AR055570A1 - Polimorfo de oxazol - pirrolidina, procesos de obtencion y composiciones farmaceuticas. - Google Patents
Polimorfo de oxazol - pirrolidina, procesos de obtencion y composiciones farmaceuticas.Info
- Publication number
- AR055570A1 AR055570A1 ARP060101079A ARP060101079A AR055570A1 AR 055570 A1 AR055570 A1 AR 055570A1 AR P060101079 A ARP060101079 A AR P060101079A AR P060101079 A ARP060101079 A AR P060101079A AR 055570 A1 AR055570 A1 AR 055570A1
- Authority
- AR
- Argentina
- Prior art keywords
- oxazol
- pharmaceutical compositions
- pirrolidine
- polymorph
- obtaining processes
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- ZCQWOFVYLHDMMC-UHFFFAOYSA-N Oxazole Chemical compound C1=COC=N1 ZCQWOFVYLHDMMC-UHFFFAOYSA-N 0.000 title 1
- RWRDLPDLKQPQOW-UHFFFAOYSA-N tetrahydropyrrole Natural products C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 title 1
- QYRWMYNQCXSWLV-INIZCTEOSA-N (2s)-1-[2-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethylamino]acetyl]pyrrolidine-2-carbonitrile Chemical compound CC=1OC(C=2C=CC=CC=2)=NC=1CCNCC(=O)N1CCC[C@H]1C#N QYRWMYNQCXSWLV-INIZCTEOSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- -1 mesylate compound Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Child & Adolescent Psychology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
Procesos de obtencion de dichos compuestos y composiciones farmacéuticas que los comprenden. Reivindicacion 1: El compuesto mesilato del (S)-1-{[2-(5-metil-2-fenil-oxazol-4-il)-etilamino]-acetil}-pirrolidin-2-carbonitrilo.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05102251 | 2005-03-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR055570A1 true AR055570A1 (es) | 2007-08-22 |
Family
ID=36406081
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP060101079A AR055570A1 (es) | 2005-03-22 | 2006-03-20 | Polimorfo de oxazol - pirrolidina, procesos de obtencion y composiciones farmaceuticas. |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US7772264B2 (es) |
| EP (1) | EP1888571A2 (es) |
| JP (1) | JP5043825B2 (es) |
| KR (1) | KR20070113305A (es) |
| CN (1) | CN101146801A (es) |
| AR (1) | AR055570A1 (es) |
| AU (1) | AU2006226447B2 (es) |
| BR (1) | BRPI0609580A2 (es) |
| CA (1) | CA2600203C (es) |
| DO (1) | DOP2006000066A (es) |
| GT (1) | GT200600125A (es) |
| IL (1) | IL185768A0 (es) |
| MX (1) | MX2007011546A (es) |
| PA (1) | PA8666701A1 (es) |
| PE (1) | PE20061109A1 (es) |
| TW (1) | TW200700415A (es) |
| WO (1) | WO2006100181A2 (es) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CL2008002427A1 (es) | 2007-08-16 | 2009-09-11 | Boehringer Ingelheim Int | Composicion farmaceutica que comprende 1-cloro-4-(b-d-glucopiranos-1-il)-2-[4-((s)-tetrahidrofurano-3-iloxi)bencil]-benceno combinado con 1-[(4-metilquinazolin-2-il)metil]-3-metil-7-(2-butin-1-il)-8-(3-(r)-aminopiperidin-1-il)xantina; y su uso para tratar diabetes mellitus tipo 2. |
| UY32030A (es) | 2008-08-06 | 2010-03-26 | Boehringer Ingelheim Int | "tratamiento para diabetes en pacientes inapropiados para terapia con metformina" |
| KR101657960B1 (ko) | 2008-08-15 | 2016-09-20 | 베링거 인겔하임 인터내셔날 게엠베하 | Fab-관련 질환의 치료에 사용하기 위한 푸린 유도체 |
| CZ2008512A3 (cs) | 2008-08-26 | 2010-03-10 | Zentiva, A. S | Zpusob prípravy vysoce cistého vildagliptinu |
| TW201036975A (en) | 2009-01-07 | 2010-10-16 | Boehringer Ingelheim Int | Treatment for diabetes in patients with inadequate glycemic control despite metformin therapy |
| AR075204A1 (es) | 2009-01-29 | 2011-03-16 | Boehringer Ingelheim Int | Inhibidores de dpp-4 y composiciones farmaceuticas que los comprenden, utiles para tratar enfermedades metabolicas en pacientes pediatricos, particularmente diabetes mellitus tipo 2 |
| CN102387795A (zh) | 2009-02-13 | 2012-03-21 | 贝林格尔.英格海姆国际有限公司 | 包含dpp-4抑制剂(利拉列汀)任选地组合其它抗糖尿病药的抗糖尿病药物 |
| AR077642A1 (es) | 2009-07-09 | 2011-09-14 | Arena Pharm Inc | Moduladores del metabolismo y el tratamiento de trastornos relacionados con el mismo |
| CN107115530A (zh) | 2009-11-27 | 2017-09-01 | 勃林格殷格翰国际有限公司 | 基因型糖尿病患者利用dpp‑iv抑制剂例如利拉利汀的治疗 |
| JP2013522279A (ja) | 2010-03-18 | 2013-06-13 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 糖尿病及び関連状態の治療で用いるgpr119作動薬とddp−iv阻害薬リナグリプチンの組合せ |
| WO2011127051A1 (en) | 2010-04-06 | 2011-10-13 | Arena Pharmaceuticals, Inc. | Modulators of the gpr119 receptor and the treatment of disorders related thereto |
| CA2797310C (en) | 2010-05-05 | 2020-03-31 | Boehringer Ingelheim International Gmbh | Glp-1 receptor agonist and dpp-4 inhibitor combination therapy |
| EP3124041A1 (en) | 2010-06-24 | 2017-02-01 | Boehringer Ingelheim International GmbH | Diabetes therapy |
| CN103221410B (zh) | 2010-09-22 | 2017-09-15 | 艾尼纳制药公司 | Gpr119受体调节剂和对与其相关的障碍的治疗 |
| US20140018371A1 (en) | 2011-04-01 | 2014-01-16 | Arena Pharmaceuticals, Inc. | Modulators Of The GPR119 Receptor And The Treatment Of Disorders Related Thereto |
| WO2012145361A1 (en) | 2011-04-19 | 2012-10-26 | Arena Pharmaceuticals, Inc. | Modulators of the gpr119 receptor and the treatment of disorders related thereto |
| WO2012145603A1 (en) | 2011-04-22 | 2012-10-26 | Arena Pharmaceuticals, Inc. | Modulators of the gpr119 receptor and the treatment of disorders related thereto |
| US20140051714A1 (en) | 2011-04-22 | 2014-02-20 | Arena Pharmaceuticals, Inc. | Modulators Of The GPR119 Receptor And The Treatment Of Disorders Related Thereto |
| WO2012170702A1 (en) | 2011-06-08 | 2012-12-13 | Arena Pharmaceuticals, Inc. | Modulators of the gpr119 receptor and the treatment of disorders related thereto |
| WO2013055910A1 (en) | 2011-10-12 | 2013-04-18 | Arena Pharmaceuticals, Inc. | Modulators of the gpr119 receptor and the treatment of disorders related thereto |
| WO2013174767A1 (en) | 2012-05-24 | 2013-11-28 | Boehringer Ingelheim International Gmbh | A xanthine derivative as dpp -4 inhibitor for use in modifying food intake and regulating food preference |
| CN103787944A (zh) * | 2012-11-01 | 2014-05-14 | 天津药物研究院 | 1-(2-氯乙酰基)-2-(s)-腈基吡咯烷的制备方法 |
| WO2014074668A1 (en) | 2012-11-08 | 2014-05-15 | Arena Pharmaceuticals, Inc. | Modulators of gpr119 and the treatment of disorders related thereto |
| CN104262227B (zh) * | 2014-09-16 | 2018-09-18 | 东北制药集团股份有限公司 | 一种制备(s)-1-(2-氯乙酰基)吡咯烷-2-甲腈的方法 |
| KR20180006881A (ko) | 2015-03-09 | 2018-01-19 | 인테크린 테라퓨틱스, 아이엔씨. | 비알코올성 지방간 질환 및/또는 지방이영양증의 치료 방법 |
| CN106699627A (zh) * | 2016-12-29 | 2017-05-24 | 青岛黄海制药有限责任公司 | 一种多相复式非连续生产法制备1‑(2‑氯乙酰基)‑2‑(s)‑氰基吡咯烷的方法 |
| AU2018249822A1 (en) | 2017-04-03 | 2019-10-31 | Coherus Biosciences Inc. | PPArgamma agonist for treatment of progressive supranuclear palsy |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH07247246A (ja) * | 1994-03-09 | 1995-09-26 | Daicel Chem Ind Ltd | 1−フェニル−3−ブチン誘導体とその製造方法 |
| TW492957B (en) * | 1996-11-07 | 2002-07-01 | Novartis Ag | N-substituted 2-cyanopyrrolidnes |
| DE69803653T2 (de) * | 1997-12-05 | 2002-08-29 | F. Hoffmann-La Roche Ag, Basel | 1,3,8-Triazaspiro[4,5]decan-4-on-derivate |
| DE19755436A1 (de) | 1997-12-13 | 1999-06-24 | Beiersdorf Ag | Verfahren zur zumindest partiellen direkten Beschichtung eines dehnfähigen Trägermaterials mit einer Haftklebemasse |
| CA2291620C (en) * | 1998-03-30 | 2003-10-07 | Japan Tobacco Inc. | Production method of isoxazolidinedione compound |
| US6861440B2 (en) * | 2001-10-26 | 2005-03-01 | Hoffmann-La Roche Inc. | DPP IV inhibitors |
| US6673815B2 (en) * | 2001-11-06 | 2004-01-06 | Bristol-Myers Squibb Company | Substituted acid derivatives useful as antidiabetic and antiobesity agents and method |
| PL374664A1 (en) * | 2002-08-29 | 2005-10-31 | Taisho Pharmaceutical Co, Ltd. | Benzenesulfonate of 4-fluoro-2-cyanopyrrolidine derivative |
| GB0313661D0 (en) * | 2003-06-13 | 2003-07-16 | Avecia Ltd | Process |
-
2006
- 2006-03-09 CN CNA2006800090213A patent/CN101146801A/zh active Pending
- 2006-03-09 KR KR1020077024075A patent/KR20070113305A/ko not_active Ceased
- 2006-03-09 AU AU2006226447A patent/AU2006226447B2/en not_active Ceased
- 2006-03-09 BR BRPI0609580-1A patent/BRPI0609580A2/pt not_active IP Right Cessation
- 2006-03-09 CA CA2600203A patent/CA2600203C/en not_active Expired - Fee Related
- 2006-03-09 EP EP06724997A patent/EP1888571A2/en not_active Withdrawn
- 2006-03-09 MX MX2007011546A patent/MX2007011546A/es active IP Right Grant
- 2006-03-09 WO PCT/EP2006/060589 patent/WO2006100181A2/en not_active Ceased
- 2006-03-09 JP JP2008502373A patent/JP5043825B2/ja not_active Expired - Fee Related
- 2006-03-16 US US11/376,862 patent/US7772264B2/en not_active Expired - Fee Related
- 2006-03-20 PE PE2006000304A patent/PE20061109A1/es not_active Application Discontinuation
- 2006-03-20 AR ARP060101079A patent/AR055570A1/es not_active Application Discontinuation
- 2006-03-21 DO DO2006000066A patent/DOP2006000066A/es unknown
- 2006-03-21 PA PA20068666701A patent/PA8666701A1/es unknown
- 2006-03-21 TW TW095109702A patent/TW200700415A/zh unknown
- 2006-03-22 GT GT200600125A patent/GT200600125A/es unknown
-
2007
- 2007-09-06 IL IL185768A patent/IL185768A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP2008534470A (ja) | 2008-08-28 |
| PA8666701A1 (es) | 2006-12-07 |
| MX2007011546A (es) | 2007-10-19 |
| US20060217428A1 (en) | 2006-09-28 |
| EP1888571A2 (en) | 2008-02-20 |
| CA2600203A1 (en) | 2006-09-28 |
| US7772264B2 (en) | 2010-08-10 |
| AU2006226447B2 (en) | 2009-07-16 |
| BRPI0609580A2 (pt) | 2010-04-20 |
| WO2006100181A2 (en) | 2006-09-28 |
| CN101146801A (zh) | 2008-03-19 |
| IL185768A0 (en) | 2008-01-06 |
| WO2006100181A3 (en) | 2006-11-30 |
| TW200700415A (en) | 2007-01-01 |
| CA2600203C (en) | 2012-12-04 |
| AU2006226447A1 (en) | 2006-09-28 |
| JP5043825B2 (ja) | 2012-10-10 |
| PE20061109A1 (es) | 2006-10-13 |
| KR20070113305A (ko) | 2007-11-28 |
| DOP2006000066A (es) | 2006-09-30 |
| GT200600125A (es) | 2007-03-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |