AR057654A1 - Derivados de quinolina como agentes antibacterianos - Google Patents
Derivados de quinolina como agentes antibacterianosInfo
- Publication number
- AR057654A1 AR057654A1 ARP060102760A ARP060102760A AR057654A1 AR 057654 A1 AR057654 A1 AR 057654A1 AR P060102760 A ARP060102760 A AR P060102760A AR P060102760 A ARP060102760 A AR P060102760A AR 057654 A1 AR057654 A1 AR 057654A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- hydrogen
- het
- alkyloxy
- alkylthio
- Prior art date
Links
- 239000003242 anti bacterial agent Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 8
- 229910052739 hydrogen Inorganic materials 0.000 abstract 6
- 239000001257 hydrogen Substances 0.000 abstract 6
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 6
- 125000003545 alkoxy group Chemical group 0.000 abstract 3
- 125000004414 alkyl thio group Chemical group 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- -1 cyano, hydroxy Chemical group 0.000 abstract 3
- 208000035143 Bacterial infection Diseases 0.000 abstract 2
- 125000004183 alkoxy alkyl group Chemical group 0.000 abstract 2
- 125000006350 alkyl thio alkyl group Chemical group 0.000 abstract 2
- 208000022362 bacterial infectious disease Diseases 0.000 abstract 2
- 125000001188 haloalkyl group Chemical group 0.000 abstract 2
- 125000001475 halogen functional group Chemical group 0.000 abstract 2
- 125000000815 N-oxide group Chemical group 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 125000004356 hydroxy functional group Chemical group O* 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229930195734 saturated hydrocarbon Natural products 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
- C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/36—Sulfur atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Quinoline Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Se describe el uso de un compuesto para la manufactura de un medicamento para el tratamiento de una infeccion bacteriana siempre que la infeccion bacteriana sea otra que una infeccion Microbacteriana, siendo dicho compuesto un compuesto de formula (1) o (2), su sal de adicion de ácido o de base farmacéuticamente aceptable, su forma estereoquímicamente isomerica, su forma tautoméricas o su forma de N-oxido, donde R1 es hidrogeno, halo, haloalquilo, ciano, hidroxi, Ar, Het, alquilo, alquiloxi, alquiltio, alquiloxialquilo, alquiltioalquilo, Ar-alquilo o di(Ar)alquilo; p es 1 a 4; R2 es hidrogeno, hidroxi, mercapto, alquiloxi, alquiloxialquiloxi, alquiltio, mono o di(alquil)amino o una formula (2), donde Y es CH2, O, S, NH o N-alquilo; R3 es Ar o Het; R4 y R5 cada uno es independientemente hidrogeno, alquilo o bencilo; o R4 y R5 son tomados en conjunto incluyendo el N al cual están unidos; R6 es hidrogeno, halo, haloalquilo, hidroxi, Ar, alquilo, alquiloxi, alquiltio, alquiloxialquilo, alquiltioalquilo, Ar-alquilo o di(Ar)alquilo ; o dos radicales R6 proximos pueden tomarse en conjunto para formar -CH=CH-CH=CH-; r es 1 a 5; R7 es hidrogeno, alquilo, Ar o Het; R8 es hidrogeno o alquilo; R9 es oxo; o R8 y R9 juntos forman -CH=CH-N=; Alk es un radical de hidrocarburo saturado de cadena recta o ramificada de C1-6.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05105769 | 2005-06-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR057654A1 true AR057654A1 (es) | 2007-12-12 |
Family
ID=35445742
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP060102760A AR057654A1 (es) | 2005-06-28 | 2006-06-27 | Derivados de quinolina como agentes antibacterianos |
Country Status (33)
| Country | Link |
|---|---|
| US (2) | US20100204270A1 (es) |
| EP (1) | EP1898910B1 (es) |
| JP (1) | JP5193859B2 (es) |
| KR (1) | KR101423229B1 (es) |
| CN (1) | CN101252928B (es) |
| AP (1) | AP2733A (es) |
| AR (1) | AR057654A1 (es) |
| AU (1) | AU2006263884B2 (es) |
| BR (1) | BRPI0612534B8 (es) |
| CA (1) | CA2612623C (es) |
| CY (1) | CY1118515T1 (es) |
| DK (1) | DK1898910T3 (es) |
| EA (1) | EA014163B1 (es) |
| ES (1) | ES2606772T3 (es) |
| HR (1) | HRP20161704T1 (es) |
| HU (1) | HUE031268T2 (es) |
| IL (1) | IL188394A (es) |
| JO (1) | JO3270B1 (es) |
| LT (1) | LT1898910T (es) |
| ME (1) | ME02690B (es) |
| MX (1) | MX2008000082A (es) |
| MY (1) | MY151030A (es) |
| NO (1) | NO341283B1 (es) |
| NZ (1) | NZ564339A (es) |
| PL (1) | PL1898910T3 (es) |
| PT (1) | PT1898910T (es) |
| RS (1) | RS55408B1 (es) |
| SG (1) | SG166799A1 (es) |
| SI (1) | SI1898910T1 (es) |
| TW (1) | TWI392494B (es) |
| UA (1) | UA91549C2 (es) |
| WO (1) | WO2007000436A1 (es) |
| ZA (1) | ZA200711149B (es) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9790186B2 (en) | 2009-07-21 | 2017-10-17 | Trustees Of Dartmouth College | Composition and method for prevention, mitigation or treatment of an enteropathogenic bacterial infection |
| US9617244B2 (en) | 2012-04-27 | 2017-04-11 | Janssen Pharmaceutica Nv | Antibacterial quinoline derivatives |
| ES2576491T3 (es) | 2012-04-27 | 2016-07-07 | Janssen Pharmaceutica, N.V. | Derivados de quinolina antibacterianos |
| CN105037497B (zh) * | 2015-03-27 | 2018-06-26 | 中牧实业股份有限公司 | 一种恩拉霉素的提纯方法 |
| WO2017035288A1 (en) * | 2015-08-27 | 2017-03-02 | Trustees Of Dartmouth College | Composition and method for prevention, mitigation or treatment of an enteropathogenic bacterial infection |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6103905A (en) * | 1997-06-19 | 2000-08-15 | Sepracor, Inc. | Quinoline-indole antimicrobial agents, uses and compositions related thereto |
| DE19937116A1 (de) * | 1999-08-06 | 2001-02-08 | Bayer Ag | Moxifloxacin Kochsalzformulierung |
| BRPI0312927B8 (pt) * | 2002-07-25 | 2021-05-25 | Janssen Pharmaceutica Nv | "compostos, derivados de quinolina, composição, seu uso como inibidores micobacteriais, bem como processo para preparação dos referidos derivados". |
| CN1976704B (zh) * | 2004-05-28 | 2012-12-05 | 詹森药业有限公司 | 取代的喹啉衍生物在治疗耐药性分枝杆菌性疾病中的用途 |
| EE05394B1 (et) * | 2004-12-24 | 2011-04-15 | Janssen Pharmaceutica N.V. | Kinoliinihendid kasutamiseks latentse tuberkuloosi ravis |
-
2006
- 2006-06-25 JO JOP/2006/0189A patent/JO3270B1/ar active
- 2006-06-26 MX MX2008000082A patent/MX2008000082A/es active IP Right Grant
- 2006-06-26 CN CN2006800313527A patent/CN101252928B/zh not_active Expired - Fee Related
- 2006-06-26 CA CA2612623A patent/CA2612623C/en active Active
- 2006-06-26 HU HUE06763891A patent/HUE031268T2/en unknown
- 2006-06-26 PL PL06763891T patent/PL1898910T3/pl unknown
- 2006-06-26 BR BRPI0612534A patent/BRPI0612534B8/pt not_active IP Right Cessation
- 2006-06-26 HR HRP20161704TT patent/HRP20161704T1/hr unknown
- 2006-06-26 EA EA200800152A patent/EA014163B1/ru unknown
- 2006-06-26 DK DK06763891.6T patent/DK1898910T3/en active
- 2006-06-26 SI SI200632126A patent/SI1898910T1/sl unknown
- 2006-06-26 RS RS20161121A patent/RS55408B1/sr unknown
- 2006-06-26 AU AU2006263884A patent/AU2006263884B2/en not_active Ceased
- 2006-06-26 ES ES06763891.6T patent/ES2606772T3/es active Active
- 2006-06-26 KR KR1020087002248A patent/KR101423229B1/ko not_active Expired - Fee Related
- 2006-06-26 EP EP06763891.6A patent/EP1898910B1/en active Active
- 2006-06-26 LT LTEP06763891.6T patent/LT1898910T/lt unknown
- 2006-06-26 JP JP2008518812A patent/JP5193859B2/ja not_active Expired - Fee Related
- 2006-06-26 SG SG201007977-0A patent/SG166799A1/en unknown
- 2006-06-26 NZ NZ564339A patent/NZ564339A/en not_active IP Right Cessation
- 2006-06-26 PT PT67638916T patent/PT1898910T/pt unknown
- 2006-06-26 UA UAA200714716A patent/UA91549C2/ru unknown
- 2006-06-26 US US11/917,923 patent/US20100204270A1/en not_active Abandoned
- 2006-06-26 WO PCT/EP2006/063556 patent/WO2007000436A1/en not_active Ceased
- 2006-06-26 AP AP2008004300A patent/AP2733A/xx active
- 2006-06-26 ME MEP-2016-291A patent/ME02690B/me unknown
- 2006-06-27 AR ARP060102760A patent/AR057654A1/es unknown
- 2006-06-27 MY MYPI20063045 patent/MY151030A/en unknown
- 2006-06-27 TW TW095123051A patent/TWI392494B/zh not_active IP Right Cessation
-
2007
- 2007-12-20 ZA ZA200711149A patent/ZA200711149B/xx unknown
- 2007-12-25 IL IL188394A patent/IL188394A/en active IP Right Grant
-
2008
- 2008-01-25 NO NO20080481A patent/NO341283B1/no not_active IP Right Cessation
-
2012
- 2012-08-07 US US13/568,597 patent/US20130030017A1/en not_active Abandoned
-
2016
- 2016-12-20 CY CY20161101322T patent/CY1118515T1/el unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |