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AR054999A1 - Un proceso para la preparacion de antagonistas del receptor cgrp - Google Patents

Un proceso para la preparacion de antagonistas del receptor cgrp

Info

Publication number
AR054999A1
AR054999A1 ARP050105057A ARP050105057A AR054999A1 AR 054999 A1 AR054999 A1 AR 054999A1 AR P050105057 A ARP050105057 A AR P050105057A AR P050105057 A ARP050105057 A AR P050105057A AR 054999 A1 AR054999 A1 AR 054999A1
Authority
AR
Argentina
Prior art keywords
compound
formula
benzyl
preparation
ether
Prior art date
Application number
ARP050105057A
Other languages
English (en)
Inventor
Xiaojun Han
Xiang Jun J Jiang
Prasad V Chaturvedula
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of AR054999A1 publication Critical patent/AR054999A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Un proceso para la preparacion de antagonistas de molécula pequena de receptores de péptido relacionados con el gen de calcitonina (ôreceptor CGRPö). Estos compuestos pueden utilizarse en el tratamiento de la vaso dilatacion nerogénico, inflamacion, migrana y enfermedades inflamatorias de las vías respiratorias. Reivindicacion 1: Un proceso para sintetizar un compuesto de la formula (1), (2) o (3), en donde: R3 es 7-metil-1H-indazol-5-ilo; R4 es alquilo C1-6 o bencilo; y PG2 es éter de metoximetilo, éter de benciloximetilo, bencilo o tri-alquilsililo C1-6; que comprende: a) hidrolizar un compuesto de la formula (4), en donde R4 es alquilo C1-6 o bencilo; RG1 es BOC, CBZ O FMOC; y R3 es 2,6-dimetilanilin-3-ilo para formar un compuesto de la formula (5), b) reducir el compuesto de la formula (5) a un compuesto de la formula (1), c) proteger la porcion hidroxi del compuesto de formula (1) con PG2, en donde PG2 es éter de metoximetilo, éter de benciloximetilo, bencilo o tri-alquilsililo C1-6; para formar un compuesto de la formula (2); y d) hidrolizar R4 para formar un compuesto de la formula (3).
ARP050105057A 2004-12-03 2005-12-02 Un proceso para la preparacion de antagonistas del receptor cgrp AR054999A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US63315904P 2004-12-03 2004-12-03

Publications (1)

Publication Number Publication Date
AR054999A1 true AR054999A1 (es) 2007-08-01

Family

ID=36204336

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP050105057A AR054999A1 (es) 2004-12-03 2005-12-02 Un proceso para la preparacion de antagonistas del receptor cgrp

Country Status (5)

Country Link
US (1) US7449586B2 (es)
AR (1) AR054999A1 (es)
PE (1) PE20061147A1 (es)
TW (1) TW200635919A (es)
WO (1) WO2006060678A2 (es)

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US7220862B2 (en) * 2002-06-05 2007-05-22 Bristol-Myers Squibb Company Calcitonin gene related peptide receptor antagonists
PT1539766T (pt) * 2002-06-05 2017-03-02 Bristol Myers Squibb Co Antagonistas de recetor de péptido relacionado com o gene de calcitonina
TW200524601A (en) 2003-12-05 2005-08-01 Bristol Myers Squibb Co Heterocyclic anti-migraine agents
TW200533398A (en) * 2004-03-29 2005-10-16 Bristol Myers Squibb Co Novel therapeutic agents for the treatment of migraine
US7384930B2 (en) 2004-11-03 2008-06-10 Bristol-Myers Squibb Company Constrained compounds as CGRP-receptor antagonists
US7384931B2 (en) 2004-11-03 2008-06-10 Bristol-Myers Squibb Company Constrained compounds as CGRP-receptor antagonists
US7449586B2 (en) 2004-12-03 2008-11-11 Bristol-Myers Squibb Company Processes for the preparation of CGRP-receptor antagonists and intermediates thereof
US7834007B2 (en) * 2005-08-25 2010-11-16 Bristol-Myers Squibb Company CGRP antagonists
US8168592B2 (en) * 2005-10-21 2012-05-01 Amgen Inc. CGRP peptide antagonists and conjugates
US8067447B2 (en) * 2006-11-01 2011-11-29 Bristol-Myers Squibb Company Modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof
KR101608096B1 (ko) 2008-01-23 2016-03-31 브리스톨-마이어스 스큅 컴퍼니 ４-피리디논 화합물 및 암을 위한 그의 용도
CN105037210A (zh) * 2015-05-27 2015-11-11 江苏大学 一种α，β-脱氢-α-氨基酸的合成方法

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Also Published As

Publication number Publication date
TW200635919A (en) 2006-10-16
WO2006060678A3 (en) 2006-07-20
US7449586B2 (en) 2008-11-11
US20060122250A1 (en) 2006-06-08
WO2006060678A2 (en) 2006-06-08
PE20061147A1 (es) 2006-10-27

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