AR057086A1 - Derivados de indol-3- il-carbonil-piperidina y piperazina, composicion farmaceutica y proceso de preparacion del compuesto - Google Patents
Derivados de indol-3- il-carbonil-piperidina y piperazina, composicion farmaceutica y proceso de preparacion del compuestoInfo
- Publication number
- AR057086A1 AR057086A1 ARP060103244A ARP060103244A AR057086A1 AR 057086 A1 AR057086 A1 AR 057086A1 AR P060103244 A ARP060103244 A AR P060103244A AR P060103244 A ARP060103244 A AR P060103244A AR 057086 A1 AR057086 A1 AR 057086A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- halogen
- optionally substituted
- nririi
- alkoxy
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 title 2
- 239000002131 composite material Substances 0.000 title 1
- 238000002360 preparation method Methods 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 24
- 229910052736 halogen Inorganic materials 0.000 abstract 14
- 150000002367 halogens Chemical class 0.000 abstract 14
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 12
- 125000003118 aryl group Chemical group 0.000 abstract 8
- 125000001072 heteroaryl group Chemical group 0.000 abstract 7
- 125000004737 (C1-C6) haloalkoxy group Chemical group 0.000 abstract 5
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 5
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 abstract 4
- 125000000592 heterocycloalkyl group Chemical group 0.000 abstract 4
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 4
- -1 -O-CH2-C2-6 alkenyl Chemical group 0.000 abstract 2
- 125000002947 alkylene group Chemical group 0.000 abstract 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000001041 indolyl group Chemical group 0.000 abstract 2
- 208000019901 Anxiety disease Diseases 0.000 abstract 1
- 206010007558 Cardiac failure chronic Diseases 0.000 abstract 1
- 208000020401 Depressive disease Diseases 0.000 abstract 1
- 208000005171 Dysmenorrhea Diseases 0.000 abstract 1
- 206010013935 Dysmenorrhoea Diseases 0.000 abstract 1
- 206010020772 Hypertension Diseases 0.000 abstract 1
- 206010053198 Inappropriate antidiuretic hormone secretion Diseases 0.000 abstract 1
- 206010065673 Nephritic syndrome Diseases 0.000 abstract 1
- 208000021384 Obsessive-Compulsive disease Diseases 0.000 abstract 1
- 125000004104 aryloxy group Chemical group 0.000 abstract 1
- 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 abstract 1
- 208000019425 cirrhosis of liver Diseases 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 238000002483 medication Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 125000000896 monocarboxylic acid group Chemical group 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/22—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an aralkyl radical attached to the ring nitrogen atom
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Cardiology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Diabetes (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Gastroenterology & Hepatology (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Indole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
La presente se refiere además un composiciones farmacéuticas que contienen tales compuestos; aptos para su utilizacion en medicamentos para la dismenorrea, hipertension, fallo cardíaco cronico, secrecion inapropiada de vasopresina, cirrosis hepática, síndrome nefrítico, trastorno obsesivo-compulsivo, trastornos de ansiedad y depresion; y un métodos para la obtencion de los mismos. Reivindicacion 1: Un compuesto de la formula general (1), en la que: R1 es H, o es alquilo C1-6 sustituido por CN, alcoxi C1-6, OH, halogeno, o por NRiRii, o es alquilo C2-6; o es arilo, heteroarilo o sulfonilo de 5 o 6 eslabones, sustituidos opcionalmente una o varias veces por B; o es -(CH2)m-Ra, en el que Ra es: CN; ORi; NRiRii; cicloalquilo C3-6, heterocicloalquilo de 4 un 7 eslabones, arilo, o heteroarilo de 5 o 6 eslabones que están opcionalmente sustituidos una o varias veces por B; o es -(CH2)n-(CO)-Rb o -(CH2)n-(SO2)-Rb, en los que Rb es: alquilo C1-6; alcoxi C1-6; cicloalquilo C3-6, -(CH2)m-NRiiiRiv; NRiRii; cicloalquilo C3-6, heterocicloalquilo de 4 un 7 eslabones, arilo, o heteroarilo de 5 o 6 eslabones que están opcionalmente sustituidos una o varias veces por B; o R1 y R3 junto con el anillo indol al que están unidos forman un heterocicloalquilo de 5 o 6 eslabones que puede estar sustituido por =O, C(O)O-alquiloC1-6 o alquilo C1-6; R2 es uno o varios de H, OH, halogeno, CN, nitro, alcoxi C1-6, -O-CH2-alqueniloC2-6, benciloxi, haloalcoxi C1-6, alquilo C1-6 opcionalmente sustituido por-NRiiRiv o halogeno, o dos R2 pueden formar un puente oxo o dioxo junto con el anillo indol al que están unidos; R3 es H; o es F; o es -(CO)-Rc, en el que Rc es: alquilo C1-6; -(CH2)nNRiRii; -(CH2)n-NRiiiRiv; heterocicloalquilo de 5 o 6 eslabones opcionalmente sustituido por alquilo C1-6; o es alquilo C1-6 está opcionalmente sustituido por halogeno; NRiRii, NRiRiv; -O(CO)-alquiloC1-6, o por-NH(CO)Rd, en el que Rd es alquilo C1-6 opcionalmente sustituido por halogeno o nitro, o Rd es arilo o un heteroarilo de 5 o 6 eslabones, que están opcionalmente sustituidos por halogeno, nitro, alquilo C1-6 o haloalquilo C1-6; A se elige entre el grupo formado por las formulas (2) un (6), en los que: R4 es - NH(CO)Re, en el que Re es alcoxi C1-6 o arilo opcionalmente sustituido por halogeno; o es alcox C1-6, CN; o es arilo, heteroarilo de 5 o 6 eslabones, bencilo, ariloxi o un anillo heteroarilo bicíclico de 9 a 10 eslabones, que están opcionalmente sustituidos por CN, halogeno, alquilo C1-6, alcoxi C1-6, haloalquilo C1-6, nitro, hidroxilo, NRiRii, NRiiiRiv, alcoxiC1-6-alquilenoC1-6, S(O)2-alquiloC1-6, haloalcoxi C1-6, o por un puente oxo o dioxo; y R5 es H, OH, CN, COORiii o CONRiiiRiv; R6 es alquilo C2-6; o es -C(O)-Rf, en el que Rf es un grupo arilo sustituido por halogeno, alcoxi C1-6, o CN; o es arilo, heteroarilo de 5 o 6 eslabones, o un anillo heteroarilo bicíclico de 9 a 10 eslabones que están opcionalmente sustituido por halogeno, alquilo C1-6, alcoxi C1-6, haloalquilo C1-6, CN, nitro, NRiRii , NRiiiRiv, alcoxiC1-6-alquilenoC1-6, COOH, S(O)2-alquiloC1-6, hidroxilo, haloalcoxiC1-6, o por un puente oxo o dioxo; o es bencilo sustituido por halogeno, alquiloC1-6, haloalquiloC1-6 o por un puente oxo o dioxo; B es halogeno, CN, NRiRii, alquilo C1-6 opcionalmente sustituido por CN, halogeno o alcoxi C1-6, haloalquilo C1-6, alcoxi C1-6, haloalcoxi C1-6, cicloalquilo C3-6, -C(O)O-alquiloC1-6, - C(O)NRiRii, -C(O)- alquiloC1-6, -S(O)2-alquiloC1-6, -S(O)2-NRiRii, (CriiiRiv)n-fenilo, o (CRiiiRiv)n-heteroarilo de 5 o 6 eslabones, en el que el fenilo o el resto heteroarilo de 5 o 6 eslabones están opcionalmente sustituidos por uno o varios sustituyentes elegidos entre el grupo formado por: halogeno, CN, NRiRii, alquilo C1-6 opcionalmente sustituido por CN o alcoxi C1-6, alcoxi C1-6, haloalcoxi C1-6, cicloalquilo C3-6, -C(O)O-alquiloC1-6, -C(O)-NRiRii, -C(O)-alquiloC1-6, -S(O)2-alquiloC1-6, -S(O)2-NRiRii; Ri y Rii son H, alquilo C1-6, alquilC1-6-NRiiiRiv, -(CO)O-alquiloC1-6, -C(O)-NRiiiRiv, -C(O)-alquiloC1-6, -S(O)2-alquiloC1-6 o -S(O)2-NRiiiRiv; Riii y Riv son H o alquilo C1-6; m es numero de 1 a 6; n es numero de 0 a 4; así como las sales farmacéuticamente aceptables del mismo.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05107044 | 2005-07-29 | ||
| EP05111072 | 2005-11-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR057086A1 true AR057086A1 (es) | 2007-11-14 |
Family
ID=37442112
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP060103244A AR057086A1 (es) | 2005-07-29 | 2006-07-27 | Derivados de indol-3- il-carbonil-piperidina y piperazina, composicion farmaceutica y proceso de preparacion del compuesto |
Country Status (15)
| Country | Link |
|---|---|
| US (3) | US7781436B2 (es) |
| EP (2) | EP1917255A2 (es) |
| JP (1) | JP2009502859A (es) |
| KR (1) | KR101020351B1 (es) |
| CN (1) | CN102295636A (es) |
| AR (1) | AR057086A1 (es) |
| AU (1) | AU2006274884B2 (es) |
| BR (1) | BRPI0614692A2 (es) |
| CA (1) | CA2616937A1 (es) |
| IL (1) | IL188928A0 (es) |
| MX (1) | MX2008001292A (es) |
| NO (1) | NO20080316L (es) |
| RU (1) | RU2422442C2 (es) |
| TW (1) | TWI314147B (es) |
| WO (1) | WO2007014851A2 (es) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5379000B2 (ja) | 2006-07-31 | 2013-12-25 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | ウロテンシンｉｉ受容体アンタゴニスト |
| EP2102186B1 (en) * | 2006-12-08 | 2011-10-05 | F. Hoffmann-La Roche AG | Indoles |
| PE20081401A1 (es) | 2006-12-28 | 2008-10-24 | Hoffmann La Roche | Derivados de indol como antagonistas de receptores vasopresina |
| PA8782701A1 (es) * | 2007-06-07 | 2009-01-23 | Janssen Pharmaceutica Nv | Antagonistas del receptor de urotensina ii |
| RU2387642C2 (ru) | 2007-10-31 | 2010-04-27 | Общество С Ограниченной Ответственностью "Бинатех" | Производные 5-замещенных индол-3-карбоновой кислоты, обладающие противовирусной активностью, способ их получения и применение |
| WO2009095162A1 (en) * | 2008-01-31 | 2009-08-06 | Sanofi-Aventis | Cyclic azaindole-3-carboxamides, their preparation and their use as pharmaceuticals |
| ATE546448T1 (de) * | 2008-08-02 | 2012-03-15 | Janssen Pharmaceutica Nv | Urotensin-ii-rezeptorantagonisten |
| WO2011058766A1 (en) * | 2009-11-16 | 2011-05-19 | Raqualia Pharma Inc. | Aryl carboxamide derivatives as ttx-s blockers |
| US9333202B2 (en) | 2012-05-01 | 2016-05-10 | The Trustees Of Columbia University In The City Of New York | Non-retinoid antagonists for treatment of age-related macular degeneration and stargardt disease |
| WO2014151936A1 (en) | 2013-03-14 | 2014-09-25 | The Trustees Of Columbia University In The City Of New York | Octahydropyrrolopyrroles, their preparation and use |
| ES2705247T3 (es) * | 2013-03-14 | 2019-03-22 | Univ Columbia | 4-fenilpiperidinas, su preparación y uso |
| EP2968303B1 (en) | 2013-03-14 | 2018-07-04 | The Trustees of Columbia University in the City of New York | Octahydrocyclopentapyrroles, their preparation and use |
| US9938291B2 (en) | 2013-03-14 | 2018-04-10 | The Trustess Of Columbia University In The City Of New York | N-alkyl-2-phenoxyethanamines, their preparation and use |
| US9981942B2 (en) * | 2013-12-20 | 2018-05-29 | Laboratorios Del Dr. Esteve S.A. | Piperidine derivatives having multimodal activity against pain |
| AU2015253232B2 (en) | 2014-04-30 | 2020-10-01 | The Trustees Of Columbia University In The City Of New York | Substituted 4-phenylpiperidines, their preparation and use |
| TW201938171A (zh) | 2017-12-15 | 2019-10-01 | 匈牙利商羅特格登公司 | 作為血管升壓素Ｖ１ａ受體拮抗劑之三環化合物 |
| HU231206B1 (hu) | 2017-12-15 | 2021-10-28 | Richter Gedeon Nyrt. | Triazolobenzazepinek |
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2006
- 2006-07-19 AU AU2006274884A patent/AU2006274884B2/en not_active Ceased
- 2006-07-19 WO PCT/EP2006/064395 patent/WO2007014851A2/en not_active Ceased
- 2006-07-19 CA CA002616937A patent/CA2616937A1/en not_active Abandoned
- 2006-07-19 KR KR1020087002304A patent/KR101020351B1/ko not_active Expired - Fee Related
- 2006-07-19 JP JP2008523320A patent/JP2009502859A/ja active Pending
- 2006-07-19 RU RU2008101962/04A patent/RU2422442C2/ru not_active IP Right Cessation
- 2006-07-19 CN CN2011101694158A patent/CN102295636A/zh active Pending
- 2006-07-19 EP EP06792523A patent/EP1917255A2/en not_active Withdrawn
- 2006-07-19 BR BRPI0614692-9A patent/BRPI0614692A2/pt not_active IP Right Cessation
- 2006-07-19 EP EP11176364A patent/EP2392571A3/en not_active Withdrawn
- 2006-07-19 MX MX2008001292A patent/MX2008001292A/es active IP Right Grant
- 2006-07-25 US US11/492,312 patent/US7781436B2/en not_active Expired - Fee Related
- 2006-07-25 TW TW095127125A patent/TWI314147B/zh not_active IP Right Cessation
- 2006-07-27 AR ARP060103244A patent/AR057086A1/es not_active Application Discontinuation
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2008
- 2008-01-18 NO NO20080316A patent/NO20080316L/no not_active Application Discontinuation
- 2008-01-21 IL IL188928A patent/IL188928A0/en unknown
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2010
- 2010-05-13 US US12/779,099 patent/US20100222357A1/en not_active Abandoned
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2011
- 2011-10-27 US US13/282,520 patent/US20120040990A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| KR20080027897A (ko) | 2008-03-28 |
| RU2008101962A (ru) | 2009-09-10 |
| EP2392571A3 (en) | 2012-03-14 |
| EP2392571A2 (en) | 2011-12-07 |
| MX2008001292A (es) | 2008-03-25 |
| US20100222357A1 (en) | 2010-09-02 |
| US20120040990A1 (en) | 2012-02-16 |
| CN102295636A (zh) | 2011-12-28 |
| TW200740790A (en) | 2007-11-01 |
| WO2007014851A2 (en) | 2007-02-08 |
| EP1917255A2 (en) | 2008-05-07 |
| US7781436B2 (en) | 2010-08-24 |
| IL188928A0 (en) | 2008-08-07 |
| RU2422442C2 (ru) | 2011-06-27 |
| US20070027163A1 (en) | 2007-02-01 |
| WO2007014851A3 (en) | 2007-05-31 |
| BRPI0614692A2 (pt) | 2009-05-19 |
| AU2006274884A1 (en) | 2007-02-08 |
| NO20080316L (no) | 2008-02-13 |
| TWI314147B (en) | 2009-09-01 |
| CA2616937A1 (en) | 2007-02-08 |
| KR101020351B1 (ko) | 2011-03-08 |
| JP2009502859A (ja) | 2009-01-29 |
| AU2006274884B2 (en) | 2012-04-05 |
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