AR057152A1 - Sistema terapeutico transdermico - Google Patents
Sistema terapeutico transdermicoInfo
- Publication number
- AR057152A1 AR057152A1 ARP060104447A ARP060104447A AR057152A1 AR 057152 A1 AR057152 A1 AR 057152A1 AR P060104447 A ARP060104447 A AR P060104447A AR P060104447 A ARP060104447 A AR P060104447A AR 057152 A1 AR057152 A1 AR 057152A1
- Authority
- AR
- Argentina
- Prior art keywords
- active ingredient
- adhesive solution
- transdermal therapeutic
- adhesive layer
- silicone
- Prior art date
Links
- 230000001225 therapeutic effect Effects 0.000 title abstract 4
- 239000004480 active ingredient Substances 0.000 abstract 6
- 239000010410 layer Substances 0.000 abstract 4
- 239000013464 silicone adhesive Substances 0.000 abstract 4
- 239000000853 adhesive Substances 0.000 abstract 3
- 230000001070 adhesive effect Effects 0.000 abstract 3
- 239000012790 adhesive layer Substances 0.000 abstract 2
- 239000000556 agonist Substances 0.000 abstract 2
- 229940035676 analgesics Drugs 0.000 abstract 2
- 229940035674 anesthetics Drugs 0.000 abstract 2
- 239000000730 antalgic agent Substances 0.000 abstract 2
- -1 antianginals Substances 0.000 abstract 2
- 239000011248 coating agent Substances 0.000 abstract 2
- 238000000576 coating method Methods 0.000 abstract 2
- ADEBPBSSDYVVLD-UHFFFAOYSA-N donepezil Chemical compound O=C1C=2C=C(OC)C(OC)=CC=2CC1CC(CC1)CCN1CC1=CC=CC=C1 ADEBPBSSDYVVLD-UHFFFAOYSA-N 0.000 abstract 2
- ASUTZQLVASHGKV-JDFRZJQESA-N galanthamine Chemical compound O1C(=C23)C(OC)=CC=C2CN(C)CC[C@]23[C@@H]1C[C@@H](O)C=C2 ASUTZQLVASHGKV-JDFRZJQESA-N 0.000 abstract 2
- 239000003193 general anesthetic agent Substances 0.000 abstract 2
- 229920000642 polymer Polymers 0.000 abstract 2
- 238000002360 preparation method Methods 0.000 abstract 2
- ZRJBHWIHUMBLCN-SEQYCRGISA-N Huperzine A Natural products N1C(=O)C=CC2=C1C[C@H]1/C(=C/C)[C@]2(N)CC(C)=C1 ZRJBHWIHUMBLCN-SEQYCRGISA-N 0.000 abstract 1
- 229930182555 Penicillin Natural products 0.000 abstract 1
- PIJVFDBKTWXHHD-UHFFFAOYSA-N Physostigmine Natural products C12=CC(OC(=O)NC)=CC=C2N(C)C2C1(C)CCN2C PIJVFDBKTWXHHD-UHFFFAOYSA-N 0.000 abstract 1
- XSVMFMHYUFZWBK-NSHDSACASA-N Rivastigmine Chemical compound CCN(C)C(=O)OC1=CC=CC([C@H](C)N(C)C)=C1 XSVMFMHYUFZWBK-NSHDSACASA-N 0.000 abstract 1
- ZRJBHWIHUMBLCN-UHFFFAOYSA-N Shuangyiping Natural products N1C(=O)C=CC2=C1CC1C(=CC)C2(N)CC(C)=C1 ZRJBHWIHUMBLCN-UHFFFAOYSA-N 0.000 abstract 1
- 102000015007 alpha-adrenergic receptor activity proteins Human genes 0.000 abstract 1
- 108040006816 alpha-adrenergic receptor activity proteins Proteins 0.000 abstract 1
- 230000003444 anaesthetic effect Effects 0.000 abstract 1
- 239000003098 androgen Substances 0.000 abstract 1
- 229940030486 androgens Drugs 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 230000003288 anthiarrhythmic effect Effects 0.000 abstract 1
- 230000003266 anti-allergic effect Effects 0.000 abstract 1
- 230000002280 anti-androgenic effect Effects 0.000 abstract 1
- 230000003257 anti-anginal effect Effects 0.000 abstract 1
- 229940005524 anti-dementia drug Drugs 0.000 abstract 1
- 230000003178 anti-diabetic effect Effects 0.000 abstract 1
- 239000000043 antiallergic agent Substances 0.000 abstract 1
- 239000000051 antiandrogen Substances 0.000 abstract 1
- 229940030495 antiandrogen sex hormone and modulator of the genital system Drugs 0.000 abstract 1
- 229940124345 antianginal agent Drugs 0.000 abstract 1
- 239000003416 antiarrhythmic agent Substances 0.000 abstract 1
- 239000000935 antidepressant agent Substances 0.000 abstract 1
- 229940005513 antidepressants Drugs 0.000 abstract 1
- 239000000739 antihistaminic agent Substances 0.000 abstract 1
- 229940125715 antihistaminic agent Drugs 0.000 abstract 1
- 229940082988 antihypertensives serotonin antagonists Drugs 0.000 abstract 1
- 229940127218 antiplatelet drug Drugs 0.000 abstract 1
- 239000003420 antiserotonin agent Substances 0.000 abstract 1
- 102000015005 beta-adrenergic receptor activity proteins Human genes 0.000 abstract 1
- 108040006818 beta-adrenergic receptor activity proteins Proteins 0.000 abstract 1
- 229940124630 bronchodilator Drugs 0.000 abstract 1
- 239000000168 bronchodilator agent Substances 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 229960003530 donepezil Drugs 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 238000001035 drying Methods 0.000 abstract 1
- 229960003133 ergot alkaloid Drugs 0.000 abstract 1
- 229940011871 estrogen Drugs 0.000 abstract 1
- 239000000262 estrogen Substances 0.000 abstract 1
- 229960003980 galantamine Drugs 0.000 abstract 1
- ASUTZQLVASHGKV-UHFFFAOYSA-N galanthamine hydrochloride Natural products O1C(=C23)C(OC)=CC=C2CN(C)CCC23C1CC(O)C=C2 ASUTZQLVASHGKV-UHFFFAOYSA-N 0.000 abstract 1
- 229940088597 hormone Drugs 0.000 abstract 1
- 239000005556 hormone Substances 0.000 abstract 1
- ZRJBHWIHUMBLCN-YQEJDHNASA-N huperzine A Chemical compound N1C(=O)C=CC2=C1C[C@H]1\C(=C/C)[C@]2(N)CC(C)=C1 ZRJBHWIHUMBLCN-YQEJDHNASA-N 0.000 abstract 1
- 238000003475 lamination Methods 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 150000002960 penicillins Chemical class 0.000 abstract 1
- PIJVFDBKTWXHHD-HIFRSBDPSA-N physostigmine Chemical compound C12=CC(OC(=O)NC)=CC=C2N(C)[C@@H]2[C@@]1(C)CCN2C PIJVFDBKTWXHHD-HIFRSBDPSA-N 0.000 abstract 1
- 229960001697 physostigmine Drugs 0.000 abstract 1
- 230000036470 plasma concentration Effects 0.000 abstract 1
- 239000000106 platelet aggregation inhibitor Substances 0.000 abstract 1
- 229920001296 polysiloxane Polymers 0.000 abstract 1
- ZRJBHWIHUMBLCN-BMIGLBTASA-N rac-huperzine A Natural products N1C(=O)C=CC2=C1C[C@@H]1C(=CC)[C@@]2(N)CC(C)=C1 ZRJBHWIHUMBLCN-BMIGLBTASA-N 0.000 abstract 1
- 229960004136 rivastigmine Drugs 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229960001685 tacrine Drugs 0.000 abstract 1
- YLJREFDVOIBQDA-UHFFFAOYSA-N tacrine Chemical compound C1=CC=C2C(N)=C(CCCC3)C3=NC2=C1 YLJREFDVOIBQDA-UHFFFAOYSA-N 0.000 abstract 1
- 229940124549 vasodilator Drugs 0.000 abstract 1
- 239000003071 vasodilator agent Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7069—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained otherwise than by reactions only involving carbon to carbon unsaturated bonds, e.g. polysiloxane, polyesters, polyurethane, polyethylene oxide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7084—Transdermal patches having a drug layer or reservoir, and one or more separate drug-free skin-adhesive layers, e.g. between drug reservoir and skin, or surrounding the drug reservoir; Liquid-filled reservoir patches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/27—Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
- A61K9/7061—Polyacrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Dermatology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Emergency Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Sistemas Terapéuticos Transdérmicos que poseen una capa adhesiva de silicona, a Sistemas Terapéuticos Transdérmicos que proveen concentraciones en plasma específicas, a su elaboracion y uso. Reivindicacion 1: Un Sistema Terapéutico Transdérmico (STT) que comprende a) una capa posterior, b) una capa reservorio que comprende uno o más ingredientes farmacéuticamente activos y uno o más polímeros, c) una capa adhesiva que comprende un taquificante y un polímero de silicona. Reivindicacion 8: El STT de acuerdo con cualquiera de las reivindicaciones 1 a 6, caracterizado en que el ingrediente activo está seleccionado del grupo integrado por agonistas de alfa-adrenoreceptor, agonistas de beta-adrenoreceptor, bloqueantes de alfa- adrenoreceptor, analgésicos anestésicos, analgésicos no anestésicos, androgenos, anestésicos, antialérgicos, antiandrogenos, antianginales, antiarrítmicos, penicilinas, antidiabéticos, antihistamínicos, agentes antimigrana, alcaloides ergot hidratados, antagonistas de Ca++, antagonistas de serotonina, inhibidores de agregacion plaquetaria, antidepresivos, bronquiolíticos, estrogenos, gestágenos, vasodilatadores, hormonas, fármacos anti-demencia. Reivindicacion 9: El STT de acuerdo con cualquiera de las reivindicaciones 1 a 6, caracterizado en que el ingrediente activo está seleccionado el grupo integrado por tacrina, rivastigmina, donepezil, galantamina, fisostigmina, huperzina A y las sales farmacologicamente aceptables de las mismas. Reivindicacion 20: Un proceso para elaborar un STT de acuerdo con cualquiera de las reivindicaciones precedentes que comprende las etapas de a) la elaboracion del ingrediente activo en solucion adhesiva; b) el recubrimiento del ingrediente activo en solucion adhesiva; c) el secado del ingrediente activo en solucion adhesiva, d) la elaboracion de la solucion adhesiva de silicona; e) el recubrimiento de la solucion adhesiva de silicona, f) el laminado de la capa adhesiva de silicona al fármaco en la capa adhesiva, g) la perforacion y el embolsado.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US74151105P | 2005-12-01 | 2005-12-01 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR057152A1 true AR057152A1 (es) | 2007-11-21 |
Family
ID=37716856
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP060104447A AR057152A1 (es) | 2005-12-01 | 2006-10-10 | Sistema terapeutico transdermico |
| ARP140102752A AR097045A2 (es) | 2005-12-01 | 2014-07-24 | Sistema terapéutico transdérmico |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP140102752A AR097045A2 (es) | 2005-12-01 | 2014-07-24 | Sistema terapéutico transdérmico |
Country Status (31)
| Country | Link |
|---|---|
| US (3) | US20070128263A1 (es) |
| EP (5) | EP1959937A1 (es) |
| JP (3) | JP2009517468A (es) |
| KR (7) | KR20130143729A (es) |
| CN (2) | CN101312717A (es) |
| AR (2) | AR057152A1 (es) |
| AT (1) | AT11185U1 (es) |
| AU (1) | AU2006320919B2 (es) |
| BR (2) | BR122013013162A2 (es) |
| CA (1) | CA2563110A1 (es) |
| DE (2) | DE14163637T1 (es) |
| DK (5) | DK2292219T3 (es) |
| EC (1) | ECSP088469A (es) |
| ES (1) | ES2414455T3 (es) |
| FI (1) | FI10268U1 (es) |
| GT (1) | GT200800075A (es) |
| IL (4) | IL191311A (es) |
| MA (1) | MA30022B1 (es) |
| MY (2) | MY151020A (es) |
| NO (1) | NO20082753L (es) |
| NZ (1) | NZ568273A (es) |
| PH (2) | PH12013500771A1 (es) |
| PL (1) | PL2292219T4 (es) |
| PT (1) | PT2292219E (es) |
| RU (1) | RU2450805C2 (es) |
| SG (1) | SG2014014989A (es) |
| SI (1) | SI2292219T1 (es) |
| TN (1) | TNSN08238A1 (es) |
| TW (1) | TWI389709B (es) |
| WO (1) | WO2007064407A1 (es) |
| ZA (1) | ZA200803882B (es) |
Families Citing this family (105)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI389709B (zh) * | 2005-12-01 | 2013-03-21 | Novartis Ag | 經皮治療系統 |
| US9248104B2 (en) * | 2006-08-17 | 2016-02-02 | Core Tech Solutions, Inc. | Transdermal methods and systems for treating Alzheimer's disease |
| TWI541246B (zh) | 2008-12-08 | 2016-07-11 | 歐陸斯迪公司 | 二氫羥戊甲嗎啡 |
| GB0823554D0 (en) | 2008-12-24 | 2009-01-28 | Novartis Ag | Process for the preparation of optically active compounds using transfer hydrogenation |
| KR101656908B1 (ko) * | 2009-04-17 | 2016-09-12 | 쓰리엠 이노베이티브 프로퍼티즈 컴파니 | 실리콘 겔 접착 구조물 |
| WO2010129689A1 (en) * | 2009-05-05 | 2010-11-11 | Forest Laboratories Holdings Limited | Milnacipran formulations |
| US10744086B2 (en) | 2009-10-30 | 2020-08-18 | Ix Biopharma Ltd. | Fast dissolving solid dosage form |
| US12186426B2 (en) | 2009-10-30 | 2025-01-07 | Ix Biopharma Ltd. | Solid dosage form |
| WO2011073362A1 (en) | 2009-12-18 | 2011-06-23 | Novartis Ag | Process for the preparation of optically active compounds using pressure hydrogenation |
| PT2515886T (pt) * | 2009-12-22 | 2018-05-23 | Luye Pharma Ag | Sistema terapêutico transdermal para a administração de rivastigmina ou de seus derivados |
| US10076502B2 (en) * | 2009-12-22 | 2018-09-18 | Luye Pharma Ag | Transdermal therapeutic system for administering rivastigmine or derivatives thereof |
| US20100178307A1 (en) * | 2010-01-13 | 2010-07-15 | Jianye Wen | Transdermal anti-dementia active agent formulations and methods for using the same |
| RU2578971C2 (ru) * | 2010-06-17 | 2016-03-27 | Лтс Ломанн Терапи-Системе Аг | Трансдермальное введение мемантина |
| DE102010024105A1 (de) * | 2010-06-17 | 2011-12-22 | Grünenthal GmbH | Transdermale Verabreichung von Memantin |
| DE102010026903A1 (de) | 2010-07-12 | 2012-01-12 | Amw Gmbh | Transdermales therapeutisches System mit Avocadoöl oder Palmöl als Hilfsstoff |
| US9375510B2 (en) * | 2010-07-21 | 2016-06-28 | 3M Innovative Properties Company | Transdermal adhesive compositions, devices and methods |
| CA2807552A1 (en) | 2010-08-06 | 2012-02-09 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| US20120046383A1 (en) * | 2010-08-19 | 2012-02-23 | Terumo Kabushiki Kaisha | Silicone rubber composition |
| DE19177059T1 (de) | 2010-10-01 | 2021-10-07 | Modernatx, Inc. | N1-methyl-pseudouracile enthältendes ribonucleinsäuren sowie ihre verwendungen |
| DK2468274T3 (en) | 2010-12-14 | 2015-08-31 | Acino Ag | Transdermal therapeutic system for administration of an active substance |
| KR101788802B1 (ko) * | 2010-12-24 | 2017-10-20 | 주식회사 삼양바이오팜 | 리바스티그민을 함유하는 경피흡수제제 |
| KR101054317B1 (ko) * | 2011-01-28 | 2011-08-08 | 신신제약 주식회사 | 리바스티그민을 함유하는 경피흡수제제 |
| KR101317158B1 (ko) * | 2011-02-18 | 2013-10-15 | 조선대학교산학협력단 | 갈란타민 또는 그의 염을 함유하는 경피흡수제제 |
| JP2014511687A (ja) | 2011-03-31 | 2014-05-19 | モデルナ セラピューティクス インコーポレイテッド | 工学操作された核酸の送達および製剤 |
| KR20120130073A (ko) * | 2011-05-20 | 2012-11-28 | 에스케이케미칼주식회사 | 리바스티그민 함유 패취 |
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| EP3936133A1 (en) | 2011-11-23 | 2022-01-12 | TherapeuticsMD, Inc. | Natural combination hormone replacement formulations and therapies |
| HRP20220717T1 (hr) | 2011-12-16 | 2022-07-22 | Modernatx, Inc. | Modificirani pripravci mrna |
| KR101399035B1 (ko) * | 2011-12-22 | 2014-05-28 | 주식회사 트랜스덤 | 리바스티그민을 함유하는 경피흡수제제 |
| DE102012000369A1 (de) | 2012-01-11 | 2013-07-11 | Alfred E. Tiefenbacher (Gmbh & Co. Kg) | Transdermales therapeutisches System mit Cholinesterase-Hemmer |
| CA2865715C (en) | 2012-02-28 | 2018-06-19 | Nichiban Co., Ltd. | Transdermal patch |
| WO2013142339A1 (en) | 2012-03-23 | 2013-09-26 | Novartis Ag | Transdermal therapeutic system and method |
| US9283287B2 (en) | 2012-04-02 | 2016-03-15 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of nuclear proteins |
| US9572897B2 (en) | 2012-04-02 | 2017-02-21 | Modernatx, Inc. | Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins |
| US9303079B2 (en) | 2012-04-02 | 2016-04-05 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins |
| JP2015516143A (ja) | 2012-04-02 | 2015-06-08 | モデルナ セラピューティクス インコーポレイテッドModerna Therapeutics,Inc. | ヒト疾患に関連するタンパク質の産生のための修飾ポリヌクレオチド |
| WO2013150542A2 (en) * | 2012-04-05 | 2013-10-10 | Sparsha Pharma International Private Limited | A transdermal patch for treatment of dementia or alzheimer type dementia |
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