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AR036812A1 - Inhibidores de la 17beta-hidroxiesteroide deshidrogenasa tipo 3, composiciones farmaceuticas y el uso de dichos compuestos para la fabricacion de medicamentos para el tratamiento de enfermedades androgeno-dependientes - Google Patents

Inhibidores de la 17beta-hidroxiesteroide deshidrogenasa tipo 3, composiciones farmaceuticas y el uso de dichos compuestos para la fabricacion de medicamentos para el tratamiento de enfermedades androgeno-dependientes

Info

Publication number
AR036812A1
AR036812A1 ARP020103851A ARP020103851A AR036812A1 AR 036812 A1 AR036812 A1 AR 036812A1 AR P020103851 A ARP020103851 A AR P020103851A AR P020103851 A ARP020103851 A AR P020103851A AR 036812 A1 AR036812 A1 AR 036812A1
Authority
AR
Argentina
Prior art keywords
group
alkyl
aryl
heteroaryl
heteroarylalkyl
Prior art date
Application number
ARP020103851A
Other languages
English (en)
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of AR036812A1 publication Critical patent/AR036812A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/28—Antiandrogens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Diabetes (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Inhibidores de la 17beta-hidroxiesteroide deshidrogenasa tipo 3 de la fórmula (1), una de sus prodrogas, o una de las sales o solvatos aceptables para uso farmacéutico del compuesto o de la prodroga, en la cual, R1 se selecciona del grupo conformado por arilo, heteroarilo, arilalquilo, heteroarilalquilo y difenilalquilo, cada uno sustituido en forma opcional con 1 a 6 grupos seleccionados del grupo conformado por: halógeno, -OCF3 u -OCHF2, -CF3, -CN, alquilo o R18-alquilo, heteroalquilo o R18-heteroalquilo, arilo o R18-arilo, heteroarilo o R18-heteroarilo, arilalquilo o R18-arilalquilo, heteroarilalquilo o R18-heteroarilalquilo, hidroxi, alcoxi, ariloxi, -SO2-alquilo, -NR11R12, -N(R11)C(O)R13, metilendioxi, difluorometilendioxi, trifluoroalcoxi, -SCH3 ó -SCF3, y -SO2CF3 ó -NHSO2CF3; R2 y R3 se seleccionan, cada uno en forma independiente, del grupo conformado por: H, -OH, alcoxi, alquilo, cicloalquilo, heterocicloalquilo, cicloalquilalquilo, trifluoroalquilo, heteroalquilo, arilalquilo, heteroarilalquilo, arilalcoxi, heteroarilalcoxi, -(CH2)n-NR11R12 y -(CH2)n-SR11, con la salvedad de que cuando X es N, entonces R2 y R3 no sean, cada uno, -OH, alcoxi, arilalcoxi ó heteroarilalcoxi; R4, R5, R7 y R8 se seleccionan, cada uno en forma independiente, del grupo conformado por: H, -OR14, -NR11R12, -N(R11)C(O)R13, alquilo, arilo, cicloalquilo, arilalquilo, heteroalquilo, heteroarilo, heteroarilalquilo, heterocicloalquilo, fórmulas (2), (3) y (4), con la salvedad de que cuando Z y/o X son N, entonces R4, R5, R7 y R8 no sean, cada uno, -OR14, -NR11R12, ó -N(R11)C(O)R13; R6 se selecciona del grupo conformado por -C(O)R15 y -SO2R15; R9 y R10 se seleccionan, cada uno en forma independiente, del grupo conformado por: H, F, -CF3, -CHF2, alquilo, cicloalquilo, arilalquilo, heteroalquilo, heteroarilalquilo, heterocicloalquilo, hidroxi, alcoxi, ariloxi, -NR11R12 y -N(R11)C(O)R13 con la salvedad de que cuando Z es N, entonces R9 y R10 no sean, cada uno, F, hidroxi, alcoxi, ariloxi, -NR11R12 ó -N(R11)C(O)R13; R11 se selecciona del grupo conformado por H, alquilo, arilo y heteroarilo; R12 se selecciona del grupo conformado por H, alquilo, arilo y heteroarilo; R13 se selecciona del grupo conformado por alquilo, alcoxi y ariloxi; R14 se selecciona del grupo conformado por H, alquilo, arilo y heteroarilo; R15 se selecciona del grupo conformado por: -NR16R17, -OR16, alquilo, cicloalquilo, heterocicloalquilo, arilo, arilalquilo y heteroarilalquilo, cada uno sustituido en forma opcional con R18; R16 y R17 se seleccionan, cada uno en forma independiente, del grupo conformado por: alquilo, arilo, arilalquilo, heteroalquilo, y heteroarilo, cada uno sustituido en forma opcional con R18, y H, con la salvedad de que cuando R15 es -OR16, entonces R16 no sea H; R18 tiene de 1 a 4 sustituyentes cada uno seleccionado en forma independiente del grupo conformado por: alquilo inferior, halo, ciano, nitro, haloalquilo, hidroxi, alcoxi, carboxi, carboxialquilo, carboxamida, mercapto, amino, alquilamino, dialquilamino, sulfonilo, sulfonamido, arilo y heteroarilo; X y Z se seleccionan, cada uno en forma independiente del grupo conformado por C y N; y n es 1-4; que son útiles como inhibidores de 17beta-hidroxiesteroide deshidrogenasa tipo 3: Se describen, además, composiciones farmacéuticas que contienen dichos compuestos y uso para la fabricación de medicamentos para el tratamiento o la prevención de enfermedades andrógeno-dependientes.
ARP020103851A 2001-10-17 2002-10-15 Inhibidores de la 17beta-hidroxiesteroide deshidrogenasa tipo 3, composiciones farmaceuticas y el uso de dichos compuestos para la fabricacion de medicamentos para el tratamiento de enfermedades androgeno-dependientes AR036812A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US33006601P 2001-10-17 2001-10-17

Publications (1)

Publication Number Publication Date
AR036812A1 true AR036812A1 (es) 2004-10-06

Family

ID=23288179

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP020103851A AR036812A1 (es) 2001-10-17 2002-10-15 Inhibidores de la 17beta-hidroxiesteroide deshidrogenasa tipo 3, composiciones farmaceuticas y el uso de dichos compuestos para la fabricacion de medicamentos para el tratamiento de enfermedades androgeno-dependientes

Country Status (12)

Country Link
US (1) US6969718B2 (es)
EP (1) EP1436281B1 (es)
JP (1) JP4309761B2 (es)
CN (1) CN1571782A (es)
AR (1) AR036812A1 (es)
AT (1) ATE471315T1 (es)
CA (1) CA2463626C (es)
DE (1) DE60236743D1 (es)
ES (1) ES2347643T3 (es)
MX (1) MXPA04003611A (es)
PE (1) PE20030705A1 (es)
WO (1) WO2003033487A1 (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4614770B2 (ja) * 2002-11-18 2011-01-19 シェーリング コーポレイション アンドロゲン依存性疾患を処置するための１７β−ヒドロキシステロイドデヒドロゲナーゼタイプ３インヒビター
AU2003293555A1 (en) 2002-12-17 2004-07-29 Schering Corporation 17 beta-hydroxysteroid dehydrogenase type 3 inhibitors for the treatment of androgen dependent diseases
GB0314733D0 (en) * 2003-06-24 2003-07-30 Glaxo Group Ltd Medicaments
US20050153976A1 (en) * 2003-12-17 2005-07-14 Schering Corporation Pharmaceutical compositions
US7365075B2 (en) * 2003-12-22 2008-04-29 Amgen Inc. Aryl sulfonamide compounds and uses related thereto
GB0513702D0 (en) 2005-07-04 2005-08-10 Sterix Ltd Compound
CA2606004A1 (en) * 2005-08-02 2007-02-08 Neurogen Corporation Dipiperazinyl ketones and related analogues
US8080540B2 (en) 2006-09-19 2011-12-20 Abbott Products Gmbh Therapeutically active triazoles and their use
US8288367B2 (en) 2006-11-30 2012-10-16 Solvay Pharmaceuticals Gmbh Substituted estratriene derivatives as 17BETA HSD inhibitors
TW201512215A (zh) 2013-06-25 2015-04-01 Forendo Pharma Ltd 治療活性雌三烯噻唑衍生物
AR096727A1 (es) 2013-06-25 2016-01-27 Forendo Pharma Ltd Derivados terapéuticamente activos de estratrien-tiazol
MX2015017879A (es) 2013-06-25 2017-03-01 Forendo Pharma Ltd Derivados de estratrientiazol 17-nitrogeno substitutidos terapeuticamente activos como inhibidores de 17.beta-hidroxiestero ide deshidrogenasa.
JP6545266B2 (ja) 2014-12-23 2019-07-17 フォレンド ファーマ リミテッド １７β‐ＨＳＤ１抑制剤のプロドラッグ
EP3237431B1 (en) 2014-12-23 2019-03-20 Forendo Pharma Ltd Prodrugs of 17.beta.-hsd1 -inhibitors
DK3634975T3 (da) 2017-06-08 2024-05-27 Organon R&D Finland Ltd 17-oximer af 15.beta.-[3-propanamido]-substituerede estra-1,3,5(10)-trien-17-oner til anvendelse i inhibition af 17.beta.-hydroxysteroid-dehydrogenaser
MA51139A (fr) * 2017-12-15 2020-10-21 Inthera Bioscience AG Dérivés de 1-(pipéridinocarbonylméthyl)-2-oxopipérazine pour le traitement du cancer
EP3891167B1 (en) 2018-12-05 2024-11-13 Organon R&D Finland Oy Estra-1,3,5(10)-triene compounds condensed in position 16(17) with a pyrazole ring as inhibitors of 17-hsd1

Family Cites Families (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3576810A (en) * 1968-06-20 1971-04-27 Robins Co Inc A H 1-substituted-3-(-4)-aroylpiperidines
DE2304154A1 (de) * 1973-01-29 1974-08-01 Ichthyol Ges Cordes Hermanni & Verfahren zur herstellung von substituierten piperazin- bzw. homopiperazinderivaten
DE2304153A1 (de) * 1973-01-29 1974-08-01 Ichthyol Ges Cordes Hermanni & Substituierte piperazin- und homopiperazinderivate
WO1986001105A1 (en) 1984-08-02 1986-02-27 Fernand Labrie Pharmaceutical composition for combination therapy of hormone dependent cancers
EP0462189B1 (en) 1989-03-10 1995-09-27 Endorecherche Inc. Combination therapy for treatment of estrogen sensitive diseases
ATE269066T1 (de) 1989-07-07 2004-07-15 Endorech Inc Kombinationstherapie zur prophylaxe und/oder behandlung von gutartiger prostatischer hyperplasie
ATE230994T1 (de) 1989-07-07 2003-02-15 Endorech Inc Methode zur behandlung androgenbedingter krankheiten
IL99320A (en) * 1990-09-05 1995-07-31 Sanofi Sa Arylalkylamines, their preparation and pharmaceutical compositions containing them
WO1992006971A1 (en) * 1990-10-10 1992-04-30 Schering Corporation Pyridine and pyridine n-oxide derivatives of diaryl methyl piperidines or piperazines, and compositions and methods of use thereof
US6060503A (en) 1991-12-02 2000-05-09 Endorecherche, Inc. Benzopyran-containing compounds and method for their use
ATE140224T1 (de) * 1992-03-27 1996-07-15 Schering Corp Unverbrückte bis-aryl-carbinol-derivate, zusammensetzungen und ihre verwendung
WO1994010165A1 (en) 1992-10-28 1994-05-11 Merck Sharp & Dohme Limited 4-arylmethyloxymethyl piperidines as tachykinin antagonists
US5661162A (en) 1992-12-14 1997-08-26 Merck Sharp & Dohme Limited 4-aminomethyl/thiomethyl/sulfonylmethyl-4-phenylpiperdines as tachykinin receptor antagonists
JP2741286B2 (ja) 1993-05-17 1998-04-15 アンドルシェルシュ・インコーポレイテッド 改良された抗アンドロゲン
JPH08511522A (ja) 1993-06-07 1996-12-03 メルク エンド カンパニー インコーポレーテッド ニューロキニンアンタゴニストとしてのスピロ置換アザ環
IL111730A (en) * 1993-11-29 1998-12-06 Fujisawa Pharmaceutical Co Piperazine derivatives processes for the preparation thereof and pharmaceutical compositions containing the same
DE69504300T2 (de) * 1994-01-13 1999-04-29 Merck Sharp & Dohme Ltd., Hoddesdon, Hertfordshire Gem-bissubstituierte azazyclische tachykinin-antagonisten
ATE242231T1 (de) * 1995-04-07 2003-06-15 Schering Corp Carbonyl-piperaznyl und piperidinyl derivate zur hemmung farnesyl protein transferase
US5688960A (en) * 1995-05-02 1997-11-18 Schering Corporation Substituted oximes, hydrazones and olefins useful as neurokinin antagonists
US5696267A (en) * 1995-05-02 1997-12-09 Schering Corporation Substituted oximes, hydrazones and olefins as neurokinin antagonists
US5719156A (en) * 1995-05-02 1998-02-17 Schering Corporation Piperazino derivatives as neurokinin antagonists
US5795894A (en) * 1995-05-02 1998-08-18 Schering Corporation Piperazino derivatives as neurokinn antagonists
US5654316A (en) * 1995-06-06 1997-08-05 Schering Corporation Piperidine derivatives as neurokinin antagonists
US5892039A (en) * 1995-08-31 1999-04-06 Schering Corporation Piperazino derivatives as neurokinin antagonists
US6124115A (en) 1995-09-22 2000-09-26 Endorecherche Inc. Production and use of isolated type 5 17β-hydroxysteroid dehydrogenase
DE19614204A1 (de) * 1996-04-10 1997-10-16 Thomae Gmbh Dr K Carbonsäurederivate, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung
US5691362A (en) * 1996-06-05 1997-11-25 Schering-Plough Corporation Substituted benzene-fused hetero- and carbocyclics as nuerokinin antagonists
US5789422A (en) * 1996-10-28 1998-08-04 Schering Corporation Substituted arylalkylamines as neurokinin antagonists
US5968929A (en) * 1996-10-30 1999-10-19 Schering Corporation Piperazino derivatives as neurokinin antagonists
US5945428A (en) * 1996-11-01 1999-08-31 Schering Corporation Substituted oximes, hydrazones and olefins as neurokinin antagonists
US5783579A (en) * 1996-12-20 1998-07-21 Schering Corporation Spiro-substituted azacyclic-substituted piperazino derivatives as neurokinin antagonists
US6063926A (en) * 1998-11-18 2000-05-16 Schering Corporation Substituted oximes as neurokinin antagonists
ATE299140T1 (de) * 1998-12-23 2005-07-15 Schering Corp Farnesyl-protein transferase inhibitoren
US6204265B1 (en) * 1998-12-23 2001-03-20 Schering Corporation Substituted oximes and hydrazones as neurokinin antagonists
EP1146873B1 (en) 1999-01-25 2005-03-16 Smithkline Beecham Corporation Anti-androgens and methods for treating disease
AU1413301A (en) * 1999-11-17 2001-05-30 Sumitomo Pharmaceuticals Company, Limited Diabetic remedy containing dipiperazine derivative
AR036492A1 (es) * 2001-09-06 2004-09-15 Schering Corp Inhibidores de la 17beta-hidroxiesteroide deshidrogenasa tipo 3, composiciones farmaceuticas y el uso de dichos inhibidores para la elaboracion de un medicamento para el tratamiento de enfermedades androgeno dependientes

Also Published As

Publication number Publication date
ATE471315T1 (de) 2010-07-15
CA2463626A1 (en) 2003-04-24
JP2005506356A (ja) 2005-03-03
DE60236743D1 (de) 2010-07-29
MXPA04003611A (es) 2004-07-30
CN1571782A (zh) 2005-01-26
EP1436281B1 (en) 2010-06-16
ES2347643T3 (es) 2010-11-03
JP4309761B2 (ja) 2009-08-05
US20030232837A1 (en) 2003-12-18
EP1436281A1 (en) 2004-07-14
PE20030705A1 (es) 2003-08-21
CA2463626C (en) 2011-05-24
WO2003033487A1 (en) 2003-04-24
US6969718B2 (en) 2005-11-29

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