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AR056943A1 - DERIVADOS DE AMIDAS, ISoMEROS DE LOS MISMOS O LAS SALES FARMACÉUTICAMENTE ACEPTABLES DE LOS MISMOS COMO EL ANTAGONISTA DEL RECEPTOR VANILOIDE Y LAS COMPOSICIONES FARMACÉUTICAS QUE CONTIENEN LOS MISMOS - Google Patents

DERIVADOS DE AMIDAS, ISoMEROS DE LOS MISMOS O LAS SALES FARMACÉUTICAMENTE ACEPTABLES DE LOS MISMOS COMO EL ANTAGONISTA DEL RECEPTOR VANILOIDE Y LAS COMPOSICIONES FARMACÉUTICAS QUE CONTIENEN LOS MISMOS

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Publication number
AR056943A1
AR056943A1 ARP060101058A ARP060101058A AR056943A1 AR 056943 A1 AR056943 A1 AR 056943A1 AR P060101058 A ARP060101058 A AR P060101058A AR P060101058 A ARP060101058 A AR P060101058A AR 056943 A1 AR056943 A1 AR 056943A1
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AR
Argentina
Prior art keywords
alkyl
same
hydrogen
alkylsulfonyl
halo
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Application number
ARP060101058A
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English (en)
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Amorepacific Corp
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Publication date
Application filed by Amorepacific Corp filed Critical Amorepacific Corp
Publication of AR056943A1 publication Critical patent/AR056943A1/es

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    • C07C275/24—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing six-membered aromatic rings
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    • A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
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    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
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  • Vascular Medicine (AREA)
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  • Ophthalmology & Optometry (AREA)
  • Epidemiology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyrane Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

REIVINDICACIoN 1.- Un compuesto de la formula (1), un isomero y/o una sal farmacéuticamente aceptable del mismo; donde X es CR11=CR12, o C=C, donde, R11 y R12 son independientemente hidrogeno, halogeno, C1-C5 alquilo, o fenilo; R1 y R2 son independientemente hidrogeno, carboxi, C1-C5 alquilo, halogeno, nitro, C1-C5 alcoxi, halo (C1-C5) alquilo, C1-C5 alquilcarbonilo, C1-C5 alquilcarbonilamino, C1-C5 alquilsulfonilamino, fenilsulfonilamino, C1-C5 alquiltio, C1-C5 alquilsulfonilo, o C1- C5 alcoxicarbonilo; R3 es hidrogeno, C1-C5 alquilo, C1-C5 alcoxi, o halo (C1-C5) alquilo; R4, R5, R6, R7 y R8 son independientemente hidrogeno, carboxi, C1-C5 alquilo, nitro, C2-C5 alquenilo, C1-C5 alcoxi, C2-C5 alquinilo, halo (C1-C5) alquilo, C1- C5 alquiltio, C1-C5 alquilsulfonilo, C1-C5 alquil carbonilo, C1-C5 alcoxicarbonilo, fenilo, o halogeno, donde, fenilo puede estar no substituido o substituido con uno o más substituyentes seleccionados de carboxi, C1-C5 alquilo, halogeno, nitro, C2- C5 alquenilo, C1-C5 alcoxi, halo (C1-C5) alquilo, C1-C5 alquil carbonilo, C1-C5 alquiltio, C1-C5 alquilsulfonilo, o C1-C5 alcoxi carbonilo; R9 es C1-C5 alquilsulfonilo o C2-C5 alquenilsulfonilo; y R10 es hidrogeno; excepto que si R3 es diferente de hidrogeno, entonces R11 y R12 no son simultáneamente hidrogeno. Los isomeros de los mismos o a las sales farmacéuticamente aceptables de los mismos como el antagonista del receptor vaniloide (Receptor Vaniloide 1; VR1; TRPV1); y una composicion farmacéutica que contiene a los mismos. La presente invencion proporciona una composicion farmacéutica para prevenir o tratar una enfermedad tal como el dolor, migrana, astralgia, neuralgia, neuropatías, herida en los nervios, desordenes de la piel, hipersensibilidad de la vejiga urinaria, síndrome del intestino irritable, urgencia fecal, un desorden respiratorio, irritacion de la piel, membrana del ojo o mucosa, ulcera duodenal-estomacal, enfermedades inflamatorias, enfermedad del oído y enfermedad del corazon.
ARP060101058A 2005-03-19 2006-03-17 DERIVADOS DE AMIDAS, ISoMEROS DE LOS MISMOS O LAS SALES FARMACÉUTICAMENTE ACEPTABLES DE LOS MISMOS COMO EL ANTAGONISTA DEL RECEPTOR VANILOIDE Y LAS COMPOSICIONES FARMACÉUTICAS QUE CONTIENEN LOS MISMOS AR056943A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR20050022986 2005-03-19
US66326905P 2005-03-21 2005-03-21

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AR056943A1 true AR056943A1 (es) 2007-11-07

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ARP060101058A AR056943A1 (es) 2005-03-19 2006-03-17 DERIVADOS DE AMIDAS, ISoMEROS DE LOS MISMOS O LAS SALES FARMACÉUTICAMENTE ACEPTABLES DE LOS MISMOS COMO EL ANTAGONISTA DEL RECEPTOR VANILOIDE Y LAS COMPOSICIONES FARMACÉUTICAS QUE CONTIENEN LOS MISMOS
ARP060101059A AR053561A1 (es) 2005-03-19 2006-03-17 Compuestos novedosos, isomeros de los mismos o las sales farmaceuticamente aceptables de los mismos como el antagonista del receptor vaniloide y las composiciones farmaceuticas que contienen los mismos

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ARP060101059A AR053561A1 (es) 2005-03-19 2006-03-17 Compuestos novedosos, isomeros de los mismos o las sales farmaceuticamente aceptables de los mismos como el antagonista del receptor vaniloide y las composiciones farmaceuticas que contienen los mismos

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US (2) US7763657B2 (es)
EP (2) EP1861357B1 (es)
JP (2) JP5159604B2 (es)
KR (2) KR101304981B1 (es)
AR (2) AR056943A1 (es)
AU (2) AU2006225496A1 (es)
BR (2) BRPI0608714A2 (es)
CA (2) CA2601871A1 (es)
EA (2) EA200702020A1 (es)
IL (2) IL185891A0 (es)
MX (2) MX2007011466A (es)
NO (2) NO20075354L (es)
TW (2) TW200716522A (es)
WO (2) WO2006101318A1 (es)

Families Citing this family (19)

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JP5159604B2 (ja) * 2005-03-19 2013-03-06 アモーレパシフィック コーポレイション バニロイド受容体拮抗薬としての新規な化合物、その異性体又はその薬剤学的に許容される塩、及びこれを含む医薬組成物
CA2658925C (en) 2006-07-27 2015-07-14 Amorepacific Corporation Novel sulfonylamino acrylamide derivatives, isomer thereof,or pharmaceutically acceptable salts thereof as vanilloid receptor antagonist; and pharmaceutical compositions containing the same
DE102007017884A1 (de) 2007-04-13 2008-10-16 Grünethal GmbH Neue Vanilloid-Rezeptor Liganden und ihre Verwendung zur Herstellung von Arzneimitteln
WO2009023025A1 (en) * 2007-08-13 2009-02-19 Board Of Trustees Of Southern Illinois University Methods for treatment and prevention of ototoxicity by sirna
KR101619341B1 (ko) * 2008-01-28 2016-05-11 (주)아모레퍼시픽 바닐로이드 수용체 길항체로서의 신규 화합물, 이의 이성질체 또는 약제학적으로 허용가능한 염, 및 이를 함유하는 약학 조성물
CA2721815C (en) * 2008-05-07 2014-06-10 Yasunori Tsuzuki Cyclic amine-1-carboxylic acid ester derivative and pharmaceutical composition containing the same
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