A ARP060105596 A AR P060105596A AR 058394 A1 AR058394 A1 AR 058394A1
- Authority
- AR
- Argentina
- Prior art keywords
- addiction
- group
- abuse
- formula
- benzo
- Prior art date
Links
- 206010012335 Dependence Diseases 0.000 title abstract 3
- 239000000126 substance Substances 0.000 title abstract 3
- NVBFHJWHLNUMCV-UHFFFAOYSA-N sulfamide Chemical class NS(N)(=O)=O NVBFHJWHLNUMCV-UHFFFAOYSA-N 0.000 title 1
- 238000000034 method Methods 0.000 abstract 6
- 208000007848 Alcoholism Diseases 0.000 abstract 4
- ZPUCINDJVBIVPJ-LJISPDSOSA-N cocaine Chemical compound O([C@H]1C[C@@H]2CC[C@@H](N2C)[C@H]1C(=O)OC)C(=O)C1=CC=CC=C1 ZPUCINDJVBIVPJ-LJISPDSOSA-N 0.000 abstract 4
- OROGSEYTTFOCAN-DNJOTXNNSA-N codeine Chemical compound C([C@H]1[C@H](N(CC[C@@]112)C)C3)=C[C@H](O)[C@@H]1OC1=C2C3=CC=C1OC OROGSEYTTFOCAN-DNJOTXNNSA-N 0.000 abstract 4
- BQJCRHHNABKAKU-KBQPJGBKSA-N morphine Chemical compound O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O BQJCRHHNABKAKU-KBQPJGBKSA-N 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 150000003839 salts Chemical class 0.000 abstract 3
- 201000009032 substance abuse Diseases 0.000 abstract 3
- SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 abstract 2
- SHXWCVYOXRDMCX-UHFFFAOYSA-N 3,4-methylenedioxymethamphetamine Chemical compound CNC(C)CC1=CC=C2OCOC2=C1 SHXWCVYOXRDMCX-UHFFFAOYSA-N 0.000 abstract 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 2
- GVGLGOZIDCSQPN-PVHGPHFFSA-N Heroin Chemical compound O([C@H]1[C@H](C=C[C@H]23)OC(C)=O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4OC(C)=O GVGLGOZIDCSQPN-PVHGPHFFSA-N 0.000 abstract 2
- YQEZLKZALYSWHR-UHFFFAOYSA-N Ketamine Chemical compound C=1C=CC=C(Cl)C=1C1(NC)CCCCC1=O YQEZLKZALYSWHR-UHFFFAOYSA-N 0.000 abstract 2
- BRUQQQPBMZOVGD-XFKAJCMBSA-N Oxycodone Chemical compound O=C([C@@H]1O2)CC[C@@]3(O)[C@H]4CC5=CC=C(OC)C2=C5[C@@]13CCN4C BRUQQQPBMZOVGD-XFKAJCMBSA-N 0.000 abstract 2
- 206010001584 alcohol abuse Diseases 0.000 abstract 2
- 208000025746 alcohol use disease Diseases 0.000 abstract 2
- 229960003920 cocaine Drugs 0.000 abstract 2
- 229960004126 codeine Drugs 0.000 abstract 2
- 229960002069 diamorphine Drugs 0.000 abstract 2
- OROGSEYTTFOCAN-UHFFFAOYSA-N hydrocodone Natural products C1C(N(CCC234)C)C2C=CC(O)C3OC2=C4C1=CC=C2OC OROGSEYTTFOCAN-UHFFFAOYSA-N 0.000 abstract 2
- 229960003299 ketamine Drugs 0.000 abstract 2
- MYWUZJCMWCOHBA-VIFPVBQESA-N methamphetamine Chemical compound CN[C@@H](C)CC1=CC=CC=C1 MYWUZJCMWCOHBA-VIFPVBQESA-N 0.000 abstract 2
- 229960001252 methamphetamine Drugs 0.000 abstract 2
- 229960005181 morphine Drugs 0.000 abstract 2
- 229960002715 nicotine Drugs 0.000 abstract 2
- SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 abstract 2
- 229960002085 oxycodone Drugs 0.000 abstract 2
- 208000011117 substance-related disease Diseases 0.000 abstract 2
- KXSAIQPPGSSNKX-ZETCQYMHSA-N (2s)-6-chloro-2-[(sulfamoylamino)methyl]-2,3-dihydro-1,4-benzodioxine Chemical compound ClC1=CC=C2O[C@@H](CNS(=O)(=O)N)COC2=C1 KXSAIQPPGSSNKX-ZETCQYMHSA-N 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- -1 heterocyclic sulfamide derivatives Chemical class 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 231100000736 substance abuse Toxicity 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
La presente es un método para el tratamiento del abuso de y/o la adiccion al alcohol que comprende administrar a un sujeto que lo necesita una cantidad terapéuticamente efectiva de uno o más derivados heterocíclicos benzo-fusionados de sulfamida de formula (1) y/o formula (2) como se definen aquí. Reivindicacion 1: Un método para tratar el abuso de o la adiccion a sustancias que comprende administrar a un sujeto que lo necesita, una cantidad terapéuticamente efectiva de un compuesto de formula (1) donde R1 y R2 se seleccionan, cada uno en forma independiente, del grupo que consiste en H y alquilo inferior; R4 se selecciona el grupo que consiste en H y alquilo inferior; a es un numero entero desde 1 hasta 2; el anillo R se selecciona del grupo que consiste en las formulas (3) a (9) donde b es un numero entero desde 0 hasta 4; y donde c es un numero entero desde 0 hasta 2; cada R5 se selecciona en forma independiente del grupo que consiste en halogeno, alquilo inferior y nitro; siempre que cuando el anillo R es como en formula (8) o (9), entonces a es 1; o una sal del mismo aceptable desde el punto de vista farmacéutico. Reivindicacion 6: El método de la reivindicacion 1, en el cual el compuesto de formula (1) se selecciona del grupo que consiste en (2S)-(-)-N-(6-cloro-2,3-dihidro-benzo[1,4]dioxin-2-ilmetil)-sulfamida; y sus sales aceptables desde el punto de vista farmacéutico. Reivindicacion 7: El método de la reivindicacion 1 donde la sustancia de abuso o adiccion se selecciona el grupo que consiste en alcohol, cocaína, heroína, metanfetamina, cetamina, Extasis, nicotina, oxicontina/oxicodona, codeína y morfina. Reivindicacion 16: Un método para el tratamiento del abuso o adiccion de alcohol que comprende administrar a un sujeto que lo necesita una cantidad terapéuticamente efectiva de un compuesto de formula (2) o una sal del mismo aceptable desde el punto de vista farmacéutico. Reivindicacion 17: El método de la reivindicacion 16, en el cual la sustancia de abuso o adiccion se selecciona del grupo que consiste en alcohol, cocaína, heroína, metanfetamina, cetamina, Extasis, nicotina, oxicontina/oxicodona, codeína y morfina.The present is a method for the treatment of alcohol abuse and / or addiction comprising administering to a subject in need thereof a therapeutically effective amount of one or more benzo-fused heterocyclic sulfamide derivatives of formula (1) and / or formula (2) as defined here. Claim 1: A method for treating substance abuse or addiction comprising administering to a subject in need thereof, a therapeutically effective amount of a compound of formula (1) wherein R1 and R2 are selected, each independently, from the group consisting of H and lower alkyl; R4 is selected from the group consisting of H and lower alkyl; a is an integer from 1 to 2; the ring R is selected from the group consisting of formulas (3) a (9) where b is an integer from 0 to 4; and where c is an integer from 0 to 2; each R5 is independently selected from the group consisting of halogen, lower alkyl and nitro; provided that when the R ring is as in formula (8) or (9), then a is 1; or a pharmaceutically acceptable salt thereof. Claim 6: The method of claim 1, wherein the compound of formula (1) is selected from the group consisting of (2S) - (-) - N- (6-chloro-2,3-dihydro-benzo [ 1,4] dioxin-2-ylmethyl) -sulfamide; and its pharmaceutically acceptable salts. Claim 7: The method of claim 1 wherein the substance of abuse or addiction is selected from the group consisting of alcohol, cocaine, heroin, methamphetamine, ketamine, Ecstasy, nicotine, oxycodine / oxycodone, codeine and morphine. Claim 16: A method for the treatment of alcohol abuse or addiction comprising administering to a subject in need thereof a therapeutically effective amount of a compound of formula (2) or a pharmaceutically acceptable salt thereof. Claim 17: The method of claim 16, wherein the substance of abuse or addiction is selected from the group consisting of alcohol, cocaine, heroin, methamphetamine, ketamine, Ecstasy, nicotine, oxycodine / oxycodone, codeine and morphine.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US75167905P | 2005-12-19 | 2005-12-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR058394A1 true AR058394A1 (en) | 2008-01-30 |
Family
ID=38813249
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP060105596 AR058394A1 (en) | 2005-12-19 | 2006-12-18 | USE OF BENZO- FUSIONATED HULEROCICLY DERIVATIVES OF SULFAMIDE FOR THE TREATMENT OF ADDICTION AND ABUSE OF SUBSTANCES |
Country Status (6)
| Country | Link |
|---|---|
| CN (1) | CN101370494B (en) |
| AR (1) | AR058394A1 (en) |
| PE (1) | PE20071134A1 (en) |
| TW (1) | TWI408129B (en) |
| UA (1) | UA97106C2 (en) |
| UY (1) | UY30038A1 (en) |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR049646A1 (en) * | 2004-06-16 | 2006-08-23 | Janssen Pharmaceutica Nv | USEFUL SULFAMATE AND SULFAMIDE DERIVATIVES FOR THE TREATMENT OF EPILEPSY AND RELATED DISORDERS |
-
2006
- 2006-12-18 TW TW95147363A patent/TWI408129B/en not_active IP Right Cessation
- 2006-12-18 AR ARP060105596 patent/AR058394A1/en not_active Application Discontinuation
- 2006-12-19 PE PE2006001631A patent/PE20071134A1/en not_active Application Discontinuation
- 2006-12-19 UA UAA200809403A patent/UA97106C2/en unknown
- 2006-12-19 CN CN200680052415.7A patent/CN101370494B/en not_active Expired - Fee Related
- 2006-12-19 UY UY30038A patent/UY30038A1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN101370494A (en) | 2009-02-18 |
| PE20071134A1 (en) | 2007-12-29 |
| UA97106C2 (en) | 2012-01-10 |
| CN101370494B (en) | 2013-04-24 |
| UY30038A1 (en) | 2007-03-30 |
| TW200800935A (en) | 2008-01-01 |
| TWI408129B (en) | 2013-09-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |