AR043395A1 - COMBINATION THERAPY FOR HYPERTENSION USING LERCANIDIPINE AND A BLOCKER OF ANGIOTENSIN II RECEPTORS - Google Patents
COMBINATION THERAPY FOR HYPERTENSION USING LERCANIDIPINE AND A BLOCKER OF ANGIOTENSIN II RECEPTORSInfo
- Publication number
- AR043395A1 AR043395A1 ARP040100592A ARP040100592A AR043395A1 AR 043395 A1 AR043395 A1 AR 043395A1 AR P040100592 A ARP040100592 A AR P040100592A AR P040100592 A ARP040100592 A AR P040100592A AR 043395 A1 AR043395 A1 AR 043395A1
- Authority
- AR
- Argentina
- Prior art keywords
- lercanidipine
- angiotensin
- hypertension
- blocker
- receptors
- Prior art date
Links
- ZDXUKAKRHYTAKV-UHFFFAOYSA-N lercanidipine Chemical compound COC(=O)C1=C(C)NC(C)=C(C(=O)OC(C)(C)CN(C)CCC(C=2C=CC=CC=2)C=2C=CC=CC=2)C1C1=CC=CC([N+]([O-])=O)=C1 ZDXUKAKRHYTAKV-UHFFFAOYSA-N 0.000 title abstract 3
- 229960004294 lercanidipine Drugs 0.000 title abstract 3
- 102000008873 Angiotensin II receptor Human genes 0.000 title abstract 2
- 108050000824 Angiotensin II receptor Proteins 0.000 title abstract 2
- 206010020772 Hypertension Diseases 0.000 title abstract 2
- 238000002648 combination therapy Methods 0.000 title 1
- RMMXLENWKUUMAY-UHFFFAOYSA-N telmisartan Chemical compound CCCC1=NC2=C(C)C=C(C=3N(C4=CC=CC=C4N=3)C)C=C2N1CC(C=C1)=CC=C1C1=CC=CC=C1C(O)=O RMMXLENWKUUMAY-UHFFFAOYSA-N 0.000 abstract 2
- 239000002083 C09CA01 - Losartan Substances 0.000 abstract 1
- 239000004072 C09CA03 - Valsartan Substances 0.000 abstract 1
- 239000002947 C09CA04 - Irbesartan Substances 0.000 abstract 1
- 239000005537 C09CA07 - Telmisartan Substances 0.000 abstract 1
- 239000005480 Olmesartan Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229960002198 irbesartan Drugs 0.000 abstract 1
- YCPOHTHPUREGFM-UHFFFAOYSA-N irbesartan Chemical compound O=C1N(CC=2C=CC(=CC=2)C=2C(=CC=CC=2)C=2[N]N=NN=2)C(CCCC)=NC21CCCC2 YCPOHTHPUREGFM-UHFFFAOYSA-N 0.000 abstract 1
- 229960004773 losartan Drugs 0.000 abstract 1
- KJJZZJSZUJXYEA-UHFFFAOYSA-N losartan Chemical compound CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C=2[N]N=NN=2)C=C1 KJJZZJSZUJXYEA-UHFFFAOYSA-N 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- VTRAEEWXHOVJFV-UHFFFAOYSA-N olmesartan Chemical compound CCCC1=NC(C(C)(C)O)=C(C(O)=O)N1CC1=CC=C(C=2C(=CC=CC=2)C=2NN=NN=2)C=C1 VTRAEEWXHOVJFV-UHFFFAOYSA-N 0.000 abstract 1
- 229960005117 olmesartan Drugs 0.000 abstract 1
- 239000003087 receptor blocking agent Substances 0.000 abstract 1
- 229960005187 telmisartan Drugs 0.000 abstract 1
- 229960004699 valsartan Drugs 0.000 abstract 1
- SJSNUMAYCRRIOM-QFIPXVFZSA-N valsartan Chemical compound C1=CC(CN(C(=O)CCCC)[C@@H](C(C)C)C(O)=O)=CC=C1C1=CC=CC=C1C1=NN=N[N]1 SJSNUMAYCRRIOM-QFIPXVFZSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4422—1,4-Dihydropyridines, e.g. nifedipine, nicardipine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La lercanidipina se utiliza en la preparación de un medicamento para el tratamiento de la hipertensión en combinación con la administración previa, concurrente o posterior de un bloqueante de los receptores de angiotensina II (ARB) seleccionado de olmesartán, irbesartán, valsartán, telmisartán y losartán. Se reivindican las composiciones que obtienen tanto lercanidipina como el ARB.Lercanidipine is used in the preparation of a medication for the treatment of hypertension in combination with the previous, concurrent or subsequent administration of an angiotensin II receptor blocker (ARB) selected from olmesartan, irbesartan, valsartan, telmisartan and losartan. Compositions that obtain both lercanidipine and ARB are claimed.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US45086403P | 2003-02-28 | 2003-02-28 | |
| US45078203P | 2003-02-28 | 2003-02-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR043395A1 true AR043395A1 (en) | 2005-07-27 |
Family
ID=32930575
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP040100592A AR043395A1 (en) | 2003-02-28 | 2004-02-25 | COMBINATION THERAPY FOR HYPERTENSION USING LERCANIDIPINE AND A BLOCKER OF ANGIOTENSIN II RECEPTORS |
Country Status (4)
| Country | Link |
|---|---|
| AR (1) | AR043395A1 (en) |
| CL (1) | CL2004000379A1 (en) |
| TW (1) | TW200501953A (en) |
| WO (1) | WO2004075892A2 (en) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006050922A1 (en) * | 2004-11-11 | 2006-05-18 | Lek Pharmaceuticals D.D. | Process for the synthesis of tetrazoles |
| CN1298389C (en) * | 2005-01-18 | 2007-02-07 | 广东省人民医院 | Compound preparation of calcium antagonist and timishatan for reducing blood pressure and its use |
| WO2008040367A1 (en) * | 2006-08-01 | 2008-04-10 | Union Quimico-Farmaceutica S.A. | Lercanidipine hydrobromide, a process for its preparation, crystalline forms and compositions thereof |
| WO2008023869A1 (en) * | 2006-08-24 | 2008-02-28 | Hanall Pharmaceutical Co., Ltd. | Combined pharmeceutical formulation with controlled-release comprising dihydropyridine calcium channel blockers and hmg-coa reductase inhibitors |
| US20080175872A1 (en) * | 2006-09-28 | 2008-07-24 | Osmotica Corp. | Controlled Release Dosage Form Containing Lercanidipine and a Performance-enhancing Acid |
| KR101247583B1 (en) * | 2006-12-08 | 2013-03-26 | 한미사이언스 주식회사 | Pharmaceutical composition comprising amlodipine or a pharmaceutically acceptable salt thereof and losartan or a pharmaceutically acceptable salt thereof |
| DE102008059206A1 (en) | 2008-11-27 | 2010-06-10 | Bayer Schering Pharma Aktiengesellschaft | Pharmaceutical dosage form containing nifedipine or nisoldipine and an angiotensin II antagonist and / or a diuretic |
| CN102600146B (en) * | 2012-04-11 | 2014-10-08 | 兆科药业(合肥)有限公司 | Lercanidipine hydrochloride and losartan potassium compound preparation and preparation method thereof |
| MX2015002170A (en) * | 2015-02-18 | 2016-08-17 | Invekra S A P I De C V | Novel pharmaceutical compositions useful for treating hypertension. |
| MX2015002169A (en) * | 2015-02-18 | 2016-08-17 | Invekra S A P I De C V | Pharmaceutical compositions for treating hypertension, based on a novel drug combination. |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU1042199A (en) * | 1998-11-06 | 2000-05-29 | Boehringer Ingelheim International Gmbh | Antihypertensive medicaments containing lacidipine and telmisartan |
| ITMI20011726A1 (en) * | 2001-08-06 | 2003-02-06 | Recordati Ind Chimica E Farma | POLYMORPHIC FORMS OF LERCANIDIPINE HYDROCHLORIDE |
-
2004
- 2004-02-25 AR ARP040100592A patent/AR043395A1/en not_active Application Discontinuation
- 2004-02-26 CL CL200400379A patent/CL2004000379A1/en unknown
- 2004-02-27 TW TW093105113A patent/TW200501953A/en unknown
- 2004-02-27 WO PCT/EP2004/002000 patent/WO2004075892A2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| CL2004000379A1 (en) | 2005-01-21 |
| WO2004075892A3 (en) | 2004-09-30 |
| TW200501953A (en) | 2005-01-16 |
| WO2004075892A2 (en) | 2004-09-10 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CY1125077T1 (en) | TREATMENT OF VITAMIN D DEFICIENCY AND DEFICIENCY WITH 25-HYDROXYVITAMIN D2 AND 25-HYDROXYVITAMIN D3 | |
| CY1110989T1 (en) | USE OF 3- (4-AMINO-1-oxo-1,3-dihydro-isoindol-2-yl) -piperidino-2,6-dione for the treatment of human lymph nodes | |
| AR051618A1 (en) | COMPRESSED BICYCLE AND METHOD | |
| CL2008001946A1 (en) | Imidazole-derived compounds, ccr2, ccr3, ccr5 receptor antagonists; preparation procedure; and use in the treatment of peripheral vascular diseases. | |
| CL2007001174A1 (en) | Compounds derived from 4h- [1,2,4] triazol-3-yl, which exhibit activity in metabotropic glutamate receptors; intermediary compounds; pharmaceutical composition comprising the compounds; pharmaceutical combination that includes the compounds; and use of the compounds in the preparation of medications | |
| CL2004000860A1 (en) | BICYCLE COMPOUND OF PIRAZOL OR IMIDAZOL OF DEFINED FORMULA, AS BINDING WITH THE CANNABINOID RECEIVER THAT ACTS AS AN ANTAGONIST OF THE CB1 RECEIVER; PHARMACEUTICAL COMPOSITION THAT INCLUDES THE COMPOUND AND USE OF THE COMPOUND IN THE PREPARATION OF A MEDICAM | |
| CL2008002521A1 (en) | Substituted pyrazole derivative compounds, androgen receptor antagonist; pharmaceutical composition comprising said compounds; and use of the compound for the treatment of cancer. | |
| ECSP088692A (en) | COMPOUNDS BASED ON IMIDAZOL, COMPOSITIONS THAT INCLUDE THE SAME AND METHODS OF THEIR USE | |
| ECSP055840A (en) | DERIVATIVES OF 4-TETRAZOLIL-4 PHENYLPIPERIDINE FOR THE TREATMENT OF PAIN | |
| NO20060900L (en) | Nitrooside derivatives of Losartan, Valsartan, Candesartan, Telmisartan, Eprosartan and Olmesartan as angiotensin II receptor blockers for the treatment of cardiovascular disease | |
| CL2011003266A1 (en) | Compounds derived from imidazolidin-2-one, with inhibitory activity of 17alpha-hydroxylase / lyase-c17,20; pharmaceutical composition comprising them; and use in the treatment of inflammation or cancer, among others. | |
| BRPI0507887A (en) | multilayer tablet | |
| CL2010000188A1 (en) | A method for treating an infection in a subject comprising the administration of 9 - [(2,2-dimethyl-propylamino) -methyl] -minocycline or a salt thereof; pharmaceutical composition comprising said compound; and its use. | |
| CL2008003595A1 (en) | Nitrogen heterocyclic compounds, tachykinin receptor antagonists; pharmaceutical agent comprising the compound; and use in the prophylaxis or treatment of a lower urinary tract disease, a gastrointestinal disease, or a disease of the central nervous system. | |
| PE20020082A1 (en) | PHARMACEUTICAL COMPOSITION INCLUDING AN ALDOSTERONE-SYNTHASE INHIBITOR AND AN ANGIOTENSIN II RECEPTOR ANTAGONIST (AT1) | |
| AR067347A1 (en) | ANTIHELMINTIC COMBINATION | |
| AR043395A1 (en) | COMBINATION THERAPY FOR HYPERTENSION USING LERCANIDIPINE AND A BLOCKER OF ANGIOTENSIN II RECEPTORS | |
| ECSP066882A (en) | IMIDAZOL COMPOUNDS | |
| NO20090119L (en) | Composition comprising controlled release nanoparticulated meloxicam and hydrocodone | |
| CL2008001238A1 (en) | Isolated anti-receptor antagonist antibody grig / pro362 / jam4 / stigma murine with deposit number atcc pat-8298; pharmaceutical composition; medical use to inhibit the complement-dependent cellulst entry mediated by crig of an intracellular pathogen (pi), or to prevent or treat an infection disease mediated by a pi | |
| CL2008003811A1 (en) | 4-aminopyrimidine-2,6-disubstituted derivative compounds, histamine h4 receptor antagonists; Preparation process; pharmaceutical composition comprising said compound; and use of the compound for the treatment of an allergic, immunological or inflammatory disease, or pain. | |
| MX2010001574A (en) | Cannabinoid receptor ligands. | |
| CL2004000545A1 (en) | USE OF AN ANTAGONIST OF ALDOSTERONE RECEPTORS AND AN ENDOTHELINE RECEIVER ANTAGONIST FOR THE TREATMENT OR PROFILAXIS OF A PATHOLOGICAL CONDITION RELATED TO HYPERTENSION, RENAL DYSFUNCTION, INSULINOPATHY AND CARDIOVASCUL DISEASES | |
| CY1114933T1 (en) | STRONG POWERFUL MEDICINAL COMPOSITIONS CONTAINING IRESARTARTAN AND AMLODIPIN, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION | |
| CL2008003266A1 (en) | Compounds derived from cycloguanidine substituted pyrimidinedione and triazinedione, useful as a prokineticin receptor antagonist; pharmaceutical composition comprising said compounds; and use in the treatment of gastrointestinal diseases. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal | ||
| FB | Suspension of granting procedure |