MX2015002170A - Novel pharmaceutical compositions useful for treating hypertension. - Google Patents
Novel pharmaceutical compositions useful for treating hypertension.Info
- Publication number
- MX2015002170A MX2015002170A MX2015002170A MX2015002170A MX2015002170A MX 2015002170 A MX2015002170 A MX 2015002170A MX 2015002170 A MX2015002170 A MX 2015002170A MX 2015002170 A MX2015002170 A MX 2015002170A MX 2015002170 A MX2015002170 A MX 2015002170A
- Authority
- MX
- Mexico
- Prior art keywords
- pharmaceutical compositions
- novel pharmaceutical
- eprosartan
- active ingredients
- lercanidipine
- Prior art date
Links
- 206010020772 Hypertension Diseases 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 239000002080 C09CA02 - Eprosartan Substances 0.000 abstract 2
- JZUFKLXOESDKRF-UHFFFAOYSA-N Chlorothiazide Chemical compound C1=C(Cl)C(S(=O)(=O)N)=CC2=C1NCNS2(=O)=O JZUFKLXOESDKRF-UHFFFAOYSA-N 0.000 abstract 2
- 239000004480 active ingredient Substances 0.000 abstract 2
- OROAFUQRIXKEMV-LDADJPATSA-N eprosartan Chemical compound C=1C=C(C(O)=O)C=CC=1CN1C(CCCC)=NC=C1\C=C(C(O)=O)/CC1=CC=CS1 OROAFUQRIXKEMV-LDADJPATSA-N 0.000 abstract 2
- 229960004563 eprosartan Drugs 0.000 abstract 2
- 229960002003 hydrochlorothiazide Drugs 0.000 abstract 2
- ZDXUKAKRHYTAKV-UHFFFAOYSA-N lercanidipine Chemical compound COC(=O)C1=C(C)NC(C)=C(C(=O)OC(C)(C)CN(C)CCC(C=2C=CC=CC=2)C=2C=CC=CC=2)C1C1=CC=CC([N+]([O-])=O)=C1 ZDXUKAKRHYTAKV-UHFFFAOYSA-N 0.000 abstract 2
- 229960004294 lercanidipine Drugs 0.000 abstract 2
- 102000001838 Angiotensin II receptor type 1 Human genes 0.000 abstract 1
- 108050009086 Angiotensin II receptor type 1 Proteins 0.000 abstract 1
- 229940127291 Calcium channel antagonist Drugs 0.000 abstract 1
- 230000002411 adverse Effects 0.000 abstract 1
- 239000000480 calcium channel blocker Substances 0.000 abstract 1
- 239000002775 capsule Substances 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 239000002934 diuretic Substances 0.000 abstract 1
- 230000001882 diuretic effect Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000037406 food intake Effects 0.000 abstract 1
- 239000005555 hypertensive agent Substances 0.000 abstract 1
- 230000001631 hypertensive effect Effects 0.000 abstract 1
- 239000012729 immediate-release (IR) formulation Substances 0.000 abstract 1
- 238000001990 intravenous administration Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000000843 powder Substances 0.000 abstract 1
- 239000000725 suspension Substances 0.000 abstract 1
- 239000007939 sustained release tablet Substances 0.000 abstract 1
- 239000003826 tablet Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
The invention relates to novel pharmaceutical compositions for treating patients with hypertension, which use, as active ingredients, the second-generation angiotensin II receptor type 1 blocker eprosartan combined with the third-generation calcium antagonist lercanidipine and the diuretic hydrochlorothiazide. These active ingredients, eprosartan, lercanidipine and hydrochlorothiazide, have proven, as single agents, to be more effective and to have less adverse effects and an increased tolerance compared to other, commercially available, hypertensives. The combinations are produced in the form of immediate-release and sustained-release tablets, as well as powders for a suspension, the latter composition being useful for certain states of patients whose physical state does not allow the ingestion of tablets or capsules and an intravenous injectable form has been developed for cases where immediate bioavailability is required.
Priority Applications (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| MX2015002170A MX2015002170A (en) | 2015-02-18 | 2015-02-18 | Novel pharmaceutical compositions useful for treating hypertension. |
| PCT/IB2015/059752 WO2016132193A1 (en) | 2015-02-18 | 2015-12-17 | Pharmaceutical composition comprising hydrochlorothiazide, eprosartan and lercanidipine, useful for treating hypertension |
| ARP160100395A AR103679A1 (en) | 2015-02-18 | 2016-02-12 | PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF HYPERTENSION |
| UY0001036556A UY36556A (en) | 2015-02-18 | 2016-02-16 | NEW PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF HYPERTENSION |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| MX2015002170A MX2015002170A (en) | 2015-02-18 | 2015-02-18 | Novel pharmaceutical compositions useful for treating hypertension. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2015002170A true MX2015002170A (en) | 2016-08-17 |
Family
ID=56692112
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2015002170A MX2015002170A (en) | 2015-02-18 | 2015-02-18 | Novel pharmaceutical compositions useful for treating hypertension. |
Country Status (4)
| Country | Link |
|---|---|
| AR (1) | AR103679A1 (en) |
| MX (1) | MX2015002170A (en) |
| UY (1) | UY36556A (en) |
| WO (1) | WO2016132193A1 (en) |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR043395A1 (en) * | 2003-02-28 | 2005-07-27 | Recordati Ireland Ltd | COMBINATION THERAPY FOR HYPERTENSION USING LERCANIDIPINE AND A BLOCKER OF ANGIOTENSIN II RECEPTORS |
-
2015
- 2015-02-18 MX MX2015002170A patent/MX2015002170A/en unknown
- 2015-12-17 WO PCT/IB2015/059752 patent/WO2016132193A1/en not_active Ceased
-
2016
- 2016-02-12 AR ARP160100395A patent/AR103679A1/en unknown
- 2016-02-16 UY UY0001036556A patent/UY36556A/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| AR103679A1 (en) | 2017-05-24 |
| WO2016132193A1 (en) | 2016-08-25 |
| UY36556A (en) | 2016-09-30 |
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