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AR054838A1 - Compuestos inhibidores del virus de la hepatitis c - Google Patents

Compuestos inhibidores del virus de la hepatitis c

Info

Publication number
AR054838A1
AR054838A1 ARP060103034A ARP060103034A AR054838A1 AR 054838 A1 AR054838 A1 AR 054838A1 AR P060103034 A ARP060103034 A AR P060103034A AR P060103034 A ARP060103034 A AR P060103034A AR 054838 A1 AR054838 A1 AR 054838A1
Authority
AR
Argentina
Prior art keywords
alkyl
cycloalkyl
och2p
alkynyl
alkenyl
Prior art date
Application number
ARP060103034A
Other languages
English (en)
Original Assignee
Gilead Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gilead Sciences Inc filed Critical Gilead Sciences Inc
Publication of AR054838A1 publication Critical patent/AR054838A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/572—Five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Se refiere a compuesto inhibidores de VHC, composiciones que contienen dichos compuestos, y métodos terapéuticos que incluyen la administracion de dichos compuestos, como también a los procesos e intermediarios utiles para preparar dichos compuestos. Reivindicacion 1: Un compuesto, incluyendo los enantiomeros del anterior, de formulas (1), (2), (3) o (4), o una sal, o un solvato de los anteriores aceptables desde el punto de vista farmacéutico, donde: R1 es selecciona de manera independiente de H, alquilo, alquenilo, alquinilo, arilo, cicloalquilo, heterociclo, halogeno, haloalquilo, alquilsulfonamido, arilsulfonamido, -C(O)NHS(O)2-, o -S(O)2-, sustituidos de manera opcional con uno o más A3; R2 se selecciona de: a) - C(Y1)(A3); b) alquilo C2-10, cicloalquilo C3-7 o alquiloCl-4-cicloalquiloC3-7, donde dicho cicloalquilo y alquil-cicloalquilo puede ser mono-, di- o tri-sustituido con alquilo C1-3; o donde dicho alquilo, cicloalquilo y alquil-cicloalquilo pueden ser mono- o di-sustituidos con sustituyentes seleccionados de hidroxi y O-alquiloC1-4; o donde cada uno de dichos grupos alquilo puede ser mono-, di- o tri-sustituido con halogeno; o donde cada uno siendo de dichos grupos cicloalquilo es de 5, 6, o 7 miembros, uno o dos grupos -CH2- que no están unidos directamente entre sí pueden reemplazarse por -O- de manera tal que el átomo de O esté unido al átomo de N al cual R2 está unido a través de por lo menos dos átomos de C; o c) fenilo, alquilC1-3- fenilo, heteroarilo o alquilC1-3-heteroarilo, donde los grupos heteroarilo son de 5 o 6 miembros y tienen desde 1 hasta 3 heteroátomos seleccionados de N, O y S, donde dichos grupos fenilo y heteroarilo pueden estar mono-, di- o tri-sustituidos con sustituyentes seleccionados de halogeno, -OH, alquilo C1-4, O-alquiloCl-4, S-alquiloCl-4, -NH2, -NHalquiloCl-4 y -N(alquiloCl-4)2, -CONH2 y -CONH-alquiloCl-4; R3 es PRT, H o alquilo Cl-6; L se selecciona de manera independiente de C o N, siempre que no haya mas de tres N consecutivos, cada uno sustituido de manera opcional con uno o más A3; Z es O, S, C o N; sustituido en forma opcional con A3; Z2a es H, alquilo Cl-l0, alquenilo C2-10, alquinilo C2-10, donde cualquier átomo de carbono puede ser reemplazado con un heteroátomo seleccionado de O, S o N, o Z2a manera opcional forma un carbociclo o heterociclo con Q1 o cualquier A3; Z2b es H, alquilo Cl-6, alquenilo C2-8, alquinilo C2-8; Q1 es alquilo Cl, alquenilo C2-8, o alquinilo C2-8; A3 se selecciona de manera independiente de PRT, H, -OH, -C(O)OH, -(CH2)m-, -C(O)O-, - NH-, ciano, alquilo, alquenilo, alquinilo, amino, amido, imido, imino, halogeno, CF3, CH2CF3, cicloalquilo, nitro, arilo, aralquilo, alcoxi, ariloxi, heterociclo, heteroarilo, -C(A2)3, -C(A2)2-C(O)A2, -C(O)A2, -C(O)OA2, -O(A2), -N(A2)2, -S(A2), -CH2P(O)(A2)(OA2), -CH2P(O)(A2)(N(A2)2), -CH2P(O)(OA2)(OA2), -OCH2P(O)(OA2)(OA2), -OCH2P(O)(A2)(OA2), -OCH2P(O)(A2)(N(A2)2), -C(O)OCH2P(O)(OA2)(OA2), - C(O)OCH2P(O)(A2)(OA2), -C(O)OCH2P(O)(A2)(N(A2)2), -CH2P(O)(OA2)(N(A2)2), -OCH2P(O)(OA2)(N(A2)2), -C(O)OCH2P(O)(OA2)(N(A2)2), -CH2P(O)(N(A2)2)(N(A2)2), -C(O)OCH2P(O)(N(A2)2)(N(A2)2), -OCH2P(O)(N(A2)2)(N(A2)2), -(CH2)m-heterociclo, - (CH2)mC(O)Oalquilo, -O-(CH2)m-O-C(O)-Oalquilo, -O-(CH2)r-O-C(O)-(CH2)m-alquilo, -(CH2)mO-C(O)-O-alquilo, -(CH2)mO-C(O)-O-cicloalquilo, -N(H)C(Me)C(O)O-alquilo, o alcoxi arilsulfonamida; donde cada A3 puede estar sustituido en forma opcional con 1 hasta 4-R1, -P(O)(OA2)(OA2), -P(O)(OA2)(N(A2)2), -P(O)(A2)(OA2), -P(O)(A2)(N(A2)2) o -P(O)(N(A2)2)(N(A2)2), halogeno, alquilo, alquenilo, alquinilo, arilo, carbociclo, heterociclo, aralquilo, arilsulfonamida, arilalquilsulfonamida, ariloxi sulfonamida, ariloxi, alquilsulfonamida, ariloxi arilsulfonamida, alquilsulfonamida, alquiloxi sulfonamida,, alquiloxi alquilsulfonamida, -(CH2)m-heterociclo, -(CH2)m-C(O)O-alquilo, -O(CH2)mOC(O)Oalquilo, -O-(CH2)m-O-C(O)-(CH2)m-alquilo, -(CH2)m-O- C(O)-O-alquilo, -(CH2)m-O-C(O)-O-cicloalquilo, -N(H)C(CH3)C(O)O-alquilo, alcoxi, -N(R3)(R3) o alcoxi arilsulfonamida, sustituida en forma opcional con -R1; o A3 forma un anillo carbocíclico o heterocíclico con cualquier otro A3 o Q1; Y1 es O, S, N(R2), N(OR2) o N(N(R2)2; A2 se selecciona de manera independiente de H, alquilo, alquenilo, alquinilo, amino, aminoácido, alcoxi, ariloxi, ciano, haloalquilo, cicloalquilo, arilo, heteroarilo, alquilsulfonamida, o arilsulfonamida, sustituida en forma opcional con A3; m es 0 a 6; r es 1 hasta 2; y q es hasta 10.
ARP060103034A 2005-07-14 2006-07-14 Compuestos inhibidores del virus de la hepatitis c AR054838A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US69909605P 2005-07-14 2005-07-14
US70055905P 2005-07-18 2005-07-18

Publications (1)

Publication Number Publication Date
AR054838A1 true AR054838A1 (es) 2007-07-18

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
ARP060103034A AR054838A1 (es) 2005-07-14 2006-07-14 Compuestos inhibidores del virus de la hepatitis c

Country Status (13)

Country Link
US (1) US20070072809A1 (es)
EP (1) EP1907403B1 (es)
JP (1) JP2009501724A (es)
KR (1) KR101345008B1 (es)
CN (1) CN101243096B (es)
AR (1) AR054838A1 (es)
AU (1) AU2006267066A1 (es)
BR (1) BRPI0613056A2 (es)
CA (1) CA2614276A1 (es)
MX (1) MX2008000609A (es)
NZ (1) NZ564830A (es)
TW (1) TWI389908B (es)
WO (1) WO2007009109A2 (es)

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KR20080027947A (ko) 2008-03-28
AU2006267066A1 (en) 2007-01-18
JP2009501724A (ja) 2009-01-22
WO2007009109A3 (en) 2007-06-07
MX2008000609A (es) 2008-03-19
EP1907403B1 (en) 2013-12-25
CN101243096A (zh) 2008-08-13
CN101243096B (zh) 2013-02-06
EP1907403A2 (en) 2008-04-09
WO2007009109A2 (en) 2007-01-18
US20070072809A1 (en) 2007-03-29
TW200738741A (en) 2007-10-16
BRPI0613056A2 (pt) 2010-12-14
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CA2614276A1 (en) 2007-01-18
KR101345008B1 (ko) 2013-12-31

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