AR057300A1 - Estirilsulfonamidas, su obtencion y uso como agentes farmaceuticos - Google Patents
Estirilsulfonamidas, su obtencion y uso como agentes farmaceuticosInfo
- Publication number
- AR057300A1 AR057300A1 ARP060102005A ARP060102005A AR057300A1 AR 057300 A1 AR057300 A1 AR 057300A1 AR P060102005 A ARP060102005 A AR P060102005A AR P060102005 A ARP060102005 A AR P060102005A AR 057300 A1 AR057300 A1 AR 057300A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- obtaining
- halogenated
- stirilsulfonamidas
- trifluoromethyl
- Prior art date
Links
- 239000008177 pharmaceutical agent Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000004414 alkyl thio group Chemical group 0.000 abstract 2
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Chemical group BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 2
- 229910052794 bromium Inorganic materials 0.000 abstract 2
- 229910052801 chlorine Inorganic materials 0.000 abstract 2
- 239000000460 chlorine Substances 0.000 abstract 2
- 125000001309 chloro group Chemical group Cl* 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
- -1 nitro, amino Chemical group 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 2
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical group FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 125000003282 alkyl amino group Chemical group 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 125000004663 dialkyl amino group Chemical group 0.000 abstract 1
- 230000006806 disease prevention Effects 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 239000011737 fluorine Chemical group 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000002483 medication Methods 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/45—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups at least one of the singly-bound nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylaminosulfonamides
- C07C311/46—Y being a hydrogen or a carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/50—Compounds containing any of the groups, X being a hetero atom, Y being any atom
- C07C311/51—Y being a hydrogen or a carbon atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/18—Sulfonamides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
- C07C303/36—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids
- C07C303/40—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids by reactions not involving the formation of sulfonamide groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La presente son sales farmacéuticamente aceptables, formas enantioméricas, diastereoisomeros y racematos, la obtencion de los compuestos anteriores, los medicamentos que los contienen y su fabricacion, así como el uso de los compuestos anteriores para el control o la prevencion de enfermedades, tales como el cáncer. Reivindicacion 1: Un compuesto de la formula (1), en la que: R1, R2 y R3 con independencia entre sí significan hidrogeno, halogeno, alquilo, alcoxi, alquilsulfanilo, alquilo halogenado, alcoxilo halogenado, alquilsulfanilo halogenado, nitro, amino, alquilamino, dialquilamino, ciano, hidroxi o heterociclilo; R4 y R5 con independencia entre sí significan hidrogeno o alquilo; R6 es cloro, bromo, metilo, trifluormetilo o metoxi; R7 es cloro, bromo, fluor, metilo o trifluormetilo; y todas las sales farmacéuticamente aceptables del mismo.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05010982 | 2005-05-20 | ||
| EP06001007 | 2006-01-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR057300A1 true AR057300A1 (es) | 2007-11-28 |
Family
ID=36607423
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP060102005A AR057300A1 (es) | 2005-05-20 | 2006-05-18 | Estirilsulfonamidas, su obtencion y uso como agentes farmaceuticos |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US7208526B2 (es) |
| EP (1) | EP1888519A2 (es) |
| JP (1) | JP2008545633A (es) |
| KR (1) | KR100929996B1 (es) |
| CN (1) | CN101268042A (es) |
| AR (1) | AR057300A1 (es) |
| AU (1) | AU2006312801A1 (es) |
| BR (1) | BRPI0611287A2 (es) |
| CA (1) | CA2607982A1 (es) |
| IL (1) | IL186851A0 (es) |
| MX (1) | MX2007014224A (es) |
| TW (1) | TW200720239A (es) |
| WO (1) | WO2007054139A2 (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101675033A (zh) * | 2007-05-16 | 2010-03-17 | 霍夫曼-拉罗奇有限公司 | 芳基吡啶基磺酰胺衍生物，它们的制备和作为药剂的应用 |
| JP6022548B2 (ja) | 2011-04-28 | 2016-11-09 | セルジーン コーポレイション | Ｐｄｅ４阻害剤を自己免疫疾患及び炎症性疾患の治療及び管理に使用する方法及び組成物 |
| AR090100A1 (es) | 2012-02-21 | 2014-10-22 | Celgene Corp | Procesos para la preparacion de la (s)-1-(3-etoxi-4-metoxifenil)-2-metanosulfoniletilamina |
| EP3010490A1 (en) | 2013-06-17 | 2016-04-27 | Celgene Corporation | Tablet formulations of (+)-2-[1 -(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4206142A (en) | 1973-06-11 | 1980-06-03 | Mead Johnson & Company | Styrylamidine process |
| US3983107A (en) | 1973-12-05 | 1976-09-28 | Pfizer Inc. | Hypolipidemic alkenesulfonamides |
| CA1071651A (en) * | 1974-04-08 | 1980-02-12 | William L. Matier | Styrylamidines |
| US4157257A (en) | 1976-10-01 | 1979-06-05 | Utsunomiya University | Benzenesulfonamide derivatives |
| JPS5936663A (ja) * | 1983-05-27 | 1984-02-28 | Ishihara Sangyo Kaisha Ltd | ベンズアミド誘導体及びそれらを含有する除草剤 |
| US5591761A (en) | 1993-05-20 | 1997-01-07 | Texas Biotechnology Corporation | Thiophenyl-, furyl-and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin |
| AU4400597A (en) * | 1996-10-08 | 1998-05-05 | Fujisawa Pharmaceutical Co., Ltd. | Indole derivatives |
| EA001803B1 (ru) * | 1997-01-29 | 2001-08-27 | Пфайзер Инк. | Производные сульфонилмочевины и их применение для контроля активности интерлейкина-1 |
| BR9810456A (pt) | 1997-06-27 | 2001-09-25 | Fujisawa Pharmaceutical Co | Composto de sulfonamida, método para sua obtenção e seu uso farmacêutico |
| DE19742951A1 (de) * | 1997-09-29 | 1999-04-15 | Hoechst Schering Agrevo Gmbh | Acylsulfamoylbenzoesäureamide, diese enthaltende nutzpflanzenschützende Mittel und Verfahren zu ihrer Herstellung |
| US6410584B1 (en) | 1998-01-14 | 2002-06-25 | Cell Pathways, Inc. | Method for inhibiting neoplastic cells with indole derivatives |
| BR0210078A (pt) | 2001-06-06 | 2004-06-22 | Lilly Co Eli | Composto, uso do mesmo, e, formulação farmacêutica |
| PL374215A1 (en) * | 2001-08-11 | 2005-10-03 | Bristol-Myers Squibb Pharma Company | Selective estrogen receptor modulators |
| AR037097A1 (es) * | 2001-10-05 | 2004-10-20 | Novartis Ag | Compuestos acilsulfonamidas, composiciones farmaceuticas y el uso de dichos compuestos para la preparacion de un medicamento |
| AU2003290592A1 (en) | 2002-11-22 | 2004-06-18 | Eli Lilly And Company | Antitumor benzoylsulfonamides |
-
2006
- 2006-04-28 US US11/414,042 patent/US7208526B2/en not_active Expired - Fee Related
- 2006-05-17 TW TW095117488A patent/TW200720239A/zh unknown
- 2006-05-18 AR ARP060102005A patent/AR057300A1/es not_active Application Discontinuation
- 2006-05-19 KR KR1020077026374A patent/KR100929996B1/ko not_active Expired - Fee Related
- 2006-05-19 AU AU2006312801A patent/AU2006312801A1/en not_active Abandoned
- 2006-05-19 WO PCT/EP2006/004756 patent/WO2007054139A2/en not_active Ceased
- 2006-05-19 CN CNA2006800175955A patent/CN101268042A/zh active Pending
- 2006-05-19 EP EP06840910A patent/EP1888519A2/en not_active Withdrawn
- 2006-05-19 MX MX2007014224A patent/MX2007014224A/es active IP Right Grant
- 2006-05-19 BR BRPI0611287-0A patent/BRPI0611287A2/pt not_active IP Right Cessation
- 2006-05-19 JP JP2008511646A patent/JP2008545633A/ja not_active Ceased
- 2006-05-19 CA CA002607982A patent/CA2607982A1/en not_active Abandoned
-
2007
- 2007-10-22 IL IL186851A patent/IL186851A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP2008545633A (ja) | 2008-12-18 |
| KR20070120195A (ko) | 2007-12-21 |
| EP1888519A2 (en) | 2008-02-20 |
| MX2007014224A (es) | 2008-02-07 |
| TW200720239A (en) | 2007-06-01 |
| CN101268042A (zh) | 2008-09-17 |
| BRPI0611287A2 (pt) | 2010-08-31 |
| US20060270874A1 (en) | 2006-11-30 |
| AU2006312801A1 (en) | 2007-05-18 |
| US7208526B2 (en) | 2007-04-24 |
| WO2007054139A3 (en) | 2008-05-29 |
| KR100929996B1 (ko) | 2009-12-07 |
| CA2607982A1 (en) | 2007-05-18 |
| IL186851A0 (en) | 2008-02-09 |
| WO2007054139A2 (en) | 2007-05-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |