AR058193A1 - Composiciones farmaceuticas - Google Patents
Composiciones farmaceuticasInfo
- Publication number
- AR058193A1 AR058193A1 ARP060105041A ARP060105041A AR058193A1 AR 058193 A1 AR058193 A1 AR 058193A1 AR P060105041 A ARP060105041 A AR P060105041A AR P060105041 A ARP060105041 A AR P060105041A AR 058193 A1 AR058193 A1 AR 058193A1
- Authority
- AR
- Argentina
- Prior art keywords
- otic
- pharmaceutically acceptable
- administration
- buprenorphine
- animal
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/60—Salicylic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
- A61K9/0017—Non-human animal skin, e.g. pour-on, spot-on
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0046—Ear
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Emergency Medicine (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Rheumatology (AREA)
- Zoology (AREA)
- Dermatology (AREA)
- Ophthalmology & Optometry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Se revela un método para proveer analgesia sistémica a gatos, perros y otros mamíferos pequenos mediante la administracion otica o transdérmica de opioides. También se revelan composiciones para utilizar en dicho método. Reivindicacion 1: Una composicion farmacéuticamente aceptable para la administracion otica a un animal que comprende buprenorfina, un sistema portador farmacéuticamente aceptable que comprende un solvente que consiste en una fase acuosa y en una fase orgánica, y al menos un agente mejorador de la penetracion. Reivindicacion 20: Uso de la composicion farmacéuticamente aceptable de la reivindicacion 1, caracterizado porque es para la manufactura de un medicamento util para introducir analgesia en un animal mediante la administracion por vía otica e buprenorfina.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US73852405P | 2005-11-21 | 2005-11-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR058193A1 true AR058193A1 (es) | 2008-01-23 |
Family
ID=37745944
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP060105041A AR058193A1 (es) | 2005-11-21 | 2006-11-16 | Composiciones farmaceuticas |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US20070117828A1 (es) |
| EP (2) | EP1954275A2 (es) |
| JP (2) | JP2009516687A (es) |
| KR (1) | KR20080071185A (es) |
| CN (1) | CN101312730A (es) |
| AR (1) | AR058193A1 (es) |
| AU (1) | AU2006316607A1 (es) |
| BR (1) | BRPI0618891A2 (es) |
| CA (2) | CA2630072A1 (es) |
| EC (1) | ECSP088461A (es) |
| NO (1) | NO20082833L (es) |
| NZ (1) | NZ568313A (es) |
| PE (1) | PE20070643A1 (es) |
| RU (1) | RU2008124805A (es) |
| TW (1) | TW200738240A (es) |
| WO (2) | WO2007061739A2 (es) |
| ZA (2) | ZA200804305B (es) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0709410A2 (pt) * | 2006-03-20 | 2011-07-12 | Javelin Pharmaceuticals Inc | composição farmacêutica e método para tratar um mamìfero necessitando de um agente analgésico, anti-inflamatório ou um antipirético |
| KR20140038575A (ko) * | 2006-03-28 | 2014-03-28 | 자블린 파머슈티칼스 인코포레이티드 | 저 복용량의 디클로페낙 및 베타-사이클로덱스트린 제형 |
| GB2461681A (en) * | 2008-04-17 | 2010-01-13 | Pharmasol Ltd | Buprenorphine liquid spray formulation with solvent and antioxidant |
| PE20081406A1 (es) * | 2006-12-20 | 2008-10-17 | Schering Plough Ltd | Composiciones farmaceuticas de flunixina |
| MX2010004373A (es) * | 2007-11-01 | 2010-05-05 | Bausch & Lomb | Materiales miscibles en agua no acuosos como vehiculos para suministro de farmacos. |
| CA2728727C (en) * | 2008-06-24 | 2018-01-23 | Intervet International B.V. | Pharmaceutical transdermal compositions and method for treating inflammation in cattle |
| WO2010072398A2 (en) | 2008-12-22 | 2010-07-01 | Boehringer Ingelheim Limited | Veterinary formulations |
| US20120277199A1 (en) * | 2009-10-21 | 2012-11-01 | Otonomy, Inc. | Modulation of Gel Temperature of Poloxamer-Containing Formulations |
| US9272044B2 (en) | 2010-06-08 | 2016-03-01 | Indivior Uk Limited | Injectable flowable composition buprenorphine |
| GB2513060B (en) | 2010-06-08 | 2015-01-07 | Rb Pharmaceuticals Ltd | Microparticle buprenorphine suspension |
| CA2808628A1 (en) * | 2010-08-17 | 2012-02-23 | Ohr Pharmaceutical, Inc. | Ophthalmic formulations of squalamine |
| CA2808237C (en) * | 2010-09-03 | 2019-08-06 | Abbott Laboratories | High dose buprenorphine compositions and use as analgesic |
| CA2804797C (en) * | 2010-10-25 | 2014-12-23 | University Of Manitoba | Therapeutic compositions for diabetic symmetrical polyneuropathy and/or tactile allodynia |
| WO2013070656A1 (en) * | 2011-11-07 | 2013-05-16 | Navinta Llc | Sustained release suspension preparation for dextromethorphan |
| US10813897B2 (en) | 2011-12-27 | 2020-10-27 | Cmpd Licensing, Llc | Composition and method for compounded therapy |
| US9468599B2 (en) | 2011-12-27 | 2016-10-18 | Cmpd Licensing, Llc | Composition and method for compounded therapy |
| US11213501B2 (en) | 2011-12-27 | 2022-01-04 | Cmpd Licensing, Llc | Composition and method for compounded therapy |
| US9962391B2 (en) | 2011-12-27 | 2018-05-08 | Cmpd Licensing, Llc | Composition and method for compounded therapy |
| US11213500B2 (en) | 2011-12-27 | 2022-01-04 | Cmpd Licensing, Llc | Composition and method for compounded therapy |
| WO2014160702A1 (en) * | 2013-03-25 | 2014-10-02 | Chs Pharma, Inc. | Retinopathy treatment |
| EP2983668A4 (en) * | 2013-04-08 | 2017-01-11 | Virginia Commonwealth University | Compositions to alleviate presystemic metabolism of opioids |
| GB201404139D0 (en) | 2014-03-10 | 2014-04-23 | Rb Pharmaceuticals Ltd | Sustained release buprenorphine solution formulations |
| SG11201703632WA (en) | 2014-11-07 | 2017-06-29 | Indivior Uk Ltd | Buprenorphine dosing regimens |
| CA3003293A1 (en) * | 2015-10-27 | 2017-05-04 | Insys Development Company, Inc. | Liquid buprenorphine formulations |
| MY196269A (en) * | 2016-09-13 | 2023-03-24 | Alar Pharmaceuticals Inc | Sustained-Release Buprenorphine Formulations |
| US10646484B2 (en) | 2017-06-16 | 2020-05-12 | Indivior Uk Limited | Methods to treat opioid use disorder |
| GB201716830D0 (en) * | 2017-10-13 | 2017-11-29 | Cambrex Charles City Inc | New Process |
| BR112020007808A2 (pt) | 2017-10-20 | 2020-10-20 | Chiesi Farmaceutici S.P.A. | formulações farmacêuticas que compreendem um agonista de receptor de opioide como ingrediente ativo, métodos de fabricação e usos terapêuticos destas |
| US11419866B2 (en) * | 2018-01-22 | 2022-08-23 | Foresee Pharmaceuticals Co., Ltd. | Pharmaceutical composition for sustained release delivery of buprenorphine |
| FR3096890B1 (fr) * | 2019-06-07 | 2021-05-14 | H4 Orphan Pharma | Utilisation d’une molécule opioïde pour traiter l’œil sec et l’œil allergique. |
| EP4408394A1 (en) * | 2021-09-30 | 2024-08-07 | Elanco Us Inc. | Stable formulations of buprenorphine |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU8533582A (en) * | 1981-07-10 | 1984-01-12 | Reckitt & Colman Products Limited | Stable solutions of buprenorphine |
| US4626539A (en) * | 1984-08-10 | 1986-12-02 | E. I. Dupont De Nemours And Company | Trandermal delivery of opioids |
| IE58110B1 (en) * | 1984-10-30 | 1993-07-14 | Elan Corp Plc | Controlled release powder and process for its preparation |
| US4931279A (en) * | 1985-08-16 | 1990-06-05 | Bausch & Lomb Incorporated | Sustained release formulation containing an ion-exchange resin |
| CA2002299A1 (en) * | 1988-11-10 | 1990-05-10 | Eugene G. Drust | Compositions for the transdermal delivery of buprenorphine salts |
| US5069909A (en) * | 1990-06-20 | 1991-12-03 | Cygnus Therapeutic Systems | Transdermal administration of buprenorphine |
| US6384043B1 (en) * | 1993-02-01 | 2002-05-07 | Gholam A. Peyman | Methods of alleviating pain sensations of the denuded eye with opioid analgesics |
| US5613958A (en) * | 1993-05-12 | 1997-03-25 | Pp Holdings Inc. | Transdermal delivery systems for the modulated administration of drugs |
| US5871723A (en) * | 1995-06-06 | 1999-02-16 | The Regent Of The University Of Michigan | CXC chemokines as regulators of angiogenesis |
| AUPN814496A0 (en) * | 1996-02-19 | 1996-03-14 | Monash University | Dermal penetration enhancer |
| PT889723E (pt) * | 1996-03-25 | 2002-11-29 | Lohmann Therapie Syst Lts | Sistema terapeutico transdermico com pequena espressura da zona de aplicacao e elevada flexibilidade assim como processo de producao |
| US6004969A (en) * | 1996-04-15 | 1999-12-21 | National Science Council | Transdermal delivery of buprenorphine preparations |
| US5900420A (en) * | 1997-06-19 | 1999-05-04 | Cole; William L. | Method for treating chronic fatigue syndrome and fibromyalgia with buprenorphine |
| IT1302682B1 (it) * | 1998-10-16 | 2000-09-29 | Formenti Farmaceutici Spa | Composizioni farmaceutiche orali contenenti buprenorfina |
| KR100383252B1 (ko) * | 1998-12-17 | 2003-07-16 | 주식회사 삼양사 | 부프레놀핀을함유하는경피투여조성물및이를포함하는패취 |
| AU5170400A (en) * | 1999-05-27 | 2000-12-18 | George F. El Khoury | Topical application of muscarinic and opioid agents for treatment of tinnitus |
| US6582724B2 (en) * | 1999-12-16 | 2003-06-24 | Dermatrends, Inc. | Dual enhancer composition for topical and transdermal drug delivery |
| KR100452972B1 (ko) * | 2000-05-16 | 2004-10-14 | 주식회사 삼양사 | 경피투여용 하이드로젤 조성물 |
| EP1272035A1 (en) * | 2000-07-13 | 2003-01-08 | Euro-Celtique, S.A. | Salts and bases of 17-(cyclopropylmethyl)-4,5 alpha-epoxy-6-methylenemorphinan-3,14 diol for optimizing dopamine homeostasis during administration of opioid analgesics |
| US20040258740A1 (en) * | 2003-04-10 | 2004-12-23 | Nene Labs | Transdermal delivery composition |
-
2006
- 2006-11-16 KR KR1020087014861A patent/KR20080071185A/ko not_active Withdrawn
- 2006-11-16 AU AU2006316607A patent/AU2006316607A1/en not_active Abandoned
- 2006-11-16 US US11/600,560 patent/US20070117828A1/en not_active Abandoned
- 2006-11-16 JP JP2008541364A patent/JP2009516687A/ja active Pending
- 2006-11-16 EP EP06844380A patent/EP1954275A2/en not_active Withdrawn
- 2006-11-16 EP EP06837885A patent/EP1951240A2/en not_active Withdrawn
- 2006-11-16 CA CA002630072A patent/CA2630072A1/en not_active Abandoned
- 2006-11-16 US US11/600,418 patent/US20070116730A1/en not_active Abandoned
- 2006-11-16 RU RU2008124805/15A patent/RU2008124805A/ru not_active Application Discontinuation
- 2006-11-16 CN CNA2006800434521A patent/CN101312730A/zh active Pending
- 2006-11-16 CA CA002629560A patent/CA2629560A1/en not_active Abandoned
- 2006-11-16 PE PE2006001462A patent/PE20070643A1/es not_active Application Discontinuation
- 2006-11-16 WO PCT/US2006/044464 patent/WO2007061739A2/en not_active Ceased
- 2006-11-16 JP JP2008541335A patent/JP2009516686A/ja not_active Withdrawn
- 2006-11-16 AR ARP060105041A patent/AR058193A1/es not_active Application Discontinuation
- 2006-11-16 NZ NZ568313A patent/NZ568313A/en not_active IP Right Cessation
- 2006-11-16 BR BRPI0618891-5A patent/BRPI0618891A2/pt not_active IP Right Cessation
- 2006-11-16 WO PCT/US2006/044640 patent/WO2007061828A2/en not_active Ceased
- 2006-11-17 TW TW095142635A patent/TW200738240A/zh unknown
-
2008
- 2008-05-19 EC EC2008008461A patent/ECSP088461A/es unknown
- 2008-05-19 ZA ZA200804305A patent/ZA200804305B/xx unknown
- 2008-05-20 ZA ZA200804355A patent/ZA200804355B/xx unknown
- 2008-06-20 NO NO20082833A patent/NO20082833L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CA2630072A1 (en) | 2007-05-31 |
| ECSP088461A (es) | 2008-06-30 |
| US20070117828A1 (en) | 2007-05-24 |
| AU2006316607A1 (en) | 2007-05-31 |
| ZA200804355B (en) | 2009-04-29 |
| ZA200804305B (en) | 2009-04-29 |
| PE20070643A1 (es) | 2007-08-10 |
| WO2007061739A2 (en) | 2007-05-31 |
| CA2629560A1 (en) | 2007-05-31 |
| CN101312730A (zh) | 2008-11-26 |
| TW200738240A (en) | 2007-10-16 |
| WO2007061828A2 (en) | 2007-05-31 |
| WO2007061828A3 (en) | 2007-07-19 |
| NZ568313A (en) | 2011-11-25 |
| JP2009516687A (ja) | 2009-04-23 |
| WO2007061739A3 (en) | 2007-07-12 |
| JP2009516686A (ja) | 2009-04-23 |
| US20070116730A1 (en) | 2007-05-24 |
| EP1954275A2 (en) | 2008-08-13 |
| BRPI0618891A2 (pt) | 2011-09-13 |
| EP1951240A2 (en) | 2008-08-06 |
| RU2008124805A (ru) | 2009-12-27 |
| NO20082833L (no) | 2008-07-29 |
| KR20080071185A (ko) | 2008-08-01 |
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