ATE466860T1 - Cgrp-rezeptorantagonisten - Google Patents
Cgrp-rezeptorantagonistenInfo
- Publication number
- ATE466860T1 ATE466860T1 AT04750028T AT04750028T ATE466860T1 AT E466860 T1 ATE466860 T1 AT E466860T1 AT 04750028 T AT04750028 T AT 04750028T AT 04750028 T AT04750028 T AT 04750028T AT E466860 T1 ATE466860 T1 AT E466860T1
- Authority
- AT
- Austria
- Prior art keywords
- receptor antagonists
- cgrp receptor
- cgrp
- compounds
- diseases
- Prior art date
Links
- 108010078311 Calcitonin Gene-Related Peptide Receptors Proteins 0.000 title abstract 2
- 102000008323 calcitonin gene-related peptide receptor activity proteins Human genes 0.000 title 1
- 239000002464 receptor antagonist Substances 0.000 title 1
- 229940044551 receptor antagonist Drugs 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 108090000932 Calcitonin Gene-Related Peptide Proteins 0.000 abstract 2
- 102100025588 Calcitonin gene-related peptide 1 Human genes 0.000 abstract 2
- 102000014468 Calcitonin Gene-Related Peptide Receptors Human genes 0.000 abstract 1
- 208000006561 Cluster Headache Diseases 0.000 abstract 1
- 206010019233 Headaches Diseases 0.000 abstract 1
- 208000019695 Migraine disease Diseases 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 208000018912 cluster headache syndrome Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 230000006806 disease prevention Effects 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 231100000869 headache Toxicity 0.000 abstract 1
- 206010027599 migraine Diseases 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pain & Pain Management (AREA)
- Public Health (AREA)
- Rheumatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US46410903P | 2003-04-15 | 2003-04-15 | |
| PCT/US2004/011254 WO2004091514A2 (en) | 2003-04-15 | 2004-04-09 | Cgrp receptor antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE466860T1 true ATE466860T1 (de) | 2010-05-15 |
Family
ID=33300105
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04750028T ATE466860T1 (de) | 2003-04-15 | 2004-04-09 | Cgrp-rezeptorantagonisten |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US7205292B2 (de) |
| EP (1) | EP1615914B1 (de) |
| JP (1) | JP4705908B2 (de) |
| CN (1) | CN100572379C (de) |
| AT (1) | ATE466860T1 (de) |
| AU (1) | AU2004229518B2 (de) |
| CA (1) | CA2522024A1 (de) |
| DE (1) | DE602004027021D1 (de) |
| WO (1) | WO2004091514A2 (de) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7220862B2 (en) | 2002-06-05 | 2007-05-22 | Bristol-Myers Squibb Company | Calcitonin gene related peptide receptor antagonists |
| US7842808B2 (en) | 2002-06-05 | 2010-11-30 | Bristol-Myers Squibb Company | Anti-migraine spirocycles |
| JO2355B1 (en) * | 2003-04-15 | 2006-12-12 | ميرك شارب اند دوم كوربوريشن | Hereditary calcitonin polypeptide receptor antagonists |
| WO2005013894A2 (en) * | 2003-06-26 | 2005-02-17 | Merck & Co., Inc. | Benzodiazepine cgrp receptor antagonists |
| JP4705911B2 (ja) * | 2003-06-26 | 2011-06-22 | メルク・シャープ・エンド・ドーム・コーポレイション | ベンゾジアゼピンｃｇｒｐ受容体拮抗物質 |
| TW200524601A (en) | 2003-12-05 | 2005-08-01 | Bristol Myers Squibb Co | Heterocyclic anti-migraine agents |
| US7491713B2 (en) * | 2004-01-29 | 2009-02-17 | Merck + Co., Inc. | CGRP receptor antagonists |
| TW200533398A (en) | 2004-03-29 | 2005-10-16 | Bristol Myers Squibb Co | Novel therapeutic agents for the treatment of migraine |
| EP1751132B1 (de) * | 2004-05-19 | 2008-03-26 | Basf Se | 2-substituierte pyrimidine und ihre verwendung als pestizide |
| AU2005294448B2 (en) * | 2004-10-07 | 2011-07-14 | Merck Sharp & Dohme Corp. | CGRP receptor antagonists |
| US7384930B2 (en) | 2004-11-03 | 2008-06-10 | Bristol-Myers Squibb Company | Constrained compounds as CGRP-receptor antagonists |
| US7384931B2 (en) | 2004-11-03 | 2008-06-10 | Bristol-Myers Squibb Company | Constrained compounds as CGRP-receptor antagonists |
| US7449586B2 (en) | 2004-12-03 | 2008-11-11 | Bristol-Myers Squibb Company | Processes for the preparation of CGRP-receptor antagonists and intermediates thereof |
| ATE466853T1 (de) * | 2005-01-18 | 2010-05-15 | Merck Sharp & Dohme | Cgrp-rezeptorantagonisten |
| US7994325B2 (en) | 2005-03-14 | 2011-08-09 | Merck Sharp & Dohme Corp. | CGRP receptor antagonists |
| US7834007B2 (en) | 2005-08-25 | 2010-11-16 | Bristol-Myers Squibb Company | CGRP antagonists |
| US8168592B2 (en) | 2005-10-21 | 2012-05-01 | Amgen Inc. | CGRP peptide antagonists and conjugates |
| EP1957106B2 (de) | 2005-11-14 | 2019-07-24 | Teva Pharmaceuticals International GmbH | Antagonisten-antikörper gegen calcitonin-gen-related-peptid und verfahren damit |
| US7470679B2 (en) * | 2006-05-02 | 2008-12-30 | Bristol-Myers Squibb Company | Constrained compounds as CGRP-receptor antagonists |
| US7470680B2 (en) * | 2006-05-03 | 2008-12-30 | Bristol-Myers Squibb Company | Constrained compounds as CGRP-receptor antagonists |
| EP2029575B1 (de) * | 2006-05-09 | 2014-10-22 | Merck Sharp & Dohme Corp. | Substituierte spirocyclische antagonisten des cgrp-rezeptors |
| WO2008070014A2 (en) * | 2006-12-04 | 2008-06-12 | Neurogen Corporation | Biaryl ketone-substituted piperidines |
| JP5537441B2 (ja) | 2008-03-04 | 2014-07-02 | ファイザー・リミテッド | 慢性疼痛を治療する方法 |
| KR101519192B1 (ko) | 2009-08-28 | 2015-05-11 | 리나트 뉴로사이언스 코프. | 칼시토닌 유전자-관련된 펩티드에 대해 지시된 길항제 항체의 투여에 의한 내장 통증의 치료 방법 |
| US9855332B2 (en) | 2011-05-20 | 2018-01-02 | Alderbio Holdings Llc | Use of anti-CGRP antibodies and antibody fragments to treat diarrhea in subjects with diseases or treatments that result in elevated CGRP levels |
| SG10201604040PA (en) | 2011-05-20 | 2016-07-28 | Alderbio Holdings Llc | Anti-cgrp compositions and use thereof |
| DK2709663T3 (da) | 2011-05-20 | 2019-05-20 | Alderbio Holdings Llc | Anvendelse af anti-CGRP-antistoffer og antistoffragmenter til forebyggelse eller inhibering af fotofobi eller aversion mod lys hos individer med behov herfor, især migrænikere |
| US20170114122A1 (en) | 2015-10-23 | 2017-04-27 | Alderbio Holdings Llc | Regulation of glucose metabolism using anti-cgrp antibodies |
| US10556945B2 (en) | 2014-03-21 | 2020-02-11 | Teva Pharmaceuticals International Gmbh | Antagonist antibodies directed against calcitonin gene-related peptide and methods using same |
| SI3119431T1 (sl) | 2014-03-21 | 2024-06-28 | Teva Pharmaceuticals International Gmbh | Antagonistična protitelesa, usmerjena proti peptidu, povezanemu z genom za kalcitonin, in postopki za uporabo le-teh |
| BR112018008448A2 (pt) * | 2015-11-06 | 2018-11-06 | Daiichi Sankyo Company, Limited | ?método para produzir um composto? |
| PE20191148A1 (es) | 2016-09-23 | 2019-09-02 | Teva Pharmaceuticals Int Gmbh | Tratamiento de la migrana refractaria |
| EP3366286A1 (de) | 2017-02-22 | 2018-08-29 | Johannes Keller | Verbindungen zur behandlung von sepsis |
| CR20210373A (es) | 2019-01-08 | 2021-08-19 | H Lundbeck As | Tratamiento agudo y tratamiento rápido de la cefalea usando anticuerpos anti-cgrp |
| AU2020202454A1 (en) | 2020-04-06 | 2021-10-21 | H. Lundbeck A/S | Treatment of most bothersome symptom (MBS) associated with migraine using anti-CGRP antibodies |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA76475B (en) * | 1975-03-10 | 1977-08-31 | Ciba Geigy Ag | Indolyalkylpiperidines |
| WO1994003447A1 (en) * | 1992-07-29 | 1994-02-17 | Merck Sharp & Dohme Limited | Benzodiazepine derivatives |
| US5661163A (en) * | 1995-06-07 | 1997-08-26 | Merck & Co., Inc. | Alpha-1a adrenergic receptor antagonists |
| AUPO284396A0 (en) * | 1996-10-08 | 1996-10-31 | Fujisawa Pharmaceutical Co., Ltd. | Benzodiazepine derivatives |
| JPH11209356A (ja) * | 1997-04-21 | 1999-08-03 | Takeda Chem Ind Ltd | 縮合環化合物、その製造法及び剤 |
| AU6211499A (en) * | 1998-09-30 | 2000-04-17 | Merck & Co., Inc. | Benzimidazolinyl piperidines as cgrp ligands |
| DE19963868A1 (de) * | 1999-12-30 | 2001-07-12 | Boehringer Ingelheim Pharma | Neue substituierte Piperidine, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung |
| CA2444595A1 (en) * | 2001-04-20 | 2002-10-31 | Banyu Pharmaceutical Co., Ltd. | Benzimidazolone derivatives |
| AU2002346048A1 (en) * | 2001-06-07 | 2002-12-16 | Merck And Co., Inc. | Benzodiazepine bradykinin antagonists |
| CA2465328C (en) * | 2001-11-01 | 2011-06-14 | Michael Francis Gross | Piperidines |
| SE0104250D0 (sv) * | 2001-12-14 | 2001-12-14 | Astrazeneca Ab | Heterocyclic compounds |
| SE0104248D0 (sv) * | 2001-12-14 | 2001-12-14 | Astrazeneca Ab | Method of treatment |
| JO2355B1 (en) * | 2003-04-15 | 2006-12-12 | ميرك شارب اند دوم كوربوريشن | Hereditary calcitonin polypeptide receptor antagonists |
| JP4705911B2 (ja) * | 2003-06-26 | 2011-06-22 | メルク・シャープ・エンド・ドーム・コーポレイション | ベンゾジアゼピンｃｇｒｐ受容体拮抗物質 |
| WO2005013894A2 (en) * | 2003-06-26 | 2005-02-17 | Merck & Co., Inc. | Benzodiazepine cgrp receptor antagonists |
| US7491713B2 (en) * | 2004-01-29 | 2009-02-17 | Merck + Co., Inc. | CGRP receptor antagonists |
-
2004
- 2004-04-09 CN CNB200480016114XA patent/CN100572379C/zh not_active Expired - Fee Related
- 2004-04-09 DE DE602004027021T patent/DE602004027021D1/de not_active Expired - Lifetime
- 2004-04-09 EP EP04750028A patent/EP1615914B1/de not_active Expired - Lifetime
- 2004-04-09 AU AU2004229518A patent/AU2004229518B2/en not_active Ceased
- 2004-04-09 CA CA002522024A patent/CA2522024A1/en not_active Abandoned
- 2004-04-09 JP JP2006509941A patent/JP4705908B2/ja not_active Expired - Fee Related
- 2004-04-09 US US10/551,830 patent/US7205292B2/en not_active Expired - Lifetime
- 2004-04-09 WO PCT/US2004/011254 patent/WO2004091514A2/en not_active Ceased
- 2004-04-09 AT AT04750028T patent/ATE466860T1/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DE602004027021D1 (de) | 2010-06-17 |
| AU2004229518A1 (en) | 2004-10-28 |
| CN1802369A (zh) | 2006-07-12 |
| EP1615914B1 (de) | 2010-05-05 |
| AU2004229518B2 (en) | 2010-02-18 |
| WO2004091514A3 (en) | 2005-09-15 |
| JP4705908B2 (ja) | 2011-06-22 |
| CA2522024A1 (en) | 2004-10-28 |
| JP2007525450A (ja) | 2007-09-06 |
| CN100572379C (zh) | 2009-12-23 |
| EP1615914A2 (de) | 2006-01-18 |
| WO2004091514A2 (en) | 2004-10-28 |
| US20060194783A1 (en) | 2006-08-31 |
| US7205292B2 (en) | 2007-04-17 |
| EP1615914A4 (de) | 2008-03-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |