AR055671A1 - Proceso de fabricacion de derivados de quinazolina - Google Patents
Proceso de fabricacion de derivados de quinazolinaInfo
- Publication number
- AR055671A1 AR055671A1 ARP060104320A ARP060104320A AR055671A1 AR 055671 A1 AR055671 A1 AR 055671A1 AR P060104320 A ARP060104320 A AR P060104320A AR P060104320 A ARP060104320 A AR P060104320A AR 055671 A1 AR055671 A1 AR 055671A1
- Authority
- AR
- Argentina
- Prior art keywords
- compound
- formula
- manufacture
- salt
- quinazoline derivatives
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 7
- JWVCLYRUEFBMGU-UHFFFAOYSA-N quinazoline Chemical class N1=CN=CC2=CC=CC=C21 JWVCLYRUEFBMGU-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 15
- NAWXUBYGYWOOIX-SFHVURJKSA-N (2s)-2-[[4-[2-(2,4-diaminoquinazolin-6-yl)ethyl]benzoyl]amino]-4-methylidenepentanedioic acid Chemical compound C1=CC2=NC(N)=NC(N)=C2C=C1CCC1=CC=C(C(=O)N[C@@H](CC(=C)C(O)=O)C(O)=O)C=C1 NAWXUBYGYWOOIX-SFHVURJKSA-N 0.000 abstract 11
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 8
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 abstract 6
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 abstract 6
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 6
- 150000003839 salts Chemical class 0.000 abstract 5
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 abstract 4
- 238000000034 method Methods 0.000 abstract 4
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 abstract 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 4
- 150000003246 quinazolines Chemical class 0.000 abstract 3
- DKPFZGUDAPQIHT-UHFFFAOYSA-N Butyl acetate Natural products CCCCOC(C)=O DKPFZGUDAPQIHT-UHFFFAOYSA-N 0.000 abstract 2
- 238000001311 chemical methods and process Methods 0.000 abstract 2
- 238000002425 crystallisation Methods 0.000 abstract 2
- 230000008025 crystallization Effects 0.000 abstract 2
- 239000012458 free base Substances 0.000 abstract 2
- FUZZWVXGSFPDMH-UHFFFAOYSA-N hexanoic acid Chemical compound CCCCCC(O)=O FUZZWVXGSFPDMH-UHFFFAOYSA-N 0.000 abstract 2
- 239000000543 intermediate Substances 0.000 abstract 2
- 239000002904 solvent Substances 0.000 abstract 2
- 238000005406 washing Methods 0.000 abstract 2
- XIHOMGRMQWNHHB-UHFFFAOYSA-N 4-(4-bromo-2-fluoroanilino)-6-methoxyquinazolin-7-ol Chemical compound N1=CN=C2C=C(O)C(OC)=CC2=C1NC1=CC=C(Br)C=C1F XIHOMGRMQWNHHB-UHFFFAOYSA-N 0.000 abstract 1
- 239000002585 base Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- UHTHHESEBZOYNR-UHFFFAOYSA-N vandetanib Chemical compound COC1=CC(C(/N=CN2)=N/C=3C(=CC(Br)=CC=3)F)=C2C=C1OCC1CCN(C)CC1 UHTHHESEBZOYNR-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
- C07D211/16—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with acylated ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/94—Nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Ophthalmology & Optometry (AREA)
- Pain & Pain Management (AREA)
- Vascular Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Urology & Nephrology (AREA)
- Dermatology (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
Procesos químicos para la fabricacion de determinados derivados de quinazolina, o sales de éstos aceptables para el uso farmacéutico. Procesos para a fabricacion de determinados intermediarios utiles en la fabricacion de los derivados de quinazolina, y procesos para la fabricacion de los derivados de quinazolina utilizando dichos intermediarios. en particular, la presente se relaciona con procesos químicos e intermediarios utiles en la fabricacion del compuesto 4-(4-bromo-2- fluoroanilino)-6-metoxi-7-(1-metilpiperidin-4-ilmetoxi)quinazolina. Reivindicacion 22: un proceso para la fabricacion de 7-(1-ter-butoxicarbonil)piperidin-4-ilmetoxi)-4-(4-bromo-2-fluoroanilino)-6-metoxiquinazolina, un compuesto de formula (10) a partir de 7-hidroxi-4-(4-bromo-2-fluoroanilino)-6-metoxiquinazolina, un compuesto de formula (9) caracterizado porque el proceso comprende los siguientes pasos: (l) hacer reaccionar el compuesto de formula (9) con un compuesto de formula (2) en presencia de una base apropiada., para proporcionar un compuesto de formula (10), o una sal de éste; y (m) aislar el compuesto de formula (10): (m-1) agregando agua y permitiendo que ocurra la cristalizacion del compuesto de formula (10), recolectando el compuesto de formula (10) y lavando el compuesto de formula (10) con agua, seguida por un solvente seleccionado entre acetato de etilo, acetato de butilo y acetonitrilo, a una temperatura en el rango de entre 25 y 55°C; o (m-2) agregando agua y un alcohol seleccionado entre metanol, etanol, isopropanol y n-propanol, y permitiendo que ocurra la cristalizacion del compuesto de formula (10), recolectando el compuesto de formula (10), y lavando el compuesto de formula (10) con una mezcla de agua y el alcohol seleccionado entre metanol, etanol, isopropanol y n-propanol, seguido por un solvente seleccionado entre acetato de etilo, acetato de butilo y acetonitrilo, a una temperatura en el rango de entre 25 y 55°C; y luego el compuesto de formula (10), obtenido en forma de base libre, puede convertirse en una forma de sal, y el compuesto de formula (10), obtenido en una forma de sal, puede convertirse en la base libre, o en forma de una sal alternativo, de ser necesario.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0519879.1A GB0519879D0 (en) | 2005-09-30 | 2005-09-30 | Chemical process |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR055671A1 true AR055671A1 (es) | 2007-08-29 |
Family
ID=35395001
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP060104320A AR055671A1 (es) | 2005-09-30 | 2006-09-29 | Proceso de fabricacion de derivados de quinazolina |
Country Status (31)
| Country | Link |
|---|---|
| US (8) | US8163926B2 (es) |
| EP (2) | EP2053048B8 (es) |
| JP (2) | JP5213715B2 (es) |
| KR (1) | KR101307641B1 (es) |
| CN (3) | CN102503898B (es) |
| AR (1) | AR055671A1 (es) |
| AT (2) | ATE448218T1 (es) |
| AU (1) | AU2006296367B2 (es) |
| BR (1) | BRPI0616715A2 (es) |
| CA (2) | CA2624045C (es) |
| CY (2) | CY1110275T1 (es) |
| DE (2) | DE602006010428D1 (es) |
| DK (2) | DK2053048T3 (es) |
| ES (2) | ES2335435T3 (es) |
| GB (1) | GB0519879D0 (es) |
| HR (2) | HRP20100019T1 (es) |
| IL (2) | IL190172A (es) |
| ME (2) | ME01531B (es) |
| MY (2) | MY145540A (es) |
| NO (1) | NO342152B1 (es) |
| NZ (2) | NZ566566A (es) |
| PL (2) | PL1943240T3 (es) |
| PT (2) | PT2053048E (es) |
| RS (2) | RS51263B (es) |
| RU (1) | RU2448102C2 (es) |
| SG (1) | SG165416A1 (es) |
| SI (2) | SI2053048T1 (es) |
| TW (2) | TWI424991B (es) |
| UY (1) | UY29824A1 (es) |
| WO (1) | WO2007036713A2 (es) |
| ZA (1) | ZA200802416B (es) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7268230B2 (en) * | 2002-02-01 | 2007-09-11 | Astrazeneca Ab | Quinazoline compounds |
| GB0519879D0 (en) * | 2005-09-30 | 2005-11-09 | Astrazeneca Ab | Chemical process |
| CL2007003158A1 (es) * | 2006-11-02 | 2008-05-16 | Astrazeneca Ab | Procedimiento de preparacion de compuestos derivados de quinazolina o sus sales farmaceuticamente aceptables; compuestos intermediarios; procedimiento de preparacion. |
| ES2547902T3 (es) * | 2011-09-01 | 2015-10-09 | Symrise Ag | Procedimiento para la preparación de derivados de indanona |
| IN2015KN00323A (es) * | 2012-08-15 | 2015-07-10 | Glaxo Group Ltd | |
| CN104098544A (zh) * | 2013-04-07 | 2014-10-15 | 浙江九洲药物科技有限公司 | 一种凡德他尼的制备方法 |
| CN106397401B (zh) * | 2016-08-30 | 2018-11-13 | 山东罗欣药业集团股份有限公司 | 一种抗癌药物的晶体化合物及其制备方法 |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4870083A (en) * | 1987-11-24 | 1989-09-26 | Merrell Dow Pharmaceuticals Inc. | 1,4-Disubstituted-piperidinyl compounds useful as analgesics and muscle relaxants |
| JP2829744B2 (ja) | 1989-05-31 | 1998-12-02 | 川研ファインケミカル株式会社 | ピペリジンカルボン酸類の製造方法 |
| WO1992006086A1 (en) | 1990-10-01 | 1992-04-16 | Janssen Pharmaceutica N.V. | Novel 4-piperidinylcarbonyl derivatives |
| PL170567B1 (pl) | 1991-03-28 | 1997-01-31 | Eisai Co Ltd | Sposób wytwarzania pochodnych aminy heterocykliczno-cyklicznej PL PL PL PL PL PL PL PL |
| SG64322A1 (en) | 1991-05-10 | 1999-04-27 | Rhone Poulenc Rorer Int | Bis mono and bicyclic aryl and heteroaryl compounds which inhibit egf and/or pdgf receptor tyrosine kinase |
| US5710158A (en) | 1991-05-10 | 1998-01-20 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Aryl and heteroaryl quinazoline compounds which inhibit EGF and/or PDGF receptor tyrosine kinase |
| EP0638567A4 (en) | 1993-02-18 | 1995-05-10 | Kyowa Hakko Kogyo Kk | ADENOSINE INHIBITORS. |
| EP0700383B1 (en) * | 1993-05-26 | 1998-09-23 | Syntex (U.S.A.) Inc. | Novel 1-phenylalkanone 5-ht 4? receptor ligands |
| DE4326344A1 (de) | 1993-08-05 | 1995-02-09 | Thomae Gmbh Dr K | Carbonamide, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung |
| CA2180746A1 (en) | 1994-01-13 | 1995-07-20 | Raymond Baker | Gem-disubstituted azacyclic tachykinin antagonists |
| GB9624482D0 (en) * | 1995-12-18 | 1997-01-15 | Zeneca Phaema S A | Chemical compounds |
| ES2169355T3 (es) | 1996-03-05 | 2002-07-01 | Astrazeneca Ab | Derivados de 4-anilinoquinazolina. |
| AU4342997A (en) | 1996-09-13 | 1998-04-02 | Sugen, Inc. | Use of quinazoline derivatives for the manufacture of a medicament in the reatment of hyperproliferative skin disorders |
| GB9718972D0 (en) * | 1996-09-25 | 1997-11-12 | Zeneca Ltd | Chemical compounds |
| EP1676845B1 (en) * | 1999-11-05 | 2008-06-11 | AstraZeneca AB | New quinazoline derivatives |
| GB0126879D0 (en) | 2001-11-08 | 2002-01-02 | Astrazeneca Ab | Combination therapy |
| WO2003053361A2 (en) | 2001-12-20 | 2003-07-03 | Osi Pharmaceuticals, Inc. | PYRROLOPYRIMIDINE A2b SELECTIVE ANTAGONIST COMPOUNDS, THEIR SYNTHESIS AND USE |
| US7268230B2 (en) | 2002-02-01 | 2007-09-11 | Astrazeneca Ab | Quinazoline compounds |
| US20050130995A1 (en) | 2002-02-06 | 2005-06-16 | Ube Industries, Ltd. | Process for producing 4-aminoquinazoline compound |
| GB0218526D0 (en) | 2002-08-09 | 2002-09-18 | Astrazeneca Ab | Combination therapy |
| AU2003249000B2 (en) | 2002-08-09 | 2007-04-05 | Astrazeneca Ab | Combination of ZD6474, an inhibitor of the vasuclar endothelial growth factor receptor, with radiotherapy in the treatment of cancer |
| GB0223380D0 (en) | 2002-10-09 | 2002-11-13 | Astrazeneca Ab | Combination therapy |
| WO2004071397A2 (en) | 2003-02-13 | 2004-08-26 | Astrazeneca Ab | Combination therapy of zd6474 with 5-fu or/and cpt-11 |
| ATE478671T1 (de) | 2003-07-10 | 2010-09-15 | Astrazeneca Ab | Verwendung des chinazolin-derivats zd6474 in kombination mit platinverbindungen und optional ionisierender strahlung bei der behandlung von erkrankungen im zusammenhang mit angiogenese und/oder erhöhter gefässpermeabilität |
| GB0318423D0 (en) | 2003-08-06 | 2003-09-10 | Astrazeneca Ab | Chemical compounds |
| GB0519879D0 (en) * | 2005-09-30 | 2005-11-09 | Astrazeneca Ab | Chemical process |
-
2005
- 2005-09-30 GB GBGB0519879.1A patent/GB0519879D0/en not_active Ceased
-
2006
- 2006-09-27 MY MYPI20080855A patent/MY145540A/en unknown
- 2006-09-27 BR BRPI0616715-2A patent/BRPI0616715A2/pt not_active IP Right Cessation
- 2006-09-27 PL PL06794582T patent/PL1943240T3/pl unknown
- 2006-09-27 SG SG201006940-9A patent/SG165416A1/en unknown
- 2006-09-27 AT AT06794582T patent/ATE448218T1/de active
- 2006-09-27 DK DK09152654.1T patent/DK2053048T3/da active
- 2006-09-27 HR HR20100019T patent/HRP20100019T1/hr unknown
- 2006-09-27 DE DE602006010428T patent/DE602006010428D1/de active Active
- 2006-09-27 CA CA2624045A patent/CA2624045C/en not_active Expired - Fee Related
- 2006-09-27 PT PT09152654T patent/PT2053048E/pt unknown
- 2006-09-27 RU RU2008116573/04A patent/RU2448102C2/ru not_active IP Right Cessation
- 2006-09-27 WO PCT/GB2006/003587 patent/WO2007036713A2/en not_active Ceased
- 2006-09-27 SI SI200630816T patent/SI2053048T1/sl unknown
- 2006-09-27 CN CN201110159729.XA patent/CN102503898B/zh active Active
- 2006-09-27 MY MYPI2011003076A patent/MY149834A/en unknown
- 2006-09-27 EP EP09152654A patent/EP2053048B8/en active Active
- 2006-09-27 EP EP06794582A patent/EP1943240B1/en active Active
- 2006-09-27 NZ NZ566566A patent/NZ566566A/en not_active IP Right Cessation
- 2006-09-27 ES ES06794582T patent/ES2335435T3/es active Active
- 2006-09-27 AT AT09152654T patent/ATE481399T1/de active
- 2006-09-27 PL PL09152654T patent/PL2053048T3/pl unknown
- 2006-09-27 CN CN201110159628.2A patent/CN102503933B/zh active Active
- 2006-09-27 DK DK06794582.4T patent/DK1943240T3/da active
- 2006-09-27 DE DE602006017004T patent/DE602006017004D1/de active Active
- 2006-09-27 RS RSP-2010/0037A patent/RS51263B/sr unknown
- 2006-09-27 AU AU2006296367A patent/AU2006296367B2/en not_active Ceased
- 2006-09-27 RS RSP-2010/0520A patent/RS51515B/sr unknown
- 2006-09-27 KR KR1020087009317A patent/KR101307641B1/ko not_active Expired - Fee Related
- 2006-09-27 JP JP2008532864A patent/JP5213715B2/ja not_active Expired - Fee Related
- 2006-09-27 US US12/088,680 patent/US8163926B2/en active Active
- 2006-09-27 CA CA2745829A patent/CA2745829C/en not_active Expired - Fee Related
- 2006-09-27 ME MEP-2013-51A patent/ME01531B/me unknown
- 2006-09-27 PT PT06794582T patent/PT1943240E/pt unknown
- 2006-09-27 CN CN200680036468XA patent/CN101277948B/zh active Active
- 2006-09-27 ME MEP-2013-21A patent/ME01466B/me unknown
- 2006-09-27 SI SI200630524T patent/SI1943240T1/sl unknown
- 2006-09-27 NZ NZ593930A patent/NZ593930A/xx not_active IP Right Cessation
- 2006-09-27 ES ES09152654T patent/ES2350513T3/es active Active
- 2006-09-29 TW TW099102690A patent/TWI424991B/zh not_active IP Right Cessation
- 2006-09-29 UY UY29824A patent/UY29824A1/es unknown
- 2006-09-29 TW TW095136340A patent/TWI328580B/zh not_active IP Right Cessation
- 2006-09-29 AR ARP060104320A patent/AR055671A1/es not_active Application Discontinuation
-
2008
- 2008-03-11 NO NO20081267A patent/NO342152B1/no not_active IP Right Cessation
- 2008-03-13 IL IL190172A patent/IL190172A/en not_active IP Right Cessation
- 2008-03-14 ZA ZA200802416A patent/ZA200802416B/xx unknown
-
2010
- 2010-01-25 CY CY20101100076T patent/CY1110275T1/el unknown
- 2010-11-12 CY CY20101101019T patent/CY1110887T1/el unknown
- 2010-11-16 HR HR20100620T patent/HRP20100620T1/hr unknown
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2011
- 2011-12-07 US US13/314,034 patent/US8865899B2/en active Active
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2012
- 2012-11-28 JP JP2012259782A patent/JP5654546B2/ja not_active Expired - Fee Related
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2013
- 2013-07-21 IL IL227574A patent/IL227574A/en not_active IP Right Cessation
-
2014
- 2014-09-09 US US14/481,302 patent/US20140378684A1/en not_active Abandoned
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2015
- 2015-07-22 US US14/805,816 patent/US9815816B2/en active Active
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2017
- 2017-10-27 US US15/796,615 patent/US10344015B2/en active Active
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2019
- 2019-05-08 US US16/406,246 patent/US20190263782A1/en not_active Abandoned
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2020
- 2020-11-02 US US17/086,666 patent/US20220033377A1/en not_active Abandoned
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2023
- 2023-03-07 US US18/118,549 patent/US20240150317A1/en not_active Abandoned
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