AR058391A1 - USE OF BENZO- FUSIONATED HULEROCICLY DERIVATIVES OF SULFAMIDE FOR THE TREATMENT OF PAIN - Google Patents
USE OF BENZO- FUSIONATED HULEROCICLY DERIVATIVES OF SULFAMIDE FOR THE TREATMENT OF PAINInfo
- Publication number
- AR058391A1 AR058391A1 ARP060105593A AR058391A1 AR 058391 A1 AR058391 A1 AR 058391A1 AR P060105593 A ARP060105593 A AR P060105593A AR 058391 A1 AR058391 A1 AR 058391A1
- Authority
- AR
- Argentina
- Prior art keywords
- formula
- pain
- treatment
- group
- benzo
- Prior art date
Links
- NVBFHJWHLNUMCV-UHFFFAOYSA-N sulfamide Chemical class NS(N)(=O)=O NVBFHJWHLNUMCV-UHFFFAOYSA-N 0.000 title 1
- 238000000034 method Methods 0.000 abstract 5
- 150000001875 compounds Chemical class 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 150000003839 salts Chemical class 0.000 abstract 3
- KXSAIQPPGSSNKX-ZETCQYMHSA-N (2s)-6-chloro-2-[(sulfamoylamino)methyl]-2,3-dihydro-1,4-benzodioxine Chemical compound ClC1=CC=C2O[C@@H](CNS(=O)(=O)N)COC2=C1 KXSAIQPPGSSNKX-ZETCQYMHSA-N 0.000 abstract 1
- 239000000730 antalgic agent Substances 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- -1 heterocyclic sulfonamide Chemical class 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 229940124530 sulfonamide Drugs 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La presente es un método para el tratamiento del dolor que comprende administrar a un sujeto que lo necesita una cantidad terapéuticamente efectiva de uno o más derivados heterocíclicos benzo-fusionados de sulfonamida de formula (1) y formula (2) como se describe aquí. La presente se refiere, además, a métodos para el tratamiento del dolor que comprenden el tratamiento concomitante con agente(s) analgésico(s) y un compuesto de formula (1) o formula (2) como se describe aquí. Reivindicacion 1: Un método para tratar el dolor, que comprende administrar a un sujeto que lo necesita, una cantidad terapéuticamente efectiva de un compuesto de formula (1) donde R1 y R2 se seleccionan, cada uno en forma independiente, del grupo que consiste en H y alquilo inferior; R4 se selecciona del grupo que consiste en H y alquilo inferior; a es un numero entero desde 1 hasta 2; el anillo R se selecciona del grupo que consiste en las formulas (3) a (9) donde b es un numero entero desde 0 hasta 4; y donde c es un numero entero desde 0 hasta 2; cada R5 se selecciona en forma independiente del grupo que consiste en halogeno, alquilo inferior y nitro; siempre que cuando el anillo R es como en formula (8) o (9), entonces a es 1; o una de sus sales aceptables desde el punto de vista farmacéutico. Reivindicacion 6: El método de la reivindicacion 1, en el cual el compuesto de formula (1) se selecciona del grupo que consiste en (2S)-(-)-N-(6-cloro-2,3-dihidro-benzo[1,4]dioxin-2-ilmetil)- sulfamida; y sus sales aceptables desde el punto de vista farmacéutico. Reivindicacion 16: Un método para el tratamiento del dolor, que comprende administrar a un sujeto que lo necesita una cantidad terapéuticamente efectiva de un compuesto de formula (2) o una de sus sales aceptables desde el punto de vista farmacéutico.The present is a method for the treatment of pain which comprises administering to a subject in need thereof a therapeutically effective amount of one or more benzo-fused heterocyclic sulfonamide derivatives of formula (1) and formula (2) as described herein. This also relates to methods for the treatment of pain that include concomitant treatment with analgesic agent (s) and a compound of formula (1) or formula (2) as described herein. Claim 1: A method of treating pain, comprising administering to a subject in need thereof, a therapeutically effective amount of a compound of formula (1) wherein R1 and R2 are each independently selected from the group consisting of H and lower alkyl; R4 is selected from the group consisting of H and lower alkyl; a is an integer from 1 to 2; the ring R is selected from the group consisting of formulas (3) a (9) where b is an integer from 0 to 4; and where c is an integer from 0 to 2; each R5 is independently selected from the group consisting of halogen, lower alkyl and nitro; provided that when the R ring is as in formula (8) or (9), then a is 1; or one of its pharmaceutically acceptable salts. Claim 6: The method of claim 1, wherein the compound of formula (1) is selected from the group consisting of (2S) - (-) - N- (6-chloro-2,3-dihydro-benzo [ 1,4] dioxin-2-ylmethyl) -sulfamide; and its pharmaceutically acceptable salts. Claim 16: A method for the treatment of pain, comprising administering to a subject in need thereof a therapeutically effective amount of a compound of formula (2) or a pharmaceutically acceptable salt thereof.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US75168605P | 2005-12-19 | 2005-12-19 | |
| US77381206P | 2006-02-15 | 2006-02-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR058391A1 true AR058391A1 (en) | 2008-01-30 |
Family
ID=38813245
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP060105593 AR058391A1 (en) | 2005-12-19 | 2006-12-18 | USE OF BENZO- FUSIONATED HULEROCICLY DERIVATIVES OF SULFAMIDE FOR THE TREATMENT OF PAIN |
Country Status (6)
| Country | Link |
|---|---|
| AR (1) | AR058391A1 (en) |
| CL (1) | CL2006003588A1 (en) |
| JO (1) | JO2586B1 (en) |
| PE (1) | PE20071066A1 (en) |
| TW (1) | TWI387455B (en) |
| UY (1) | UY30034A1 (en) |
-
2006
- 2006-12-18 AR ARP060105593 patent/AR058391A1/en not_active Application Discontinuation
- 2006-12-18 TW TW95147360A patent/TWI387455B/en not_active IP Right Cessation
- 2006-12-19 CL CL2006003588A patent/CL2006003588A1/en unknown
- 2006-12-19 UY UY30034A patent/UY30034A1/en not_active Application Discontinuation
- 2006-12-19 PE PE2006001637A patent/PE20071066A1/en not_active Application Discontinuation
- 2006-12-19 JO JO2006464A patent/JO2586B1/en active
Also Published As
| Publication number | Publication date |
|---|---|
| TWI387455B (en) | 2013-03-01 |
| CL2006003588A1 (en) | 2008-02-08 |
| UY30034A1 (en) | 2007-03-30 |
| PE20071066A1 (en) | 2007-11-19 |
| TW200744580A (en) | 2007-12-16 |
| JO2586B1 (en) | 2011-02-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |