AR056121A1 - 4-oxi-n- [1.3.4 -tiadiazol-2-il-bencenosulfonamidas, procesos para su preparacion y su uso como productos farmaceuticos - Google Patents
4-oxi-n- [1.3.4 -tiadiazol-2-il-bencenosulfonamidas, procesos para su preparacion y su uso como productos farmaceuticosInfo
- Publication number
- AR056121A1 AR056121A1 ARP060104361A ARP060104361A AR056121A1 AR 056121 A1 AR056121 A1 AR 056121A1 AR P060104361 A ARP060104361 A AR P060104361A AR P060104361 A ARP060104361 A AR P060104361A AR 056121 A1 AR056121 A1 AR 056121A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- alkylene
- aryl
- trisubstituted
- unsubstituted
- Prior art date
Links
- 239000000825 pharmaceutical preparation Substances 0.000 title 1
- 229940127557 pharmaceutical product Drugs 0.000 title 1
- 125000002947 alkylene group Chemical group 0.000 abstract 12
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 9
- 125000003118 aryl group Chemical group 0.000 abstract 5
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 125000001072 heteroaryl group Chemical group 0.000 abstract 4
- 229910052794 bromium Inorganic materials 0.000 abstract 3
- 229910052801 chlorine Inorganic materials 0.000 abstract 3
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 3
- 229910052731 fluorine Inorganic materials 0.000 abstract 3
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 3
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 2
- 125000005915 C6-C14 aryl group Chemical group 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 125000006652 (C3-C12) cycloalkyl group Chemical group 0.000 abstract 1
- -1 O- C1-6 alkyl Chemical group 0.000 abstract 1
- 101100054666 Streptomyces halstedii sch3 gene Proteins 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000004366 heterocycloalkenyl group Chemical group 0.000 abstract 1
- 125000000592 heterocycloalkyl group Chemical group 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/01—Five-membered rings
- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
- C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
- C07D285/12—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/01—Five-membered rings
- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
- C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
- C07D285/12—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles
- C07D285/125—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
- C07D285/135—Nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/433—Thidiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Hospice & Palliative Care (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Reivindicacion 1: Compuestos de formula (1), en la que: R1 is alquilo C1-6, alquilenoC0-6-cicloalquiloC3-6, alquilenoC0-6-O-alquiloC1-6, alquilenoC0-6-O-cicloalquiloC3-6, alquilenoC0-6-ariloC6-14, alquilenoC0-6-heteroariloC5-15, donde los grupos alquilo, alquileno, arilo y cicloalquilo están sin sustituir o mono-, di- o trisustituidos con F, Cl, Br, alquilo C1-6, O-alquiloC1-6, CF3, OCF3, CN, CO-alquiloC1-6, COO-alquiloC1-6, CON(alquilenoC0-6-H)(alquilenoC0-6-H), o S(O)malquiloC1-6; R2, R3 son independientemente H, halogeno, alquilo C1-6, alquilenoC0-4-O-alquilenoC0-4-H, SCH3, o CN, donde los grupos alquilo y alquileno están sin sustituir o mono-, di- o trisustituidos con F; R4, R5, R6, R7 son independientemente H, alquilo C1-6, alquilenoC0-4-cicloalquiloC3-6, alquilenoC0-6-ariloC6-14, alquilenoC0-6-heteroariloC5-15, alquilenoC0-6-heterocicloalquiloC3-15, alquilenoC0-6-heterocicloalqueniloC3-15, donde los grupos alquilo, cicloalquilo, arilo, heterocicloalquilo, heterocicloalquenilo y heteroarilo están sin sustituir o mono-, di- o trisustituidos con F, Cl, Br, CF3, alquilo C1-4 y alquilenoC0-4-O-alquilenoC0-4-H; m es 0, 1; A es arilo C6-14, o heteroarilo C5-15; B es arilo C6-14, cicloalquilo C3-12, o heteroarilo C5-15; Z es un enlace, O; o el anillo A y el anillo juntos forman un sistema de anillos heterocíclicos C5-15 o aromáticos C8-14; y Z está ausente; R8, R9 son independientemente H, halogeno, alquilo C1-6, alquilenoC0-4-O-alquilenoC0-4-H, SCF3, SF5, S(O)2CF3, O-ariloC6-14, arilo C6-14, o NO2, donde los grupos alquilo y alquileno están sin sustituir o mono, bi- o trisustituidos con F y donde el grupo arilo está sin sustituir o mono-, di- o trisustituidos con F, Cl, Br, CF3, alquilo C1- 4 y alquilenoC0-4-O-alquilenoC0-4-H; p es 0, 1, 2 o3; q es 0, 1, o 2; en todas sus formas estereoisoméricas, formas enantioméricas y mezclas en cualquier relacion, y sus sales fisiologicamente aceptables y formas tautoméricas.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05021786 | 2005-10-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR056121A1 true AR056121A1 (es) | 2007-09-19 |
Family
ID=35455941
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP060104361A AR056121A1 (es) | 2005-10-06 | 2006-10-04 | 4-oxi-n- [1.3.4 -tiadiazol-2-il-bencenosulfonamidas, procesos para su preparacion y su uso como productos farmaceuticos |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US7910612B2 (es) |
| EP (1) | EP1937658A1 (es) |
| JP (1) | JP2009510144A (es) |
| KR (1) | KR20080053931A (es) |
| CN (1) | CN101277940A (es) |
| AR (1) | AR056121A1 (es) |
| AU (1) | AU2006299085A1 (es) |
| CA (1) | CA2624726A1 (es) |
| IL (1) | IL190460A0 (es) |
| MA (1) | MA29810B1 (es) |
| NO (1) | NO20081682L (es) |
| RU (1) | RU2008113210A (es) |
| TW (1) | TW200804324A (es) |
| WO (1) | WO2007039171A1 (es) |
| ZA (1) | ZA200801988B (es) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2008340756A1 (en) | 2007-12-26 | 2009-07-02 | Sanofi-Aventis | Cyclic pyridyl-N-(1,3,4)-thiadiazol-2-yl-benzene sulfonamides, processes for their preparation and their use as pharmaceuticals |
| CU24099B1 (es) | 2009-01-12 | 2015-06-30 | Pfizer Ltd | Derivados de sulfonamida para el tratamiento del dolor |
| GB0907551D0 (en) * | 2009-05-01 | 2009-06-10 | Univ Dundee | Treatment or prophylaxis of proliferative conditions |
| JP5872552B2 (ja) | 2010-07-09 | 2016-03-01 | ファイザー・リミテッドＰｆｉｚｅｒ Ｌｉｍｉｔｅｄ | 化学化合物 |
| WO2012122368A1 (en) * | 2011-03-08 | 2012-09-13 | The Regents Of The University Of California | Deoxycytidine kinase binding compounds |
| TN2018000385A1 (en) | 2016-05-20 | 2020-06-15 | Xenon Pharmaceuticals Inc | Benzenesulfonamide compounds and their use as therapeutic agents |
| WO2017202376A1 (zh) * | 2016-05-26 | 2017-11-30 | 南京明德新药研发股份有限公司 | 磺酰胺衍生物 |
| SG10201912376VA (en) | 2016-12-09 | 2020-02-27 | Xenon Pharmaceuticals Inc | Benzenesulfonamide compounds and their use as therapeutic agents |
| MX2020008188A (es) | 2018-02-02 | 2020-11-18 | Maverix Oncology Inc | Conjugados de fármacos de molécula pequeña de monofosfato de gemcitabina. |
| BR112020024729A2 (pt) | 2018-06-13 | 2021-03-23 | Xenon Pharmaceuticals, Inc. | compostos de benzenossulfonamida e seu uso como agentes terapêuticos |
| JP7383012B2 (ja) | 2018-08-31 | 2023-11-17 | ゼノン・ファーマシューティカルズ・インコーポレイテッド | ヘテロアリール置換スルホンアミド化合物、およびナトリウムチャネル阻害剤としてのその使用 |
| IL279810B2 (en) | 2018-08-31 | 2025-03-01 | Xenon Pharmaceuticals Inc | Heteroaryl-modified sulfonamide compounds and their use as medicinal agents |
| PE20231656A1 (es) | 2020-11-02 | 2023-10-17 | Trethera Corp | Formas cristalinas de un inhibidor de cinasa de desoxicitidina y sus usos |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA200400708A1 (ru) * | 2001-11-22 | 2004-10-28 | Биовитрум Аб | Ингибиторы 11-бета-гидроксистероиддегидрогеназы типа 1 |
| WO2004103980A1 (en) * | 2003-05-21 | 2004-12-02 | Biovitrum Ab | Inhibitors of 11-beta-hydroxy steroid dehydrogenase type i |
| US7173030B2 (en) * | 2003-05-21 | 2007-02-06 | Biovitrum Ab | Inhibitors of 11-β-hydroxy steroid dehydrogenase type 1 |
| WO2005005421A1 (en) * | 2003-07-08 | 2005-01-20 | Novartis Ag | Benzenesulfonylamino compounds and pharmaceutical compositions containing these compounds |
| CN1909902A (zh) * | 2003-12-22 | 2007-02-07 | 伊莱利利公司 | 用于治疗糖尿病的作为ppar调节剂的三唑、噁二唑和噻二唑衍生物 |
-
2006
- 2006-09-26 CN CNA2006800368676A patent/CN101277940A/zh active Pending
- 2006-09-26 CA CA002624726A patent/CA2624726A1/en not_active Abandoned
- 2006-09-26 AU AU2006299085A patent/AU2006299085A1/en not_active Abandoned
- 2006-09-26 RU RU2008113210/04A patent/RU2008113210A/ru not_active Application Discontinuation
- 2006-09-26 EP EP06805856A patent/EP1937658A1/en not_active Withdrawn
- 2006-09-26 JP JP2008533904A patent/JP2009510144A/ja not_active Abandoned
- 2006-09-26 KR KR1020087008301A patent/KR20080053931A/ko not_active Withdrawn
- 2006-09-26 WO PCT/EP2006/009297 patent/WO2007039171A1/en not_active Ceased
- 2006-09-27 TW TW095135653A patent/TW200804324A/zh unknown
- 2006-10-04 AR ARP060104361A patent/AR056121A1/es not_active Application Discontinuation
-
2008
- 2008-03-03 ZA ZA200801988A patent/ZA200801988B/xx unknown
- 2008-03-26 IL IL190460A patent/IL190460A0/en unknown
- 2008-03-31 MA MA30788A patent/MA29810B1/fr unknown
- 2008-04-04 US US12/062,769 patent/US7910612B2/en not_active Expired - Fee Related
- 2008-04-04 NO NO20081682A patent/NO20081682L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| US7910612B2 (en) | 2011-03-22 |
| ZA200801988B (en) | 2008-12-31 |
| KR20080053931A (ko) | 2008-06-16 |
| IL190460A0 (en) | 2008-11-03 |
| CN101277940A (zh) | 2008-10-01 |
| US20090012131A1 (en) | 2009-01-08 |
| WO2007039171A1 (en) | 2007-04-12 |
| TW200804324A (en) | 2008-01-16 |
| EP1937658A1 (en) | 2008-07-02 |
| RU2008113210A (ru) | 2009-10-10 |
| NO20081682L (no) | 2008-05-06 |
| CA2624726A1 (en) | 2007-04-12 |
| AU2006299085A1 (en) | 2007-04-12 |
| MA29810B1 (fr) | 2008-09-01 |
| JP2009510144A (ja) | 2009-03-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |