AR057005A1 - Derivados de 4-fenil-5-oxo-1,4,5,6,7,8-hexahidroquinolina, una composicion farmaceutica y uso del compuesto para preparar un medicamento - Google Patents
Derivados de 4-fenil-5-oxo-1,4,5,6,7,8-hexahidroquinolina, una composicion farmaceutica y uso del compuesto para preparar un medicamentoInfo
- Publication number
- AR057005A1 AR057005A1 ARP060101779A ARP060101779A AR057005A1 AR 057005 A1 AR057005 A1 AR 057005A1 AR P060101779 A ARP060101779 A AR P060101779A AR P060101779 A ARP060101779 A AR P060101779A AR 057005 A1 AR057005 A1 AR 057005A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- 4alkyl
- alkoxy
- substituents selected
- optionally substituted
- Prior art date
Links
- GTFDKLAZHJQLIA-UHFFFAOYSA-N 4-phenyl-4,6,7,8-tetrahydro-1h-quinolin-5-one Chemical class O=C1CCCC(NC=C2)=C1C2C1=CC=CC=C1 GTFDKLAZHJQLIA-UHFFFAOYSA-N 0.000 title abstract 3
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 229940126601 medicinal product Drugs 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 34
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 19
- 125000001424 substituent group Chemical group 0.000 abstract 13
- 125000000592 heterocycloalkyl group Chemical group 0.000 abstract 10
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 9
- 229910052736 halogen Inorganic materials 0.000 abstract 8
- 150000002367 halogens Chemical class 0.000 abstract 8
- -1 hydroxy, amino Chemical group 0.000 abstract 8
- 125000003282 alkyl amino group Chemical group 0.000 abstract 7
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 7
- 125000005842 heteroatom Chemical group 0.000 abstract 7
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 7
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 7
- 125000003118 aryl group Chemical group 0.000 abstract 6
- 125000004366 heterocycloalkenyl group Chemical group 0.000 abstract 6
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 5
- 125000003545 alkoxy group Chemical group 0.000 abstract 5
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 5
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 4
- 125000003342 alkenyl group Chemical group 0.000 abstract 4
- 125000000304 alkynyl group Chemical group 0.000 abstract 4
- 125000004769 (C1-C4) alkylsulfonyl group Chemical group 0.000 abstract 3
- 125000004457 alkyl amino carbonyl group Chemical group 0.000 abstract 3
- 125000006254 cycloalkyl carbonyl group Chemical group 0.000 abstract 3
- 125000001072 heteroaryl group Chemical group 0.000 abstract 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
- 125000004916 (C1-C6) alkylcarbonyl group Chemical group 0.000 abstract 2
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 2
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 abstract 2
- 125000005092 alkenyloxycarbonyl group Chemical group 0.000 abstract 2
- 125000004414 alkyl thio group Chemical group 0.000 abstract 2
- 125000005133 alkynyloxy group Chemical group 0.000 abstract 2
- 125000004103 aminoalkyl group Chemical group 0.000 abstract 2
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 2
- 125000005223 heteroarylcarbonyl group Chemical group 0.000 abstract 2
- 125000006645 (C3-C4) cycloalkyl group Chemical group 0.000 abstract 1
- 125000005090 alkenylcarbonyl group Chemical group 0.000 abstract 1
- 125000003302 alkenyloxy group Chemical group 0.000 abstract 1
- 125000004448 alkyl carbonyl group Chemical group 0.000 abstract 1
- 125000005087 alkynylcarbonyl group Chemical group 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 125000005143 heteroarylsulfonyl group Chemical group 0.000 abstract 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
- 208000000509 infertility Diseases 0.000 abstract 1
- 230000036512 infertility Effects 0.000 abstract 1
- 231100000535 infertility Toxicity 0.000 abstract 1
- 125000003884 phenylalkyl group Chemical group 0.000 abstract 1
- 125000003170 phenylsulfonyl group Chemical group C1(=CC=CC=C1)S(=O)(=O)* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Diabetes (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
La presente se refiere a composiciones farmacéuticas que comprenden dichos derivados, y además al uso de estos derivados de 4-fenil-5-oxo-1,4,5,6,7,8-hexahidro-quinolina para preparar un medicamento específicamente para el tratamiento de la infertilidad. Reivindicacion 1: Un derivado de 4-fenil-5-oxo-l,4,5,6,7,8-hexahidroquinolina caracterizado porque tiene la formula (1), o una sal farmacéuticamente aceptable del mismo, donde: R1 es alquilo C1-6, alquenilo C2-6 o alquinilo C2-6; R2, R3 son independientemente halogeno, alquilo C1-4, alquenilo C2-4, alquinilo C2-4, alcoxi C1-4, alqueniloxi C3-4 o alquiniloxi C3-4; R4 es fenilo o heteroarilo C2-5, ambos sustituidos con R7 y opcionalmente sustituidos en el anillo (hetero)aromático con uno o más sustituyentes seleccionados entre hidroxi, amino, halogeno, nitro, trifluorometilo, ciano, alquilo C1-4, alcoxi C1-4, alquiltio C1-4 y di-alquilaminoC1-4; R7 es H, alquiltio C1-4, alquilsulfonilo C1-4, di-alquilaminoC1-4 , R8R9-amino, R10R11-aminocarbonilo, R12R13-amino-alquilcarbonilaminoC1-4, R14R15- amino-alquiloC1-4, R16-oxi, R17R18-aminocarbonil-alcoxiC1-4, R19-oxi-alquiloCl-4, R19-oxicarbonil-alquiloC1-4, R20R21-aminosulfonilo, R20-oxisulfonilo, aminoiminometilo, di- alquilC1-4-aminoiminometilo o heterocicloalquiliminometilo C2-6, trifluorometilsulfonilo; R23-oxicarbonilo, R23-carbonilo o R23R24-aminocarbonilo; R8 es H o alquilo C1-4; R9 es alquilsulfonilo C1-4, alquilcarbonilo C1-6, alquenilcarbonilo C2-6, alquinilcarbonilo C2-6, cicloalquilcarbonilo C3-6, cicloalquilC3-6-alquilcarboniloC1-4, alcoxicarbonilo C1-4, alqueniloxicarbonilo C3-4, alquiniloxiC3-4-carbonilo, di-alquilaminocarboniloC1-4, heterocicloC2-6-alquilcarbonilo, alquilo C5-8, cicloalquilo C3-6, cicloalquilC3-6-alquiloC1-4, di-alquilaminoC1-4-alquiloC2-4, heterocicloalquilC2-6-alquiloC2-4 o fenilcarbonilo, fenil-sulfonilo, fenil-alcoxiC1-4-alquilcarboniloC1-4, fenil-alquiloC1-4, heteroarilcarbonilo C2-5, heteroarilsulfonilo C2-5, heteroarilC2-5-alquiloC1-4, opcionalmente sustituidos en el anillo (hetero)aromático con uno o más sustituyentes seleccionados entre hidroxi, amino, halogeno, nitro, trifluorometilo, ciano, alquilo C1-4, alcoxi C1-4 o di- alquilaminoC1-4; R10 es H o alquilo C1-4; R11 es hidroxi-alquiloC2-4, amino-alquiloC2-4, alcoxiC1-4-alquiloC2-4 o di-alquilaminoC1-4-alquiloC2-4; o R10R11 en R10R11-aminocarbonilo pueden estar unidos en un anillo heterocicloalquenilo C4-6 o un anillo heterocicloalquilo C2-6 sustituido con uno o más sustituyentes seleccionados entre alquilo C1-4, alcoxiC1-4-alquiloC1-4 e hidroxi-alquiloC1-4; R12, R13 son independientemente H, alquilo C1-6, alquenilo C2-6, alquinilo C2-6, cicloalquilo C3-6, hidroxi-alquiloC2-4, alcoxiC1-4-alquiloC2-4, cicloalquilC3-6-alquiloC1-4, heterocicloalquilC1-4-alquiloC1-4, amino-alquiloC2-4, di-alquilaminoC1-4-alquiloC2-4 o fenilo-alquiloC1-4, heteroarilC2-5-alquiloC1-4, opcionalmente sustituidos en el anillo (hetero)aromático con uno o más sustituyentes seleccionados entre hidroxi, amino, halogeno, nitro, trifluorometilo, ciano, alquilo C1-4, alcoxi C1-4 y di-alquilaminoC1-4; o R12R13 en R12R13-amino-alquilcarbonilaminoC1-4 pueden estar unidos en un anillo heterocicloalquenilo C4-6 o un anillo heterocicloalquilo C2-6, opcionalmente sustituido con uno o más sustituyentes seleccionados entre alquilo C1-4, alcoxiC1-4-alquiloC1-4 e hidroxi-alquiloC1-4; R14, R15 son independientemente H, alquilo C1- 6, heterocicloalquilC2-6-alquiloC1-4, cicloalquilC3-6-alquiloC1-4, alcoxiC1-4-alquiloC2-4, hidroxi-alquiloC2-4, di-alquilaminoC1-4-alquiloC2-4, amino-alquiloC2-4, alcoxicarbonilC1-4-alquilo C1-4, alquilcarbonilo C1-6, cicloalquilcarbonilo C3-6, alcoxicarbonilo C1-4, alqueniloxiC3-4-carbonilo, di-alquilaminocarboniloC1-4, heterocicloC2-6-alquilcarbonilo o heteroarilC2-5-alquiloC1-4, fenil-alquiloC1-4, heteroarilcarbonilo C2-5, fenilcarbonilo, opcionalmente sustituidos en el anillo (hetero)aromático con uno o más sustituyentes seleccionados entre hidroxi, amino, halogeno, nitro, trifluorometilo, ciano, alquilo C1-4, alcoxi C1-4, y di-alquilaminoC1-4; o R14R15 en R14R15-amino-alquilo C1-4 pueden estar unidos en un anillo heterocicloalquenilo C4-6 o un anillo heterocicloalquilo C2-6, opcionalmente sustituidos con uno o más sustituyentes seleccionados entre alquilo C1-4, alcoxiC1-4-alquiloC1-4 e hidroxi-alquiloC1-4; R16 es heterocicloalquilC2-6-alquiloC1-4, di- alquilaminoC1-4-alquiloC2-4, alcoxiC2-4-alquilo C1-4, hidroxi-alquiloC2-4, amino-alquiloC2-4, hidroxicarbonil-alquiloC1-4, alcoxicarbonilC1-4-alquiloC1-4, alcoxiC1-4-carbonilo, alqueniloxicarbonilo C3-4, alquiniloxiC3-4-carbonilo, di- alquilaminocarboniloC1-4, heterocicloC2-6-alquilcarbonilo, o fenil-alquiloC1-4, heteroarilC2-5-alquilo C1-4, opcionalmente sustituidos en el anillo (hetero)aromático con uno o más sustituyentes seleccionados entre hidroxi, amino, halogeno, nitro, trifluorometilo, ciano, alquilo C1-4, alcoxi C1-4 y di-alquilaminoC1-4; R17, R18 son independientemente H, alquilo C1-6, cicloalquilC3-6-alquiloC1-4, alcoxiC1-4-alquiloC2-4, hidroxi-alquiloC2-4, amino-alquiloC2-4, di-alquilaminoC1-4-alquiloC2-4, heterocicloalquilC2-6-alquiloC2-4, o fenil-alquiloC1-4, heteroarilC2-5-alquilo C1-4, opcionalmente sustituidos en el anillo (hetero)aromático con uno o más sustituyentes seleccionados entre hidroxi, amino, halogeno, nitro, trifluorometilo, ciano, alquilo C1-4, alcoxi C1-4 y di-alquilaminoC1-4; o R17R18 en R17R18-aminocarbonil-alcoxiC1-4 pueden estar unidos en un anillo heterocicloalquenilo C4-6 o un anillo heterocicloalquilo C2-6, opcionalmente sustituidos con uno o más sustituyentes seleccionados entre alquilo C1-4, alcoxiC1-4-alquiloC1-4 e hidroxi-alquiloC1-4; R19 es H o alquilo C1-6; R20, R21 son independientemente H, alquilo C1-6, alquenilo C1-6, alquinilo C1-6 o alcoxiC1-4-alquiloC1-4; o R20R21 en R20R21-aminosulfonilo pueden estar unidos en un anillo heterocicloalquenilo C4-6 o un anillo heterocicloalquilo C2-6, opcionalmente sustituido con uno o más sustituyentes seleccionados entre alquilo C1-4, alcoxiC1-4-alquiloC1-4 e hidroxi-alquilo C1-4; X es O o N-R22; Y es CH2, C(O) o SO2; Z es CN o NO2; R22 es H, alquilo C1-4; R23, R24 son independientemente H, alquilo C1-4, alquenilo C2-4, alquinilo C2-4, cicloalquilo C3-6, cicloalquilC3-6-alquiloC1-4, heterocicloalquilo C2-6, heterocicloalquilC2-6-alquiloC1-4, alcoxicarbonilC1-4-alquiloC1-4, di-alquilaminocarbonilC1-4-alquiloC1-4 o fenilaminocarbonil-alquiloC1-4, heteroarilaminocarbonilC2-5-alquiloC1-4, fenilo, heteroarilo C2-5, fenilo-alquiloC1-4, heteroarilC2-5-alquiloC1-4, opcionalmente sustituidos en el (hetero)átomo con uno o más sustituyentes seleccionados entre hidroxi, amino, halogeno, nitro, trifluorometilo, ciano, alquiloC1-4, alquenilo C2-4, alquinilo C2-4, alcoxiC1-4 y di-alquilaminoC1-4-; o R23R24 en R23R24-aminocarbonilo pueden estar unidos en un anillo heterocicloalquenilo C4-6 o un anillo heterocicloalquilo C2-6, opcionalmente sustituido con uno o más sustituyentes seleccionados entre alquilo C1-4, alcoxiC1-4-alquiloC1-4 e hidroxi-alquiloC1-4; con la salvedad de que los compuestos de formula (1) donde X es O, R4 es fenilo y R7 es seleccionado entre H, alquiltio C1-4, alquilsulfonilo C1-4, di-alquilaminoC1-4, R23-oxicarbonilo, R23-carbonilo y R23R24-aminocarbonilo, y los compuestos de formula (1) donde X es O, R4 es heteroarilo C2-5 y R7 es H o di-alquilaminoC1-4, están excluidos.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05103735 | 2005-05-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR057005A1 true AR057005A1 (es) | 2007-11-07 |
Family
ID=34939693
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP060101779A AR057005A1 (es) | 2005-05-04 | 2006-05-03 | Derivados de 4-fenil-5-oxo-1,4,5,6,7,8-hexahidroquinolina, una composicion farmaceutica y uso del compuesto para preparar un medicamento |
Country Status (29)
| Country | Link |
|---|---|
| US (1) | US8022218B2 (es) |
| EP (1) | EP1881830B1 (es) |
| JP (1) | JP5129737B2 (es) |
| KR (1) | KR20080010426A (es) |
| CN (1) | CN101212973B (es) |
| AR (1) | AR057005A1 (es) |
| AT (1) | ATE410166T1 (es) |
| AU (1) | AU2006243868B2 (es) |
| BR (1) | BRPI0611120A2 (es) |
| CA (1) | CA2606683C (es) |
| CY (1) | CY1108632T1 (es) |
| DE (1) | DE602006003094D1 (es) |
| DK (1) | DK1881830T3 (es) |
| ES (1) | ES2314908T3 (es) |
| HR (1) | HRP20080667T3 (es) |
| IL (1) | IL186748A (es) |
| MX (1) | MX2007013751A (es) |
| NO (1) | NO20075617L (es) |
| NZ (1) | NZ562686A (es) |
| PE (1) | PE20061363A1 (es) |
| PL (1) | PL1881830T3 (es) |
| PT (1) | PT1881830E (es) |
| RS (1) | RS50707B (es) |
| RU (1) | RU2412170C2 (es) |
| SI (1) | SI1881830T1 (es) |
| TW (1) | TW200719894A (es) |
| UA (1) | UA92007C2 (es) |
| WO (1) | WO2006117368A1 (es) |
| ZA (1) | ZA200709090B (es) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA92009C2 (ru) * | 2005-05-04 | 2010-09-27 | Н.В. Органон | Производные 4-фенил-5-оксо-1,4,5,6,7,8-гексагидрохинолина для лечения бесплодия |
| CA2606521C (en) * | 2005-05-04 | 2012-09-18 | N.V. Organon | Dihydropyridine derivatives |
| UA92008C2 (en) * | 2005-05-04 | 2010-09-27 | Н.В. Органон | 4-PHENYL-5-OXO-l,4,5,6,7,8-HEXAHYDROQUINOLINE DERIVATIVES AS MEDICAMENTS FOR THE TREATMENT OF INFERTILITY |
| TW200944523A (en) | 2008-02-08 | 2009-11-01 | Organon Nv | (Dihydro)pyrrolo[2,1-a]isoquinolines |
| US8071587B2 (en) | 2009-05-27 | 2011-12-06 | N. V. Organon | (Dihydro)imidazoiso[5,1-A]quinolines |
| US8431564B2 (en) | 2009-07-29 | 2013-04-30 | Merck Sharp & Dohme B.V. | Ring-annulated dihydropyrrolo[2,1-α]isoquinolines |
| TW201116531A (en) | 2009-07-29 | 2011-05-16 | Organon Nv | Ring-annulated dihydropyrrolo[2,1-a]isoquinolines |
| TW201116515A (en) | 2009-07-31 | 2011-05-16 | Organon Nv | Dihydrobenzoindazoles |
| JP5976011B2 (ja) | 2011-04-05 | 2016-08-23 | 武田薬品工業株式会社 | スルホンアミド誘導体およびその用途 |
| WO2014083383A1 (en) * | 2012-11-28 | 2014-06-05 | Stichting Dienst Landbouwkundig Onderzoek | Substituted dihydropyrtoines for somatic embryogenesis iν plants |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1070162B (de) | 1959-12-03 | Farbwerke Hoechst Aktiengesellschaft vormals Meister Lucius &. Brüning, Frankfurt/M | Verfahren zur Herstellung von 5 - Brom - 3 - nitro - 4 - hydroxybenzaldehyd bzw. 5 - Chlor - 3 - nitro - 4 - hydroxybenzaldehyd | |
| GB9318935D0 (en) * | 1992-10-20 | 1993-10-27 | Zeneca Ltd | Heterocyclic derivatives |
| US5455253A (en) * | 1992-10-20 | 1995-10-03 | Zeneca Limited | Heterocyclic derivatives |
| DE4430639A1 (de) * | 1994-08-29 | 1996-03-07 | Bayer Ag | Verwendung von 5-substituierten Pyridin- und Hexahydrochinolin-3-carbonsäurederivaten |
| GB9515445D0 (en) | 1995-07-27 | 1995-09-27 | Pharmacia Spa | Dihydropyridine and pyridine derivatives and process for their preparation |
| CA2229201A1 (en) * | 1995-10-19 | 1997-04-24 | Satoshi Sasaki | Quinoline derivatives, their production and use |
| US6593335B1 (en) * | 1997-12-18 | 2003-07-15 | Abbott Laboratories | Potassium channel openers |
| IL141063A (en) | 1998-08-07 | 2005-06-19 | Applied Research Systems | Derivatives of pyrrolidine-2-carboxylic acid and piperidine-2-carboxylic acids and pharmaceutical compositions comprising said derivatives for treating infertility |
| WO2002009706A1 (en) | 2000-07-27 | 2002-02-07 | Smithkline Beecham Corporation | Agonists of follicle stimulating hormone activity |
| JP4523273B2 (ja) * | 2001-07-02 | 2010-08-11 | ナームローゼ・フエンノートチヤツプ・オルガノン | テトラヒドロキノリン誘導体 |
| JP2003026630A (ja) | 2001-07-13 | 2003-01-29 | Taoka Chem Co Ltd | カラーカプラー中間体用カルボン酸クロリド類の製造法 |
| TWI322012B (en) | 2002-12-20 | 2010-03-21 | Organon Nv | Tetrahydroquinoline derivatives |
| CA2606521C (en) * | 2005-05-04 | 2012-09-18 | N.V. Organon | Dihydropyridine derivatives |
| UA92008C2 (en) * | 2005-05-04 | 2010-09-27 | Н.В. Органон | 4-PHENYL-5-OXO-l,4,5,6,7,8-HEXAHYDROQUINOLINE DERIVATIVES AS MEDICAMENTS FOR THE TREATMENT OF INFERTILITY |
| UA92009C2 (ru) * | 2005-05-04 | 2010-09-27 | Н.В. Органон | Производные 4-фенил-5-оксо-1,4,5,6,7,8-гексагидрохинолина для лечения бесплодия |
-
2006
- 2006-02-05 UA UAA200711802A patent/UA92007C2/ru unknown
- 2006-05-02 AU AU2006243868A patent/AU2006243868B2/en not_active Ceased
- 2006-05-02 HR HR20080667T patent/HRP20080667T3/xx unknown
- 2006-05-02 BR BRPI0611120-3A patent/BRPI0611120A2/pt not_active IP Right Cessation
- 2006-05-02 SI SI200630157T patent/SI1881830T1/sl unknown
- 2006-05-02 CN CN2006800237595A patent/CN101212973B/zh not_active Expired - Fee Related
- 2006-05-02 ES ES06743394T patent/ES2314908T3/es active Active
- 2006-05-02 PT PT06743394T patent/PT1881830E/pt unknown
- 2006-05-02 RS RSP-2008/0582A patent/RS50707B/sr unknown
- 2006-05-02 EP EP06743394A patent/EP1881830B1/en active Active
- 2006-05-02 JP JP2008509434A patent/JP5129737B2/ja not_active Expired - Fee Related
- 2006-05-02 WO PCT/EP2006/061972 patent/WO2006117368A1/en not_active Ceased
- 2006-05-02 KR KR1020077026919A patent/KR20080010426A/ko not_active Ceased
- 2006-05-02 RU RU2007144989/04A patent/RU2412170C2/ru not_active IP Right Cessation
- 2006-05-02 US US11/912,736 patent/US8022218B2/en active Active
- 2006-05-02 DE DE602006003094T patent/DE602006003094D1/de active Active
- 2006-05-02 DK DK06743394T patent/DK1881830T3/da active
- 2006-05-02 MX MX2007013751A patent/MX2007013751A/es active IP Right Grant
- 2006-05-02 PL PL06743394T patent/PL1881830T3/pl unknown
- 2006-05-02 NZ NZ562686A patent/NZ562686A/en not_active IP Right Cessation
- 2006-05-02 AT AT06743394T patent/ATE410166T1/de active
- 2006-05-02 CA CA2606683A patent/CA2606683C/en not_active Expired - Fee Related
- 2006-05-03 PE PE2006000464A patent/PE20061363A1/es not_active Application Discontinuation
- 2006-05-03 AR ARP060101779A patent/AR057005A1/es unknown
- 2006-05-03 TW TW095115774A patent/TW200719894A/zh unknown
-
2007
- 2007-10-18 IL IL186748A patent/IL186748A/en not_active IP Right Cessation
- 2007-10-22 ZA ZA200709090A patent/ZA200709090B/xx unknown
- 2007-11-06 NO NO20075617A patent/NO20075617L/no not_active Application Discontinuation
-
2008
- 2008-12-22 CY CY20081101479T patent/CY1108632T1/el unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PE20070218A1 (es) | COMPUESTOS DE CICLOALQUILO AMINO-HIDANTOINA Y USO DE ESTOS PARA LA MODULACION DE ß-SECRETASA | |
| EA200970461A1 (ru) | ЗАМЕЩЕННЫЕ ПРОИЗВОДНЫЕ 3-ИЗОБУТИЛ-9,10-ДИМЕТОКСИ-1,3,4,6,7,11b-ГЕКСАГИДРО-2Н-ПИРИДО[2,1-a]ИЗОХИНОЛИН-2-ОЛА И СВЯЗАННЫЕ С НИМИ СПОСОБЫ | |
| AR084768A1 (es) | Moduladores de la senda de complemento y usos de los mismos | |
| AR038240A1 (es) | Compuesto de piperidina, uso del mismo para la fabricacion de un medicamento, composicion farmaceutica que lo comprende y procedimiento para su preparacion | |
| AR040031A1 (es) | Compuestos de pirazol-pirimidina anilina utiles como inhibidores de cinasa y composiciones farmaceuticas que los contienen | |
| AR042956A1 (es) | Inhibidores de girasa y usos de los mismos | |
| AR033379A1 (es) | Compuestos de difenilurea, procedimiento para su preparacion y composiciones farmaceuticas que los contienen | |
| ES2328820T3 (es) | Derivados de 4-(pirazol-3-ilamino)pirimidina para uso en el tratamiento de cancer. | |
| ECSP105253A (es) | Derivados de 5-feniltiazol y uso como inhibidores de pi3 cinasa | |
| PE20090042A1 (es) | Analogos de ciclopamina | |
| AR065811A1 (es) | Derivados de 2-amino-4h-imidazol-4-ona,composiciones farmaceuticas que los contienen y usos para el tratamiento de la enfermedad de alzheimer y otros trastornos neurodegenerativos. | |
| AR083367A1 (es) | Compuestos de tipo quinazolinona como antagonistas de crth | |
| AR058287A1 (es) | Derivados de isoquinolina y composicion farmaceutica | |
| AR036032A1 (es) | Compuesto derivado de quinolina, composicion que lo comprende; uso del mismo en la fabricacion de medicamentos, proceso para prepararlo, y metodo para detectar y seleccionar un agente que module la actividad del mif | |
| AR020551A2 (es) | Compuestos macrolidos, composiciones y su uso para la preparacion de medicamentos. | |
| AR070345A1 (es) | (dihidro ) pirrolo (2,1-a) isoquinolinas | |
| AR054481A1 (es) | Derivados de 2-azetidinonas como inhibidores de la absorcion de colesterol | |
| AR037681A1 (es) | Antagonistas receptores de adenosina a2a de 5-amino-[1,2,4]-triazol biciclico, composiciones farmaceuticas que los comprenden, el uso de las mismas, solo o en combinacion de los compuestos y otros agentes para la preparacion de medicamentos utiles en el tratamiento de la enfermedad de parkinson y un | |
| AR045819A1 (es) | Derivados de benzimidazol composiciones que los contienen, preparacion de los mismos y usos de los mismos | |
| ECSP066948A (es) | Benzoxazinas para el tratamiento de enfermedades de las vías respiratorias | |
| ECSP066947A (es) | Combinaciones farmacológicas que contienen benzoxazina para el tratamiento de enfermedades de las vías respiratorias | |
| AR057005A1 (es) | Derivados de 4-fenil-5-oxo-1,4,5,6,7,8-hexahidroquinolina, una composicion farmaceutica y uso del compuesto para preparar un medicamento | |
| AR049711A1 (es) | Compuestos heterociclicos condensados como inhibidores de la aldosterona sintasa; composiciones farmaceuticas que los contienen y su uso en la preparacion de un medicamento para el tratamiento o prevencion de enfermedades relacionadas con el hiperaldosterismo y por una liberacion excesiva de cortiso | |
| UY27803A1 (es) | Derivados de benzoxazina y usos de los mismos. | |
| AR050698A1 (es) | Compuesto de benzazepina, composicion farmaceutica que lo comprende, su uso para la fabricacion de un medicamento y procedimiento para la preparacion de dicho compuesto |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |