AR043652A1 - Derivados de p-diaminobenceno substituidos como abridores de los canales del ion de potasio de la familia de kcnq - Google Patents
Derivados de p-diaminobenceno substituidos como abridores de los canales del ion de potasio de la familia de kcnqInfo
- Publication number
- AR043652A1 AR043652A1 ARP040100905A ARP040100905A AR043652A1 AR 043652 A1 AR043652 A1 AR 043652A1 AR P040100905 A ARP040100905 A AR P040100905A AR P040100905 A ARP040100905 A AR P040100905A AR 043652 A1 AR043652 A1 AR 043652A1
- Authority
- AR
- Argentina
- Prior art keywords
- ilo
- alkyl
- cycloalkyl
- halo
- cyano
- Prior art date
Links
- 102000004257 Potassium Channel Human genes 0.000 title 1
- 108020001213 potassium channel Proteins 0.000 title 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 20
- 125000000217 alkyl group Chemical group 0.000 abstract 13
- 125000005350 hydroxycycloalkyl group Chemical group 0.000 abstract 10
- 229910052739 hydrogen Inorganic materials 0.000 abstract 9
- 125000004966 cyanoalkyl group Chemical group 0.000 abstract 7
- 125000005347 halocycloalkyl group Chemical group 0.000 abstract 7
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 7
- 125000001188 haloalkyl group Chemical group 0.000 abstract 6
- 229910052760 oxygen Inorganic materials 0.000 abstract 6
- 125000002252 acyl group Chemical group 0.000 abstract 5
- 125000005842 heteroatom Chemical group 0.000 abstract 5
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 4
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 4
- 229920006395 saturated elastomer Polymers 0.000 abstract 4
- 229910052717 sulfur Inorganic materials 0.000 abstract 4
- 125000005354 acylalkyl group Chemical group 0.000 abstract 3
- 229910052736 halogen Inorganic materials 0.000 abstract 3
- 125000005843 halogen group Chemical group 0.000 abstract 3
- 125000000592 heterocycloalkyl group Chemical group 0.000 abstract 3
- 150000002367 halogens Chemical class 0.000 abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 abstract 2
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 abstract 1
- CBCKQZAAMUWICA-UHFFFAOYSA-N 1,4-phenylenediamine Chemical class NC1=CC=C(N)C=C1 CBCKQZAAMUWICA-UHFFFAOYSA-N 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- -1 substituted Chemical class 0.000 abstract 1
- 125000005346 substituted cycloalkyl group Chemical group 0.000 abstract 1
- RAHZWNYVWXNFOC-UHFFFAOYSA-N sulfur dioxide Inorganic materials O=S=O RAHZWNYVWXNFOC-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
- C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/42—Radicals substituted by singly-bound nitrogen atoms having hetero atoms attached to the substituent nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D333/58—Radicals substituted by nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200300441 | 2003-03-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR043652A1 true AR043652A1 (es) | 2005-08-03 |
Family
ID=58707221
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP040100905A AR043652A1 (es) | 2003-03-21 | 2004-03-18 | Derivados de p-diaminobenceno substituidos como abridores de los canales del ion de potasio de la familia de kcnq |
Country Status (9)
| Country | Link |
|---|---|
| KR (1) | KR20050115919A (is) |
| CN (1) | CN1761464A (is) |
| AR (1) | AR043652A1 (is) |
| CL (1) | CL2004000575A1 (is) |
| EA (1) | EA200501499A1 (is) |
| IS (1) | IS7991A (is) |
| NZ (1) | NZ541945A (is) |
| UA (1) | UA81019C2 (is) |
| ZA (1) | ZA200507183B (is) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103073455B (zh) * | 2011-10-25 | 2015-08-19 | 中国科学院上海药物研究所 | 一类新型的kcnq钾通道激动剂、其制备方法和用途 |
| CN105017085B (zh) * | 2014-04-28 | 2018-06-29 | 中国科学院上海药物研究所 | 一类kcnq钾通道激动剂、其制备方法和用途 |
| CN108707087B (zh) | 2018-06-29 | 2020-10-16 | 河北医科大学 | 一种4-(对三氟甲基苄基)-3-氟-1,2,4三苯胺衍生物及其药物组合物与用途 |
| KR102643653B1 (ko) * | 2020-11-13 | 2024-03-06 | 기초과학연구원 | 신규한 아미노방향족 화합물 또는 이의 약학적으로 허용가능한 염 및 이를 유효성분으로 포함하는 신경퇴행성 질환의 예방 또는 치료용 약학적 조성물 |
| CN114672483B (zh) * | 2022-05-31 | 2022-09-02 | 上海百力格生物技术有限公司 | 超声法核酸探针制备方法 |
| WO2025075467A1 (ko) * | 2023-10-06 | 2025-04-10 | 기초과학연구원 | 허혈성 뇌혈관 질환 및 이의 후유증의 치료를 위한 화합물 및 이를 포함하는 조성물 |
-
2004
- 2004-03-18 ZA ZA200507183A patent/ZA200507183B/en unknown
- 2004-03-18 NZ NZ541945A patent/NZ541945A/en unknown
- 2004-03-18 EA EA200501499A patent/EA200501499A1/ru unknown
- 2004-03-18 KR KR1020057017581A patent/KR20050115919A/ko not_active Ceased
- 2004-03-18 AR ARP040100905A patent/AR043652A1/es unknown
- 2004-03-18 UA UAA200509094A patent/UA81019C2/uk unknown
- 2004-03-18 CN CNA2004800075074A patent/CN1761464A/zh active Pending
- 2004-03-19 CL CL200400575A patent/CL2004000575A1/es unknown
-
2005
- 2005-08-18 IS IS7991A patent/IS7991A/is unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NZ541945A (en) | 2009-02-28 |
| CL2004000575A1 (es) | 2005-01-21 |
| UA81019C2 (en) | 2007-11-26 |
| IS7991A (is) | 2005-08-18 |
| EA200501499A1 (ru) | 2006-02-24 |
| ZA200507183B (en) | 2007-03-28 |
| CN1761464A (zh) | 2006-04-19 |
| KR20050115919A (ko) | 2005-12-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |