AR043964A1 - Derivados de 4- ( 2-fenilsulfanil-fenil) 1,2,3,6-tetrahidropiridina como anhibidores de la recaptacion de serotonina - Google Patents
Derivados de 4- ( 2-fenilsulfanil-fenil) 1,2,3,6-tetrahidropiridina como anhibidores de la recaptacion de serotoninaInfo
- Publication number
- AR043964A1 AR043964A1 ARP040101130A ARP040101130A AR043964A1 AR 043964 A1 AR043964 A1 AR 043964A1 AR P040101130 A ARP040101130 A AR P040101130A AR P040101130 A ARP040101130 A AR P040101130A AR 043964 A1 AR043964 A1 AR 043964A1
- Authority
- AR
- Argentina
- Prior art keywords
- ilo
- alkyl
- hydrogen
- independently selected
- cycloalkyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Los compuestos son útiles en el tratamiento de un trastorno afectivo, incluyendo depresión, trastornos de ansiedad incluyendo trastorno de ansiedad general y trastorno de pánico y trastorno obsesivo compulsivo. Reivindicación 1: Un compuesto representado por la fórmula general (1), en la cual: R1, R2, R3, R4, R5 se seleccionan independientemente entre hidrógeno, halógeno, ciano, alqu(en/in)ilo C1-6, alqu(en/in)iloxi C1-6, alqu(en/in)ilsulfanilo C1-6, hidroxi, hidroxi-alqu(en/in)ilo C1-6, halo-alqu(en/in)ilo C1-6, halo-alqu(en/in)iloxi C1-6, o NRxRy en donde Rx y Ry se seleccionan independientemente entre hidrógeno, alqu(en/in)ilo C1-6, cicloalqu(en)ilo C3-8, cicloalqu(en)ilo(C3-8)-alqu(en/in)ilo-(C1-6), o NRzRw-alqu(en/in)ilo-C1-6, en donde Rz y Rw se seleccionan independientemente entre hidrógeno, alqu(en/in)ilo-C1-6, cicloalqu(en)ilo-C3-8, o cicloalqu(en)ilo-(C3-8)-alqu(en/in)ilo-(C1-6); o Rx y Ry junto con el nitrógeno al cual están unidos forman un anillo de 3-7 miembros el cual opcionalmente contiene un heteroátomo adicional; o R2 y R3 juntos forman un heterociclo fusionado al anillo de fenilo seleccionado entre la fórmula (2); R1, R4, R5 son según lo definido anteriormente; R6, R7, R8, R9 se seleccionan independientemente entre hidrógeno, halógeno, alqu(en/in)ilo-C1-6, alqu(en/in)iloxi-C1-6, alqu(en/in)ilsulfanilo-C1-6, hidroxi, hidroxi-alqu(en/in)ilo-C1-6, halo-alqu(en/in)ilo-C1-6, halo-alqu(en/in)iloxi-C1-6, o NRxRy en donde Rx y Ry se seleccionan independientemente entre hidrógeno, alqu(en/in)ilo C1-6, cicloalqu(en)ilo C3-8, cicloalqu(en)ilo-(C3-8)-alqu(en/in)ilo-(C1-6), o NRzRw-alqu(en/in)ilo-C1-6, en donde Rz y Rw se seleccionan independientemente entre hidrógeno, alqu(en/in)ilo C1-6, cicloalqu(en)ilo C3-8, o cicloalqu(en)ilo (C3-8)-alqu(en/in)ilo (C1-6); o Rx y Ry junto con el nitrógeno al cual están unidos forman un anillo de 3-7 miembros el cual opcionalmente contiene un heteroátomo adicional; siempre que al menos uno de R1, R2, R3, R4, R5, R6, R7, R8, y R9 sea diferente de hidrógeno; también siempre y cuando R3 es metilo o metoxi, entonces al menos uno de R1, R2, R3, R4, R5, R6, R7, R8 y R9 es diferente de hidrógeno; o una sal del mismo.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200300518 | 2003-04-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR043964A1 true AR043964A1 (es) | 2005-08-17 |
Family
ID=35432910
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP040101130A AR043964A1 (es) | 2003-04-04 | 2004-04-02 | Derivados de 4- ( 2-fenilsulfanil-fenil) 1,2,3,6-tetrahidropiridina como anhibidores de la recaptacion de serotonina |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US20070173522A1 (es) |
| EP (1) | EP1613594B1 (es) |
| JP (1) | JP2006522029A (es) |
| KR (1) | KR20060021825A (es) |
| CN (1) | CN100384822C (es) |
| AR (1) | AR043964A1 (es) |
| AT (1) | ATE390413T1 (es) |
| AU (1) | AU2004226319A1 (es) |
| BR (1) | BRPI0408453A (es) |
| CA (1) | CA2521172A1 (es) |
| CL (1) | CL2004000730A1 (es) |
| CO (1) | CO5700777A2 (es) |
| DE (1) | DE602004012724T2 (es) |
| DK (1) | DK1613594T3 (es) |
| EA (1) | EA009282B1 (es) |
| ES (1) | ES2301979T3 (es) |
| HR (1) | HRP20080243T3 (es) |
| IS (1) | IS8007A (es) |
| MX (1) | MXPA05010678A (es) |
| NO (1) | NO20055205L (es) |
| NZ (1) | NZ541944A (es) |
| PL (1) | PL1613594T3 (es) |
| PT (1) | PT1613594E (es) |
| SI (1) | SI1613594T1 (es) |
| UA (1) | UA81300C2 (es) |
| WO (1) | WO2004087662A1 (es) |
| ZA (1) | ZA200507182B (es) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1626720B1 (en) | 2003-04-04 | 2008-09-03 | H. Lundbeck A/S | 4-(2-phenylsulfanyl-phenyl)-piperidine derivatives as serotonin reuptake inhibitors |
| JP5173190B2 (ja) | 2004-08-25 | 2013-03-27 | 武田薬品工業株式会社 | 腹圧性尿失禁の予防・治療剤及びそのスクリーニング方法 |
| WO2007132841A1 (ja) | 2006-05-16 | 2007-11-22 | Takeda Pharmaceutical Company Limited | 縮合複素環化合物およびその用途 |
| WO2009063992A1 (ja) | 2007-11-15 | 2009-05-22 | Takeda Pharmaceutical Company Limited | 縮合ピリジン誘導体およびその用途 |
| UA98698C2 (en) * | 2008-03-03 | 2012-06-11 | Х. Луннбек А/С | Phenylsulfanylphenyl-piperidines and process for the preparation thereof |
| JPWO2011071136A1 (ja) | 2009-12-11 | 2013-04-22 | アステラス製薬株式会社 | 線維筋痛症治療剤 |
| EP2930171A1 (en) * | 2014-04-07 | 2015-10-14 | LEK Pharmaceuticals d.d. | Synthesis of vortioxetine via (2,4-dimethylphenyl)(2-iodophenyl)sulfane intermediate |
| CN105294554B (zh) * | 2015-11-18 | 2017-11-07 | 乳源瑶族自治县大众药品贸易有限公司 | 苯基哌嗪衍生物及其使用方法和用途 |
| JPWO2019131902A1 (ja) | 2017-12-27 | 2020-12-10 | 武田薬品工業株式会社 | 腹圧性尿失禁および便失禁の治療薬 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3803143A (en) * | 1969-09-08 | 1974-04-09 | Eisai Co Ltd | 6-amino alkylene 6,7-dihydro-5h-dibenzo (b,g),(1,5)thiazocines |
| US4018830A (en) * | 1969-09-22 | 1977-04-19 | Merck & Co., Inc. | Phenylthioaralkylamines |
| US4055665A (en) * | 1974-11-25 | 1977-10-25 | Merck & Co., Inc. | Treating arrythmia with phenylthioaralkylamines |
| US4066654A (en) * | 1975-04-16 | 1978-01-03 | G. D. Searle & Co. | 1-triarylalkyl-4-phenyl-4-piperidine carboxylic acids and derivatives |
| US4056632A (en) * | 1975-07-21 | 1977-11-01 | Burroughs Wellcome Co. | 2-Hydroxymethyl-2'-aminomethyl-diphenylsulfides and method of use |
| DE2802306A1 (de) * | 1977-01-27 | 1978-08-10 | Hoechst Ag | Azacycloalkane, azacycloalkene und ihre derivate |
| US4241071A (en) * | 1977-01-27 | 1980-12-23 | American Hoechst Corporation | Antidepressant (α-phenyl-2-tolyl)azacycloalkanes |
| US4198417A (en) * | 1979-01-10 | 1980-04-15 | American Hoechst Corporation | Phenoxyphenylpiperidines |
| US4198419A (en) * | 1979-01-10 | 1980-04-15 | American Hoechst Corporation | Phenylthiophenylpiperidines |
| GB8912971D0 (en) * | 1989-06-06 | 1989-07-26 | Wellcome Found | Halogen substituted diphenylsulfides |
| PL355289A1 (en) * | 1999-10-13 | 2004-04-05 | Pfizer Products Inc. | Biaryl ether derivatives useful as monoamine reuptake inhibitors |
| US6410736B1 (en) * | 1999-11-29 | 2002-06-25 | Pfizer Inc. | Biaryl ether derivatives useful as monoamine reuptake inhibitors |
| NZ519647A (en) * | 1999-12-30 | 2004-02-27 | H | Substituted phenyl-piperazine derivatives, their preparation and use |
| US6436938B1 (en) * | 2001-01-22 | 2002-08-20 | Pfizer Inc. | Combination treatment for depression |
| US20020107244A1 (en) * | 2001-02-02 | 2002-08-08 | Howard Harry R. | Combination treatment for depression |
| UA81749C2 (uk) * | 2001-10-04 | 2008-02-11 | Х. Луннбек А/С | Фенілпіперазинові похідні як інгібітори зворотного захоплення серотоніну |
-
2004
- 2004-02-04 UA UAA200508779A patent/UA81300C2/uk unknown
- 2004-04-02 JP JP2006504348A patent/JP2006522029A/ja active Pending
- 2004-04-02 CA CA002521172A patent/CA2521172A1/en not_active Abandoned
- 2004-04-02 US US10/551,869 patent/US20070173522A1/en not_active Abandoned
- 2004-04-02 AU AU2004226319A patent/AU2004226319A1/en not_active Abandoned
- 2004-04-02 DK DK04725299T patent/DK1613594T3/da active
- 2004-04-02 PT PT04725299T patent/PT1613594E/pt unknown
- 2004-04-02 CL CL200400730A patent/CL2004000730A1/es unknown
- 2004-04-02 ZA ZA200507182A patent/ZA200507182B/en unknown
- 2004-04-02 AR ARP040101130A patent/AR043964A1/es not_active Application Discontinuation
- 2004-04-02 AT AT04725299T patent/ATE390413T1/de not_active IP Right Cessation
- 2004-04-02 DE DE602004012724T patent/DE602004012724T2/de not_active Expired - Fee Related
- 2004-04-02 CN CNB2004800094713A patent/CN100384822C/zh not_active Expired - Fee Related
- 2004-04-02 BR BRPI0408453-5A patent/BRPI0408453A/pt not_active IP Right Cessation
- 2004-04-02 EP EP04725299A patent/EP1613594B1/en not_active Expired - Lifetime
- 2004-04-02 NZ NZ541944A patent/NZ541944A/en unknown
- 2004-04-02 PL PL04725299T patent/PL1613594T3/pl unknown
- 2004-04-02 WO PCT/DK2004/000243 patent/WO2004087662A1/en not_active Ceased
- 2004-04-02 KR KR1020057018870A patent/KR20060021825A/ko not_active Withdrawn
- 2004-04-02 SI SI200430727T patent/SI1613594T1/sl unknown
- 2004-04-02 HR HR20080243T patent/HRP20080243T3/xx unknown
- 2004-04-02 MX MXPA05010678A patent/MXPA05010678A/es active IP Right Grant
- 2004-04-02 EA EA200501579A patent/EA009282B1/ru not_active IP Right Cessation
- 2004-04-02 ES ES04725299T patent/ES2301979T3/es not_active Expired - Lifetime
-
2005
- 2005-08-29 IS IS8007A patent/IS8007A/is unknown
- 2005-11-02 CO CO05111852A patent/CO5700777A2/es unknown
- 2005-11-04 NO NO20055205A patent/NO20055205L/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PT1613594E (pt) | 2008-07-01 |
| ES2301979T3 (es) | 2008-07-01 |
| ATE390413T1 (de) | 2008-04-15 |
| ZA200507182B (en) | 2006-12-27 |
| IS8007A (is) | 2005-08-29 |
| HK1090051A1 (en) | 2006-12-15 |
| KR20060021825A (ko) | 2006-03-08 |
| WO2004087662A1 (en) | 2004-10-14 |
| MXPA05010678A (es) | 2005-12-12 |
| EA200501579A1 (ru) | 2006-04-28 |
| BRPI0408453A (pt) | 2006-04-04 |
| CL2004000730A1 (es) | 2005-02-18 |
| CA2521172A1 (en) | 2004-10-14 |
| DK1613594T3 (da) | 2008-07-14 |
| UA81300C2 (en) | 2007-12-25 |
| CN100384822C (zh) | 2008-04-30 |
| EP1613594A1 (en) | 2006-01-11 |
| US20070173522A1 (en) | 2007-07-26 |
| DE602004012724T2 (de) | 2009-04-09 |
| NZ541944A (en) | 2008-05-30 |
| SI1613594T1 (sl) | 2008-08-31 |
| CN1777585A (zh) | 2006-05-24 |
| PL1613594T3 (pl) | 2008-09-30 |
| AU2004226319A1 (en) | 2004-10-14 |
| JP2006522029A (ja) | 2006-09-28 |
| DE602004012724D1 (de) | 2008-05-08 |
| HRP20080243T3 (hr) | 2009-04-30 |
| EP1613594B1 (en) | 2008-03-26 |
| NO20055205L (no) | 2005-11-04 |
| EA009282B1 (ru) | 2007-12-28 |
| CO5700777A2 (es) | 2006-11-30 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AR066210A1 (es) | Proceso para producir compuesto amida | |
| ES2613538T3 (es) | Derivados de arilamida como bloqueadores de TTX-S | |
| CO6160234A2 (es) | Nuevos compuestos ciclicos fusionados que presentan una accion moduladora de la funcion del recptor gpr40 | |
| AR054024A1 (es) | Derivados de piridina -3- carboxamida como agonistas inversos de cb1 | |
| AR064355A1 (es) | Herbicidas derivados de isoxazol | |
| MX2009008465A (es) | Nuevas 2-aminooxazolinas como ligandos de taar1. | |
| AR085615A1 (es) | Derivados de fluoropiridinona utiles como agentes antibacterianos y composiciones farmaceuticas que los contienen | |
| JO2864B1 (en) | Circular amine compounds | |
| TNSN07255A1 (en) | Cyclohexylamides as dopamine d3, d2 and 5ht 1a antagonists | |
| AR060489A1 (es) | Derivados del acido benzoazepin - oxi- acetico como agonistas de ppar - delta usados para aumentar hdl- c, reducir ldl-c y reducir colesterol | |
| CU23926B1 (es) | Derivado de oxopirazina y herbicida | |
| AR073136A1 (es) | Compuestos de pirrol | |
| AR082886A1 (es) | Compuestos y composiciones farmaceuticas que los contienen | |
| AR069480A1 (es) | Derivados de 2-amino-pirimidina | |
| PE20060583A1 (es) | Tiazolil-dihidro-indazoles como inhibidores de pi3-quinasas | |
| AR084913A1 (es) | Derivados de aril-benzocicloalquil-amida | |
| AR050266A1 (es) | Derivados de bencil-triazolona como inhibidores no nucleosidos de transcriptasa inversa | |
| ECSP14013296A (es) | Derivados de etinilo | |
| DK2197860T3 (da) | Nye forbindelser som adenosin-A1-receptorantagonister | |
| AR044715A1 (es) | Compuestos tipo amidas que inhiben la reabsorcion de las monoaminas | |
| EA201071012A1 (ru) | Производные азетидинов, способ их получения и применение их в терапии | |
| ES2421896T3 (es) | Compuestos de aril-(imidazol)-metil-fenilo sustituidos como moduladores selectivos de los subtipos de receptores adrenérgicos alfa 2B y/o alfa 2C | |
| AR075531A1 (es) | Derivados de piperazin-ciclopropil benzamidas, composiciones farmaceuticas que los contienen y uso de los mismos para el tratamiento de trastornos del sistema nervioso central, tales como alzheimer y esquizofrenia, entre otros | |
| AR043964A1 (es) | Derivados de 4- ( 2-fenilsulfanil-fenil) 1,2,3,6-tetrahidropiridina como anhibidores de la recaptacion de serotonina | |
| CO5700747A2 (es) | Piperidinas novedosas como moduladores de quimoquina (ccr) |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |